Confidence in Concept 2012 - University of Sheffield

Lead Research Organisation: University of Sheffield

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

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Gotham VJ (2016) Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay. in Organic & biomolecular chemistry

 
Description CBMNet NIBB Proof of Concept
Amount £42,500 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 10/2017 
End 09/2018
 
Description Clinical Lectureship
Amount £200,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2016 
End 09/2019
 
Description Clinical Research Fellowship
Amount £1,760,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 08/2022
 
Description Determining Novel SMURF1 Signalling Pathways and Precision Medicine Strategies in Patients with Pulmonary Arterial Hypertension
Amount £460,409 (GBP)
Funding ID 206632/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2017 
End 02/2023
 
Description Developmental Pathway Funding Scheme
Amount £2,401,085 (GBP)
Funding ID MR/M015491/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2015 
End 01/2018
 
Description Developmental Pathway Funding Scheme
Amount £521,681 (GBP)
Funding ID MR/L023040/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2014 
End 02/2016
 
Description HC Roscoe Grant
Amount £50,000 (GBP)
Organisation British Medical Association (BMA) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2014 
End 09/2015
 
Description PhD studentship
Amount £21,000 (GBP)
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 09/2020
 
Description Research Grant
Amount £1,204,230 (GBP)
Funding ID MR/M004864/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2014 
End 09/2019
 
Description Senior Basic Science Research Fellowship
Amount £1,010,100 (GBP)
Funding ID FS/13/48/30453 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2013 
End 11/2018
 
Description Collaborator on a project awarded under The University of Sheffield's institutional award from Round 1 of the Confidence in Concept Scheme 
Organisation Kymab
Country United Kingdom 
Sector Private 
PI Contribution Lead on a project developing Anti-OPG and TRAIL therapies for Pulmonary hypertension
Collaborator Contribution Developed monoclonal antibodies and partner on successful DPFS application.
Impact Partner on successful DPFS application.
Start Year 2013
 
Description Collaborator on a project awarded under The University of Sheffield's institutional award from Round 1 of the Confidence in Concept Scheme 
Organisation Medtronic
Country United States 
Sector Private 
PI Contribution Lead and carry out a project on radiofrequency ablation for the treatment of pulmonary hypertension
Collaborator Contribution In kind provision of cardiac stents
Impact Presentation at TCT 2013 conference. Applications for further grants resulting in part from CiC funding are pending.
Start Year 2013
 
Description Collaborator on a project awarded under The University of Sheffield's institutional award from Round 1 of the Confidence in Concept Scheme 
Organisation National Institute for Health Research
Department NIHR Devices for Dignity Healthcare Technology Co-Operative
Country United Kingdom 
Sector Public 
PI Contribution Lead on a project looking at detecting early onset of urinary tract infection in patients.
Collaborator Contribution D4D's input adds a monetary contribution and expertise in target condition management and working with the NHS. D4D also provide market and intellectual property expertise.
Impact Intended outputs are currently confidential. This is a multi-discplinary project involving clinicians, engineers, bioscientists and market expertise and product design.
Start Year 2013
 
Description Collaborator on a project awarded under The University of Sheffield's institutional award from Round 1 of the Confidence in Concept Scheme 
Organisation PhytoQuest Ltd
Country United Kingdom 
Sector Private 
PI Contribution Lead with developing small molecule channel modulators to treat polycystic kidney disease.
Collaborator Contribution Provided a set of natural compounds
Impact None
Start Year 2013
 
Description Collaborator on a project awarded under The University of Sheffield's institutional award from Round 1 of the Confidence in Concept Scheme 
Organisation University of Leicester
Country United Kingdom 
Sector Academic/University 
PI Contribution Lead on a project to develop a new drug to inhibit viral-induced airway inflammation.
Collaborator Contribution Input into new study ideas developing from CiC award.
Impact Collaborative opportunities are still under discussion.
Start Year 2013
 
Description Collaborator on a project awarded under The University of Sheffield's institutional award from Round 1 of the Confidence in Concept Scheme 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution Lead project on development of a long-acting clotting factor to provide a prophylactic therapy for haemophiliac patients.
Collaborator Contribution Identification of a new programme of work to further develop project.
Impact Discussions are ongoing as to further outcomes.
Start Year 2013
 
Title Developing therapies for Pulmonary Hypertension 
Description The disclosure relates to agents that inhibit the activity of osteoprotegerin (OPG) and their use in the treatment of pulmonary hypertension. 
IP Reference US20140255404 
Protection Patent granted
Year Protection Granted 2016
Licensed Commercial In Confidence
Impact Other patent application: EP2773668
 
Company Name PH Therapeutics Limited 
Description PH Therapeutics Ltd is a new business that intends to develop novel antibody therapies to treat the orphan disease Pulmonary Arterial Hypertension (PAH). The goal is to develop these new therapies to the clinic and to bring benefit to patients suffering from this rare and debilitating disease. 
Year Established 2013 
Impact Through the work of Dr Allan Lawrie at the University of Sheffield, PH Therapeutics is developing novel antibody therapies that aim to reverse the progression of pulmonary arterial hypertension leading to improved treatments for patients.
Website http://phtherapeutics.com/