United Kingdom Collaborative Trial of Ovarian Cancer (UKCTOCS)

Lead Research Organisation: University College London
Department Name: Maternal & Fetal Medicine

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

Ovarian cancer (OC) is responsible for over 4000 deaths in the UK each year. The overall 5 year survival rate is only 35% but women diagnosed with early stage disease have survival rates as high as 90%. During the last decade the applicants have conducted large prospective screening trials which have identified two screening strategies with encouraging sensitivity and specificity for preclinical detection of OC. The proposal is for a three armed randomised controlled trial to assess the impact of these screening strategies in the general population. A total of 200,000 postmenopausal women, aged 50-74 years will be randomised in a 1:1:2 ratio to ultrasound screening, multimodal screening or a control group who will not be screened. Screening will occur in 12 collaborating gynaecological oncology centres in the UK and participants randomised to screening will undergo 6 screens at annual intervals. Ultrasound screening will involve a level I screen with transvaginal ultrasonography (TVS) to document abnormalities of ovarian morphology and volume. Multimodal screening will involve a level I screen with CA 125 to calculate the Risk of OC. Women with abnormal level I screening results in either group will be recalled for a level II screen with TVS and the small proportion of women with abnormal level II results will be referred for specialist surgical assessment. All participants will be followed up by postal questionnaire and via the cancer registry. The primary end point of the study will be OC mortality at 7 years after randomisation. Additional end points will include quality of life, health economics, morbidity and compliance with screening. The trial has 90% power to detect a 30% reduction in OC mortality in the screened groups compared to the control group. The results of the trial will form the basis for an informed decision about the place of general population screening for OC.

Publications

10 25 50
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Alexander-Sefre F (2002) Ovarian cancer screening. in Hospital medicine (London, England : 1998)

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Blyuss O (2018) Comparison of Longitudinal CA125 Algorithms as a First-Line Screen for Ovarian Cancer in the General Population. in Clinical cancer research : an official journal of the American Association for Cancer Research

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Borges M (2017) Metabolic Profiling of Adiponectin Levels in Adults Mendelian Randomization Analysis in Circulation: Cardiovascular Genetics

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Devetyarov D (2012) Conformal predictors in early diagnostics of ovarian and breast cancers in Progress in Artificial Intelligence

 
Title Creation of artwork for thank you card for UKCTOCS volunteers 
Description A painting of a primary ovarian follicle was created by a commissioned artist (Dr Lizzie Burns). The image of painting was digitized so that each dot represented 8 women participants in the trial. This digitized image was then used on the front of a card that was posted at the end of the screening period to all the the UKCTOCS volunteers to thank them for their participation in the trial. mailin was performed in collaboration with the charity, The Eve Appeal. The package also contained information about the trial and what was to happen during the follow-up period of UKCTOCS. 
Type Of Art Artwork 
Year Produced 2012 
Impact Approximately 30,000 replies were received back from the women within three weeks of mailing- expressing huge appreciation of the trial and what its was trying to achieve, that the team had 'remembered' the volunteers. Many volunteers touched by the gesture. In women where a cancer had been detected, felt that the trial had saved their lives. Added benefit was that the The Eve Appeal database of donors was increased . 
URL https://www.ucl.ac.uk/instituteforwomenshealth/news/oldnewsletters/new-letters-tabbed-box/2012/2012m...
 
Description Ovarian cancer awareness consultation
Geographic Reach National 
Policy Influence Type Participation in a national consultation
 
Description Training of UKCTOCS sonographers
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
 
Description CRUK BIDD Project Grant
Amount £185,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2011 
End 03/2013
 
Description CRUK TRICC Project Grant
Amount £145,154 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 11/2010
 
Description DH Service Support Costs UKCTOCS
Amount £6,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
End 06/2015
 
Description EU FP7
Amount £90,000 (GBP)
Funding ID HEALTH-F5-2012-305428 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start  
 
Description MRC Clinical Trial Grant (UKCTOCS Extension of Screening)
Amount £2,303,175 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2010 
End 08/2015
 
Description MRC Training Grant: Industrial Case Award
Amount £118,230 (GBP)
Funding ID MR/J006718/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2012 
End 08/2016
 
Description NIHR UCLH Biomedical Research Centre Cancer Programme Funding
Amount £100,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2014 
End 05/2016
 
Description PRC Programme Grant -CRUK component
Amount £1,620,000 (GBP)
Funding ID C1005/A12677 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2011 
End 08/2016
 
Description PRC Programme grant - EVE Appeal component
Amount £1,641,890 (GBP)
Organisation The Eve Appeal 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2011 
End 08/2016
 
Description Pancreatic Cancer UK Project grant
Amount £149,391 (GBP)
Organisation Pancreatic Cancer UK 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2011 
End 07/2013
 
Description Pancreatic cancer UK Pump priming grant
Amount £10,000 (GBP)
Organisation Pancreatic Society of Great Britain and Ireland (PanSoc) 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Programme of Translational Research in Gynaecological cancer (UCL & Special Trustees UCLH)
Amount £1,100,000 (GBP)
Organisation University College London 
Sector Academic/University
Country United Kingdom
Start  
 
Description UCL/UCLH CBRC New Initiatives
Amount £35,647 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 01/2009 
End 01/2010
 
Description UCLH/UCL Comprehensive Biomedical Research Centre (Epigenetic and Genetic analysis in UKCTOCS)
Amount £800,000 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 03/2009 
End 12/2014
 
Title A database of serum peptide identifications 
Description The identities of low-molecular weight serum peptides found using our profiling platform has been determined and a database of these assembled for reference in future profiling studies 
Type Of Material Biological samples 
Year Produced 2009 
Provided To Others? Yes  
Impact Publication of the data and use in other biomarker discovery projects 
 
Title A reproducible platform for serum peptide profiling 
Description A platform incorporating robotic extraction of peptides from serum on magnetic beads and sample spotting linked to automated MALDI-TOF MS data acquisition was developed for high-throughput profiling of low-mass polypeptides in the serum of clinical sample sets 
Type Of Material Technology assay or reagent 
Year Produced 2009 
Provided To Others? Yes  
Impact The platform has been applied on mutliple biomarker discovery projects using serum from case control collections and pre-diagnosis samples from UKCTOCS 
 
Title UKCTOCS trial management system 
Description Database system that assists in running of the trial. 
Type Of Material Biological samples 
Provided To Others? No  
Impact Streamlined running of all aspects of UKCTOCS. 
 
Title Ultrasound Record Archive 
Description We are databasing static ultrasound images collected during the UKCTOCS trial which will serve as an electronic source for review and management of women on the trial. In addition it enables training and refinement of techniques for assessing the ultrasound images. There is huge potential also for pursuing future research in imaging postmenopausal ovaries in health and in cancer. Currently have 255,472 archived TVS examinations. 
Type Of Material Biological samples 
Provided To Others? No  
Impact The database is currently incomplete but represents a major resource for investigation and training. The major benefit of this electronic resource is ease of access and rapidity to volunteer scanning results. It also provides a means for checking the quality of ultrasonography in UKCTOCS. In terms of research efforts it represent a significant resource for a variety of analyses, including assessment of ultrasound findings in malignant lesions in ovarian and other gynaecological cancers. The URA also has the potential to help refine and set standards for ultrasound image analysis. 
 
Description Biomarker assessment in preclinical samples from UKCTOCS 
Organisation Fred Hutchinson Cancer Research Center (FHCRC)
Department Molecular Diagnostics Program (FHCRC)
Country United States 
Sector Charity/Non Profit 
PI Contribution Providing samples and data from controls and ovarian cancer cases
Collaborator Contribution Access to novel biomarker assays
Impact Bilateral partnership - Agreement, Ethics and MTA in place.
Start Year 2010
 
Description Discovery of biomarkers of biliary tract and pancreatic cancer 
Organisation University College London
Department Institute of Liver and Digestive Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Proteomic profiling of clinical and control samples of biliary tract cancer and training of a PhD student. Proteomic profiling of pre-diagnosis and matched healthy control serum samples and case controls in a pancreatic cancer biomarker discovery and validation project.
Collaborator Contribution Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryAccess to case control samples of benign pancreatic disease and pancreatic cancer for biomarker discovery
Impact Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers and one publications accepted and another submitted.
Start Year 2008
 
Description Discovery of biomarkers of biliary tract and pancreatic cancer 
Organisation University of Liverpool
Department Medicine and Surgery
Country United Kingdom 
Sector Academic/University 
PI Contribution Proteomic profiling of clinical and control samples of biliary tract cancer and training of a PhD student. Proteomic profiling of pre-diagnosis and matched healthy control serum samples and case controls in a pancreatic cancer biomarker discovery and validation project.
Collaborator Contribution Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryAccess to case control samples of benign pancreatic disease and pancreatic cancer for biomarker discovery
Impact Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers and one publications accepted and another submitted.
Start Year 2008
 
Description Discovery of biomarkers of pancreatobiliary disease 
Organisation University College London
Department Institute of Liver and Digestive Health
Country United Kingdom 
Sector Academic/University 
PI Contribution Samples from UKCTOCS have been provided to collaborators for biomarker testing and discovery using complementary techniques to those applied at UCL
Collaborator Contribution Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryProvision of expertise in pancreatic cancer and access to additional case control serum samples relevant to biomarker discovery
Impact Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers with one publication accepted and another submitted.
Start Year 2008
 
Description Discovery of biomarkers of pancreatobiliary disease 
Organisation University of Liverpool
Department Department of Molecular and Clinical Cancer Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Samples from UKCTOCS have been provided to collaborators for biomarker testing and discovery using complementary techniques to those applied at UCL
Collaborator Contribution Provision of expertise in pancreatic and biliary tract cancers and access to clinical samples for biomarker discoveryProvision of expertise in pancreatic cancer and access to additional case control serum samples relevant to biomarker discovery
Impact Award of PancSoc GB&I pump priming grant to validate reported markers of pancreatic cancer in prediagnosis and control samples. Award of CRUK TRICC pilot grant, CRUK BIDD Project grant and Pancreatic cancer UK grant aimed at discovery of serum biomarkers of pancreatic cancer. Identification of promising candidate biomarkers with one publication accepted and another submitted.
Start Year 2008
 
Description Hormonal Profile in Breast cancer 
Organisation University College London
Department UCL Cancer Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Samples and data from UKCTOCS volunteers who developed breast cancer
Collaborator Contribution Expertise in Breast cancer
Impact A PhD awarded and two publications: Fourkala EO et al Endocrine-related cancer. 2012 Apr;19(2):137-47. Fourkala EO et al Br J Cancer. 2012 Jun 5;106(12):1910-6.
Start Year 2008
 
Description MRC Proteomics biomarker discovery 
Organisation University College London
Department UCL Cancer Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Use of UKCTOCS samples for the biomarker discovery project.
Impact MRC Grant for proteomic discovery of biomarkers for ovarian cancer.Project complete. Details of publications are provided in the publications section.
Start Year 2006
 
Description Multianalyte assay for early diagnosis of ovarian cancer 
Organisation University of Pittsburgh
Department School of Medicine Pittsburgh
Country United States 
Sector Academic/University 
PI Contribution Input into the study design and data interpretation. Preclinical samples and data from ovarian cancer cases and controls
Collaborator Contribution Enabling assessment of serum biomarkers in multiplex system.
Impact Project ongoing - intial sample sets have been shipped to our Collaborators and are being assayed. Results from sample testing are pending.
Start Year 2007
 
Description Pilot study-Ovarian Cancer Biomarker discovery 
Organisation Becton, Dickinson and Company
Country United States 
Sector Private 
PI Contribution Provision of serum and data
Collaborator Contribution Ovarian cancer multimarker assays
Impact No outputs so far as BD withdrew from collaboration. The tem was multi-disciplinary involving biomedical scientists, physicians and statistics
Start Year 2011
 
Description Proteomic analysis of UKCTOCS serum samples-PROMISE Manchester component 
Organisation University of Manchester
Department Institute of Cancer Sciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Provision of serum and data
Collaborator Contribution Expertise and access to state of the art facilities
Impact Study has started and a number of potential biomarkers for ovarian cancers have been identified in UKCTOCS serum and are under investigation. A translational project grant application to update proteomic methodology has been submitted to the charity 'Target Ovarian Cancer' and the result is pending . The team involved is multi-disciplinary involving researchers from clinical, proteomic and bioinformatics backgrounds
Start Year 2012
 
Description Proteomic profiling of human sera for biomarker discovery 
Organisation University of Reading
Department School of Biological Sciences Reading
Country United Kingdom 
Sector Academic/University 
PI Contribution The development of technologies for serum profiling and the provision of clinical, control and pre-diagnosis serum samples from cases of ovarian, breast cancer and heart disease
Collaborator Contribution The development and application of different proteomic technologies for serum biomarker discovery and data analysis
Impact Five peer-reviewed publications. Award of CR-UK Programme Grant in risk prediction and ealry detection of ovarian cancer. The collaboration on biomarker discovery continues.
 
Description Risk factors for coronary artery disease 
Organisation University College London
Department Institute of Cardiovascular Science
Country United Kingdom 
Sector Academic/University 
PI Contribution Study design , grant application and identification of appropriate sample sets.
Collaborator Contribution Expertise in Heart disease
Impact ULCH CBRC grant. Multidisciplinary - Epidemiology and Public Health, Cardiovascular Genetics and Gynaecological Oncology. Data from the study will go into the UCLEB consortia.
Start Year 2009
 
Description Use of the Multimarker Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women 
Organisation University of Texas
Department M. D. Anderson Cancer Center
Country United States 
Sector Academic/University 
PI Contribution Input into the study design and data interpretation. Preclinical samples from ovarian cancer cases and controls
Collaborator Contribution This collaboration with Professor Bast will enable new technologies and new biomarkers to be assessed in UKCTOCS samples.
Impact Experimental work has been completed and data analysis is underway. The team is multi-disciplinary and are experienced researchers from clinical, biomedical, statistical and proteomic backgrounds
Start Year 2010
 
Description cancer specific serum response and development of colorectal cancer 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution study design, serum samples and data interpretion
Collaborator Contribution bioassays and expertise in colorectal cancer
Impact Two publications: Pedersen et al BJC 2013;15;108(1):107-14. Pedersen et al International journal of cancer Journal international du cancer. 2013 Oct 11.
Start Year 2009
 
Company Name Abcodia 
Description Abcodia is involved in discovery and validation of molecular biomarkers for disease diagnosis and screening. It is the means by which diagnostic, pharmaceutical and technology companies can access serum samples collected in UKCTOCS for the purpose of ethical biomarker validation and discovery. Abcodia are part of the global alliance 'Early Diagnosis Consortium' with Cancer Research UK and Cancer Research Technology Please see website for further information: http://abcodia.com/ 
Year Established 2010 
Impact The company is now involved in a number of collaborations including a nested case control study in pancreatic cancer. In Dec 2012,Abcodia won 4 prizes at the NatWest Start up awards : (1) the NatWest Start-Up business of the year (Top prize); (2) Most Innovative business of the year; (3) Best Angel or VC backed business of the year; and (4) Start-Up business woman of the year (Julie Barnes as our Abcodia CEO). Abcodia have steadily been building up th number of collaborations with a variety of partners. To date the company are involved in 13 projects.
Website http://www.abcodia.com/
 
Description BBC Radio - Interview with Usha Menon regarding UKCTOCS and ovarian cancer screening 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact As part of Ovarian Cancer Awareness Month (March), Prof Menon spoke about ovarian cancer, screening for the disease and the preliminary results of the UKCTOCS trial.

Expanding knowledge of ovarian cancer in the general population.
Year(s) Of Engagement Activity 2009
 
Description BBC article 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Media coverage of the publication of the prevalence screening results of the UKCTOCS trial.

Wide publising of the work to other medical researchers.
Year(s) Of Engagement Activity 2009
 
Description Hello magazine 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Interview with Professor Menon

raised awareness for gynaecological cancer and increased traffic too charities such as Eve Appeal
Year(s) Of Engagement Activity 2013
 
Description Jacobs IJ, Menon U, Campbell S, Fallowfield L, Parmar S, and Skates SJ. Live Streamed Presentation: UKCTOCS Mortality Results Public Meeting. Royal College of Obstetricians and Gynecologists, London, UK, 17 Dec 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact UKCTOCS Mortality Results Public Meeting
Year(s) Of Engagement Activity 2015
URL https://www.youtube.com/watch?v=gD8PGK3ieyw
 
Description Laboratory visits 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The visitors are interested to learn about the work that the research groups do in the field of ovarian cancer. They have an opportunity to speak directly to the researchers and ask questions and to observe samples being processed.

Some of visitors have then made donations to charitable organisations such as Eve Appeal.
Year(s) Of Engagement Activity 2008,2009,2010
 
Description Media Coverage 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Numerous magazine articles, newspapers, features and journals.
During 2013 Comments provided for ovarian cancer awareness article following news of death Pierce Brosnan's daughter were published between 17 July 2013 and 2 August 2013 in 23 regional print newspapers and numerous websites:

Raised awareness of ovarian cancer and interest in the group's research. Increase in traffic to ovarian cancer support charities such as Eve Appeal has been noted.
Year(s) Of Engagement Activity 2006,2007,2008,2009,2010,2011,2012,2013
 
Description Menon U. Invited Talk: Advances in Ovarian Cancer Research: Exploiting Vulnerabilities, 17 - 20 Oct 2015, Orlando, Florida, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Advances in Ovarian Cancer Research: Exploiting Vulnerabilities, 17 - 20 Oct 2015, Orlando, Florida, USA
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: Memorable research moments in the context of Women's Health, Perinatal Research Meeting UCLH, 4 Mar 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Memorable research moments in the context of Women's Health, Perinatal Research Meeting UCLH, 4 Mar 2016
Year(s) Of Engagement Activity 2016
 
Description Menon U. Invited Talk: Ovarian Cancer - UKCTOCS study: the outcomes, 3rd ENGAGe Patient Seminar, Nice, France, 24 Oct 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Ovarian Cancer - UKCTOCS study: the outcomes, 3rd ENGAGe Patient Seminar, Nice, France, 24 Oct 2015
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: Ovarian Cancer screening - update from the UK trials, 2015 NCRI Cancer Conference, 1 - 4 Nov 2015, Liverpool, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Ovarian Cancer screening - update from the UK trials, 2015 NCRI Cancer Conference, 1 - 4 Nov 2015, Liverpool, UK
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: Ovarian cancer screening - role of biomarkers, 4th Biomarkers in Diagnostics, 8 Oct 2015, Berlin, Germany 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Ovarian cancer screening - role of biomarkers, 4th Biomarkers in Diagnostics, 8 Oct 2015, Berlin, Germany
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: Ovarian cancer screening: where are we now? South Wales Gynaecological Oncology Group - 12th Educational Meeting, Innovations Hub in Cardiiff Bay, 3 Assembly Square, Cardiff Bay, 27 Nov 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Ovarian cancer screening: where are we now? South Wales Gynaecological Oncology Group - 12th Educational Meeting, Innovations Hub in Cardiiff Bay, 3 Assembly Square, Cardiff Bay, 27 Nov 2015
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: Ovarian screening latest news, London Cancer Gynaecology Annual Education Open Meeting, UCLPartners, London, UK, 18 June 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: Ovarian screening latest news, London Cancer Gynaecology Annual Education Open Meeting, UCLPartners, London, UK, 18 June 2015
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: The UKCTOCS and UKFOCSS trials - what have we learnt so far? 2nd International Ovarian Tumor Analysis Congress (IOTA 2015), 17 Apr 2015, Leuven, Belgium 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: The UKCTOCS and UKFOCSS trials - what have we learnt so far? 2nd International Ovarian Tumor Analysis Congress (IOTA 2015), 17 Apr 2015, Leuven, Belgium
Year(s) Of Engagement Activity 2015
 
Description Menon U. Invited Talk: UKCTOCS update, RCOG Annual Professional Development Conference, 24 - 26 Nov 2015, London, UK 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Menon U. Invited Talk: UKCTOCS update, RCOG Annual Professional Development Conference, 24 - 26 Nov 2015, London, UK
Year(s) Of Engagement Activity 2015
 
Description Research Feedback Event 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Supporters
Results and Impact Approximately 150 people attended the meeting which consisted of oral and poster presentations allowing opportunities for networking between charity supporters, trustees and researchers.

members of the public who attended signed up to receive regular newsletters from the charity and also to participate in fund raising events or make donations to the charity
Year(s) Of Engagement Activity 2013
 
Description Thank you card 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Paper Presentation
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact With the help of an artist we designed a card to thank women in UKCTOCS which was posted out to approximately 200,000 participants after the close of screening in the trial. Approximately 30,000 women responded within 3 weeks with positive feedback about the trial's impact on them.

As a consequence of the thank you card the study team obtained health status updates from the participants and change of address notifications which will assist for the mailing out our final study questionnaire. In addition, women had an opportunity to undertake fund raising activity via the charity Eve Appeal.
The project relating to generation of the card was presented as the Institute for Women's health annual meeting as a poster
Year(s) Of Engagement Activity 2012
 
Description UKCTOCS Newsletter 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Participants in your research and patient groups
Results and Impact This is difficult to assess as we have more than 200,000 women in our trial and only a very small fraction wrote in to provide feedback.


Women in UKCTOCS were informed of the trial progress and new developments.
Year(s) Of Engagement Activity 2007