The neurobiology of impulse control and empathy in normal, antisocial and anxious individuals
Lead Research Organisation:
University of Manchester
Department Name: Unlisted
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Publications
Alves-Neto WC
(2010)
Effect of escitalopram on the processing of emotional faces.
in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Anderson IM
(2002)
5-HT(2C) receptor activation by m-chlorophenylpiperazine detected in humans with fMRI.
in Neuroreport
Anderson IM
(2008)
Assessing human 5-HT function in vivo with pharmacoMRI.
in Neuropharmacology
Anderson IM
(2007)
Citalopram modulation of neuronal responses to aversive face emotions: a functional MRI study.
in Neuroreport
Da Costa Araújo S
(2010)
Choice between reinforcer delays versus choice between reinforcer magnitudes: differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core.
in Behavioural brain research
Elliott R
(2008)
Medial orbitofrontal cortex codes relative rather than absolute value of financial rewards in humans.
in The European journal of neuroscience
Elliott R
(2003)
Differential response patterns in the striatum and orbitofrontal cortex to financial reward in humans: a parametric functional magnetic resonance imaging study.
in The Journal of neuroscience : the official journal of the Society for Neuroscience
Elliott R
(2010)
Hedonic and informational functions of the human orbitofrontal cortex.
in Cerebral cortex (New York, N.Y. : 1991)
Elliott R
(2006)
Co-operation with another player in a financially rewarded guessing game activates regions implicated in theory of mind.
in Social neuroscience
Horn NR
(2003)
Response inhibition and impulsivity: an fMRI study.
in Neuropsychologia
| Description | Clinical Research Fellowship |
| Amount | £240,492 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2008 |
| End | 06/2019 |
| Description | FP6 Integrated Programme |
| Amount | € 7,300,000 (EUR) |
| Organisation | Sixth Framework Programme (FP6) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 01/2004 |
| End | 03/2010 |
| Description | Heptares Therapeutics Ltd |
| Amount | £528,093 (GBP) |
| Organisation | P1vital Consortium |
| Sector | Private |
| Country | United Kingdom |
| Start | |
| End | 03/2017 |
| Description | Lundbeck commercial/academic |
| Amount | £237,068 (GBP) |
| Organisation | P1vital Consortium |
| Sector | Private |
| Country | United Kingdom |
| Start | 05/2012 |
| End | 12/2013 |
| Description | Project resilience |
| Amount | £517,529 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 11/2009 |
| Description | project opiate |
| Amount | £300,000 (GBP) |
| Funding ID | G1000018 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2009 |
| End | 04/2011 |
| Title | NIHR antisocial personality disorder recruitment |
| Description | database of recruitment for nihr portfolio |
| Type Of Material | Biological samples |
| Provided To Others? | No |
| Impact | Support from CLRN for recruitment to current studies |
| Title | neurobiology of emotionality in people with aspd |
| Description | Publications and presentations showing that the amygdala is abnormally reactive in aspd and less regulated by prefrontal cortex. It is also larger and overdeveloped |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2007 |
| Provided To Others? | Yes |
| Impact | presentations to conferences |
| Title | p-block pharmaco MRI analysis method |
| Description | Publications about a new way of visualising and quantifying neurotransmitter function by experimental drug challenge in MRI scanner |
| Type Of Material | Model of mechanisms or symptoms - human |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | Other groups use it |
| Description | Manchester PET imaging aggression |
| Organisation | University of Manchester |
| Department | Faculty of Life Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | A PET imaging study has been carried out of the brain 5HT transporter andf 5HT2A receptor in impulsive aggressive individuals. Current analysis of genetic association with PET markers |
| Collaborator Contribution | Recruited participants from MRC grant on antisocial personality disorder |
| Impact | Pre- and postsynaptic serotonergic differences in males with extreme levels of impulsive aggression without callous unemotional traits: a positron emission tomography study using (11)C-DASB and (11)C-MDL100907. Rylands AJ, Hinz R, Jones M, Holmes SE, Feldmann M, Brown G, McMahon AW, Talbot PS. Biol Psychiatry. 2012 Dec 15;72(12):1004-11. doi: 10.1016/j.biopsych.2012.06.024. Epub 2012 Jul 25. PMID: 22835812 |
| Start Year | 2007 |
| Company Name | p1vital |
| Description | www.p1vital.com Aims to develop biomarkers for CNS drug efficacy in early clinical development with academic departments and to use them in commercial studies with the pharmaceutical industry |
| Impact | several academic and commercial projects with results presented at major international meeting in europe and the USA |
| Website | http://www.p1vital.com |
| Description | "Transmissions" - Lowry Theatre production by Dr. Tuheen Huda. |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Drama theatre production at Lowry Theatre Salford about addiction. Advised the director and producer about addiction and gave a recorded interview. Creative use of clips of my remarks to communicate changes in the brain and behaviour in addiction in the drama. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.culturalshenanigans.co.uk/2014/10/24/transmissions-the-lowry-salford-review/ |
| Description | Cafe Muse |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Lecture on fMRI Talk on schizophrenia neurobiology Talk on neurobiology of depression to 6th formers Collaboration with an artist instigated. Medical undergraduate in audience came to do a Project Option with me. Very positive feedback from organisers and prolonged Q&A after Dalton talk |
| Year(s) Of Engagement Activity | 2008,2012,2013 |
| Description | The Lady Killers, Channel 4 TV |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Further requests for media activities about antisocial personality problems |
| Year(s) Of Engagement Activity | 2008 |
| Description | Work experience |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | hosted student for 2 weeks. university course applied for in related area Got into Nottingham Medical school |
| Year(s) Of Engagement Activity | 2009 |