Immunology of filariasis: pathways to immunity and tolerance

Lead Research Organisation: University of Edinburgh
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Publications

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Allen JE (2008) Of mice, cattle, and humans: the immunology and treatment of river blindness. in PLoS neglected tropical diseases

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Arora M (2006) Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. in Proceedings of the National Academy of Sciences of the United States of America

 
Description Asthma UK Project Grant
Amount £153,000 (GBP)
Funding ID 06/057 
Organisation Asthma UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2007 
End 12/2009
 
Description EU project as part of an international consortium
Amount £250,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 11/2006 
End 10/2010
 
Description MRC Programme Grant
Amount £1,571,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2007 
End 01/2013
 
Description Royal Society International Joint Grant
Amount £12,000 (GBP)
Organisation The Royal Society 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2008 
End 12/2009
 
Description Cape Town 
Organisation University of Cape Town
Country South Africa 
Sector Academic/University 
PI Contribution made intellectual contributions to their research
Collaborator Contribution provided transgenic mice
Impact Publication: 17785830
Start Year 2006
 
Description EU partnership Edinburgh 
Organisation University of Edinburgh
Department College of Medicine & Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Work from this programme on immune mechanisms against filariasis contributed toward a successful application to the European Union to fund studies on the vaccination against River Blindness. This is an ongoing collaboration utilizing the Litomosoides sigmodontis life cycle run by my laboratory and funded in part by this MRC grant.
Collaborator Contribution scientific expertise and discussion with regard to filariasis vaccination
Impact succesfull FP7 application to the EU which will commence in 2010. Publications: 18446236, 16765354
 
Description Edinburgh Fibrosis 
Organisation University of Edinburgh
Department College of Medicine & Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution shared expertise and reagents
Collaborator Contribution Shared expertise and reagents
Impact Publication: 18436582
Start Year 2006
 
Description Paris MNH 
Organisation National Museum of Natural History
Country United States 
Sector Academic/University 
PI Contribution We provide detailed immunological expertise and perform shared experiments.
Collaborator Contribution The laboratory of Odile Bain's provides invaluable expertise on the Litomosoides life cycle and methods of analysis. Members of my laboratory went to the Natural History museum to learn several aspects of parasite analysis critical to these studies.
Impact 18446236,16765354
 
Description Pittsburgh 
Organisation University of Pittsburgh
Department School of Medicine Pittsburgh
Country United States 
Sector Academic/University 
PI Contribution We provided an antibody that was critical to their work
Collaborator Contribution Scientific knowldege about one of the key proteins we study
Impact Pubmed ID: 16682645
 
Description Uruguay 
Organisation University of the Republic
Country Uruguay 
Sector Academic/University 
PI Contribution intellectual input and joint grant writing
Collaborator Contribution Joint funding resulted in a PhD student coming from Uruguay to work in my lab for 9 months.
Impact A Royal Society Joint International project grant. Publication: 18000958
Start Year 2007