Linking measles virus genotypes to phenotypes
Lead Research Organisation:
Queen's University of Belfast
Department Name: Sch of Biological Sciences
Abstract
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Publications
Moeller-Ehrlich K
(2007)
Two functionally linked amino acids in the stem 2 region of measles virus haemagglutinin determine infectivity and virulence in the rodent central nervous system.
in The Journal of general virology
Pohl C
(2007)
Measles virus M and F proteins associate with detergent-resistant membrane fractions and promote formation of virus-like particles.
in The Journal of general virology
Ralston SH
(2007)
Multicenter blinded analysis of RT-PCR detection methods for paramyxoviruses in relation to Paget's disease of bone.
in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Rennick LJ
(2007)
Measles virus minigenomes encoding two autofluorescent proteins reveal cell-to-cell variation in reporter expression dependent on viral sequences between the transcription units.
in The Journal of general virology
Rima BK
(2006)
Morbilliviruses and human disease.
in The Journal of pathology
Schubert S
(2006)
A mouse model of persistent brain infection with recombinant Measles virus.
in The Journal of general virology
Singethan K
(2006)
CD9-dependent regulation of Canine distemper virus-induced cell-cell fusion segregates with the extracellular domain of the haemagglutinin.
in The Journal of general virology
| Description | MRC Programme Grant (G0501427) |
| Amount | £633,184 (GBP) |
| Funding ID | G0501427 |
| Organisation | Medical Research Council (MRC) |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 08/2006 |
| End | 07/2010 |
| Description | project grant support: molecular determinants of morbillivirus pathogenesis |
| Amount | £237,275 (GBP) |
| Organisation | Department of Health Social Services and Public Safety (DHSSPS) |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2006 |
| End | 06/2008 |
| Title | new version of measles virus vectors and viruses with new phenotypes |
| Description | viruses that express autofluorescent proteins such as dsRED1, and 2 and Cyan fluorescent protein |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | increased collbaoration with others |
| Description | Belfast - Wuerzburg Partnership |
| Organisation | University of Wurzburg |
| Department | Institute of Virology and Immunobiology Würzburg |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We organise an annual invitation only meeting of European measles virus researchers in Wuerzburg. Through this wehave provided ideas for development of work; supervised students when they visited here; supplied recombinant viruses and technology |
| Collaborator Contribution | Long standing exchange of reagents; occasional visits and most importantly ideas |
| Impact | PMedId: 16690928; 16760404; 17374768;17947537 |
| Description | Belfast Rotterdam partnership |
| Organisation | Erasmus University Rotterdam |
| Department | Department of Virology |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | We supply recombinant viruses and analyse histology and bio-imaging data for the joint project that resulted |
| Collaborator Contribution | This partnesrship allowed us to apply for the grant under the MRC models call which we obtained because it allowed to contemplate work on macaques |
| Impact | PMID: 18020706 |
| Start Year | 2007 |
| Description | Assisting the US vaccine Court in claims re MMR and autism |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Primary Audience | Public/other audiences |
| Results and Impact | Based on my reserach experience on measles and mumps viruses I was able to appear as a witness for the US department of justice in the vaccine court cases re the claim that meMMR vaccine causes autism. My evidence was a crucial part of the that pesented thta led the Court to dismiss the claim that MMR caused autism in a test case which was part of a large claim agains the Vccine Court. |
| Year(s) Of Engagement Activity | 2007 |