MRC/WT Human Tissue Resource

Lead Research Organisation: University College London
Department Name: Unlisted

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50

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Burns AJ (2008) Development of the neural crest-derived intrinsic innervation of the human lung. in American journal of respiratory cell and molecular biology

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Cadman SM (2007) Molecular pathogenesis of Kallmann's syndrome. in Hormone research

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Cale CM (2000) Inflammatory mediators in human renal dysplasia. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

 
Description Human Developmental Biology Resource (HDBR): an embryonic and fetal tissue bank for functional genetics and cell-based research
Amount £4,117,367 (GBP)
Funding ID MR/R006237/1 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2018 
End 01/2023
 
Description Human Developmental Biology Resource (HDBR): an embryonic and fetal tissue bank for functional genetics and cell-based research
Amount £4,117,367 (GBP)
Funding ID MR/R006237/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2018 
End 01/2023
 
Description Human Developmental Biology Resource: support for Human Cell Atlas
Amount £686,407 (GBP)
Funding ID MR/S036334/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 12/2018 
End 12/2020
 
Description MRC HDBR Grant (2008-13)
Amount £1,353,090 (GBP)
Funding ID G0700089 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2008 
End 02/2013
 
Description Partnership Grant
Amount £4,117,367 (GBP)
Funding ID MR/R006237/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2018 
End 01/2023
 
Description UK Human Developmental Biology Initiative
Amount £6,148,973 (GBP)
Funding ID 215116/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2019 
End 09/2024
 
Description Wellcome Trust HDBR grant (2008-13)
Amount £783,438 (GBP)
Funding ID 082557 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2008 
End 02/2013
 
Title HDBR human fetal tissue bank 
Description The Human Developmental Biology Resource (HDBR) is an MRC/Wellcome Trust funded human fetal tissue bank established to provide material to any project that is studying human embryonic and fetal gene expression in relation to congenital disease. In addition, gene expression studies are undertaken in-house by staff of the HDBR on behalf of workers who supply gene probes or antibodies. The HDBR provides expert advice on interpretation of gene expression patterns in relation to embryonic and fetal anatomy. 
Type Of Material Improvements to research infrastructure 
Year Produced 2008 
Provided To Others? Yes  
Impact Continuing increase in the number of gene discovery papers in which there are now human embryonic and fetal gene expression data, to establish the timing and tissue localisation of gene expression. Improved understanding of human fetal development as relevant to congenital disease 
URL http://www.hdbr.org
 
Description British Pregnancy Advisory Service (BPAS) 
Organisation British Pregnancy Advisory Service (BPAS)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Research projects that have benefited BPAS in its overall mission.
Collaborator Contribution Provision of fetal material for HDBR projects.
Impact Ongoing working relationship.
 
Description Collaboration with HDBR user groups, e.g. as below (but many other partners as well) 
Organisation Oxford University Hospitals NHS Foundation Trust
Department Clinical Genetics
Country United Kingdom 
Sector Hospitals 
PI Contribution The purpose of the HDBR is to provide human fetal material to a wide range of research laboratories in the UK and beyond, in order to enable studies of gene expression and related research in humans. To this end, a great many collaborations were established, with each laboratory being a registered user of the HDBR. Full details of these registered users were provided to the MRC as part of the successful application for follow-on funding in 2007 (G0700089), and are available upon request.
Collaborator Contribution The collaborating HDBR user groups brought research questions (usually newly identified human disease genes) for which human developmental gene expression data were obtained by HDBR staff.
Impact All publications in section 2 are the result of the collaborations with HDBR user groups.
 
Description HDBR web site 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach International
Primary Audience Health professionals
Results and Impact Web site gives details and examples of work completed using fetal material from the HDBR and encourages registration of new projects with the service

Increase in requests for project registration with HDBR
Year(s) Of Engagement Activity 2006,2007,2008,2009