Structural studies on biological regulatory mechanisms

Lead Research Organisation: University of Oxford
Department Name: Biochemistry


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Lowe ED (2006) Structures of the Dsk2 UBL and UBA domains and their complex. in Acta crystallographica. Section D, Biological crystallography

Description MRC Co-operative Group Grant
Amount £63,406 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Description Collaboration on polo-like kinase 
Organisation Max Planck Society
Department Max Planck Institute of Biochemistry
Country Germany 
Sector Public 
PI Contribution LNJ: Structural studies on polo-like kinase; EN supply of cDNA and discussions on role of plk1 incells
Collaborator Contribution Our collaborator provided cDNA for polo-like kinase (Plk1) and provided input for discussions o cellular significance of the enzyme
Impact The crystal structure of the polo box domain (Cheng et al EMBO J. 2006. See eval report for grant G400957
Description Development of protein kinase inhibitors 
Organisation Newcastle University
Country United Kingdom 
Sector Academic/University 
PI Contribution as described above
Collaborator Contribution Collaborations with colleagues at the University of Newcastle led to a programme for CDK inhibitors in which the Newcastle groups provided synthetic organic chemistry and cellular studies and the Oxford group structural studies
Impact Several publications listed in collaborators reports
Description Structural studies on cell cycle proteins 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution As above. Collaborations were with other MRC funded colleagues and further details will be added on their eval reports.
Collaborator Contribution Frequent experimental collaborations and dicsussions that led to a joint MRC appplication for both project grant and Co-operative grant
Impact New grant applications and several joint publications (see later)
Description kinetic studies on protein kinases and protein kinase inhibitors 
Organisation National Hellenic Research Foundation (NHRF)
Country Greece 
Sector Public 
PI Contribution As above
Collaborator Contribution Collaboration with colleagues in Greece contributed substantially to understanding the kinetic properties of the kinases and led to several publications prior to 2006. (This MRC grant ended 30.6.2006)
Impact several publications prior to 2006
Description Julia Bodmer Memorial lecture, Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact A lecture to a general audience on structural biology

Year(s) Of Engagement Activity 2006
Description School visit Magdalen School Oxford 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Presented lecture on use of synchrotron radiation and Diamond Light Source

Year(s) Of Engagement Activity 2006