Genomic interpretation in Caenorhabditis elegans

Lead Research Organisation: The Wellcome Trust Ltd
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description Wormbase2
Amount £518,451 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 04/2005 
End 03/2008
 
Title WormBase 
Description WormBase (www.wormbase.org) is the major publicly available database of information about Caenorhabditis elegans, an important system for basic biological and biomedical research. Derived from the initial ACeDB database of C. elegans genetic and sequence information, WormBase now includes the genomic, anatomical and functional information about C. elegans, other Caenorhabditis species and other nematodes. As such, it is a crucial resource not only for C. elegans biologists but the larger biomedical and bioinformatics communities. Coverage of core areas of C. elegans biology will allow the biomedical community to make full use of the results of intensive molecular genetic analysis and functional genomic studies of this organism. Improved search and display tools, wider cross-species comparisons and extended ontologies are some of the features that will help scientists extend their research and take advantage of other nematode species genome sequences. 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2006 
Provided To Others? Yes  
Impact There are probably very few C. elegans researchers that have not made use of the data made available through WormBase in their research, but the database is not always cited in their publications. It is often just relied on as something that is always there. Beyond genetic research in development, aging, cell function etc., recently the ModENCODE project to look at genome function in C.elegans has been based strongly on WormBase data. 
URL http://www.wormbase.org
 
Title Wormbase 
Description genomic and research database for the model organism C. elegans and related nematodes 
Type Of Material Database/Collection of data 
Provided To Others? Yes  
Impact Widely used by all nematode researchers. 
URL http://www.wormbase.org
 
Description The WormBase Consortium 
Organisation California Institute of Technology
Department Division of Biology and Biological Engineering (BBE)
Country United States 
Sector Academic/University 
PI Contribution The consortium is responsible for the production, maintenance and development of Wormbase and associated tools and resources. The two MRC-funded posts actively contribute to the curation of core data in the database (such as gene structures), the addition of new genomes and datasets, and to the monthly production cycle.
Collaborator Contribution Enter They contribute curated data into the database, and other input into WormBase design and activities. We receive NIH funding via them as a named co-applicant on an NHGRI grant. Curated genome annotation data on C. elegans, sequence and annotation for other nematodes, and general contributions to the WormBase project.They produce and manage the web site for the project, and provide general input into the project design and operations.
Impact All data and services provided by the consortium are made available via a central web hub, www.wormbase.org (PMIDs:16381915). The consortium is multi-disciplinary, ranging from computer scientists / software engineers, through bioinformaticians (whose duties cover both curation biological data and computer programming), to biologists (whose principle role is the curation of biological data)
 
Description The WormBase Consortium 
Organisation Ontario Institute for Cancer Research (OICR)
Department Informatics & Bio-computing; Ontario Institute of Cancer Research
Country Canada 
Sector Public 
PI Contribution The consortium is responsible for the production, maintenance and development of Wormbase and associated tools and resources. The two MRC-funded posts actively contribute to the curation of core data in the database (such as gene structures), the addition of new genomes and datasets, and to the monthly production cycle.
Collaborator Contribution Enter They contribute curated data into the database, and other input into WormBase design and activities. We receive NIH funding via them as a named co-applicant on an NHGRI grant. Curated genome annotation data on C. elegans, sequence and annotation for other nematodes, and general contributions to the WormBase project.They produce and manage the web site for the project, and provide general input into the project design and operations.
Impact All data and services provided by the consortium are made available via a central web hub, www.wormbase.org (PMIDs:16381915). The consortium is multi-disciplinary, ranging from computer scientists / software engineers, through bioinformaticians (whose duties cover both curation biological data and computer programming), to biologists (whose principle role is the curation of biological data)
 
Description The WormBase Consortium 
Organisation Washington University in St Louis
Department Genome Center
Country United States 
Sector Academic/University 
PI Contribution The consortium is responsible for the production, maintenance and development of Wormbase and associated tools and resources. The two MRC-funded posts actively contribute to the curation of core data in the database (such as gene structures), the addition of new genomes and datasets, and to the monthly production cycle.
Collaborator Contribution Enter They contribute curated data into the database, and other input into WormBase design and activities. We receive NIH funding via them as a named co-applicant on an NHGRI grant. Curated genome annotation data on C. elegans, sequence and annotation for other nematodes, and general contributions to the WormBase project.They produce and manage the web site for the project, and provide general input into the project design and operations.
Impact All data and services provided by the consortium are made available via a central web hub, www.wormbase.org (PMIDs:16381915). The consortium is multi-disciplinary, ranging from computer scientists / software engineers, through bioinformaticians (whose duties cover both curation biological data and computer programming), to biologists (whose principle role is the curation of biological data)
 
Description WormBase 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Media (as a channel to the public)
Results and Impact The whole purpose of the project is data dissemination. WormBase is a freely available online resource providing access to all of the data in the database. Usage has continually increased since the inception of the project. During 2007 the site served 18.5 million page views.

Unknown as WormBase is not always cited (as described elsewhere)
Year(s) Of Engagement Activity 2006,2007,2008