Untangling the Roles of Selection and Demography in Shaping mitochondrial DNA Evolution

Lead Research Organisation: Newcastle University
Department Name: Institute of Neuroscience


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Description RCUK Fellowship
Amount £150,000 (GBP)
Organisation Research Councils UK (RCUK) 
Sector Public
Country United Kingdom
Start 03/2006 
End 02/2011
Title mitochondrial LOVD database 
Description Buikding a locus specfic database to better understand variation on human mtDNA. 
Type Of Material Database/Collection of Data/Biological Samples 
Provided To Others? No  
Impact In development phase. Working with mitiochondrial groupo at UCL in the first instance. Plans to work with other groups in europe and get EU funding. 
Description MitoKor 
Organisation MitoKor
Country United States 
Sector Private 
PI Contribution I carried data analysis on large database looking at wheather the mitochondrial genome play a role in the etiology of Alzheimer's disease post 2006 - resulting in a publication.
Collaborator Contribution Hunderds of mitochondrial genome sequences - at a time when this was very expensive to produce
Impact There where a number of publications pre-2006 during the time when I was funded by the MRC which tackled the question in my grant application of 2002. Post my MRC funding this collaboration produced more papers using the principles learnt to disease 16408223
Description mtDNA selection and inheritance 
Organisation Karolinska Institute
Department Division of Metabolic Diseases
Country Sweden 
Sector Academic/University 
PI Contribution analysis of data
Collaborator Contribution To use lots of excellent data. I was brought in to apply what I had learnt during my MRC fellowship.
Impact publications listed in. Strong purifying selection in transmission of mammalian mitochondrial DNA. Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease.
Start Year 2007
Description patient infromation evening 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Participants in your research and patient groups
Results and Impact Patients attend an evening hear talks find out a more about mitochondrial disease and the work of the research group.

Events also used to get support for activities such as the quality of life questionnaire.
Year(s) Of Engagement Activity 2006,2007,2008,2009