Safety and feasibility of neural transplantation in early to moderate Huntington's disease in the UK.
Lead Research Organisation:
University of Cambridge
Department Name: Cambridge Centre for Brain Repair
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Quinn L
(2014)
Task-specific training in Huntington disease: a randomized controlled feasibility trial.
in Physical therapy
Barker R
(2013)
The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease
in Journal of Neurology, Neurosurgery & Psychiatry
| Description | Citations in clinical guidelines and reviews |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in clinical reviews |
| Impact | we contribute to ongoing debate and updating of guidelines on ethical sourcing of human fetal tissues for research and clinical cell transplantation. |
| Description | GTAC |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| Impact | development of national ethical and regulatory guidelines |
| Description | GTAC |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Impact | member of GTAC committee reviewing applications and developing policy on stem cell and gene therapy trials in the UK |
| Description | MRC |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Impact | Targetted direction, policy and funding of UK stem cell research . |
| Description | MRC Stem Cells |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Impact | I participate in the MRC UK Stem Cell Bank users group and contribute regularly to the policy discussions at head office on stem cell strategy and funding. |
| Description | MRC stem cell |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Impact | I participate in the MRC Stem Cell Bank User's group and participate regularly in MRC stem cell policy and funding strategy meetings at Head Office. |
| Description | MRC stem cells |
| Geographic Reach | National |
| Policy Influence Type | Participation in advisory committee |
| Impact | I participate in the MRC Stem Cell Bank User's group and participate regularly in MRC stem cell policy and funding strategy meetings at Head Office. |
| Description | regular citations in clinical reviews and publications |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in other policy documents |
| Impact | influence on development of NECTAR and ASNTR guidelines |
| Description | MRC Programme Grant |
| Amount | £2,941,590 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2010 |
| End | 03/2013 |
| Description | PDS international collaboration |
| Amount | £161,923 (GBP) |
| Funding ID | J-0703 |
| Organisation | Parkinson's UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2007 |
| End | 09/2009 |
| Description | REPLACES Restorative plasticity at corticostriatal excitatory synapses (4.2m euros across 12 participants) |
| Amount | £873,507 (GBP) |
| Funding ID | 222918 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 11/2008 |
| End | 10/2012 |
| Title | mTOPs |
| Description | Validation of alternative protocols for consented collection of human fetal tissue |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2009 |
| Provided To Others? | Yes |
| Impact | Resolves the outstanding block on limited tissue availability to allow multiple international research and clinical trials to resume. |
| Description | 10-15 presentations to HDA and PDS patient groups |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 10-15 presentations to HDA and PDS patient groups. I present regular medical and lay seminars around the country and internationally. I am afraid I am unable to list all the individual presentations. academic, medical and patient contacts |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | 10-15 presentations to HDA and PDS patient groups. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | I present regular medical and lay seminars around the country and internationally. I am afraid I am unable to list all the individual presentations. various |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | 10-15 presentations to HDA and PDS patient groups. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Participants in your research and patient groups |
| Results and Impact | 10-15 presentations to HDA and PDS patient groups. I present regular medical and lay seminars around the country and internationally. I am afraid I am unable to list all the individual presentations. various |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | 10-15 presentations to HDA and PDS patient groups. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | I present regular medical and lay seminars around the country and internationally. I am afraid I am unable to list all the individual presentations. various |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | results included in multiple public and academic lectures and seminars |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | results included in multiple public and academic lectures and seminars various |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |
| Description | results included in multiple public and academic lectures and seminars |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | results included in multiple public and academic lectures and seminars various |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009,2010 |