Confidence in Concept 2012 - University of Strathclyde

Lead Research Organisation: University of Strathclyde

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

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Alniss HY (2014) Recognition of the DNA minor groove by thiazotropsin analogues. in Chembiochem : a European journal of chemical biology

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Barrett MP (2013) Minor groove binders as anti-infective agents. in Pharmacology & therapeutics

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Crilly A (2012) Immunomodulatory role of proteinase-activated receptor-2. in Annals of the rheumatic diseases

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Llona-Minguez S (2014) Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0). in Beilstein journal of organic chemistry

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Llona-Minguez S (2013) Small-molecule inhibitors of I?B kinase (IKK) and IKK-related kinases. in Pharmaceutical patent analyst

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McKittrick CM (2015) Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemia. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

 
Description Arthritis Research UK project grant
Amount £175,000 (GBP)
Funding ID 20199 
Organisation Versus Arthritis 
Start 09/2013 
End 08/2016
 
Description BBSRC Responsive mode, Panel D, The differing biological fates of DNA minor groove-binding (MGB) antibiotics in Gram-negative and Gram-Positive bacteria.
Amount £369,782 (GBP)
Funding ID BB/K019600/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 02/2014 
End 02/2017
 
Description Chief Scientist's Office grant
Amount £116,784 (GBP)
Funding ID 160125 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 09/2016 
End 09/2017
 
Description Development Pathway Funding Scheme
Amount £1,230,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2015 
End 05/2017
 
Description Drug Discovery Project Award
Amount £200,000 (GBP)
Funding ID A18474 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2015 
End 10/2016
 
Description MSD / SULSA
Amount £49,000 (GBP)
Organisation Scottish Universities Life Sciences Alliance 
Sector Academic/University
Country United Kingdom
Start  
 
Description Prostate Cancer UK Project Grant
Amount £249,289 (GBP)
Funding ID PG12-27 
Organisation Prostate Cancer UK 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2013 
End 04/2016
 
Description SIPBS KE Hub
Amount £10,000 (GBP)
Organisation European Commission 
Department European Regional Development Fund (ERDF)
Sector Public
Country European Union (EU)
Start 03/2013 
End 12/2013
 
Description SMART grant
Amount £60,000 (GBP)
Organisation Scottish Enterprise 
Sector Public
Country United Kingdom
Start 04/2015 
End 03/2016
 
Description SULSA-MSD
Amount £50,000 (GBP)
Organisation Scottish Universities Life Sciences Alliance 
Sector Academic/University
Country United Kingdom
Start 10/2013 
End 09/2014
 
Description Research collaboration: Carswell 
Organisation Biogelx
Country United Kingdom 
Sector Private 
PI Contribution Collaboration to demonstrate in vivo compatibility of BioGelX scaffolds with ReNeuron stem cells
Collaborator Contribution Contribution of materials
Impact Data is being generated of benefit to all 3 parties
Start Year 2012
 
Description Research collaboration: Carswell 
Organisation Reneuron
Country United Kingdom 
Sector Private 
PI Contribution Collaboration to demonstrate in vivo compatibility of BioGelX scaffolds with ReNeuron stem cells
Collaborator Contribution Contribution of materials
Impact Data is being generated of benefit to all 3 parties
Start Year 2012
 
Description Research collaboration: Mackay 
Organisation Mayo Clinic
Country United States 
Sector Charity/Non Profit 
PI Contribution First-in-class IKKalpha inhibitors provided to UCSD for in vivo studies in prostate cancer and to Mayo Clinic for in vivo studies in pancreatic cancer.
Collaborator Contribution Provision of in vivo models
Impact Data being generated that will add to pre-clinical package for licensing or investment
Start Year 2013
 
Description Research collaboration: Mackay 
Organisation University of California, San Diego (UCSD)
Country United States 
Sector Academic/University 
PI Contribution First-in-class IKKalpha inhibitors provided to UCSD for in vivo studies in prostate cancer and to Mayo Clinic for in vivo studies in pancreatic cancer.
Collaborator Contribution Provision of in vivo models
Impact Data being generated that will add to pre-clinical package for licensing or investment
Start Year 2013
 
Description Research collaboration: Pickard 
Organisation SB Drug Discovery
Country United Kingdom 
Sector Private 
PI Contribution Development of novel in vitro genetic screening approach for identifying new targets in inflammatory disease.
Collaborator Contribution Inflammatory disease assay development expertise
Impact Data being generated
Start Year 2013
 
Description Research collaboration: Tucker 
Organisation MGB Biopharma Ltd, Glasgow
Country United Kingdom 
Sector Private 
PI Contribution Data generated contributing to pre-clinical data package
Collaborator Contribution Provision of compounds
Impact Demonstration of Gram negative activity for compounds
Start Year 2012