Linking structure and function in the normal and in the disease human brain
Lead Research Organisation:
University of Oxford
Department Name: Medical Sciences Division
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
Publications
Suri S
(2015)
Reduced cerebrovascular reactivity in young adults carrying the APOE e4 allele.
in Alzheimer's & dementia : the journal of the Alzheimer's Association
Schmidt R
(2005)
White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study.
in Annals of neurology
Enzinger C
(2004)
Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4.
in Annals of neurology
Zarei M
(2011)
Changes in gray matter volume and white matter microstructure in adolescents with obsessive-compulsive disorder.
in Biological psychiatry
Bhagwagar Z
(2007)
Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects.
in Biological psychiatry
James A
(2011)
Structural brain and neuropsychometric changes associated with pediatric bipolar disorder with psychosis.
in Bipolar disorders
Ciccarelli O
(2006)
Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis.
in Brain : a journal of neurology
Cader S
(2006)
Reduced brain functional reserve and altered functional connectivity in patients with multiple sclerosis.
in Brain : a journal of neurology
Matthews PM
(2015)
The UK Biobank.
in Brain : a journal of neurology
Douaud G
(2007)
Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia.
in Brain : a journal of neurology
| Description | Public consultation roll out of participant involvement in research- MRC/WT sponsorted |
| Geographic Reach | National |
| Policy Influence Type | Participation in a advisory committee |
| Impact | Changes in perception of clinical trials |
| Description | Centre for Mathematics of Precision Healthcare |
| Amount | £1,899,999 (GBP) |
| Funding ID | EP/N014529/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 09/2019 |
| Description | Dementias Platform |
| Amount | £4,500,000 (GBP) |
| Funding ID | MR/L023784/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2014 |
| End | 03/2019 |
| Description | MRC Experimental Medicine |
| Amount | £897,903 (GBP) |
| Funding ID | MR/N026934/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2019 |
| Description | MS Society Project grant |
| Amount | £175,000 (GBP) |
| Organisation | Multiple Sclerosis Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2003 |
| End | 03/2006 |
| Description | OPTIMISE |
| Amount | € 725,000 (EUR) |
| Organisation | Biogen |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2014 |
| End | 08/2017 |
| Description | Pilot Grant |
| Amount | € 74,995 (EUR) |
| Organisation | International Progressive MS Alliance |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 07/2015 |
| Description | Pilot Grant |
| Amount | £75,000 (GBP) |
| Organisation | Multiple Sclerosis Society |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 06/2016 |
| Description | Senior Investigator Award |
| Amount | £450,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Biomedical Research Centre |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 02/2020 |
| Description | WT-GSK Clinical Training Fellowships |
| Amount | £2,750,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2008 |
| End | 08/2017 |
| Title | FSL |
| Description | On line software analysis |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Widespread academic and pharmaceutical use |
| Description | Austrian Stroke Study |
| Organisation | Medical University of Graz |
| Department | Department of Neurology |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Advanced analysis support; mentorship for trainees; interpretative framework |
| Collaborator Contribution | Data. fellow for analysis |
| Impact | Publications |
| Description | FMRIB Centre Oxford |
| Organisation | John Radcliffe Hospital |
| Department | Centre for Functional MRI of the Brain (fMRI) |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Collaborative supervision of fellows and research |
| Collaborator Contribution | Collaborative research, support for fellows and students, research environment |
| Impact | Papers since 2006 with FMRIB coauthors |
| Description | Stroke adaptive plasticity |
| Organisation | GlaxoSmithKline (GSK) |
| Department | Neurology and GI Centre of Excellence for Drug Discovery (CEDD) GSK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Proposed extenstion of current work as paradigm for evaluation of new drug targeting plasticity |
| Collaborator Contribution | Provision of leadership, target objectives |
| Impact | Publications |
| Start Year | 2006 |
| Description | UK Biobank |
| Organisation | UK Biobank |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Expert input as member of steering committee and chair of working group |
| Collaborator Contribution | Organisational structure and expertise |
| Impact | Open access to database 2013 Publications describing Imaging Enhancment Successful funding for imaging enhancement and set up of new centre |
| Start Year | 2008 |
| Description | Univ of Siena |
| Organisation | University of Siena |
| Department | Clinical Neurosciences |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Research training, software, guidance for new problems |
| Collaborator Contribution | Data, research support |
| Impact | Publications, support for R and D in GlaxoSmith Kline |
| Start Year | 2006 |
| Title | GlaxoSmithKline Early Development |
| Description | Over last 5 years, research and group have contributed to development of more than 18 different molecules in early development (see letter from Dr. Phil Murphy in 2013 REF submission). Here these contributions all have been "lumped" into a single entry |
| Type | Therapeutic Intervention - Drug |
| Current Stage Of Development | Early clinical assessment |
| Year Development Stage Completed | 2013 |
| Development Status | Actively seeking support |
| Impact | reducing costs for commercial development, increased competitiveness of UK environment |
| Description | Bard |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Wrote popular book to highlight brain research- "Bard on the Brain". Follow up lectures. Led to creation of Oxford Centre for the Creative Brain Multiple public presentation requests inUK, Europe and US |
| Year(s) Of Engagement Activity | 2006,2009,2015 |
| Description | Consortium of MS Centers Annual Meeting, Montreal |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Health professionals |
| Results and Impact | Consortium of MS Centers Annual Meeting, Montreal, Canada 1 June 2011 - Lessons from brain plasticity in multiple sclerosis Improved understanding for better care management especially by nurses |
| Year(s) Of Engagement Activity | 2011 |
| Description | European Dana Alliance |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Public lectures Contact for followup book |
| Year(s) Of Engagement Activity | 2006,2007,2008 |
| Description | London Health Forum |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | 2013 London Health Forum, Korean Healthcare IDI, London, May 2013 - Opportunities for International Collaborative Healthcare Science Commercial engagement with UK academic base |
| Year(s) Of Engagement Activity | 2013 |
| Description | U3A Annual Conference |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | U3A Annual Conference, East Grinstead, UK - Healthy brain aging Better informed lay audience |
| Year(s) Of Engagement Activity | 2013 |