Host determinants of malaria immunity and pathogenesis
Lead Research Organisation:
University of Oxford
Department Name: Wellcome Trust Centre for Human Genetics
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- University of Oxford, United Kingdom (Lead Research Organisation)
- Addis Ababa University, Ethiopia (Collaboration)
- Pasteur Institute of Madagascar (Collaboration)
- University of Bamako (Collaboration)
- The Wellcome Trust Sanger Institute (Collaboration)
- Kenyan Institute for Medical Research (KEMRI) (Collaboration)
- University of Buea, Cameroon (Collaboration)
- Medical Research Council (Collaboration)
People |
ORCID iD |
| Dominic Peter Kwiatkowski (Principal Investigator) |
Publications
Martin-Peprah R
(2006)
Investigation of familial segregation of hyperreactive malarial splenomegaly in Kumasi, Ghana.
in Transactions of the Royal Society of Tropical Medicine and Hygiene
Fry AE
(2006)
Haplotype homozygosity and derived alleles in the human genome.
in American journal of human genetics
Hanchard NA
(2006)
Screening for recently selected alleles by analysis of human haplotype similarity.
in American journal of human genetics
Hanchard N
(2006)
Implications of inter-population linkage disequilibrium patterns on the approach to a disease association study in the human MHC class III.
in Immunogenetics
Hanchard N
(2006)
An investigation of transmission ratio distortion in the central region of the human MHC.
in Genes and immunity
Forton JT
(2006)
Searching for the regulators of human gene expression.
in BioEssays : news and reviews in molecular, cellular and developmental biology
Taylor T
(2006)
Standardized data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network.
in Transactions of the Royal Society of Tropical Medicine and Hygiene
Forton JT
(2007)
Localization of a long-range cis-regulatory element of IL13 by allelic transcript ratio mapping.
in Genome research
| Description | PAMGEM |
| Organisation | Addis Ababa University |
| Country | Ethiopia |
| Sector | Academic/University |
| PI Contribution | The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through web interfaces. |
| Collaborator Contribution | PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa. |
| Impact | The partnership has resulted in funding of $3m for PAMGEM. |
| Start Year | 2017 |
| Description | PAMGEM |
| Organisation | Kenyan Institute for Medical Research (KEMRI) |
| Country | Kenya |
| Sector | Public |
| PI Contribution | The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through web interfaces. |
| Collaborator Contribution | PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa. |
| Impact | The partnership has resulted in funding of $3m for PAMGEM. |
| Start Year | 2017 |
| Description | PAMGEM |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Unit, The Gambia |
| Country | Gambia |
| Sector | Public |
| PI Contribution | The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through web interfaces. |
| Collaborator Contribution | PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa. |
| Impact | The partnership has resulted in funding of $3m for PAMGEM. |
| Start Year | 2017 |
| Description | PAMGEM |
| Organisation | Pasteur Institute of Madagascar |
| Country | Madagascar |
| Sector | Academic/University |
| PI Contribution | The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through web interfaces. |
| Collaborator Contribution | PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa. |
| Impact | The partnership has resulted in funding of $3m for PAMGEM. |
| Start Year | 2017 |
| Description | PAMGEM |
| Organisation | The Wellcome Trust Sanger Institute |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through web interfaces. |
| Collaborator Contribution | PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa. |
| Impact | The partnership has resulted in funding of $3m for PAMGEM. |
| Start Year | 2017 |
| Description | PAMGEM |
| Organisation | University of Bamako |
| Department | Malaria Research and Training Centre (MRTC) Bamako |
| Country | Mali |
| Sector | Academic/University |
| PI Contribution | The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through web interfaces. |
| Collaborator Contribution | PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa. |
| Impact | The partnership has resulted in funding of $3m for PAMGEM. |
| Start Year | 2017 |
| Description | PAMGEM |
| Organisation | University of Buea |
| Country | Cameroon |
| Sector | Academic/University |
| PI Contribution | The Pan-African Malaria Genetic Epidemiology Network (PAMGEN) is a robust network of African scientists - within and outside Africa- working in collaboration with leading researchers around the world, to use the latest genetics and genomics science to contribute towards efforts at malaria elimination in Africa. We are supporting this initiative in various ways and our overarching goal is to support this team of African scientists to harness advanced genomic and computational technologies to better understand how variation in human, parasite and mosquito genomes, as well as in the ecological environment, impact on malaria at individuals and population level. This will involve supporting the establishment of an appropriate governance structure and project management support, technical support for genotyping and genome sequencing in country, data management and processing and the visualisation of their data through web interfaces. |
| Collaborator Contribution | PAMGEM will be led by African scientists, placing them at the centre of international research efforts to find sustainable ways to drive down the huge burden of malaria in Africa. Specifically, they will focus on the genetic interactions between human populations and malaria parasites in different environmental settings across Africa. |
| Impact | The partnership has resulted in funding of $3m for PAMGEM. |
| Start Year | 2017 |