Neural stem cells and neuroglial lineages in the central nervous system

Lead Research Organisation: University College London
Department Name: The Wolfson Inst for Biomedical Research

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Anselmi F (2008) ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. in Proceedings of the National Academy of Sciences of the United States of America

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Billon N (2007) The generation of adipocytes by the neural crest. in Development (Cambridge, England)

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Costa MR (2007) The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex. in The Journal of neuroscience : the official journal of the Society for Neuroscience

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Gomez-Sanchez JA (2009) Sustained axon-glial signaling induces Schwann cell hyperproliferation, Remak bundle myelination, and tumorigenesis. in The Journal of neuroscience : the official journal of the Society for Neuroscience

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Kessaris N (2008) Specification of CNS glia from neural stem cells in the embryonic neuroepithelium. in Philosophical transactions of the Royal Society of London. Series B, Biological sciences

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Li H (2007) Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes. in The Journal of neuroscience : the official journal of the Society for Neuroscience

 
Description AERES Research Evaluating Committee for French Government
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description SAB Institute for Brain and Spinal Cord (ICM), Paris
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description SAB Max Planck Institute for Experimental Medicine
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description ART Collaborative Career Development Award
Amount £330,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description ERC Advanced Grant (MOTOGLIA: axoglial synapses, adult myelination and motor skills learning)
Amount £1,857,744 (GBP)
Funding ID 293544 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 02/2012 
End 01/2017
 
Description MRC Programme Grant
Amount £1,874,630 (GBP)
Funding ID G0800575 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Royal Society USA/Canada Fellowship
Amount £246,489 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust Programme Grant (Diversity and functions of CNS glia: a transgenic and electrophysiological approach)
Amount £1,262,730 (GBP)
Funding ID GR080513 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust Project Grant (Oligodendrocyte lineage (Olig) genes in development and disease.)
Amount £525,692 (GBP)
Funding ID WT084299MF 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Wellcome Trust Senior Investigator Award
Amount £1,900,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2013 
End 02/2018
 
Title genetically manipulated mice 
Description multiple lines of mice expressing Cre recombinase under transcriptional control of genes that are important for stem/precursor cell development and function 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2006 
Provided To Others? Yes  
Impact Collaborative publications, non-collaborative publications. Our mice have been distributed to more than 100 labs world-wide for a wide range of studies on diverse subjects including central and peripheral nervous systems, immune system, adipose (fat) tissue, the inner ear, early embryos, demyelinating disease, Alzheimers disease, motor neuron disease, spinal injury etc etc 
 
Description Control of myelination by lactate and glucose 
Organisation University College London
Department Neuroscience, Physiology & Pharmacology
Country United Kingdom 
Sector Academic/University 
PI Contribution We generated and maintained a transgenic mouse line that was central to this research and provided input to the interpretation of results
Impact Published paper in Journal of Neuroscience 2010
Start Year 2009
 
Description Remyelination by NG2 cells 
Organisation University of Cambridge
Department Department of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution We made the transgenic mice central to this work, maintained the mice, helped analyze the experiments and helped write the paper
Collaborator Contribution It has resulted in a grant application (recently funded) to the Wellcome Trust for a Veterinary Clinical Training Fellowship for collaborative research between our lab and that of Robin Franklin
Impact Publication Zawadzka et al. in Cell Stem Cell 2010
Start Year 2008
 
Description Role of Neuregulin 1 in peripheral myelination 
Organisation Miguel Hernández University of Elche (UMH)
Department Neurosciences Institute UMH
Country Spain 
Sector Academic/University 
PI Contribution Hosted the collaborator in our lab, taught him BAC recombineering and transgenesis, successfully made transgenic line that was central to the collaboration
Impact Publication, Cabedo et al., in Journal of Neuroscience 2009
Start Year 2008
 
Description Transcriptional control of oligodendrocyte development 
Organisation Friedrich-Alexander University Erlangen-Nuremberg
Country Germany 
Sector Academic/University 
PI Contribution we provided transgenic mice
Collaborator Contribution joint publication
Impact 17084361
Start Year 2006
 
Description development of adipocytes 
Organisation College of France
Country France 
Sector Academic/University 
PI Contribution we provided transgenic mice
Collaborator Contribution they performed the analysis
Impact collaborative publication
Start Year 2006
 
Description forebrain wiring 
Organisation Catholic University of Louvain
Country Belgium 
Sector Academic/University 
PI Contribution we provided transgenic mice
Collaborator Contribution collaborative publication
Impact 18487195
Start Year 2006
 
Description neural stem cells 
Organisation Helmholtz Association of German Research Centres
Department Helmholtz Zentrum Munchen
Country Germany 
Sector Academic/University 
PI Contribution we provided transgenic mice
Collaborator Contribution collaborative publication
Impact 17942732
Start Year 2006
 
Description pituitary development 
Organisation Marie Curie
Department Marie Curie Research Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution we hosted a visiting researcher from the collaborator's lab
Collaborator Contribution collaborative publication
Impact 18534921
Start Year 2006
 
Description thymus development 
Organisation University of Ulm
Country Germany 
Sector Academic/University 
PI Contribution we provided transgenic mice
Collaborator Contribution Collaborative publication
Impact 18390716
Start Year 2006
 
Description Presentation of our research using transgenic mice to Lynne Featherstone, MP and Home Office Minister 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact I subsequently received a hand-written letter of thanks and appreciation from Lynne Featherstone stating " My knowledge and understanding were genuinely broadened by our encounter" and "Absolutely and reassuringly impressed with the condition of laboratories and the important work being done."

Too early to say. However, it is crucially important to reassure the Home Office of the worth of animal research and I believe my presentation and conversation with the MP helped to achieve this.
Year(s) Of Engagement Activity 2011
 
Description Radio interview (Science Now BBC4) 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact This half-hour radio show in the late afternoon gets large numbers of listeners on their way home from work.

unknown
Year(s) Of Engagement Activity Pre-2006
 
Description Scientific and Literary Society - London 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact A member of the team gave a talk about stem cell research at Highgate Scientific and Literary Society

Public awareness
Year(s) Of Engagement Activity 2006,2007