Epilepsy

Lead Research Organisation: University College London
Department Name: UNLISTED

Abstract

The Group’s research will involve a variety of medical and scientific disciplines and the researchers will collaborate within the group, within UCL and also more widely with research workers in Britain and abroad, in order to add value to the research and to provide the optimal environment for speedy and innovative work. The COG has a good record in public engagement in science (see enclosed progress report) via lecturing, exhibitions, talks, interviews. JD is also the Medical Director of the National Society of Epilepsy a national charity with a major commitment to public information provision and engagement. The COG also benefits from the from the existence of the NSE’s Department of Communication, Information and Education which is very active and provides a natural vehicle for the dissemination of research findings to professional medical and paramedical groups, the lay public and the media. In addition to a programme of intramural and extramural updates and symposia, there are a range of written and CD materials and a very popular website www.epilepsynse.org.uk.

Technical Summary

This application is for the renewal of a Collaborative Group (COG) grant (G9805989). The proposed COG grouping is of seven principal applicants and eight members. The proposed COG research programme, over the next 5 year period has the following four overall aims:
1: To characterise the role of genetic mechanisms in the causation of epilepsy and in the response of epilepsy to drug therapy - The programme will consist of human linkage disequilibrium mapping, family linkage studies and mutation screening of candidate genes for epilepsy and treatment response, MRI phenotype-genotype correlation and experimental physiological and pharmacological studies of mutations identified.
2: To elucidate the mechanisms of initiation and termination of epileptic seizures - The programme will conduct studies of human cortical excitability using TMS, excitatory and inhibitory neurotransmission using PET and MRS, seizure initiation using fMRI, and experimental physiological and pharmacological studies of GABAergic and glutaminergic transmission.
3: To elucidate, experimentally and clinically, the mechanisms causes and associations of cerebral damage consequent upon epileptic seizures and epilepsy - The programme will conduct human studies of the cognitive and MRI changes due to epilepsy, and experimental studies of mitochondrial. GABAergic and glutaminergic changes after status epilepticus.
4. To develop and evaluate new antiepileptic treatment modalities clinically and
experimentally, and Health Service Research into provision of epilepsy care -
The programme will consist of experimental studies of neuroprotection and novel therapy, clinical trials of experimental medical and surgical therapy, studies of TMS, MRI to predict of surgical outcome, and epidemiology and Health Services Research.

The COG will have a strong emphasis on multidisciplinarity and cross-boundary collaboration. A range of advanced techniques will be utilised in: neuro-imaging, neurogenetics, neurophysiology, medical physics, neuropathology, pharmacology, epidemiology and clinical trials. The research methodologies will have strong statistical and technical support. The applicants have inter-related research and also wide collaborations within the UK and abroad. The COG is currently supported by 38 grants (including 4 under current review). The COG provides adds value in terms of (a) shared expertise, equipment, facilities, personnel, human tissue and patient material; (b) the mix of basic and clinical science and (c) the intellectual environment created by the COG identity. The COG will also take a strong emphasis on research training, and currently has 14 students registered for PhD or other higher degrees. The resources required are to provide core support in the areas of histology, image analysis, computing and databasing.

Publications

10 25 50
 
Guideline Title NICE Epilepsy guideline revision 2011
Description Epilepsy guideline revision
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact The CoG work on epilespytreatemtniotionsd informed the guidleine development and I ama member of the epilepsy revision GDG
 
Description EURIPIDES EUropean Research initiative to develop Imaging Probes for early In-vivo Diagnosis and Evaluation of response to therapeutic Substances (7m euros across 14 participants)
Amount £409,698 (GBP)
Funding ID 201380 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 02/2008 
End 01/2012
 
Description Project grant/UCLH/UCL CBRC
Amount £180,000 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2008 
End 03/2012
 
Description Project grant/UCLH/UCL CBRC
Amount £229,568 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 07/2009 
End 06/2012
 
Description Project grant/UCLH/UCL CBRC
Amount £161,351 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2008 
End 03/2011
 
Description Training fellowship
Amount £203,200 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2009 
End 08/2012
 
Description Wellcome Trust Programme Grant (The consequences of temporal lobe epilepsy surgery)
Amount £1,487,687 (GBP)
Funding ID 083148 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2007 
End 01/2012
 
Description project grant
Amount £199,000 (GBP)
Organisation Action Medical Research 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2009 
End 06/2012
 
Title Epilepsy surgery database 
Description Detailed prospective follow-up over up of 20 years of the outcome of epilepsy surgery in the largest UK epilepsy surgery programme 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2008 
Provided To Others? Yes  
Impact Determination of the long-term outcome of epilepsy surgery. Effects on seizures, congnition, employemnt, medication use. prediction of outcome from pre-operative data. 
 
Description Microelectonics applied to epilepsy 
Organisation Imperial College London
Department Department of Electrical and Electronic Engineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Clinicl ainput t odefineing pthe problem and the criteria for novel technical solutions
Collaborator Contribution Design of low power electronic circuits for monitoring vital life functions
Impact Development of waearable apnoea monitor, now undergoing clinical trials.
Start Year 2006
 
Description Public and aptient involvement 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Twice a year, reserch presentations to conferences run by the National Society for Epilepsy for patients and public, around the UK. Attended by >120 delagates.
Alos write ups of research on NSE website and written material.

The oublic and apteitns are up to date with the direction of resarch and have the opportunity to influence this.
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010