Replicational DNA repair in mammalian cells and its role in genomic instability and cancer predisposition

Lead Research Organisation: University of Cambridge
Department Name: Clinical Oncology

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

10 25 50
 
Description EPSRC- Fellowship
Amount £252,944 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 12/2009 
End 11/2012
 
Description EU FP7 Award
Amount £464,000 (GBP)
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 01/2008 
End 12/2011
 
Description Wellcome Trust Project Grant (Connecting defective replication initiation to inherited human diseases: Biochemical and genetic analysis of the RecQL4 helicase)
Amount £164,396 (GBP)
Funding ID 081437/Z/06/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2007 
End 12/2010
 
Description Wellcome Trust Strategic Award
Amount £2,400,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2010 
End 05/2016
 
Title Kinase/inhibitor analysis 
Description New computational method for the analysis of biomolecular structures to identify features of the interactions between protein kinases and their inhibitors. 
Type Of Material Technology assay or reagent 
Year Produced 2006 
Provided To Others? Yes  
Impact Cited by other researchers. 
 
Title Thermosensitive degron 
Description Production of thermosensitive degron for conditional genetics in an avian cell line 
Type Of Material Technology assay or reagent 
Year Produced 2008 
Provided To Others? Yes  
Impact Cited by other researchers. Facilitated further research. 
 
Description Dave Tuveson 
Organisation Cancer Research UK Cambridge Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of research methods and knowledge
Collaborator Contribution Exchange of research tools and knowledge
Impact Yes
Start Year 2008
 
Description David Klenerman 
Organisation University of Cambridge
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of research methods and knowledge
Collaborator Contribution Exchange of research methods and knowledge
Impact PubMed ID- 19628690
Start Year 2008
 
Description Jon Pines 
Organisation University of Cambridge
Department Gurdon Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of knowledge and research tools
Collaborator Contribution Exchange of knowledge and research tools
Impact PubMed ID- 19820702
Start Year 2008
 
Description Luca Pellegrini 
Organisation University of Cambridge
Department Department of Biochemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of research methods and knowledge
Collaborator Contribution Exchange of research methods and knowledge
Impact PubMed ID- 16914443
 
Description Stephen C. Kowalczykowski 
Organisation University of California, Berkeley
Department Department of Molecular & Cell Biology
Country United States 
Sector Academic/University 
PI Contribution Exchange of knowledge and research methods
Collaborator Contribution Exchange of knowledge and research methods
Impact PubMed ID- 19303847
Start Year 2007
 
Description Tom Blundell 
Organisation University of Cambridge
Department Department of Biochemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of knowledge and research methods
Collaborator Contribution Exchange of knowledge and research methods
Impact PubMed ID- 19141287
Start Year 2006
 
Title Marker for Taxol-resistance in cancer therapy 
Description AURORA A overexpression as a marker for Taxol-resistance in cancer therapy. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Refinement. Clinical
Year Development Stage Completed 2006
Development Status Actively seeking support
Impact Facilitated further improvements in healthcare. 
 
Description CAM magazine interview 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interviewed for Cambridge University alumni magazine, CAM.

Increased awareness of research in alumni community.
Year(s) Of Engagement Activity 2008
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Schools
Results and Impact Members of the group coordinated activities and spoke to the public about their work.

Increased knowledge about science.
Year(s) Of Engagement Activity 2007,2008,2009
 
Description Interview on Ecancer.tv 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Interview on Ecancer.tv web channel- The mitotic spindle and potential development for targeting novel types of interactions

Increased knowledge and awareness of research.
Year(s) Of Engagement Activity 2009
 
Description MRC Press Release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Press release on 'New insights to cancer drug resistance found' http://www.mrc.ac.uk/Newspublications/News/MRC006393

Increased knowledge and awareness of research.
Year(s) Of Engagement Activity 2009
URL http://www.mrc.ac.uk/Newspublications/News/MRC006393
 
Description MRC Press Release 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Press release on 'Unravelling the workings of BRCA2' http://www.mrc.ac.uk/Newspublications/News/MRC006223

Increased knowledge and awareness of research.
Year(s) Of Engagement Activity 2009
URL http://www.mrc.ac.uk/Newspublications/News/MRC006223
 
Description MRC webstory 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Pancreatic cancer and BRCA2 http://www.mrc.ac.uk/Newspublications/News/MRC007553

Increased knowledge and awareness of research.
Year(s) Of Engagement Activity 2010
URL http://www.mrc.ac.uk/Newspublications/News/MRC007553
 
Description Royal Institution Schools event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Schools
Results and Impact Gave lecture to schools audience at Disneyland, Paris.

Increased understanding of science.
Year(s) Of Engagement Activity 2008