Gene - environment interplay in early-onset psychopathology

Lead Research Organisation: King's College London
Department Name: Unlisted

Abstract

Lay summary:
The E-risk Longitudinal Twin Study examines environmental risks for mental disorders, and genes that influence how people react to the environmental risks they encounter. The study focuses especially on antisocial behaviour, depression, and psychosis. We have studied 2200 twins and their parents at the twins birth, age 5 and age 7, and we will follow up these families when the twins are ages 10 and 12 years. Our aim is to uncover gene-environment interactions affecting the mental health of children. A gene-environment interaction occurs when the effect on a person of exposure to environmental risk depends upon their genotype (or conversely, when environmental experience controls the action of genes). We have discovered two such interactions already, and if more are found to influence behaviour disorders, this will improve basic-science methodology in psychiatric genetics. Moreover, specific environmental effects revealed to be stronger in the presence of genetic risk would encourage more environmental prevention programmes, and would help to identify who needs prevention most. Specific genes revealed to be stronger in the presence of environmental risk would guide strategic research and development, possibly leading to genetic diagnostics and pharmacological interventions.

Technical Summary

We propose to carry forward the E-risk Longitudinal Twin Study of environmental risks for childhood behaviour disorders, expanding the research programme to study the developmental origins of antisocial behaviour, depression, and psychosis. For these 3 disorders, symptoms that emerge at pre-adolescent ages have serious later clinical consequences; thus we will study the 2200 E-risk Study twins at ages 10-12 years. Antisocial, depressive, and psychotic disorders have high heritability coefficients, and this fact directs us to propose research to uncover gene-environment interactions affecting them. A gene-environment interaction (?GxE?) occurs when the effect on a person of exposure to environmental risk is conditional upon their genotype (or conversely, when environmental experience moderates gene expression). We propose to conduct theory-guided hypothesis tests for GxE by using measured candidate genes and measured environmental pathogens. We have tested two GxE to date, and the findings provide proof of principle for the feasibility of this proposed research. If more GxE are found to influence behaviour disorders, this will improve basic-science methodology in psychiatric genetics. Moreover, specific environmental effects revealed to be stronger in the presence of genetic risk would prompt a new impetus for specific environmental preventions, and would help to identify who needs prevention most. Specific genes revealed to be stronger in the presence of environmental risk would guide strategic research and development into those genes? expression, possibly leading to genetic diagnostics and pharmacological interventions.

Publications

10 25 50

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Arseneault L (2005) Psychometric evaluation of 5- and 7-year-old children's self-reports of conduct problems. in Journal of abnormal child psychology

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Ball HA (2008) Genetic and environmental influences on victims, bullies and bully-victims in childhood. in Journal of child psychology and psychiatry, and allied disciplines

 
Description Adult ADHD paper selected by NEJM as in top 10 findings of psychiatry in 2015
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL http://www.jwatch.org/na39791/2015/12/28/nejm-journal-watch-psychiatry-top-stories-2015?
 
Description Anti-bullying policy promotion activitiesby L Arseneault
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a national consultation
Impact ** Speaker for the Day Conference of the Open University Psychological Society London Region. "Bullying victimisation and its harmful effect on children's mental health problems and responses to stress". UK, January 2011. (E-RISK) ** Speaker for the 2011 Anti-Bullying Alliance Regional Network Meeting. "Bullying: new trends, impacts and interventions that work". UK, March 2011. (E-RISK)
 
Description Consultant to the Council of Europe Directorate General I - Legal Affairs Bioethics Department, on psychiatric genetics state of the science, 2006.
Geographic Reach Europe 
Policy Influence Type Gave evidence to a government review
Impact Law was written to prevent misuse of genetic tests in European states. ; Law was written to prevent misuse of genetic tests in European states.
 
Description DSM-V working party to write diagnostic criteria disruptive disorders
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
Impact Will establish diagnoses of pcychiatric disorders for practice and research
 
Description Fraser, E. et al. (2009) Multiple Choice: The educational needs and experiences of multiple birth children. London: TAMBA.
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
Impact changed parliamentary law on educational practices
 
Description Institute Of Medicine 2011: Hunger and Obesity: understanding a food insecurity paradigm.
Geographic Reach North America 
Policy Influence Type Citation in other policy documents
Impact Melchior M. 'Socioecological perspectives: the family and household level'. In IOM (Institute Of Medicine). 2011: Hunger and Obesity: understanding a food insecurity paradigm. The National Academies Press, Washington DC.
 
Description Nuffield Bioethics Council Report on The Ethical context of Genetics in Human Behaviour
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
Impact More than 6,300 copies were requested in the first year of publication and 15,600 copies have been downloaded from the Nuffield council's website. This book was covered by major British and European newspapers, radio, and television when it was released in October, because it addressed ethical issues arising from application of behaviour genetic findings, such as genetic testing, personal eugenics, designer babies, and criminal culpability.; More than 6,300 copies were requested in the first year of publication and 15,600 copies have been downloaded from the Nuffield council's website. This book was covered by major British and European newspapers, radio, and television when it was released in October, because it addressed ethical issues arising from application of behaviour genetic findings, such as genetic testing, personal eugenics, designer babies, and criminal culpability.
 
Description Ready to be counted 2015 report by Transforming Education
Geographic Reach North America 
Policy Influence Type Citation in other policy documents
Impact Dunedin research featured as rationale for reform of early years education in USA.
 
Description Science News named our paper the 4th best science story of 2015
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact not sure yet
URL https://www.sciencenews.org/article/top-stories-2015-pluto-gene-editing-new-hominid-and-more
 
Description Social Science and Family Policies. London: The British Academy.
Geographic Reach National 
Policy Influence Type Participation in a national consultation
Impact not clear yet, UK government in disarray
 
Description U.S. Department of Health & Human Services policy for Maltreated Children:
Geographic Reach North America 
Policy Influence Type Influenced training of practitioners or researchers
Impact Our MRC-funded research into the effects of maltreatment on children's health and development is cited in report to Office of the Assistant Secretary for Planning and Evaluation, U.S. Department of Health & Human Services. This report describes the most common problems that maltreated infants and toddlers experience, and it highlights the benefits of early interventions for this population. The report aims to aid child welfare personnel and policymakers who are responsible for assessing, referring, and advocating for maltreated children so they can make evidence-based decisions. Sara Jaffee See: APSE report on Developmental Problems of Maltreated Children and Early Intervention Options for Maltreated Children: http://aspe.hhs.gov/hsp/07/Children-CPS/litrev/index.htm
URL http://aspe.hhs.gov/hsp/07/Children-CPS/litrev/index.htm
 
Description US National Academy of Sciences Committee on Law and Justice
Geographic Reach North America 
Policy Influence Type Participation in advisory committee
Impact 2004 book Firearms and Violence: A Critical Review. REcommends policy based on the scientific evidence for guncontrol; US Government funding for firearms research
 
Description US National Research Council (2011). Assessing 21st Century Skills
Geographic Reach North America 
Policy Influence Type Participation in a national consultation
Impact See pages 80 to 86 in the following National Academies of Science Publication describing our research : http://books.nap.edu/catalog.php?record_id=13215 National Research Council (2011). Assessing 21st Century Skills: Summary of a Workshop. J.A. Koenig, Rapporteur. Committee on the Assessment of 21st Century Skills. Board on Testing and Assessment, Division of Behavioral and Social Sciences and Education. Washington, DC: The National Academies of Press. Invited member on the Royal Society of Canada - Canadian Academy of Health Sciences Expert Panel on Early Child Development Production of report detailing Dunedinand E-Risk Findings which was submitted to the Royal Society of Canada in September 2011. Early Childhood Adversities and Developmental Health in Adolescence and Young Adulthood [I will forward a copy of the published report when available]
URL http://books.nap.edu/catalog.php?record_id=13215
 
Description US Natl Academy of Sciences Panel: Understanding the Demand for Illegal Drugs.
Geographic Reach North America 
Policy Influence Type Participation in advisory committee
Impact Reuter, P. et al. (October 2010). Understanding the Demand for Illegal Drugs. Washington, DC: National Academy of Sciences.
 
Description USA NIH State of the Science Consensus Statement on Preventing Violence and Related Health Risking Behaviors in Adolescents, 2004
Geographic Reach North America 
Policy Influence Type Gave evidence to a government review
Impact Set policy for effective prevention programmes in the USA. Our work cited in US Surgeon General's Report on youth violence policy, WHO REport on Health Impact of violence worldwide, and US Presidents Commission on Drug Policy. ; programmes are now in widespread use in the USA, UK, and other countries
 
Guideline Title US Law
Description United States Supreme Court death penalty case Roper v. Simmons
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
Impact Our findings that show how brain development in violent life-course persistent antisocial adolescent criminal offenders lags behind normal brain development were cited in an the Amicus Curiae brief that was used to overturn the death penalty for juveniles in the United States Supreme Court. Website that discusses the case Roper v. Simmons: http://www.deathpenaltyinfo.org/article.php?did=885?id; Our findings that show how brain development in violent life-course persistent antisocial adolescent criminal offenders lags behind normal brain development were cited in an the Amicus Curiae brief that was used to overturn the death penalty for juveniles in the United States Supreme Court. Website that discusses the case Roper v. Simmons: http://www.deathpenaltyinfo.org/article.php?did=885?id
URL http://www.deathpenaltyinfo.org/article.php?did=885&scid
 
Description impact on policy and education
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact a lot, can provide details on demand but too much to type here
 
Description British Academy small grant L Arseneault
Amount £20,000 (GBP)
Organisation The British Academy 
Sector Academic/University
Country United Kingdom
Start  
 
Description CIHR postdoc fellowship I Ouellet-Morin
Amount £100,000 (GBP)
Organisation Canadian Institutes of Health Research 
Sector Public
Country Canada
Start 09/2008 
End 09/2011
 
Description Dept of Health Fellowship L arseneault
Amount £300,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2006 
End 01/2011
 
Description ESRC SCOPIC network with Cambridge TE Moffitt
Amount £278,000 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 08/2006 
End 07/2009
 
Description ESRC, PhD Studentship L Bowes
Amount £100,000 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2008 
End 06/2011
 
Description ESRC, Project Grant Arseneault & Caspi
Amount £350,000 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2006 
End 01/2009
 
Description Google Corp C Odgers
Amount £25,000 (GBP)
Organisation Google 
Sector Private
Country United States
Start 07/2011 
End 07/2013
 
Description Jacobs foundation L Arseneault
Amount £130,000 (GBP)
Organisation Jacobs Foundation 
Sector Charity/Non Profit
Country Switzerland
Start  
 
Description Jacobs foundation Postdoc Fellowship L Bowes
Amount £100,000 (GBP)
Organisation Jacobs Foundation 
Sector Charity/Non Profit
Country Switzerland
Start 09/2011 
End 09/2013
 
Description Jacobs foundation Prize Moffitt & Caspi
Amount £750,000 (GBP)
Organisation Jacobs Foundation 
Sector Charity/Non Profit
Country Switzerland
Start 12/2010 
End 12/2017
 
Description MRC Population Health Scientist Postdoc H fisher
Amount £100,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
 
Description MRC Programme Grant G1002190 E-Risk Study L Arseneault
Amount £3,000,000 (GBP)
Funding ID G1002190 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2011 
End 04/2016
 
Description NARSAD Young Investigator Award A Danese
Amount £35,000 (GBP)
Organisation Brain & Behaviour Research Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2007 
End 01/2009
 
Description NARSAD Young investigator Award G Polanczyk
Amount £35,000 (GBP)
Organisation Autism Speaks 
Sector Charity/Non Profit
Country United States
Start  
 
Description NHLBI project grant R21 A Danese
Amount £50,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2011 
End 09/2013
 
Description NIA Dunedin Phase 45 grant
Amount $3,000,000 (USD)
Funding ID 1R01AG049789-01 
Organisation National Institute on Aging 
Sector Public
Country United States
Start 09/2015 
End 08/2020
 
Description NIA Neuroimaging grant
Amount $7,000,000 (USD)
Funding ID 2 R01 AG032282-06 
Organisation National Institute on Aging 
Sector Public
Country United States
Start 07/2015 
End 06/2020
 
Description NICHD project grant on social inequalities in health Caspi Moffitt
Amount £250,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 07/2009 
End 07/2013
 
Description NIHR Biomedical REsearch Centre L Arseneault A Danese
Amount £20,000 (GBP)
Organisation National Institute for Health Research 
Department NIHR Comprehensive Biomedical Research Centre, Guy's and St Thomas
Sector Public
Country United Kingdom
Start  
 
Description NIMH RO1 grant Gene environment interaction A Caspi
Amount £2,000,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 07/2009 
End 07/2011
 
Description Nuffield Foundation small grant L Arseneault
Amount £10,000 (GBP)
Organisation Nuffield Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Psychiatry Research Trust UK C Pariente
Amount £50,000 (GBP)
Organisation King's College London 
Department Psychiatry Research Trust
Sector Charity/Non Profit
Country United Kingdom
Start 07/2011 
End 07/2013
 
Description RSPCA data analysis fund F McEwen
Amount £2,000 (GBP)
Organisation Royal Society for the Prevention of Cruelty to Animals 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Royal Society wolfson Merit award, TE Moffitt
Amount £175,000 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start 07/2006 
End 06/2007
 
Description US Center for Disease control special project L Arseneault
Amount £5,000 (GBP)
Organisation Centers for Disease Control and Prevention (CDC) 
Sector Public
Country United States
Start  
 
Description Wellcome Trust Clinical Phd Fellowship A Danese
Amount £300,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2006 
End 01/2009
 
Description Wellcome Trust Clinical Research Senior Fellow A Stringaris
Amount £500,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2008 
End 01/2013
 
Description William T Grant Young Investigator Award C Odgers
Amount £350,000 (GBP)
Organisation William T. Grant Foundation 
Sector Charity/Non Profit
Country United States
Start 05/2009 
End 05/2012
 
Description Wolfson MERIT Award A Caspi
Amount £150,000 (GBP)
Organisation The Royal Society 
Sector Academic/University
Country United Kingdom
Start  
 
Title C-reactive protein as a salivary biomarker of inflammation in children 
Description C-reactive protein as a salivary biomarker of inflammation in children 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2010 
Provided To Others? Yes  
Impact A biomarker assayedin blood from adults can now be used with children, 
 
Title E-risk cohort data base 
Description 4 waves of longitudinal data for cohort and DNA 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2006 
Provided To Others? Yes  
Impact more publications 
 
Title Genomic imprint of stress, lab and clinical validation of minimally invasive assay 
Description lab and clinical validation of minimally invasive assay for genomic imprint of stress 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact not finished yet 
 
Title Life History Calendar 
Description Our Life History Calendar, which we developed as a research tool, has now been exported for use in many depression clinics, for collecting data to research stressful life events and for ascertaining stressful life events as part of treatment planning. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2006 
Provided To Others? Yes  
Impact improved standardised method for valid retrospective recall of events and disease 
 
Title Neighbourhood systematic observation via Google Earth 
Description developed coding scheme and training materials on the web to use google earth to observe research participants physical environments Development and validation of an online systematic social observation tool for use in the assessment of children's neighborhoods. [E-Risk] Website description: https://adaptlab.soceco.uci.edu/systematic-social-observation/ References: Odgers, CL., Bates, CJ., Caspi, C., Moffitt, TE & Sampson, RJ. Neighborhood effects on children's health: What can we learn by taking a ride in the Google Van? Featured Symposium: Stockholm Criminology Prize Conference. June 2011: Stockholm, Sweden. [E-Risk] Odgers, CL., Bates, CJ., Caspi, C., Sampson, RJ & Moffitt, TE. (in prep*). Systematic social observation of local neighborhoods using Google Street View. [E-Risk] 
Type Of Material Improvements to research infrastructure 
Year Produced 2010 
Provided To Others? Yes  
Impact Funded by Google, and now adopted so far by teams in Australia, UK, Finland, and USA 
 
Title Policy & procedure for research governance in cohort studies 
Description manual and training materials for managing a large ongoing cohort study, staff management, ethical matters, data sharing, authorship, and financial matters, 
Type Of Material Improvements to research infrastructure 
Year Produced 2007 
Provided To Others? Yes  
Impact adapted by teams in many countries 
 
Title child temperament rating scheme 
Description a training package for data collection of observational measures of childtemperament 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2006 
Provided To Others? Yes  
Impact used by teams in many countries 
 
Title expressed emotion training package 
Description exportable technology for collecting data on mate4rnal expressed emotion 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2008 
Provided To Others? Yes  
Impact used by research teams in many countries 
 
Title TEDS-Peers data 
Description Between 2008 and 2009, the TEDS-Peers Study team invited twins discordant for being bullied to come to the SGDP laboratory for further in depth assessment. The data collection ended with a total sample of 190 twins interviewed. 
Type Of Material Database/Collection of data 
Year Produced 2009 
Provided To Others? Yes  
Impact Several papers have been published using the data made available via this database. See publications list for more details 
 
Description Bristol University dept of psychology 
Organisation University of Bristol
Department School of Experimental Psychology
Country United Kingdom 
Sector Academic/University 
PI Contribution collaborate on papers sponsoring a postdoc Lucy Bowes
Collaborator Contribution ideas
Impact several papers
Start Year 2011
 
Description Cambridge Cognition CANTAB 
Organisation Cambridge Cognition Ltd
Country United Kingdom 
Sector Private 
PI Contribution collected data with E-risk twins
Collaborator Contribution measurement technology
Impact n/a
Start Year 2011
 
Description Cambridge Inst of Criminology 
Organisation University of Cambridge
Department Institute of Criminology
Country United Kingdom 
Sector Academic/University 
PI Contribution We were one of 4 teams in the network, with HQ at Cambridge, ESRC SCOPIC Network
Collaborator Contribution meetings
Impact several meetings, edited books and papers
 
Description Cambridge university studies of theory of mind 
Organisation University of Cambridge
Department School of the Humanities and Social Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution we collected data for dr. hughes, co-wrote papers
Collaborator Contribution data and idea exchange
Impact 2 articles on theory of mind in children
 
Description Cardiff Univ replicating genetic findings 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution replication of genetic findings across cohorts
Collaborator Contribution replication of genetic findings across cohorts
Impact Caspi, Thapar, et al. 2008
Start Year 2006
 
Description Data sharing from the Dunedin Study 
Organisation University of Otago
Country New Zealand 
Sector Academic/University 
PI Contribution we collect and share the data
Collaborator Contribution The Dunedin Study data set is shared among a consortium of 6 research teams, from Canada, Australia, New Zealand, and us, in the UK. Via our Unit based at the Univ of Otago in New Zealand, we share the data with more than 80 other research teams outside the Study group, including with 23 universities in the USA. This study has been ongoing since 1972, has a 32 year dataset, and has had 12 assessments.
Impact more than 1200 scientific publications since 1973
 
Description Duke University Geriatrics School of Medicine 
Organisation Duke University
Department School of Medicine Duke
Country United States 
Sector Academic/University 
PI Contribution coauthor papears
Collaborator Contribution coauthor papers
Impact PNAS publication
Start Year 2014
 
Description Duke university co-directing phase 18 
Organisation Duke University
Department Insitute of Genome Sciences and Policy
Country United States 
Sector Academic/University 
PI Contribution Moffitt and Caspi have joint appointments at Duke, and are co-investigators in phase 18 of the E-risk study led by Louise Arseneault
Collaborator Contribution ideas
Impact Phase 18 data collection
 
Description Global Burden of Disease 
Organisation Global Burden of Disease Study
Country Global 
Sector Academic/University 
PI Contribution collaborate
Collaborator Contribution collaborate
Impact 3 publications
Start Year 2011
 
Description Global burden of Disease 
Organisation Global Burden of Disease Study
Country Global 
Sector Academic/University 
PI Contribution coauthor
Collaborator Contribution run the GBD
Impact publications
Start Year 2013
 
Description Harvard studies of child epidemiology 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution we provided data and co-wrote papers with Dr Koenen
Collaborator Contribution data and idea exchange
Impact 2 publications
 
Description INSERM France studies of social and health inequality 
Organisation National Institute of Health and Medical Research (INSERM)
Department UMRS 1018 (Centre for Research in Epidemiology and Population Health (CESP))
Country France 
Sector Public 
PI Contribution collaborated on data analyses
Collaborator Contribution writing
Impact several publications
Start Year 2006
 
Description MAx Planck Institute of Psychiatry 
Organisation Max Planck Society
Department Max Planck Institute of Psychiatry
Country Germany 
Sector Public 
PI Contribution replication on findings in independent studies
Collaborator Contribution replication of findings
Impact publication
Start Year 2010
 
Description MRC HArwell 
Organisation MRC Harwell
Country United Kingdom 
Sector Academic/University 
PI Contribution datasets
Collaborator Contribution coauthors papers
Impact Publicaton
Start Year 2012
 
Description Murcia Spain studies of child injury 
Organisation University of Murcia, Spain
Country Spain 
Sector Academic/University 
PI Contribution we provided data and co wrote paper
Collaborator Contribution data and idea exchange, visiting professor
Impact 1 publication
Start Year 2007
 
Description Rijkshospitalet Psychiatry Denmark 
Organisation Rigshospitalet
Country Denmark 
Sector Hospitals 
PI Contribution coauthor and train students
Collaborator Contribution data registries
Impact publication
Start Year 2014
 
Description UCL psychology stuides of callous unemotional traits 
Organisation University College London
Department Division of Psychology & Language Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution we co wrote papers with dr viding
Collaborator Contribution idea and data exchange
Impact 3 publications
Start Year 2007
 
Description Univ of Calif at Irvine Neighbourhood REsearch 
Organisation University of California, Irvine
Country United States 
Sector Academic/University 
PI Contribution E-risk data sharing with team at UC Irvine who has geocoded indicators of neighbourhood level health and poverty indicators to study hwo these affect children's mental health development.
Collaborator Contribution augmented data base
Impact 6 papers in the analysis stage
Start Year 2008
 
Description Univ of Montreal Dept of Criminology 
Organisation University of Montreal
Department School of Criminology
Country Canada 
Sector Academic/University 
PI Contribution collaborate on publications
Collaborator Contribution ideas
Impact several papers
Start Year 2011
 
Description Univ of Pennsylvania studies of child abuse 
Organisation University of Pennsylvania
Department Department of Psychology
Country United States 
Sector Academic/University 
PI Contribution we provided data
Collaborator Contribution data and idea exchange
Impact 2 articles
Start Year 2007
 
Description University of Otago replications of genetic findings 
Organisation University of Otago
Department Dunedin School of Medicine
Country New Zealand 
Sector Academic/University 
PI Contribution WE replicated findings from the NZ Dunedin cohort in the UK E-risk cohort.
Collaborator Contribution sister studies in two countries, both funded in part by MRC, we can build in replication checks for any and all findings
Impact 4 articles, reported to MRC eval under our other grant, for the Dunedin Study. All are multidisciplinary, involving genetics and pscyhiatry and psychology.
Start Year 2006
 
Description Yale University studies of child risk 
Organisation Yale University
Department Department of Psychology
Country United States 
Sector Academic/University 
PI Contribution we provided data
Collaborator Contribution idea exchange and data exchange
Impact 2 articles
Start Year 2008
 
Title DSM-IV and DSM-V conduct disorder subtype criterion 
Description Our research has lead the field of child psychiatry to recognise childhood-onsert versus adolescent-onset as the subtyping scheme for Conduct Disorder encoded in the DSM-4 and DSM-5 diagnostic systems of the American Psychaitric Association 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact Worldwide method for diagnosing conduct disorder in children 
 
Title FADS2 gene link with IQ 
Description We discovered that babies' genotype on FADS2 is associated with elevated IQ in response to breastfeeding, and replicated this finding. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2008
Development Status On hold
Impact none 
 
Title Genetic tests to subtype ADHD 
Description We identified genetic polymorphisms that help to divide ADHD children into subtypes on the basis of their aggressiveness, low intelligence, and poor adult prognosis. The initial MRC-funded findings were replicated. If further replicated, the findings may eventually feed into a genetically informed diagnostic practice for childhood ADHD. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2007
Development Status On hold
Impact none 
 
Title pediatric psychiatric screening 
Description A follow-back study of the MRC-funded Dunedin cohort revealed that 75% of adults treated for psychiatric disorders had first evidenced a diagnoseable mental disorder prior to age 18. This finding identifies child psychiatric screening as a strategy for prevention to reduce adult psychiatric disorder, disability, and health service costs. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Refinement. Non-clinical
Year Development Stage Completed 2010
Development Status Under active development/distribution
Impact none 
 
Description 2011 media coverage of findings about self control 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Public Broadcasting System Lehrer News Hour programme on how this work has been translated by Sesame Street puppets to teach children financial literacy and saving behaviour http://www.pbs.org/newshour/bb/business/jan-june11/makingsense_06-03.html.
http://www.sesameworkshop.org/program_overview/for_me_for_you_for_later


/Blog interview with Paul Salmon of PNS: http://newshour.tumblr.com/post/6250720530/the-key-to-a-successful-life

Stephen Colbert covered the above PBS story:
http://www.colbertnation.com/the-colbert-report-videos/389614/june-14-2011/close-sesame

Editorial by Angela Duckworth, (2011) The significance of self-control. PNAS

F1000 of Biology, Excellent new finding.

NPR radio story: http://www.npr.org/2011/02/14/133629477/for-kids-self-control-factors-into-future-success

This paper was covered widely in the media, including TIME, Science, Wall St Journal, Science News,
Reuters, WebMD, The New Scientist, USA Today, News and Observer, Daily Telegraph, Toronto Globe & Mail, Parenting, Parenting Early Years, Boston Globe, etc.

Perhaps the best coverage is in Discover Magazine:
http://blogs.discovermagazine.com/notrocketscience/2011/01/24/self-control-in-childhood-predicts-health-and-wealth-in-adulthood/
Scientific American is also good: http://www.scientificamerican.com/article.cfm?id=how-self-control-works
Wall Street journal http://online.wsj.com/article/SB10001424053111904716604576542593019231326.html
http://www.scientificamerican.com/article.cfm?id=where-theres-a-will
http://www.nytimes.com/2011/06/20/arts/genetics-and-crime-at-institute-of-justice-conference.html?_r=1&hpw

http://articles.boston.com/2011-06-12/bostonglobe/29650724_1_marshmallow-control-children

http://www.newsobserver.com/2011/01/30/955533/unruly-kids-may-not-change.html
http://www.voxy.co.nz/lifestyle/children-more-self-control-turn-healthier-and-wealthier-adults/5/79430
http://blogs.wsj.com/health/2011/01/24/toddlers-with-low-self-control-face-problems-in-adulthood/
http://online.wsj.com/article/SB10001424052748704279704576102164041456434.html
http://www.physorg.com/news/2011-01-childhood-self-control-adult-health-wealth.html
http://healthland.time.com/2011/01/24/the-key-to-health-wealth-and-success-self-control/
http://www.parentcentral.ca/parent/newsfeatures/article/927209--self-discipline-determines-kids-success
http://www.sciencenews.org/view/generic/id/69090/title/Stage_set_early_for_success,_or_failure
http://www.healthfinder.gov/news/newsstory.aspx?docID=649156
http://kidshealth.org/parent/emotions/behavior/self_control.html )
http://news.discovery.com/human/children-self-control-success-110124.html
http://in.reuters.com/article/idINIndia-54371120110124
http://www.theglobeandmail.com/life/health/the-secret-of-success/article1881494/
http://www.myhealthnewsdaily.com/self-control-children-health-wealth-finances-110124-1082/
http://children.webmd.com/news/20110124/self-control-in-childhood-brings-adults-success
http://content.usatoday.com/communities/sciencefair/post/2011/01/study-self-control-at-age-5-key-to-future/1
http://www.radio-canada.ca/nouvelles/sante/2011/01/24/002-enfant-maitrise-soi.shtml
http://www.newscientist.com/article/dn20029-kids-with-low-selfcontrol-are-less-successful-adults.html
http://www.voanews.com/english/news/asia/Childs-Self-control-Predicts-Future-Health-Success-114791594.html
http://news.sciencemag.org/sciencenow/2011/01/dont-take-that-cookie.html


new programming on Sesame Street children's television
Year(s) Of Engagement Activity 2011
 
Description 2011 media coverage of our work on depression 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact http://news.bbc.co.uk/today/hi/today/newsid_9564000/9564795.stm

http://www.bbc.co.uk/programmes/p00jftsh

http://www.bbc.co.uk/news/health-14503479

http://www.bbc.co.uk/mundo/noticias/2011/08/110815_salud_maltrato_infantil_depresion_sao.shtml

http://www.bbc.co.uk/news/science-environment-14562120


http://www.guardian.co.uk/society/2011/aug/15/depression-childhood-abuse-maltreatment

http://www.thetimes.co.uk/tto/health/news/article3134048.ece

http://www.dailymail.co.uk/sciencetech/article-2026108/Childhood-abuse-victims-twice-likely-suffer-lifetime-depression.html

http://www.channel4.com/news/depression-link-to-childhood-abuse

http://news.scotsman.com/health/Experts-link-depression-to-abuse.6818723.jp

http://www.bmj.com/content/343/bmj.d5246.extract

http://alert.psychiatricnews.org/2011/08/childhood-maltreatment-worsens-adult.html

http://www.medscape.com/viewarticle/748462

http://www.cbsnews.com/8301-504763_162-20092607-10391704.html?tag=contentMain;contentBody

http://www.foxnews.com/health/2011/08/15/study-links-persistent-depression-to-childhood-abuse/

http://health.usnews.com/health-news/family-health/brain-and-behavior/articles/2011/08/22/abuse-neglect-in-childhood-linked-to-depression-in-adulthood

http://www.sciencemediacentre.org/pages/press_releases/11-09-12_biologist_day_care.htm

http://www.newyorker.com/reporting/2011/03/21/110321fa_fact_tough



public understanding of recurrent depression
Year(s) Of Engagement Activity 2011
 
Description 3-page story about our research in the journal: Science. 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact 3-page feature article about our careers in the Dunedin Study.
Year(s) Of Engagement Activity 2018
URL http://science.sciencemag.org/content/359/6375/510.full
 
Description 6 editorials about our findings 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Health professionals
Results and Impact 6 different articles reporting new findings from our work were selected by the journal editors to be featured in special editorials discussing their implications and impact

greater dissemination of new findings
Year(s) Of Engagement Activity 2010,2011
 
Description Arseneault paper selected for Medical Continuinig Education in USA 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Health professionals
Results and Impact Arseneault L, Cannon M, Fisher HL, Polanczyk G, Moffitt TE, Caspi A (2011). Childhood trauma and children's emerging psychotic symptoms: a genetically sensitive longitudinal cohort study. American Journal of Psychiatry, 168, 65-72.

This paper was covered in an editorial by Patricia Cohen, Abuse in Childhood and the Risk for Psychotic Symptoms in Later life,
American J Psychiatry 168:7-8, January 2011
This paper was selected by the editor for Continuing Medical Education credit.


education of psychiatrists
Year(s) Of Engagement Activity 2011
 
Description Blog on stress and health 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Primary Audience Policymakers/politicians
Results and Impact http://www.psychologytoday.com/blog/genes-and-the-environment/201011/childhood-stress-and-lifelong-health



na
Year(s) Of Engagement Activity 2010
 
Description Home office, Council of Europe, etc. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Primary Audience Policymakers/politicians
Results and Impact consultations and reports

more than I can describe here
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description Media interest Odgers2015 Antisocial behaviours and inequality 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Dr Odgers' work on antisocial behaviours and inequality has been reviewed by:
Washington Post

Our research on neighborhood inequality and boys' antisocial behaviours was recently released only and attracted attention from the media.

Citation:
Odgers, CL, Donley, S, Caspi, A., Bates, CJ. & Moffitt, TE. Living alongside more affluent neighbours predicts greater involvement in antisocial behavior among low-income boys. (2015). Journal of Child Psychology and Psychiatry. doi:10.1111/jcpp.12380

Media coverage:

Washington Post
The surprising cost of growing up poor in the shadow of wealth"
http://www.washingtonpost.com/blogs/wonkblog/wp/2015/01/23/the-surprising-cost-of-growing-up-poor-in-the-shadow-of-wealth/

Today @ Duke
Low-Income Boys Fare Worse In Wealth's Shadow
http://today.duke.edu/2015/01/low-incomeboys

BBC News - Education and Family
Poor boys fare worse in rich areas, suggests research
http://www.bbc.com/news/education-30950523

London Times - Education (misleading coverage; we are responding with a letter to the editor)
Boys behave badly when surrounded by better off families
http://www.thetimes.co.uk/tto/education/article4331786.ece

New Republic
Study: Poor Boys are more likely to fight, lie and steal if they live in mixed-income housing
http://www.newrepublic.com/article/120827/study-low-income-boys-perform-worse-mixed-income-housing

Medical Daily
Antisocial Behavior Higher For Low-Income Boys Living Beside Wealthier Neighbors
http://www.medicaldaily.com/antisocial-behavior-higher-low-income-boys-living-beside-wealthier-neighbors-319126

Reprinted media release:
PsychCentral: http://psychcentral.com/news/2015/01/24/low-income-boys-fare-worse-in-wealthier-neighborhoods/80336.html
Science Blog: http://scienceblog.com/76599/low-income-boys-fare-worse-wealths-shadow/#g06vMtXvculJIBLH.97

The Economist: http://www.economist.com/news/britain/21641283-unnervingly-poor-children-seem-fare-better-poor-neighbourhoods-paradox-ghetto


The research was covered on the MacArthur Foundation Housing Matters SmartBrief: http://www2.smartbrief.com/servlet/encodeServlet?issueid=1A250F3E-8760-4701-9E62-1B6EF2AF1E8B&sid=8d9444c2-87b5-4506-9421-0f6344afc31d


The William T. Grant Foundation also featured the story on their home page, and has invited a 800 word blog post on our research. They are particularly interested in commentary on how growing inequality may be influencing children. http://blog.wtgrantfoundation.org/post/114539962232/the-hidden-costs-of-growing-up-in-the-shadow-of

February 3, 2015 Candice Odgers appeared on HuffPost Live at noon February 3, discussing her research on anti-social behaviors of low-income children living in mixed-income housing. The HuffPost live: http://live.huffingtonpost.com/r/segment/mixed-income-housing-bad-for-low-income-boys/54c911e078c90a46e8000567

The Conversation:
Poor doors highlight social costs of growing up in the shadow of wealth
http://theconversation.com/poor-doors-highlight-social-costs-of-growing-up-in-the-shadow-of-wealth-39846


None so far
Year(s) Of Engagement Activity 2015
URL http://childandfamilypolicy.duke.edu/news/
 
Description REport to UK Parliament on twin separation in schools 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Primary Audience Policymakers/politicians
Results and Impact Fraser, E. et al. (2009) Multiple Choice: The educational needs and experiences of multiple birth children. London: TAMBA.
Covered in the Guardian. October 22, 2009.


educational policy changed.
Year(s) Of Engagement Activity 2010
 
Description Royal Society Soiree and Webcast Behaving Badly 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact "Behaving badly", http://royalsociety.tv/dpx_royalsociety/dpx.php?dpxuser=dpx_v12 A Royal Society and soiree and webcast debate concerning the criminal mind, featuring John Banville, whose latest novel, The Sea, won the 2005 Man-Booker Prize; Dr James Blair from the US National Institute of Mental Health, Professor Uta Frith from the Institute of Cognitive Neuroscience & Department of Psychology at University College London; Professor Terrie Moffitt from the Institute of Psychiatry; and Fay Weldon, acclaimed novelist, playwright, screenwriter and columnist. October 15, 2007, London, UK.

better public understanding of genetics research
Year(s) Of Engagement Activity 2008
URL http://royalsociety.tv/dpx_royalsociety/dpx.php?dpxuser=dpx_v12
 
Description US Instititue of Medicine Report on hunger and obesity 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Primary Audience Policymakers/politicians
Results and Impact Melchior M. 'Socioecological perspectives: the family and household level'. In IOM (Institute Of Medicine). 2011: Hunger and Obesity: understanding a food insecurity paradigm. The National Academies Press, Washington DC.
- <>, IOM Worskshop on understanding the relationship between food insecurity and obesity, Washington DC, 16-18/11/2010

funding programme launched on food insecurity in the USA
Year(s) Of Engagement Activity 2010
 
Description US National Scientific Council on the Developing Child report 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Primary Audience Policymakers/politicians
Results and Impact Danese et al 2011 paper was reported by the US National Scientific Council on the Developing Child report The Foundations of Lifelong Health are Built in Early Childhood. http://developingchild.harvard.edu/index.php/library/reports_and_working_papers/foundations-of-lifelong-health/

na
Year(s) Of Engagement Activity 2011
 
Description US Natl Acad of Sciences, UK Home Office, Insititute of Medicine, etc 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Policymakers/politicians
Results and Impact AS one example...US-NIH "State of the Science" Congress on Youth Violence, October 2004, Washington, DC. Webcast.

As another example:
- The US Institute of Medicine, 2010:
http://www.iom.edu/Activities/Children/Neuronstoneighborhoods/2010-OCT-28/Panel-1/Panel-1-3.aspx
- The US National Institute of Health, 2011: http://obssr.od.nih.gov/scientific_areas/social_culture_factors_in_health/health_disparities/esrc-grantee-workshop2011.aspx


Government funding priorities for violence research in the USA were altered.
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
URL http://obssr.od.nih.gov/scientific_areas/social_culture_factors_in_health/health_disparities/esrc-gr...
 
Description Wellcome Trust Art Exhibit Nature's Great Experiment 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact AS one example... "Nature's Great Experiment," http://www.naturesgreatexperiment.com This is an installation of three videos inspired by our Environmental Risk Longitudinal Twin Study (E-risk) in collaboration with artist Jordan Baseman. The show had its debut at the Monash University Museum of Art and Design in February, 2007, and shows at the Wellcome Trust Museum of Medicine in London in May, 2007. "Laws of Variation" films a very bloody multiple-birth delivery, with voiceover of Terrie Moffitt discussing the joys and traumas of human variation. "Tape1 Tape2" presents a mother of MZ twins explaining to a researcher the reasons why she adores one daughter and dislikes the other. "Nature's great experiment" narrates a research workers' view of the science of behavioural genetics, and describes her day-to-day experiences with families, some of whom harm or neglect their twins. The art was funded by the Wellcome Trust. The art was funded by the Wellcome Trust. The website has been visited by more than 30,000 viewers each year since 2007. In 2010 the films are screened in lecture theatres and galleries in Belfast, Dundee, Aberdeen, Hull, and Bury St. Edmunds, as part of the Wellcome Trust "identity" series.

better public understanding of genetics research
Year(s) Of Engagement Activity 2008
URL http://www.naturesgreatexperiment.com
 
Description amicus brief to US Supreme Court 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Primary Audience Policymakers/politicians
Results and Impact juvenile offenders no longer subject to death penalty
Year(s) Of Engagement Activity 2010
 
Description film documentary Jacobs Foundation 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact www.jacobs.foundation.org shows 2 video documentaries about our research as part of their prize materials
Video interview about our research by the Jacobs Foundation, 10 minutes:
http://award.jacobsfoundation.org/research-laureate-2010/


just went on line
Year(s) Of Engagement Activity 2010
 
Description keynote and plenary lectures 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Health professionals
Results and Impact International conference presentations, keynotes, invited lectures, plenaries, approximately 8-12 per year

education
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010
 
Description keynotes, plenary talks 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Primary Audience Health professionals
Results and Impact Publice lectures about the Dunedin Study findings

more than I can describe here
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description magazine,broadsheet, TV, radio, internet news coverage 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact Our GxE findings have had enormous press coverage in 2002, 2003, and 2007, other findings have also been covered by the media

public understanding of genetics
Year(s) Of Engagement Activity 2006,2007,2008
 
Description media coverage in 2010 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact our findings were covered extensively in broadsheet, radio, television, and web news outlets in the UK and abroad, will provide details if asked, too much to type here
Discussed in Editorial: E. Susser & P. Shrout (2009). Psychological Medicine, 39.
Covered by http://www.sciencenews.org/view/generic/id/47444/title/Rates_of_common_mental_disorders_double_up
Recommended as a must read by Faculty 1000 of Medicine: http://www.f1000medicine.com/article/id/1165344/evaluation
listed as a resource by Tepou: http://www.tepou.co.nz/knowledge-exchange/research/view/listing/392/
http://www.eurekalert.org/pub_releases/2009-09/du-cmd091009.php
http://www.sciencedaily.com/releases/2009/09/090910151925.htm
http://www.innovations-report.com/html/reports/studies/common_mental_disorders_common_139664.html
http://latimesblogs.latimes.com/booster_shots/2009/09/common-mental-illnesses-more-common-than-you-think-duke-study.html
http://current.com/items/90916401_is-mental-illness-more-common-than-we-think.htm
http://www.elementsbehavioralhealth.com/behavioral-health-news/anxiety-depression-and-substance-abuse-may-be-more-common-than-we-think/
http://www.huliq.com/11/86156/mental-disorders-may-be-more-common-thought
http://psychcentral.com/news/2009/09/10/how-common-are-mental-disorders/8303.html http://www.bigmedicine.ca/bioscitech.htm#0912_Common_mental_disorders_may_be_more_common_than_we_think


public understanding of science
Year(s) Of Engagement Activity 2010
 
Description media coverage of our research in 2015 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Print coverage
Cosmopolitan Magazine: http://www.cosmopolitan.com/health-fitness/news/a35586/what-your-social-life-is-doing-to-your-body/
Daily Mail 20.01.2015 - p13
http://www.dailymail.co.uk/health/article-2918139/Do-suffer-social-jetlag-two-hour-lie-weekend-increases-risk-OBESE-scientists-warn.html
Daily Telegraph - 20.01.2015 - p14
http://www.telegraph.co.uk/news/science/science-news/11358195/Social-jet-lag-is-driving-obesity-and-illness-say-scientists.html
The Independent - 20.01.2015 - p15
http://www.independent.co.uk/life-style/health-and-families/fancy-a-liein-on-weekends-new-study-finds-it-could-lead-obesity-and-diabetes-9990661.html
The Times - 20.01.2015 - p14
The Sun - 20.01.2015 - p25
Online
https://www.sciencenews.org/blog/scicurious/weekly-grind-social-jetlag-could-be-weighty-issue
NHS choices - http://www.nhs.uk/news/2015/01January/Pages/Social-jet-lag-linked-to-obesity-and-unhealthy-metabolism.aspx
Diabetes.co.uk - http://www.diabetes.co.uk/news/2015/jan/sleeping-late-at-the-weekend-linked-to-obesity-and-type-2-diabetes-97385674.html
Yahoo News UK - https://uk.lifestyle.yahoo.com/blogs/icymi/no-more-weekend-lie-ins--study-finds-they-re-making-us-sick-and-fat-112510799.html
Huffington Post UK - http://www.huffingtonpost.co.uk/2015/01/21/obesity-social-jet-lag-sleep_n_6514568.html
Shape Magazine US - http://www.shape.com/weight-loss/weight-maintenance/how-your-sleep-schedule-affects-your-weight-gain-and-disease-risk
Australian's Women Weekly - http://www.aww.com.au/diet-health/health-news/2015/1/do-you-have-social-jet-lag/
New Kerala India - http://www.newkerala.com/news/2015/fullnews-9245.html
Zee News India - http://zeenews.india.com/news/health/health-news/heres-how-social-jet-lag-can-affect-your-weight-gain-and-disease-risks_1534053.html
Why Some People May Be Harder Hit by Daylight Saving Time http://www.livescience.com/50078-daylight-saving-time-unhealthy.html
Broadcast
BBC Radio 5 Live - 21.01.2015 - 51:30, http://www.bbc.co.uk/programmes/b04yg8l4
BBC Radio Scotland - 21.01.2015 - 55:44, http://www.bbc.co.uk/programmes/b04ykb7n
BBC Radio Kent - 21.01.2015 - 01:28:12. http://www.bbc.co.uk/programmes/p02gh8ys
BBC Radio Sheffield - 21.01.2015 - 52:44, http://www.bbc.co.uk/programmes/p02grdyy
BBC Hereford and Worcestershire - 22.01.2015 - 02:05:40, http://www.bbc.co.uk/programmes/p02ghczy
VIDEO: (http://today.duke.edu/2015/01/low-incomeboys )
Live interview: http://live.huffingtonpost.com/r/segment/mixed-income-housing-bad-for-low-income-boys/54c911e078c90a46e8000567
Op-Ed: http://theconversation.com/poor-doors-highlight-social-costs-of-growing-up-in-the-shadow-of-wealth-39846

NPR National Public Radio: http://wunc.org/post/mixed-income-housing-pros-cons

This article got lots of news coverage, among the best articles are:
http://www.economist.com/news/britain/21641283-unnervingly-poor-children-seem-fare-better-poor-neighbourhoods-paradox-ghetto
http://www.newrepublic.com/article/120827/study-low-income-boys-perform-worse-mixed-income-housing
http://www.washingtonpost.com/blogs/wonkblog/wp/2015/01/23/the-surprising-cost-of-growing-up-poor-in-the-shadow-of-wealth/
http://www.bbc.com/news/education-30950523 http://www.thetimes.co.uk/tto/education/article4331786.ece
http://www.medicaldaily.com/antisocial-behavior-higher-low-income-boys-living-beside-wealthier-neighbors-319126
http://psychcentral.com/news/2015/01/24/low-income-boys-fare-worse-in-wealthier-neighborhoods/80336.html
http://scienceblog.com/76599/low-income-boys-fare-worse-wealths-shadow/#g06vMtXvculJIBLH.97

MacArthur Foundation Housing Matters SmartBrief: http://www2.smartbrief.com/servlet/encodeServlet?issueid=1A250F3E-8760-4701-9E62-1B6EF2AF1E8B&sid=8d9444c2-87b5-4506-9421-0f6344afc31d


http://johnraissmd.com/blog/?p=64
Selected at CME for American Psychiatirc Association. (1 Continuing Medical Education credit)
NEJM Journal watch: http://www.jwatch.org/na38100/2015/06/05/how-related-are-adult-and-childhood-adhd?query=topic_substabuse
http://www.psychcongress.com/article/adult-adhd-may-be-separate-childhood-adhd-22824
http://alert.psychnews.org/2015/06/adult-adhd-may-be-distinct-from.html
http://www.healio.com/psychiatry/add-adhd/news/online/%7B08ca3e86-938b-4576-9f5b-66db4e6eeb02%7D/adults-with-adhd-may-not-have-had-onset-of-disorder-in-childhood
http://www.medwirenews.com/47/106298/Psychiatry/Adult_ADHD_could_be_distinct_condition.html

BBC WORLD NEWS interview: http://www.bbc.co.uk/programmes/p002vsnk/episodes/downloads

ALTMETRICS: tracking all internet mentions: http://pnas.altmetric.com/details/4248247/news

VIDEO Wall St. Journal: http://www.wsj.com/articles/how-quickly-are-you-growing-old-1436808166
ScitechNow: http://scitechnow.org/technology/old-really/#

http://thedoctorweighsin.com/predicting-the-speed-of-aging/
http://www.theonion.com/americanvoices/researchers-people-age-different-rates-50802
http://www.haaretz.co.il/news/science/.premium-1.2678930
http://www.maariv.co.il/news/world/Article-487817
http://www.corriere.it/salute/15_luglio_08/invecchiamento-inizia-giovani-non-uguale-tutti-10c41f7e-2545-11e5-85c7-ee55c, 78b3bf9.shtml

A summary of coverage links is here:
USA
Print
Wall Street Journal (with video), Washington Post, LA Times, TIME, US News and World Report
Radio/TV
CBS News (with video), NBC News (with video), Science Friday (audio @7:45 min in), Voice of America, BBC News Hour (audio)

UK
BBC News, The Guardian, The Telegraph, The Times, Daily Mail,

EU & AUSTRALIA
Deutche Welle, Der Spiegel, El Pais, Science et Avenir, Le Science, Australian Broadcasting Corp.

OTHER
Al Jazeera America, Jerusalem Post, Haaretz, Times of India, The Hindu, Gazete Istambul

INTERNET
NEJM Journalwatch, Huffington Post, Yahoo News, Medical News Today, MedPage Today, Medical Xpress, WebMD, The Conversation, SciTech, SciTech Today, Big Think, Science World Report, The Mermaid's Tale, IFLS, The Onion.
http://www.thedailymash.co.uk/news/science-technology/number-of-years-youve-been-alive-tells-you-how-old-you-really-are-20150907101749


enormous interest in five of our publicatons this year
Year(s) Of Engagement Activity 2015
 
Description secondary school education 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Schools
Results and Impact The 'Ethical Emporium.' http://www.windfalldigital.com/ethicalemporium/ A digital website and DVD module for high school science and citizenship teachers and students exploring the interaction between genes and environment in behavior, focusing on our 2002 MAOA/maltreatment research. This digital resource is funded by the Wellcome Trust and NESTA, produced by the Wellcome Trust Sanger Institute, Oxford University.

is being adopted for UK secondary schools curriculum
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description video documentary by NARSAD 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact Video interview about our research by NARSAD, the Brain and Behavior Research Foundation, 5 minutes:
http://www.narsad.org/?q=node/13/disorder


public understanding of mental illness
Year(s) Of Engagement Activity 2010
 
Description workshops, CDs, booklets for training professionals 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Primary Audience Health professionals
Results and Impact As one example, our paper on the serotonin transporter is disseminated as a PharmD training program for psychiatrists: slide kit, guidebook, and accompanying CD-ROM: "Causes & Consequences of Depression: Rationale for Early, Vigorous, & Complete Treatment to Prevent Remission, 2005."

training pharmacists
Year(s) Of Engagement Activity 2006,2007,2009,2010,2011
 
Description workshops, training CDs 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Primary Audience Health professionals
Results and Impact teaching continuing education workshops to clinicians, training CD's, booklets

more than I can describe here
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description you-tube video 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Primary Audience Public/other audiences
Results and Impact http://www.youtube.com/watch?v=Nm_u_r5F0Sc



just went on line
Year(s) Of Engagement Activity 2010