The Dundee p53 Pathway cooperative group

Lead Research Organisation: University of Dundee
Department Name: Unlisted

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description NTRAC Research Nurse
Amount £143,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2004 
End 05/2008
 
Description Renewal of Cancer Tissue Bank
Amount £396,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2006 
End 05/2009
 
Title Tissue Micro Array 
Description A technique whereby 100's of paraffin embedded cores are inserted into a single paraffin block in an organised manner. TMA blocks can constructed with either similar or a variety of different tumour types. Although time consuming in manufacture the resulting TMA is a valuable resource for testing new antibodies and is also cost saving in respect of immunohistochemistry reagents and in the comparison of protein expression in different tumours immunostained identically. 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact TMA's have been used in 25 projects and has proved to be a important addition to the Bank's technical repertoire. 
 
Description Czech collaboration on antibodies 
Organisation Masaryk University
Country Czech Republic 
Sector Academic/University 
PI Contribution NA
Collaborator Contribution testing of antibodies developed by Borek on our tissue arrays
Impact A collaboration with Borek Vojtesek and Dr Rudolph Nenutil from the Department of Cellular and Molecular Oncology at the Masaryk Memorial Cancer Institute in Brno Czech Republic, is continuing with the testing of antibodies developed by Borek on our tissue arrays.
 
Description Gasteroenterology collaboration with Manchester 
Organisation University of Manchester
Department School of Medicine Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution A recently begun collaboration (October 2005) with gastroenterologists in Manchester (Levison, Hammond, McLaughlin) on inflammatory bowel disease
Impact has already resulted in submission of an abstract to the Digestive Disorders Week 2006 in Los Angeles
 
Description Joint lymphoma group 
Organisation University of Dundee
Department Division of Neuroscience
Country United Kingdom 
Sector Academic/University 
PI Contribution A joint lymphoma group, comprising of Professor David Levison and Dr Neil Kernohan from Dundee and Dr John Goodlad from the Department of Histopathology in the Western General Hospital, Edinburgh, have produced a series of lymphoma tissue micro arrays, using material from both sites.
Collaborator Contribution Produced a series of lymphoma tissue micro arrays, using material from both sitesProduced a series of lymphoma tissue micro arrays, using material from both sites
Impact NA
 
Description Joint lymphoma group 
Organisation Western General Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution A joint lymphoma group, comprising of Professor David Levison and Dr Neil Kernohan from Dundee and Dr John Goodlad from the Department of Histopathology in the Western General Hospital, Edinburgh, have produced a series of lymphoma tissue micro arrays, using material from both sites.
Collaborator Contribution Produced a series of lymphoma tissue micro arrays, using material from both sitesProduced a series of lymphoma tissue micro arrays, using material from both sites
Impact NA
 
Description Montpellier collaboration 
Organisation University of Montpellier
Department Pharmacy Montpellier
Country France 
Sector Academic/University 
PI Contribution Collaborative project with a group in Montpellier headed by Dr Pascale Cohen looking at gene expression profiles that are associated with Tamoxifen resistance in breast cancer. Our study involves the production of tissue micro arrays from breast cancer tissue samples obtained in Dundee and comparing the immunocytochemical staining with the gene expression data generated in France.
Collaborator Contribution NA
Impact NA
 
Description Renal Cell Carcinoma collaboration 
Organisation Institute of Cancer Research UK
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaborations with Dr Tim Crook at the Breakthrough Breast Cancer Centre at the Chester Beatty Laboratories and with Dr Fran Balkwill at the Translational Oncology Laboratory at Barts and the London
Impact resulted in the supply of 250 DNA samples and 7 frozen renal cell carcinomas (tumour and normal) from the bank.
 
Description Renal Cell Carcinoma collaboration 
Organisation Queen Mary University of London
Department Barts and The London School of Medicine and Dentistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Collaborations with Dr Tim Crook at the Breakthrough Breast Cancer Centre at the Chester Beatty Laboratories and with Dr Fran Balkwill at the Translational Oncology Laboratory at Barts and the London
Impact resulted in the supply of 250 DNA samples and 7 frozen renal cell carcinomas (tumour and normal) from the bank.
 
Description Confederation of Cancer Biobanks 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Primary Audience Participants in your research and patient groups
Results and Impact The co-ordinator of the Bank, the research scientist and the research nurse have given a number of well received local presentations to members of the public and the wider NHS community. In these talks the rationale for tissue banks, the nature of our activities, and some of the research results are presented.

NA
Year(s) Of Engagement Activity 2006