European Collaborative Study on HIV infection in women and children

Lead Research Organisation: University College London
Department Name: Unlisted

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Collaboration Of Observational HIV Epidemiological Research Europe (COHERE) Study Group (2008) Response to combination antiretroviral therapy: variation by age. in AIDS (London, England)

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European Collaborative Study (2007) Time to undetectable viral load after highly active antiretroviral therapy initiation among HIV-infected pregnant women. in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

 
Guideline Title British HIV Association and Children's HIV Association guidelines for the management of HIV infection in pregnant women 2008
Description BHIVA Pregnancy
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
Impact Therapeutic and obstetric management of pregnant HIV-infected women
 
Guideline Title PENTA guidelines for the use of antiretroviral therapy in paediatric infection
Description PENTA guidelines
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
Impact when to start treatment in children with HIV; therapeutic managment
 
Description Prendergast A et al. International perspectives, progress, and future challenges of paediatric HIV infection, Lancet 2007 http://dx.doi.org/10.1016/S0140-6736(07)61051-4
Geographic Reach National 
Policy Influence Type Citation in clinical reviews
Impact Widely disseminated clinical review on HIV infection in children and its prevention
URL http://dx.doi.org/10.1016/S0140-6736(07)61051-4
 
Guideline Title Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV Transmission in the United States
Description US Pregnancy
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact Therapeutic management of HIV-infected pregnant women
URL http://aidsinfo.nih.gov/contentfiles/lvguidelines/perinatalgl.pdf
 
Guideline Title WHO Europe Clinical
Description WHO Europe pregnancy
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
Impact management of HIV-infected pregnant women and their infants
 
Description EC FP7 Funding
Amount £250,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 01/2011 
End 12/2015
 
Description MRC Centre of Epidemiology for Child Health PhD studentship
Amount £61,725 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2008 
End 12/2011
 
Description MRC PhD Studentship
Amount £61,725 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2008 
End 09/2012
 
Description Wellcome Trust Research Career Development Fellowship (Pregnancy, antiretroviral therapy and HIV disease progression in women)
Amount £436,495 (GBP)
Funding ID 081082 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2007 
End 04/2012
 
Title ECS data 
Description Anonymous coded linked individual patient data on HIV-infected pregnant women and their children 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2007 
Provided To Others? Yes  
Impact Pooled analyses published from COHERE and PLATO-II (listed in other section) 
 
Description COHERE (Collaboration of HIV Epidemiological Research in Europe) 
Organisation Academic Medical Center
Country Netherlands 
Sector Academic/University 
PI Contribution Individual patient data for pooled analyses on use of combination antiretroviral therapy across the ages in Europe, on extensive virologic failure among HIV-infected individuals in Europe (PLATO-II project) and on transmitted drug resistance among HIV-positive naive individuals.
Collaborator Contribution Access to data and expertiseShared data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertise
Impact Publications (PM ID 18614870, PMID 0212176)
Start Year 2006
 
Description COHERE (Collaboration of HIV Epidemiological Research in Europe) 
Organisation Autonomous University of Madrid
Country Spain 
Sector Academic/University 
PI Contribution Individual patient data for pooled analyses on use of combination antiretroviral therapy across the ages in Europe, on extensive virologic failure among HIV-infected individuals in Europe (PLATO-II project) and on transmitted drug resistance among HIV-positive naive individuals.
Collaborator Contribution Access to data and expertiseShared data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertise
Impact Publications (PM ID 18614870, PMID 0212176)
Start Year 2006
 
Description COHERE (Collaboration of HIV Epidemiological Research in Europe) 
Organisation Center for Epidemiological Studies on HIV/AIDS of Catalonia (CEESCAT)
Country Spain 
Sector Academic/University 
PI Contribution Individual patient data for pooled analyses on use of combination antiretroviral therapy across the ages in Europe, on extensive virologic failure among HIV-infected individuals in Europe (PLATO-II project) and on transmitted drug resistance among HIV-positive naive individuals.
Collaborator Contribution Access to data and expertiseShared data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertise
Impact Publications (PM ID 18614870, PMID 0212176)
Start Year 2006
 
Description COHERE (Collaboration of HIV Epidemiological Research in Europe) 
Organisation French National Agency for Research on AIDS and Viral Hepatitis (ANRS)
Country France 
Sector Public 
PI Contribution Individual patient data for pooled analyses on use of combination antiretroviral therapy across the ages in Europe, on extensive virologic failure among HIV-infected individuals in Europe (PLATO-II project) and on transmitted drug resistance among HIV-positive naive individuals.
Collaborator Contribution Access to data and expertiseShared data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertise
Impact Publications (PM ID 18614870, PMID 0212176)
Start Year 2006
 
Description COHERE (Collaboration of HIV Epidemiological Research in Europe) 
Organisation Hospital St Pierre
Country Belgium 
Sector Hospitals 
PI Contribution Individual patient data for pooled analyses on use of combination antiretroviral therapy across the ages in Europe, on extensive virologic failure among HIV-infected individuals in Europe (PLATO-II project) and on transmitted drug resistance among HIV-positive naive individuals.
Collaborator Contribution Access to data and expertiseShared data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertise
Impact Publications (PM ID 18614870, PMID 0212176)
Start Year 2006
 
Description COHERE (Collaboration of HIV Epidemiological Research in Europe) 
Organisation Medical Research Council (MRC)
Department MRC Clinical Trials Unit
Country United Kingdom 
Sector Public 
PI Contribution Individual patient data for pooled analyses on use of combination antiretroviral therapy across the ages in Europe, on extensive virologic failure among HIV-infected individuals in Europe (PLATO-II project) and on transmitted drug resistance among HIV-positive naive individuals.
Collaborator Contribution Access to data and expertiseShared data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertise
Impact Publications (PM ID 18614870, PMID 0212176)
Start Year 2006
 
Description COHERE (Collaboration of HIV Epidemiological Research in Europe) 
Organisation National Institutes of Health (NIH)
Department Italian register of HIV infection in children NCBI
Country United States 
Sector Public 
PI Contribution Individual patient data for pooled analyses on use of combination antiretroviral therapy across the ages in Europe, on extensive virologic failure among HIV-infected individuals in Europe (PLATO-II project) and on transmitted drug resistance among HIV-positive naive individuals.
Collaborator Contribution Access to data and expertiseShared data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertise
Impact Publications (PM ID 18614870, PMID 0212176)
Start Year 2006
 
Description COHERE (Collaboration of HIV Epidemiological Research in Europe) 
Organisation University Children's Hospital, Basel
Department Division of Paediatrics
Country Switzerland 
Sector Hospitals 
PI Contribution Individual patient data for pooled analyses on use of combination antiretroviral therapy across the ages in Europe, on extensive virologic failure among HIV-infected individuals in Europe (PLATO-II project) and on transmitted drug resistance among HIV-positive naive individuals.
Collaborator Contribution Access to data and expertiseShared data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertise
Impact Publications (PM ID 18614870, PMID 0212176)
Start Year 2006
 
Description COHERE (Collaboration of HIV Epidemiological Research in Europe) 
Organisation University of Bordeaux
Country France 
Sector Academic/University 
PI Contribution Individual patient data for pooled analyses on use of combination antiretroviral therapy across the ages in Europe, on extensive virologic failure among HIV-infected individuals in Europe (PLATO-II project) and on transmitted drug resistance among HIV-positive naive individuals.
Collaborator Contribution Access to data and expertiseShared data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertise
Impact Publications (PM ID 18614870, PMID 0212176)
Start Year 2006
 
Description COHERE (Collaboration of HIV Epidemiological Research in Europe) 
Organisation University of Copenhagen
Department Copenhagen HIV Programme (CHIP)
Country Denmark 
Sector Academic/University 
PI Contribution Individual patient data for pooled analyses on use of combination antiretroviral therapy across the ages in Europe, on extensive virologic failure among HIV-infected individuals in Europe (PLATO-II project) and on transmitted drug resistance among HIV-positive naive individuals.
Collaborator Contribution Access to data and expertiseShared data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertiseAccess to data and expertise
Impact Publications (PM ID 18614870, PMID 0212176)
Start Year 2006
 
Description European Pregnancy and Paediatric HIV Cohort Collaboration 
Organisation French National Perinatal Surveys
Country France 
Sector Public 
PI Contribution Data, analysis, interpretation of analysis
Collaborator Contribution Data and analysisDataDataDataAccess to data and expertiseData and expertiseData and expertise
Impact Publication to date: one: 18025899. We have had several presentations at workshops and conferences and a paper is currently under consideration.
Start Year 2007
 
Description European Pregnancy and Paediatric HIV Cohort Collaboration 
Organisation Hospital St Pierre
Country Belgium 
Sector Hospitals 
PI Contribution Data, analysis, interpretation of analysis
Collaborator Contribution Data and analysisDataDataDataAccess to data and expertiseData and expertiseData and expertise
Impact Publication to date: one: 18025899. We have had several presentations at workshops and conferences and a paper is currently under consideration.
Start Year 2007
 
Description European Pregnancy and Paediatric HIV Cohort Collaboration 
Organisation Medical Research Council (MRC)
Department MRC Clinical Trials Unit
Country United Kingdom 
Sector Public 
PI Contribution Data, analysis, interpretation of analysis
Collaborator Contribution Data and analysisDataDataDataAccess to data and expertiseData and expertiseData and expertise
Impact Publication to date: one: 18025899. We have had several presentations at workshops and conferences and a paper is currently under consideration.
Start Year 2007
 
Description European Pregnancy and Paediatric HIV Cohort Collaboration 
Organisation National Institutes of Health (NIH)
Department Italian register of HIV infection in children NCBI
Country United States 
Sector Public 
PI Contribution Data, analysis, interpretation of analysis
Collaborator Contribution Data and analysisDataDataDataAccess to data and expertiseData and expertiseData and expertise
Impact Publication to date: one: 18025899. We have had several presentations at workshops and conferences and a paper is currently under consideration.
Start Year 2007
 
Description European Pregnancy and Paediatric HIV Cohort Collaboration 
Organisation National and Kapodistrian University of Athens
Department Paediatrics Athens
Country Greece 
Sector Academic/University 
PI Contribution Data, analysis, interpretation of analysis
Collaborator Contribution Data and analysisDataDataDataAccess to data and expertiseData and expertiseData and expertise
Impact Publication to date: one: 18025899. We have had several presentations at workshops and conferences and a paper is currently under consideration.
Start Year 2007
 
Description European Pregnancy and Paediatric HIV Cohort Collaboration 
Organisation University Children's Hospital, Basel
Department Division of Paediatrics
Country Switzerland 
Sector Hospitals 
PI Contribution Data, analysis, interpretation of analysis
Collaborator Contribution Data and analysisDataDataDataAccess to data and expertiseData and expertiseData and expertise
Impact Publication to date: one: 18025899. We have had several presentations at workshops and conferences and a paper is currently under consideration.
Start Year 2007
 
Description European Pregnancy and Paediatric HIV Cohort Collaboration 
Organisation Victor Babes Hospital
Country Romania 
Sector Hospitals 
PI Contribution Data, analysis, interpretation of analysis
Collaborator Contribution Data and analysisDataDataDataAccess to data and expertiseData and expertiseData and expertise
Impact Publication to date: one: 18025899. We have had several presentations at workshops and conferences and a paper is currently under consideration.
Start Year 2007
 
Description MRC Centre of Epidemiology for Child Health 
Organisation University College London
Department MRC Centre for Epidemiology for Child Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Participation in scientific and academic seminars, workshops and training sessions within the Centre. Contribution to multidisciplinary team working. PhD studentships: supervision and data.
Collaborator Contribution • Access to a critical mass of epidemiological and statistical expertise applied to children's health creating a positive working environment that contributes to researcher capacity, scientific excellence, methodological expertise and impact in this field. The mission of the MRC Centre of Epidemiology for Child Health is to improve the health and well being of children by conducting, and contributing to the application of, high quality interdisciplinary research. The MRC Centre adds value by: developing and applying advanced statistical methods; capacity building in genetic epidemiology; and developing approaches to policy research in child health. • Provision of epiLab: The epiLab is an advanced computing environment and data management service that has been developed at the MRC Centre to support researchers through all aspects of the research data management life-cycle. The service provides core data storage and backup provision in conjunction with a virtualised desktop and backend-server infrastructure, designed to provide high levels of resilience and information security. Additional services provide users with tools, training and assistance with data transfer, metadata management, data collection, archival and destruction and pseudonymisation. • Statistical support: several statisticians within the Centre provide statistical support for ongoing projects, in terms of study design, e.g. power calculations, or analysis, advising on and helping to interpret the analyses, or else doing the analyses in collaboration. • A strong track record in delivering excellent training and early career development support with opportunities to access supervision and supervisory experience for epidemiologists, statisticians and other population health scientists as well as clinicians from public health, paediatrics and paediatric sub-specialties reflecting the focus of the Centre's work on longitudinal epidemiological studies of population samples or patient cohorts.
Impact Several publications (listed in publication section) have resulted from PhD studentships within the Centre based on networks and/or data of the European Collaborative Study.
Start Year 2007
 
Description Amsterdam symposium 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Presented ECS results on use of antiretroviral therapy in pregnancy to a group of health professionals from across the Netherlands attending a symposium on HIV in pregnancy and childhood in Amsterdam

The symposium was highly rated by those attending.
Year(s) Of Engagement Activity 2008
 
Description ECS newsletters 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Newsletters disseminating results, updating collaborators on ongoing analyses and preliminary results, future research plans etc. Circulated 2-3 times per year.

Essential for continued interest and enrollments in the study. Has led to new inputs from collaborators regarding future analyses.
Year(s) Of Engagement Activity 2006,2007,2008
 
Description European teaching 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Health professionals
Results and Impact I have given presentations and co-facilitated training workshops focussed on mother-to-child transmission and paediatric HIV, attended by a range of clinicians, pharmacists and other health care professionals from across Europe

These courses have contributed to the participants' continuing professional development
Year(s) Of Engagement Activity 2007,2008,2009,2010
 
Description PENTA Meetings 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact presented results from the ECS to a group of paediatricians, HIV clinical nurse specialists and other health care professionals from a range of hospitals from across Europe

Increased interest in participating in epidemiological research into HIV and children
Year(s) Of Engagement Activity 2007,2008,2009,2010
 
Description STI talk BASHH 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact An invited oral presentation at the BASHH / Department of Health / MRC meeting on current research to support the UK's sexual health strategies

Contact made with future research collaborators
Year(s) Of Engagement Activity 2006
 
Description School Visit - Winchester 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Schools
Results and Impact Single school visit - presenting results from the European Collaborative Study in the context of speaking to young people about epidemiology

This has not been evaluated
Year(s) Of Engagement Activity 2008
 
Description World AIDS Day news story 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Results of three publications published in past year were highlighted in a news story published on World AIDS Day 2011 on the EuroCoord website.

This occurred today so I am not aware of any impacts as yet.
Year(s) Of Engagement Activity 2011