Confidence in Concept 2012 - University of Strathclyde
Lead Research Organisation:
University of Strathclyde
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
People |
ORCID iD |
| Philip Winn (Principal Investigator) |
Publications
Alniss HY
(2014)
Recognition of the DNA minor groove by thiazotropsin analogues.
in Chembiochem : a European journal of chemical biology
Barrett MP
(2013)
Minor groove binders as anti-infective agents.
in Pharmacology & therapeutics
Crilly A
(2012)
Immunomodulatory role of proteinase-activated receptor-2.
in Annals of the rheumatic diseases
Llona-Minguez S
(2013)
Small-molecule inhibitors of I?B kinase (IKK) and IKK-related kinases.
in Pharmaceutical patent analyst
Llona-Minguez S
(2014)
Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ 0 )
in Beilstein Journal of Organic Chemistry
McKittrick CM
(2015)
Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemia.
in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Salvia MV
(2013)
Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove.
in Biophysical chemistry
| Description | Arthritis Research UK project grant |
| Amount | £175,000 (GBP) |
| Funding ID | 20199 |
| Organisation | Versus Arthritis |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2013 |
| End | 08/2016 |
| Description | BBSRC Responsive mode, Panel D, The differing biological fates of DNA minor groove-binding (MGB) antibiotics in Gram-negative and Gram-Positive bacteria. |
| Amount | £369,782 (GBP) |
| Funding ID | BB/K019600/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2014 |
| End | 02/2017 |
| Description | Chief Scientist's Office grant |
| Amount | £116,784 (GBP) |
| Funding ID | 160125 |
| Organisation | Chief Scientist Office |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 09/2017 |
| Description | Development Pathway Funding Scheme |
| Amount | £1,230,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2015 |
| End | 05/2017 |
| Description | Drug Discovery Project Award |
| Amount | £200,000 (GBP) |
| Funding ID | A18474 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2015 |
| End | 10/2016 |
| Description | MSD / SULSA |
| Amount | £49,000 (GBP) |
| Organisation | Scottish Universities Life Sciences Alliance |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | |
| Description | Prostate Cancer UK Project Grant |
| Amount | £249,289 (GBP) |
| Funding ID | PG12-27 |
| Organisation | Prostate Cancer UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2013 |
| End | 04/2016 |
| Description | SIPBS KE Hub |
| Amount | £10,000 (GBP) |
| Organisation | European Commission |
| Department | European Regional Development Fund (ERDF) |
| Sector | Public |
| Country | Belgium |
| Start | 03/2013 |
| End | 12/2013 |
| Description | SMART grant |
| Amount | £60,000 (GBP) |
| Organisation | Scottish Enterprise |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2015 |
| End | 03/2016 |
| Description | SULSA-MSD |
| Amount | £50,000 (GBP) |
| Organisation | Scottish Universities Life Sciences Alliance |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 09/2013 |
| End | 09/2014 |
| Description | Research collaboration: Carswell |
| Organisation | Biogelx |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Collaboration to demonstrate in vivo compatibility of BioGelX scaffolds with ReNeuron stem cells |
| Collaborator Contribution | Contribution of materials |
| Impact | Data is being generated of benefit to all 3 parties |
| Start Year | 2012 |
| Description | Research collaboration: Carswell |
| Organisation | Reneuron |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Collaboration to demonstrate in vivo compatibility of BioGelX scaffolds with ReNeuron stem cells |
| Collaborator Contribution | Contribution of materials |
| Impact | Data is being generated of benefit to all 3 parties |
| Start Year | 2012 |
| Description | Research collaboration: Mackay |
| Organisation | Mayo Clinic |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | First-in-class IKKalpha inhibitors provided to UCSD for in vivo studies in prostate cancer and to Mayo Clinic for in vivo studies in pancreatic cancer. |
| Collaborator Contribution | Provision of in vivo models |
| Impact | Data being generated that will add to pre-clinical package for licensing or investment |
| Start Year | 2013 |
| Description | Research collaboration: Mackay |
| Organisation | University of California, San Diego (UCSD) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | First-in-class IKKalpha inhibitors provided to UCSD for in vivo studies in prostate cancer and to Mayo Clinic for in vivo studies in pancreatic cancer. |
| Collaborator Contribution | Provision of in vivo models |
| Impact | Data being generated that will add to pre-clinical package for licensing or investment |
| Start Year | 2013 |
| Description | Research collaboration: Pickard |
| Organisation | SB Drug Discovery |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Development of novel in vitro genetic screening approach for identifying new targets in inflammatory disease. |
| Collaborator Contribution | Inflammatory disease assay development expertise |
| Impact | Data being generated |
| Start Year | 2013 |
| Description | Research collaboration: Tucker |
| Organisation | MGB Biopharma Ltd, Glasgow |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Data generated contributing to pre-clinical data package |
| Collaborator Contribution | Provision of compounds |
| Impact | Demonstration of Gram negative activity for compounds |
| Start Year | 2012 |