The neurobiology of impulse control and empathy in normal, antisocial and anxious individuals

Lead Research Organisation: University of Manchester
Department Name: Unlisted

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Alves-Neto WC (2010) Effect of escitalopram on the processing of emotional faces. in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

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Anderson IM (2008) Assessing human 5-HT function in vivo with pharmacoMRI. in Neuropharmacology

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Elliott R (2010) Hedonic and informational functions of the human orbitofrontal cortex. in Cerebral cortex (New York, N.Y. : 1991)

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Horn NR (2003) Response inhibition and impulsivity: an fMRI study. in Neuropsychologia

 
Description Clinical Research Fellowship
Amount £240,492 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2008 
End 06/2019
 
Description FP6 Integrated Programme
Amount € 7,300,000 (EUR)
Organisation Sixth Framework Programme (FP6) 
Sector Public
Country European Union (EU)
Start 01/2004 
End 03/2010
 
Description Heptares Therapeutics Ltd
Amount £528,093 (GBP)
Organisation P1vital Consortium 
Sector Private
Country United Kingdom
Start  
End 03/2017
 
Description Lundbeck commercial/academic
Amount £237,068 (GBP)
Organisation P1vital Consortium 
Sector Private
Country United Kingdom
Start 05/2012 
End 12/2013
 
Description Project resilience
Amount £517,529 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 11/2009 
 
Description project opiate
Amount £300,000 (GBP)
Funding ID G1000018 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2009 
End 04/2011
 
Title NIHR antisocial personality disorder recruitment 
Description database of recruitment for nihr portfolio 
Type Of Material Biological samples 
Provided To Others? No  
Impact Support from CLRN for recruitment to current studies 
 
Title neurobiology of emotionality in people with aspd 
Description Publications and presentations showing that the amygdala is abnormally reactive in aspd and less regulated by prefrontal cortex. It is also larger and overdeveloped 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2007 
Provided To Others? Yes  
Impact presentations to conferences 
 
Title p-block pharmaco MRI analysis method 
Description Publications about a new way of visualising and quantifying neurotransmitter function by experimental drug challenge in MRI scanner 
Type Of Material Model of mechanisms or symptoms - human 
Year Produced 2008 
Provided To Others? Yes  
Impact Other groups use it 
 
Description Manchester PET imaging aggression 
Organisation University of Manchester
Department Faculty of Life Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution A PET imaging study has been carried out of the brain 5HT transporter andf 5HT2A receptor in impulsive aggressive individuals. Current analysis of genetic association with PET markers
Collaborator Contribution Recruited participants from MRC grant on antisocial personality disorder
Impact Pre- and postsynaptic serotonergic differences in males with extreme levels of impulsive aggression without callous unemotional traits: a positron emission tomography study using (11)C-DASB and (11)C-MDL100907. Rylands AJ, Hinz R, Jones M, Holmes SE, Feldmann M, Brown G, McMahon AW, Talbot PS. Biol Psychiatry. 2012 Dec 15;72(12):1004-11. doi: 10.1016/j.biopsych.2012.06.024. Epub 2012 Jul 25. PMID: 22835812
Start Year 2007
 
Company Name p1vital 
Description www.p1vital.com Aims to develop biomarkers for CNS drug efficacy in early clinical development with academic departments and to use them in commercial studies with the pharmaceutical industry 
Impact several academic and commercial projects with results presented at major international meeting in europe and the USA
Website http://www.p1vital.com
 
Description "Transmissions" - Lowry Theatre production by Dr. Tuheen Huda. 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Drama theatre production at Lowry Theatre Salford about addiction. Advised the director and producer about addiction and gave a recorded interview. Creative use of clips of my remarks to communicate changes in the brain and behaviour in addiction in the drama.
Year(s) Of Engagement Activity 2015
URL http://www.culturalshenanigans.co.uk/2014/10/24/transmissions-the-lowry-salford-review/
 
Description Cafe Muse 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Media (as a channel to the public)
Results and Impact Lecture on fMRI
Talk on schizophrenia neurobiology
Talk on neurobiology of depression to 6th formers


Collaboration with an artist instigated.
Medical undergraduate in audience came to do a Project Option with me.
Very positive feedback from organisers and prolonged Q&A after Dalton talk
Year(s) Of Engagement Activity 2008,2012,2013
 
Description The Lady Killers, Channel 4 TV  
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Further requests for media activities about antisocial personality problems
Year(s) Of Engagement Activity 2008
 
Description Work experience 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Schools
Results and Impact hosted student for 2 weeks.

university course applied for in related area
Got into Nottingham Medical school
Year(s) Of Engagement Activity 2009