MRC Clinical Trials Unit as the London Hub for Trials Methodology Research
Lead Research Organisation:
University College London
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Organisations
- University College London (Lead Research Organisation)
- European Medicines Agency (Collaboration)
- University of Sydney (Collaboration)
- KEELE UNIVERSITY (Collaboration)
- University of Basel (Collaboration)
- Medicines and Healthcare Regulatory Agency (Collaboration)
- University of Warwick (Collaboration)
- Health Data Research UK (Collaboration)
- University of Hasselt (Collaboration)
- QUEEN MARY UNIVERSITY OF LONDON (Collaboration)
- UNIVERSITY OF ABERDEEN (Collaboration)
- The Global Health Network (Collaboration)
- University College Cork (Collaboration)
- UNIVERSITY OF BIRMINGHAM (Collaboration)
- University Medical Center Utrecht (UMC) (Collaboration)
- Radboud University Nijmegen (Collaboration)
- UNIVERSITY OF LIVERPOOL (Collaboration)
- University of Bristol (Collaboration)
- HARVARD UNIVERSITY (Collaboration)
- Trials Methodology Research Network (Collaboration)
- PUBLIC HEALTH ENGLAND (Collaboration)
- UKCRC Registered trials CTU network (Collaboration)
- QUEEN'S UNIVERSITY BELFAST (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- Cancer Research UK (Collaboration)
- AstraZeneca (United Kingdom) (Collaboration)
- UK Trial Managers Network (Collaboration)
- Brown University (Collaboration)
- London School of Hygiene and Tropical Medicine (LSHTM) (Collaboration)
- NHS HEALTH RESEARCH AUTHORITY (Collaboration)
- UNIVERSITY OF YORK (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
- National Cancer Registration and Analysis Service (Collaboration)
People |
ORCID iD |
Publications
Adams R
(2018)
Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2-3 randomised trial.
in The lancet. Gastroenterology & hepatology
Ahmed HU
(2017)
Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study.
in Lancet (London, England)
Bratton D
(2015)
Comments on 'A modest proposal for dropping poor arms in clinical trials' by Proschan and Dodd LETTER TO THE EDITOR
in Statistics in Medicine
Bratton DJ
(2016)
Type I error rates of multi-arm multi-stage clinical trials: strong control and impact of intermediate outcomes.
in Trials
Brueton V
(2017)
Best practice guidance for the use of strategies to improve retention in randomized trials developed from two consensus workshops.
in Journal of clinical epidemiology
Choodari-Oskooei B
(2015)
The extension of total gain (TG) statistic in survival models: properties and applications.
in BMC medical research methodology
Clayton GL
(2017)
The INVEST project: investigating the use of evidence synthesis in the design and analysis of clinical trials.
in Trials
| Title | Induction Pack for PPI (Public Patient Involvement) Contributorson Trial Oversight Committees |
| Description | A guidance pack to help researchers design relevant PPI for their trial |
| Type Of Material | Improvements to research infrastructure |
| Year Produced | 2018 |
| Provided To Others? | Yes |
| Impact | None yet |
| URL | https://www.ctu.mrc.ac.uk/media/1416/induction_pack_for_ppi_contributors_on_trial_oversight_committe... |
| Description | Cochrane IPD Synthesis Working Group |
| Organisation | Brown University |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Participated in teleconference discussions and preparation of the final report |
| Collaborator Contribution | Participated in teleconference discussions and preparation of the final report |
| Impact | Cochrane IPD Synthesis Working Group Report |
| Start Year | 2017 |
| Description | Cochrane IPD Synthesis Working Group |
| Organisation | Keele University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Participated in teleconference discussions and preparation of the final report |
| Collaborator Contribution | Participated in teleconference discussions and preparation of the final report |
| Impact | Cochrane IPD Synthesis Working Group Report |
| Start Year | 2017 |
| Description | Cochrane IPD Synthesis Working Group |
| Organisation | Queen's University Belfast |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Participated in teleconference discussions and preparation of the final report |
| Collaborator Contribution | Participated in teleconference discussions and preparation of the final report |
| Impact | Cochrane IPD Synthesis Working Group Report |
| Start Year | 2017 |
| Description | Cochrane IPD Synthesis Working Group |
| Organisation | Radboud University Nijmegen |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Participated in teleconference discussions and preparation of the final report |
| Collaborator Contribution | Participated in teleconference discussions and preparation of the final report |
| Impact | Cochrane IPD Synthesis Working Group Report |
| Start Year | 2017 |
| Description | Cochrane IPD Synthesis Working Group |
| Organisation | University Medical Center Utrecht (UMC) |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Participated in teleconference discussions and preparation of the final report |
| Collaborator Contribution | Participated in teleconference discussions and preparation of the final report |
| Impact | Cochrane IPD Synthesis Working Group Report |
| Start Year | 2017 |
| Description | Cochrane IPD Synthesis Working Group |
| Organisation | University of Bristol |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Participated in teleconference discussions and preparation of the final report |
| Collaborator Contribution | Participated in teleconference discussions and preparation of the final report |
| Impact | Cochrane IPD Synthesis Working Group Report |
| Start Year | 2017 |
| Description | Cochrane IPD Synthesis Working Group |
| Organisation | University of Hasselt |
| Department | International Drug Development Institute |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Participated in teleconference discussions and preparation of the final report |
| Collaborator Contribution | Participated in teleconference discussions and preparation of the final report |
| Impact | Cochrane IPD Synthesis Working Group Report |
| Start Year | 2017 |
| Description | Cochrane IPD Synthesis Working Group |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Participated in teleconference discussions and preparation of the final report |
| Collaborator Contribution | Participated in teleconference discussions and preparation of the final report |
| Impact | Cochrane IPD Synthesis Working Group Report |
| Start Year | 2017 |
| Description | Cochrane IPD Synthesis Working Group |
| Organisation | University of Sydney |
| Country | Australia |
| Sector | Academic/University |
| PI Contribution | Participated in teleconference discussions and preparation of the final report |
| Collaborator Contribution | Participated in teleconference discussions and preparation of the final report |
| Impact | Cochrane IPD Synthesis Working Group Report |
| Start Year | 2017 |
| Description | Cochrane IPD Synthesis Working Group |
| Organisation | University of York |
| Department | Centre for Reviews and Dissemination (CRD) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Participated in teleconference discussions and preparation of the final report |
| Collaborator Contribution | Participated in teleconference discussions and preparation of the final report |
| Impact | Cochrane IPD Synthesis Working Group Report |
| Start Year | 2017 |
| Description | Collaboration with AstraZeneca on cedaranib following ICON6 trial outcome |
| Organisation | AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Sponsored and ran the ICON6 trial after AZ abandoned development of this compound. Worked closely with them to produce licensing application. Established strong working relationship which helped with some of our other projects. |
| Collaborator Contribution | Drug supply only until positive outcome of the study was reported. Subsequently, close colloaboration on preparation of regulatory package. |
| Impact | Full study report and published manuscripts |
| Start Year | 2007 |
| Description | HDR London (Health Data Research, London) |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Lead the London bid for the trials component, one of five active sites in London |
| Collaborator Contribution | Active in HDR UK team for London sites |
| Impact | None yet |
| Start Year | 2018 |
| Description | HDR London (Health Data Research, London) |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Lead the London bid for the trials component, one of five active sites in London |
| Collaborator Contribution | Active in HDR UK team for London sites |
| Impact | None yet |
| Start Year | 2018 |
| Description | HDR London (Health Data Research, London) |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Lead the London bid for the trials component, one of five active sites in London |
| Collaborator Contribution | Active in HDR UK team for London sites |
| Impact | None yet |
| Start Year | 2018 |
| Description | HDR London (Health Data Research, London) |
| Organisation | Queen Mary University of London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Lead the London bid for the trials component, one of five active sites in London |
| Collaborator Contribution | Active in HDR UK team for London sites |
| Impact | None yet |
| Start Year | 2018 |
| Description | HDR UK (Health Data Research, UK) |
| Organisation | Health Data Research UK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Unit is part of HDR UK, which is a new UK-wide partnership investigating how health research can be improved through access to routine and study-specific health data |
| Collaborator Contribution | Led the London-wide bid for trials activity. Actively contributing to other areas. |
| Impact | None yet |
| Start Year | 2018 |
| Description | Honorary contract with EMA |
| Organisation | European Medicines Agency |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Accessing information at the EMA to inform design and conduct of trials to ensure they are better positioned for future licensing applications |
| Collaborator Contribution | Providing access to the EMA documents and databases |
| Impact | Not yet. PhD chapter in development |
| Start Year | 2018 |
| Description | ORCCA2 |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Screening of abstracts to form the database for this project |
| Collaborator Contribution | Initating and management of this project |
| Impact | None yet |
| Start Year | 2018 |
| Description | Partnership with HRA, MHRA and NCRAS/PHE for source data verification project |
| Organisation | Medicines and Healthcare Regulatory Agency |
| Department | General Practice Research Database (GPRD) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | MRC CTU is leading some work on whether electronic health record data could be used to check the quality of clinical trial data. |
| Collaborator Contribution | The partner organisations are helping us set this up and discussing relevant issues; NCRAS/PHE will help by providing data if the project is successful. |
| Impact | None so far |
| Start Year | 2017 |
| Description | Partnership with HRA, MHRA and NCRAS/PHE for source data verification project |
| Organisation | NHS Health Research Authority |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | MRC CTU is leading some work on whether electronic health record data could be used to check the quality of clinical trial data. |
| Collaborator Contribution | The partner organisations are helping us set this up and discussing relevant issues; NCRAS/PHE will help by providing data if the project is successful. |
| Impact | None so far |
| Start Year | 2017 |
| Description | Partnership with HRA, MHRA and NCRAS/PHE for source data verification project |
| Organisation | National Cancer Registration and Analysis Service |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | MRC CTU is leading some work on whether electronic health record data could be used to check the quality of clinical trial data. |
| Collaborator Contribution | The partner organisations are helping us set this up and discussing relevant issues; NCRAS/PHE will help by providing data if the project is successful. |
| Impact | None so far |
| Start Year | 2017 |
| Description | Protocol for systematic review of trial monitoring |
| Organisation | University of Basel |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Assitance and input to plans to develop a Protocol |
| Collaborator Contribution | Assitance and input to plans to develop a Protocol |
| Impact | Not yet |
| Start Year | 2018 |
| Description | Routine electronic health records (EHR) used as trial data by randomised controlled trials in the UK |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of a Protocol for a systematic review, undertaking review activities and manuscript preparation |
| Collaborator Contribution | Guidance and advice on the development of the Protocol, assistance with review activities |
| Impact | Published Protocol at url above |
| Start Year | 2018 |
| Description | Routine electronic health records (EHR) used as trial data by randomised controlled trials in the UK |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Development of a Protocol for a systematic review, undertaking review activities and manuscript preparation |
| Collaborator Contribution | Guidance and advice on the development of the Protocol, assistance with review activities |
| Impact | Published Protocol at url above |
| Start Year | 2018 |
| Description | Show RESPECT study collaboration |
| Organisation | Cancer Research UK |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Leading Show RESPECT study, looking at best ways to disseminate study results to study participants |
| Collaborator Contribution | Members of steering group, helping to design, conduct and disseminate results of study |
| Impact | None yet |
| Start Year | 2017 |
| Description | Show RESPECT study collaboration |
| Organisation | Harvard University |
| Department | Harvard Medical School |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Leading Show RESPECT study, looking at best ways to disseminate study results to study participants |
| Collaborator Contribution | Members of steering group, helping to design, conduct and disseminate results of study |
| Impact | None yet |
| Start Year | 2017 |
| Description | Show RESPECT study collaboration |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Leading Show RESPECT study, looking at best ways to disseminate study results to study participants |
| Collaborator Contribution | Members of steering group, helping to design, conduct and disseminate results of study |
| Impact | None yet |
| Start Year | 2017 |
| Description | Show RESPECT study collaboration |
| Organisation | NHS Health Research Authority |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Leading Show RESPECT study, looking at best ways to disseminate study results to study participants |
| Collaborator Contribution | Members of steering group, helping to design, conduct and disseminate results of study |
| Impact | None yet |
| Start Year | 2017 |
| Description | Show RESPECT study collaboration |
| Organisation | University of Aberdeen |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Leading Show RESPECT study, looking at best ways to disseminate study results to study participants |
| Collaborator Contribution | Members of steering group, helping to design, conduct and disseminate results of study |
| Impact | None yet |
| Start Year | 2017 |
| Description | TEMPER-related collaboration |
| Organisation | University College Cork |
| Country | Ireland |
| Sector | Academic/University |
| PI Contribution | Coordinating two pieces of work related to (extensions of) the TEMPER monitoring study (run from MRC CTU at UCL, funded by CRUK and MRC) |
| Collaborator Contribution | PhD student at Cork, helping plan, conduct and analyse the two small projects. |
| Impact | None yet |
| Start Year | 2017 |
| Description | Trials methodology research partnership |
| Organisation | Health Data Research UK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Key member of the executive group, designed and formed the network, oversight, provision of PhD student, courses |
| Collaborator Contribution | Key member of the executive group, designed and formed the network, oversight, provision of PhD student, courses |
| Impact | None yet |
| Start Year | 2018 |
| Description | Trials methodology research partnership |
| Organisation | The Global Health Network |
| Country | Global |
| Sector | Charity/Non Profit |
| PI Contribution | Key member of the executive group, designed and formed the network, oversight, provision of PhD student, courses |
| Collaborator Contribution | Key member of the executive group, designed and formed the network, oversight, provision of PhD student, courses |
| Impact | None yet |
| Start Year | 2018 |
| Description | Trials methodology research partnership |
| Organisation | Trials Methodology Research Network |
| Country | Ireland |
| Sector | Private |
| PI Contribution | Key member of the executive group, designed and formed the network, oversight, provision of PhD student, courses |
| Collaborator Contribution | Key member of the executive group, designed and formed the network, oversight, provision of PhD student, courses |
| Impact | None yet |
| Start Year | 2018 |
| Description | Trials methodology research partnership |
| Organisation | UK Trial Managers Network |
| Sector | Academic/University |
| PI Contribution | Key member of the executive group, designed and formed the network, oversight, provision of PhD student, courses |
| Collaborator Contribution | Key member of the executive group, designed and formed the network, oversight, provision of PhD student, courses |
| Impact | None yet |
| Start Year | 2018 |
| Description | Trials methodology research partnership |
| Organisation | UKCRC Registered trials CTU network |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Key member of the executive group, designed and formed the network, oversight, provision of PhD student, courses |
| Collaborator Contribution | Key member of the executive group, designed and formed the network, oversight, provision of PhD student, courses |
| Impact | None yet |
| Start Year | 2018 |
| Description | Use of routinely collected data for progression and side-effects (PhD related to STAMPEDE) |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Guidance on study protocol, application for data access |
| Collaborator Contribution | Supervision of PhD, data analysis |
| Impact | Not yet |
| Start Year | 2017 |
| Description | Use of routinely collected data for progression and side-effects (PhD related to STAMPEDE) |
| Organisation | University of Birmingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Guidance on study protocol, application for data access |
| Collaborator Contribution | Supervision of PhD, data analysis |
| Impact | Not yet |
| Start Year | 2017 |
| Description | Use of routinely collected data for progression and side-effects (PhD related to STAMPEDE) |
| Organisation | University of Warwick |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Guidance on study protocol, application for data access |
| Collaborator Contribution | Supervision of PhD, data analysis |
| Impact | Not yet |
| Start Year | 2017 |
| Title | Show RESPECT |
| Description | The Show RESPECT study is aiming to find practical ways to share the results of clinical trials with the people taking part in it. It is doing this by testing several different approaches within a large ovarian cancer trial (the ICON8 trial). |
| Type | Products with applications outside of medicine |
| Current Stage Of Development | Late clinical evaluation |
| Year Development Stage Completed | 2018 |
| Development Status | Under active development/distribution |
| Clinical Trial? | Yes |
| Impact | Nil |
| URL | http://www.isrctn.com/ISRCTN96189403 |
| Description | PPI Induction Pack development workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Patients, carers and/or patient groups |
| Results and Impact | A workshop to develop a PPI package |
| Year(s) Of Engagement Activity | 2018 |