MOSAIC - cohort of hospitalised H1N1 patients

Lead Research Organisation: Imperial College London

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

We have assembled a team of 42 investigators from England and Scotland, bringing their combined expertise to the intensive study of a group of hospitalised patients with influenza. The integration and coordination of all the studies is a logistic challenge, and case ascertainment, definition and sample collection underpins the collaborative network. On this base, some of the UKs best clinical and basic research groups will conduct an integrated|study of influenza virology, host RNA transcriptome and of cellular and humoral immune responses to influenza viral infection. The same patients will also be tested for levels of soluble mediators (cytokines and chemokines) in various body fluids, so allowing the crosscorrelation of the clinical features, virology and RNA transcription profiles on a population|basis. All of this will be linked to the study of the host genome and the bacterial and viral|microbiota present in the respiratory tract as disease evolves, using 16s RNA methods to characterise bacterial populations without the need for culture. The collaborative study of a single set of hospitalised individuals will lead to a wealth of information and the cross correlations between different research outputs will provide|unprecedented opportunities for understanding the pathogenesis of influenza.Research Framework, the Health Protection Agency, London School of Hygiene and Tropical Medicine and the Sanger Institute.|

Publications

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Barclay W (2018) The 1918 Influenza Pandemic: one hundred years of progress, but where now? in The Lancet. Respiratory medicine

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Chiu C (2015) Antiviral B cell and T cell immunity in the lungs. in Nature immunology

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Chiu C (2013) Cross-reactive humoral responses to influenza and their implications for a universal vaccine. in Annals of the New York Academy of Sciences

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Dunning J (2010) Impact of the 2009 influenza pandemic. in Thorax

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Dunning J (2011) Doctors accepting flu vaccination is the sensible and responsible choice. in BMJ (Clinical research ed.)

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Dunning JW (2014) Open source clinical science for emerging infections. in The Lancet. Infectious diseases

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Edwards MR (2012) The microbiology of asthma. in Nature reviews. Microbiology

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Ellebedy AH (2014) Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans. in Proceedings of the National Academy of Sciences of the United States of America

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Enstone JE (2011) Nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010. in Emerging infectious diseases

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Fraser CS (2017) Vaccines in the Prevention of Viral Pneumonia. in Clinics in chest medicine

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Guvenel AK (2014) Current concepts and progress in RSV vaccine development. in Expert review of vaccines

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Hansel T (2013) Microbes and mucosal immune responses in asthma in The Lancet

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Li GM (2012) Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. in Proceedings of the National Academy of Sciences of the United States of America

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Marchant A (2017) Maternal immunisation: collaborating with mother nature. in The Lancet. Infectious diseases

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Sheerin D (2017) Issues in vaccinology: Present challenges and future directions. in European journal of immunology

 
Title How to Catch Flu 
Description We commissioned the famous illustrator Steven Appleby and animator Pete Bishop to create a video 'How to Catch Flu' and an interactive stand exemplifying MOSAIC's research. A novel flu dominoes game was created with a range of 100 hand-drawn characters, including the 'at-risk' groups (elderly, obsess, pregnant, asthmatic etc.); some dominoes were 'vaccinated' (unable to topple). A table-top city scape was designed which allowed members of the public to create outbreaks. Participants were also invited to sketch their own virus. https://www.flickr.com/photos/123813534@N03/sets/ 'How to Catch Flu' was developed with a wide age range in mind. It conveys clear but subtle messages about how to prevent flu and what to do if you catch it. It has been shown to focus groups of children, to planners from Health Protection England, to groups of paediatricians and others and has been acclaimed as a highly engaging and memorable output from the grant. https://www.youtube.com/watch?v=nTtCBzOV0BY http://www.mediafire.com/download/39pocth3p6i0jcv/Happy720p.mp4.zip See also: http://www1.imperial.ac.uk/mosaic/ https://twitter.com/MOSAICStudy 
Type Of Art Film/Video/Animation 
Year Produced 2014 
Impact Video has since been uploaded onto National STEM database as a resource for teachers 
URL http://www1.imperial.ac.uk/mosaic/howtocatchflu/
 
Description BSI President
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
Impact The British Society for Immunology (BSI) is the largest immunology society in Europe and the second largest in the world. We are a learned society representing the interests of members working in academia, clinical medicine, and industry. Our main objective is to promote and support excellence in research, scholarship and clinical practice in immunology for the benefit of human and animal health.
URL https://immunology.org/resources-careers--education/policy-and-public-affairs/--bsi-resources-policy...
 
Description European Scientific Working Group on Influenza (ESWI)
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
Impact I am Vice-President of ESWI, which works to promote understanding of influenza as a disease, and to increas the use of vaccines and antiviral drugs in order to lessen the impact of flu in Europe.
 
Description ISARIC
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
Impact Large consortium of consortia, co-ordinating pandemic research internationally.
 
Description Invitation to participate in International Influenza Networks Meeting
Geographic Reach Multiple continents/international 
Policy Influence Type Participation in advisory committee
 
Description Joint Committee on Vaccination and Immunisation (influenza/RSV)
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description PREPARE
Geographic Reach Asia 
Policy Influence Type Membership of a guidance committee
 
Description Scientific Advisory Group in Emergencies
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact Part of small advisory group, chaired by the Government Chief Scientist, advising the Cabinet on pandemic responses. This committee took a central role in steering the pandemic response.
 
Description Biomedical Research
Amount £400,000 (GBP)
Organisation Imperial College Healthcare NHS Trust 
Sector Hospitals
Country United Kingdom
Start 01/2013 
End 03/2015
 
Description Biomedical Research Centre (BRC)
Amount £568,695 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 03/2016
 
Description FP7
Amount € 1,352,200 (EUR)
Funding ID 602525 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2014 
End 12/2018
 
Description MRC EMINENT grant
Amount £8,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 01/2016 
End 01/2021
 
Description NIHR Imperial Biomedical Research Centre
Amount £90,008,747 (GBP)
Organisation Barts Health NHS Trust 
Department NIHR Biomedical Research Unit
Sector Academic/University
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description PREPARE
Amount € 1,000,000 (EUR)
Funding ID 60525 
Organisation University of Antwerp 
Sector Academic/University
Country Belgium
Start 02/2014 
End 01/2019
 
Description Respiratory Infection Health Protection Unit (HPRU)
Amount £3,427,262 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 01/2013 
End 03/2019
 
Description Senior Investigator
Amount £75,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2014 
End 03/2019
 
Description Wellcome Trust Translational Fund
Amount £2,550,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
End 09/2018
 
Title Clinical information 
Description We have an extensive database of clinical information from 256 cases of influenza-like illness, mostly from pH1N1 influenza but also from control groups. 
Type Of Material Biological samples 
Year Produced 2010 
Provided To Others? Yes  
Impact Extensive material that can be cross-correlated with laboratory outputs 
 
Title Dataset 
Description The team within MOSAIC has produced a database linking all the outputs from MOSAIC in searchable form. This unique resource contains all data collected or generated in MOSAIC. Additionally, it contains detailed documentation about what is located within the databases, methods for generating the information and other methodological details. 
Type Of Material Technology assay or reagent 
Year Produced 2014 
Provided To Others? Yes  
Impact No impacts yet 
 
Title Diverse timed samples collected from cases of influenza-like illness 
Description We have 8000 samples archived. Processing almost complete 
Type Of Material Biological samples 
Year Produced 2010 
Provided To Others? Yes  
Impact Laboratory analysis across the consortium is approaching conclusion having encompassed multiple disciplines. These inlcude host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses. 
 
Title FLU-CIN 
Description The Influenza Clinical Information Network (FLU-CIN) surveillance network was established by the Department of Health in England on 11 May 2009. We have used the FLUCIN data collection form as the principal method of collecting clinical data from the study recruits 
Type Of Material Biological samples 
Provided To Others? No  
Impact Using this tool has enabled us to build a rich clinical dataset to complement the laboratory gerenated data from the biological samples that the study recruits provided. We have implemented rigourous validation and quality control procedures to ensure that this information is correct and in a format that will be flexible and easy to use in analysis 
 
Title Dataset 
Description The data team within MOSAIC has produced a database linking all the outputs from MOSAIC in searchable form. This unique resource contains all data collected or generated in MOSAIC. Additionally, it contains detailed documentation about what is located within the databases, methods for generating the information and other methodological details. These data were centrally managed in our core data team, headed by a researcher with over 10 years' experience collecting, managing and analysing clinical information. All data were validated and where appropriate double entered/double checked for accuracy. Documentation and clinical decisions regarding how patients should be classified were organised by the data team through documented expert meetings and assessment of the data. These data are shared across the MOSAIC investigator teams and with other researchers through a data request scheme. Once checked and mined by MOSAIC investigators, these data will be available to any researcher on request. 
Type Of Material Database/Collection of data 
Year Produced 2014 
Provided To Others? Yes  
Impact N/A 
 
Description ESWI 
Organisation European Scientific Working group on Influenza (ESWI)
Country European Union (EU) 
Sector Charity/Non Profit 
PI Contribution Openshaw served as ESWI's vice-president for 5 years, stepping down in September 2014.
Collaborator Contribution ESWI ()European Scientific Working Group on Influenza) was established in 1993. Along with the main stakeholders ESWI aims to educe the burden of influenza in Europe. The Members are twelve scientific experts, health care professionals, public health officials, at-risk patients and the elderly. ESWI collaborates with the World Health Organisation to enhance vaccine coverage of people at high risk of getting severe complications when infected with influenza.
Impact Openshaw acted as vice president
Start Year 2009
 
Description HPRU 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Health Protection Research Unit on Respiratory Viruses, Openshaw is lead on 'RSV theme' and a member of the management committee.
Collaborator Contribution Building on research done by MOSAIC
Impact Continuing research already undertaken by MOSAIC
Start Year 2013
 
Description HPRU 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Health Protection Research Unit on Respiratory Viruses, Openshaw is lead on 'RSV theme' and a member of the management committee.
Collaborator Contribution Building on research done by MOSAIC
Impact Continuing research already undertaken by MOSAIC
Start Year 2013
 
Description ISARIC 
Organisation The Global Health Network
Department International Severe Acute Respiratory Infection Consortium (ISARIC)
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution MOSAIC contributed to the initial set up of the project with core document development and refinement, as well as suggesting ways to measure nCoV cytokines. Openshaw, Dunning and Semple are ISARIC Council members
Collaborator Contribution ISARIC (International Severe Acute Respiratory and Emerging Infection Consortium) is a global initiative aiming to ensure that clinical researchers have the open access protocols and data-sharing processes needed to facilitate a rapid response to emerging diseases that may turn into epidemics or pandemics https://isaric.tghn.org
Impact MOSAIC assisted in initial set up of of ISARIC and MOSAIC members are active in Council
Start Year 2012
 
Description MOSAIC (Mechanisms of Severe Acute Influenza Consortium 
Organisation Health Protection Agency
Country United Kingdom 
Sector Public 
PI Contribution Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections.
Collaborator Contribution MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input.
Impact The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis.
Start Year 2009
 
Description MOSAIC (Mechanisms of Severe Acute Influenza Consortium 
Organisation Liverpool School of Tropical Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections.
Collaborator Contribution MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input.
Impact The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis.
Start Year 2009
 
Description MOSAIC (Mechanisms of Severe Acute Influenza Consortium 
Organisation NHS Greater Glasgow and Clyde (NHSGGC)
Department Gartnaval West of Scotland Specialist Virology Centre
Country United Kingdom 
Sector Hospitals 
PI Contribution Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections.
Collaborator Contribution MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input.
Impact The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis.
Start Year 2009
 
Description MOSAIC (Mechanisms of Severe Acute Influenza Consortium 
Organisation Royal Liverpool University Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections.
Collaborator Contribution MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input.
Impact The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis.
Start Year 2009
 
Description MOSAIC (Mechanisms of Severe Acute Influenza Consortium 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections.
Collaborator Contribution MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input.
Impact The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis.
Start Year 2009
 
Description MOSAIC (Mechanisms of Severe Acute Influenza Consortium 
Organisation University of Edinburgh
Department The Roslin Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections.
Collaborator Contribution MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input.
Impact The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis.
Start Year 2009
 
Description MOSAIC (Mechanisms of Severe Acute Influenza Consortium 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections.
Collaborator Contribution MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input.
Impact The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis.
Start Year 2009
 
Description MOSAIC (Mechanisms of Severe Acute Influenza Consortium 
Organisation University of Nottingham
Department School of Community Health Sciences Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections.
Collaborator Contribution MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input.
Impact The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis.
Start Year 2009
 
Description MOSAIC (Mechanisms of Severe Acute Influenza Consortium 
Organisation University of Oxford
Department Weatherall Institute of Molecular Medicine (WIMM)
Country United Kingdom 
Sector Public 
PI Contribution Primary site for patient recruitment. Consortium management and research leadership. Anaylsis of cytokine/ chemokine profiles and transcriptomic signatures of patients recrutied to the study using a variety of sample types at the Centre for Respiratory Infections.
Collaborator Contribution MOSAIC was set up to comprehensively investigate the pathogenesis of pH1N1/09 swine flu. With this objective in mind samples from patients recrutied to the project were sent to our partners in UK research centres in England and Scotland, who between them have produced data on host factors (cellular immunology, soluble mediator responses, transcriptomics and genomics), pathogen variations (influenza virus genetic and antigenic characteristics, viral shedding and viral load) and co pathogens (co-infecting or secondarily-infecting bacteria and viruses). The aim of this collaborative, multi-discipline approach is to establish those factors that contribute to variations in disease severity. In addition several of our collaborators have provided clinical, methodological and analytical input.
Impact The Consortium has generated a diverse range of clinical and laboratory datasets (as described above) and we are now entering the analytical phase where clinical data is being aligned with the laboratory output and ultimately the entire dataset will be brought together in a cross-cutting analysis.
Start Year 2009
 
Description PREPARE 
Organisation Public Health England
Department Centre for Emergency Preparedness and Response Unit
Country United Kingdom 
Sector Public 
PI Contribution Openshaw is active in several of the work packages
Collaborator Contribution PREPARE (Platform foR European Preparedness Against (RE-) emegering Epidemics) was funded by the EU commission in 2013. It is a consortium of 21 organisations that aims to identify and implement solutions to roadblocks against rapid implementation of clinical research during severe outbreakshttp://www.prepare-europe.eu
Impact Openshaw is a co-applicant and receives funding to do work that builds on the findings of MOSAIC
Start Year 2014
 
Description PREPARE 
Organisation Public Health England
Department Centre for Emergency Preparedness and Response Unit
Country United Kingdom 
Sector Public 
PI Contribution Openshaw is active in several of the work packages
Collaborator Contribution PREPARE (Platform foR European Preparedness Against (RE-) emerging Epidemics) was funded by the EU commission in 2013. It is a consortium of 21 organisations that aims to identify and implement solutions to roadblocks against rapid implementation of clinical research during severe outbreaks http://www.prepare-europe.eu
Impact Openshaw is a co-applicant and receives funding to do work that builds on the findings of MOSAIC
Start Year 2014
 
Title Synthetic adsorbative matrix (SAM) strips 
Description The adsorbative strips are placed in the nose or lung to obtain fluid samples for prognostic and diagnostic use. These were developed by Dr Hansel (a MOSAIC investigator) and have been tested experimentally in asthma and hay fever, but not on the scale used in MOSAIC. 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Early clinical assessment
Year Development Stage Completed 2008
Development Status Under active development/distribution
Impact The novel sampling method is expected to have clinical impact once the experimental phase is completed. 
 
Description BBC Newsnight feature 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Part of a BBC Newsnight feature on pH1N1 influenza, the impact it was having during the winter of 2010/11 and research efforts to understand pathogenesis.

N/A
Year(s) Of Engagement Activity 2011
 
Description British Society of Immunology response to annual vaccination statistics for England 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Peter Openshaw quoted in BBC News Online, Daily Telegraph and Huffington Post - 22nd September 2016
Year(s) Of Engagement Activity 2016
 
Description Cafe' Scientifique 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Regional
Primary Audience Schools
Results and Impact The presentation was given in relation to the H1N1 Influenza Pandemic

Students were interested in the discussion
Year(s) Of Engagement Activity 2011
 
Description Cheltenham Science Festival 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Openshaw also delivered a talk on 'Flu A Pandemic In Waiting?' at the Festival

N/A
Year(s) Of Engagement Activity 2014
URL http://www1.imperial.ac.uk/mosaic/events/cheltenham2014/
 
Description Croonian lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact Croonian Lecture

RCP Croonian lecture in 2013
Year(s) Of Engagement Activity 2013
 
Description How to Catch Flu film 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact We commissioned the famous illustrator Steven Appleby and animator Pete Bishop to create a video 'How to Catch Flu' and an interactive stand exemplifying MOSAIC's research. A novel flu dominoes game was created with a range of 100 hand-drawn cahracters, including 'at risk' groups (elderly, obese, pregnant, asthmatic, etc); some dominoes were 'vaccinated' (unable to topple). A table-top cityscape was designed which allowed members of the public to vreate outbreaks. Participants were also invited to sketch their own virus. http://www.flickr.com/photos/123813534@N03/sets

'How to Catch Flu' was developed with a wide range in mind. It conveys clear but subtle messages about how to rpevent flu and what to do if you catch it. It has been shown to focus groups of children, to planners from Health Protection England, to groups of paediatricians and others and has been acclaimed as a highly engaging and memorable output.

It has been added to the National STEM Centre database for teaching tools
Year(s) Of Engagement Activity 2014
URL http://www1.imperial.ac.uk/mosaic/howtocatchflu/
 
Description Imperial Festival of Science 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Festival attended by over 10,000 people and the MOSAIC stall was one of the most popular with visitors. Openshaw also gave a talk 'Spanish Flu to Swine Flu' which was open to the public

N/A
Year(s) Of Engagement Activity 2014
URL http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/eventssummary/event_30-4-2014-10-44-37
 
Description Interview on BBC Radio 2 - immune system 
Form Of Engagement Activity A broadcast e.g. TV/radio/film/podcast (other than news/press)
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Peter Openshaw interviewed about how to keep your immune system healthy. You can listen to the interview - 4th January 2016 at 16 min 40 sec into this recording.
Year(s) Of Engagement Activity 2016
 
Description Live Presentation in Brussels 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Last year I gave a 30 minute stage performance in a theatre in Brussels (the Albert Hall) to a public audience, recounting anecdotes and describing my sources of scientific inspiration.

N/A
Year(s) Of Engagement Activity 2012
 
Description Medical marvels: how vaccines protect, and what can go wrong 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach Local
Primary Audience Schools
Results and Impact 120 staff, pupils and parents attened this talk, which aimed to entertain and inform about the science, policy and pitfalls behind vaccines.

Several enquiries about internships and university applications.
Year(s) Of Engagement Activity 2012
 
Description Natural History Museum Science Event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact MOSAIC stand at Natural History Museum Science Uncovered event

N/A
Year(s) Of Engagement Activity 2014
URL http://www1.imperial.ac.uk/mosaic/events/scienceuncovered/
 
Description Openshaw lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Stimulate conversation as part of RSV talks

N/A
Year(s) Of Engagement Activity 2014
 
Description Openshaw plenary lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact EFIS Lecture Award: "Protective and inflammatory responses in respiratory virus infections."

N/A
Year(s) Of Engagement Activity 2014
URL http://www.irishimmunology.ie/ISI%20Programme%202014.pdf
 
Description Openshaw talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact The BSI Summer School is a unique learning experience aimed primarily at individuals who are new to the field of immunology or who want to enhance their immunological knowledge. To be held within the historic city of Edinburgh, the 2014 BSI summer school will feature presentations from leading immunologists who will teach the fundamental principles of immunology in the context of cutting edge research.
• Immunology taught by world-leading Immunologists
• Fundamental and current topics in Immunology
• Interactive tutorials and workshops
• Immunology 'Dragon's Den'
• Fantastic Social activities.


N/A
Year(s) Of Engagement Activity 2014
URL https://immunology.org/events--meetings/summer-schoo-2014/--bsi-events--meeting-edinburgh-summer-sch...
 
Description Openshaw talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Openshaw gave keynote lecture

N/A
Year(s) Of Engagement Activity 2014
 
Description Openshaw talk 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Openshaw Chaired sessions at conference as well as giving talks on RSV

N/A
Year(s) Of Engagement Activity 2014
 
Description Openshaw talk (open to public) 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Talk on influenza outbreaks, open to members of the public

Raise public awareness
Year(s) Of Engagement Activity 2014
URL http://www.friendsofimperial.org.uk/FOIC-Index.php?pg=FullEvent&from=Past-Events&yr=13&ev=130
 
Description Openshaw talks 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Openshaw Chaired sessions and gave keynote speeches during conference

N/A
Year(s) Of Engagement Activity 2014
 
Description Panel discussion 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact International Influenza Networks Meeting (Arizona)

We would like you to participate in the Panel on "Clinical/Research Networks" on Monday, January 14, 2013. During the panel discussion, you would present on the Mechanisms of Severe Acute Influenza Consortium (MOSAIC) - their goals, unique attributes, information gathered, and current strengths/gaps. A preliminary meeting agenda is attached for your review.
Year(s) Of Engagement Activity 2013
 
Description Press conference, Wellcome Trust 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Excellent turnout of specialist science journalists and those looking for a flu story. About 30 attenees

Several national newspapers published stories mentioning ongoing studies, contributing to the awareness for the need for seasonal flu vaccines
Year(s) Of Engagement Activity 2010,2011
 
Description Press release (Sanger Isntitute) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact News release outlined major findings from a consortium publication. The work described identified a human gene (IFITM3) that influences how we respond to influenza infection. People who carry a particular variant are significantly more likely to be hospitalised when they fall ill with influenza than those who carry other variants

Significant media interest followed this release including and interview on BBC radio 4's today programme
Year(s) Of Engagement Activity 2012
 
Description Radio Interview (Today Programme, BBC R4) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Following a press release from the Sanger institute that outlined the findings from a consortium publication on a genetic correlate of influenza severity, the Today programme ran a report on the subject which featured interviews with the head of the consortium and the PI from the Sanger. The report also showcased the scope and originality of the MOSAIC consortium and it's potential impact on the study and treatment of future pandemics.

This activity raised the profile of MOSAIC and it's output to a non-scientific audience.
Year(s) Of Engagement Activity 2012
 
Description Rule that patients must finish antibiotics course is wrong, study says - Interview for the Guardian 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Comments in relation to the article on antibiotics
Year(s) Of Engagement Activity 2017
 
Description Science Inspired Tales 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Keynote/Invited Speaker
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Video edited and put online

Asked if I would do another on a different topic
Year(s) Of Engagement Activity 2012
 
Description Society for General Microbiology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Public outreach for MOSAIC study

N/A
Year(s) Of Engagement Activity 2014
URL http://www1.imperial.ac.uk/mosaic/events/sgm2014/
 
Description TV interview 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Keynote/Invited Speaker
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact TV appearance on "Daybreak"

Asked to speak on flu vaccines
Year(s) Of Engagement Activity 2013
 
Description Talk about research on MOSAIC to the Imperial College Academic Health Science Centre 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact To speak at the AHSC seminar series about the research into influenza and the MOSAIC project.
Year(s) Of Engagement Activity 2016
 
Description Understanding and treating the flu virus AHSC Seminar 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Peter Openshaw will discuss the MOSAIC project which collected data from over 250 flu patients to inform new treatments
Year(s) Of Engagement Activity 2016
 
Description Wellcome Trust Masterclass 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Schools
Results and Impact We hosted a publically accessible immunology 'Masterclass' last year at the Wellcome Trust at which Jonathan Yewdell inspired an audience that included many students from London schools.

N/A
Year(s) Of Engagement Activity 2011
 
Description Why some people catch every cold going and others none: Genetics, stress and even childhood can all affect immune system 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Peter Openshaw quoted in Daily Mail article - 18th January 2016
Year(s) Of Engagement Activity 2016