A randomised controlled trial of eicosapentaenoic acid (EPA) and/or aspirin for colorectal adenoma (or polyp) preve

Lead Research Organisation: University of Leeds

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

Scientific Abstract
Research design: A randomised, double-blind, placebo-controlled 2 x 2 factorial trials integrated into the screening and surveillance phases of the National Bowel Cancer Screening Programme (BCSP).
Study population: BCSP patients str

Publications

10 25 50

publication icon
Sprange K (2015) No drug, no trial? Think again! in Trials

publication icon
Volpato M (2017) A liquid chromatography-tandem mass spectrometry method to measure fatty acids in biological samples. in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

 
Description Project Grant
Amount £1,496,870 (GBP)
Organisation Yorkshire Cancer Research 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2015 
End 09/2020
 
Description Project grant scheme
Amount £11,000 (GBP)
Organisation Leeds Teaching Hospitals NHS Trust 
Sector Public
Country United Kingdom
Start 09/2014 
End 08/2015
 
Description Yorkshire Cancer Research Project Grant
Amount £216,941 (GBP)
Organisation Yorkshire Cancer Research 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2011 
End 04/2014
 
Description Consultancy for Thetis Pharma 
Organisation Thetis Pharmaceuticals LLC
Country United States 
Sector Private 
PI Contribution Advice on design of pre-clinical and clinical studies for omega-3 derivative IMP. Contribution to pre-clinical investigation of TP-252 efficacy for prevention of intestinal tumorigenesis in ApcD14 model
Collaborator Contribution Sharing of data
Impact Carcinogenesis 2017; doi: 10.1093/carcin/bgx136
Start Year 2016
 
Description partnership with Igennus Healthcare Nutrition 
Organisation Igennus Healthcare Nutrition
Country United Kingdom 
Sector Private 
PI Contribution We obtained active EPA and placebo capsules from Igennus at cost price after the previous supplier to the seAFOod Trial (SLA Pharma AG) was unable to continue to supply IMP free of charge.
Collaborator Contribution Discount purchase of capsules and support developing MHRA CTA amendment
Impact supply of capsules for continued recruitment
Start Year 2014
 
Description seAFOod Trial Biomarker analysis 
Organisation University of Bologna
Department Department of Gastroenterology
Country Italy 
Sector Academic/University 
PI Contribution study design, sample collection and Trial organisation
Collaborator Contribution biological sample handling, fatty acid measurement and lipidomic analyses
Impact Neoplasia 2010;12:618-27; Br J Pharmacol 2012;166:1724-37; J Chromatogr B Analyt Technol Biomed Life Sci 2017;1055-1056:125-134; Prostaglandins Leukotrienes Essential Fatty Acids 2016;115:60-66; Gut 2017 DOI:10.1136/gutjnl-2017-314968
Start Year 2009
 
Description seAFOod Trial Biomarker analysis 
Organisation University of Bradford
Department Institute of Cancer Therapeutics
Country United Kingdom 
Sector Academic/University 
PI Contribution study design, sample collection and Trial organisation
Collaborator Contribution biological sample handling, fatty acid measurement and lipidomic analyses
Impact Neoplasia 2010;12:618-27; Br J Pharmacol 2012;166:1724-37; J Chromatogr B Analyt Technol Biomed Life Sci 2017;1055-1056:125-134; Prostaglandins Leukotrienes Essential Fatty Acids 2016;115:60-66; Gut 2017 DOI:10.1136/gutjnl-2017-314968
Start Year 2009
 
Description seAFOod Trial TTR 
Organisation University of Sussex
Department School of Business, Management and Economics Sussex
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributed to MRC request to add to Tracking Translational Research project by Dr Michael Hopkins
Collaborator Contribution Interviews with me and collaborators
Impact nil
Start Year 2015
 
Description seaFOod Trial link with MRC START programme to test improved materials for trial recruitment 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Cluster randomised sites to use of multimedia materials for particpant recruitment within the seAFOod Trial
Collaborator Contribution worked with MRC START team to develop video and website material and submitted SA to REC.
Impact nil
Start Year 2014
 
Description Press release about Trial funding 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Primary Audience Public/other audiences
Results and Impact written and audio media

none recognised
Year(s) Of Engagement Activity 2010
 
Description Public information website 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact CancerHelpUK information about seAFOod Trial

increased public (patient) awareness of Trial
Year(s) Of Engagement Activity 2012