UoCardiff Confidence in Concept 2013

Lead Research Organisation: Cardiff University

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

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Khalid U (2015) A Localized Ischemic Preconditioning Regimen Increases Tumor Necrosis Factor a Expression in a Rat Model of Kidney Ischemia-Reperfusion Injury. in Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

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Kopczynska M (2019) Complement system biomarkers in first episode psychosis. in Schizophrenia research

 
Description 747278 ILTIS - Innate-Like T-Cells In Sepsis (ILTIS): Implications for Early Diagnosis and Rescue of Immune Suppression.
Amount € 97,727 (EUR)
Funding ID 747278 ILTIS 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2017 
End 08/2018
 
Description Health Technology Challenge Fund
Amount £25,000 (GBP)
Organisation South East Wales Academic Health Sciences Partnerships 
Sector Academic/University
Country United Kingdom
Start 06/2016 
End 05/2017
 
Description Identifying a microRNA signature of Chronic Kidney Disease (CKD) progression in blood and urine
Amount £255,000 (GBP)
Organisation UCB Pharma 
Sector Private
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description Immune fingerprints in haemodialysis patients with acute infection
Amount £49,995 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2018 
End 02/2019
 
Description Innate-like T-cells in sepsis (ILTIS): Implications for early diagnosis and rescue of immune suppression
Amount £80,000 (GBP)
Funding ID 747278-ILTIS-H2020-MSCA-IF-2016 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 07/2017 
End 06/2018
 
Description Life Science Bridging Fund
Amount £75,000 (GBP)
Organisation Government of Wales 
Sector Public
Country United Kingdom
Start 04/2016 
End 02/2017
 
Description Life Sciences Bridging Fund
Amount £75,000 (GBP)
Organisation Government of Wales 
Sector Public
Country United Kingdom
Start 07/2016 
End 07/2017
 
Description MRC
Amount £534,009 (GBP)
Funding ID MR/N023145/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2016 
End 11/2019
 
Description Machine-learning guided immune fingerprinting for rapid detection of life-threatening infection in liver cirrhosis
Amount £60,000 (GBP)
Funding ID 2122971 
Organisation Cardiff University 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2021
 
Description Sepsis and the newborn's immune system - Linking microbiome metabolites to protective immunity
Amount £60,000 (GBP)
Organisation Cardiff University 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2021
 
Description Systemic immune fingerprints in patients with acute severe sepsis
Amount £60,000 (GBP)
Organisation Cardiff University 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 09/2021
 
Description Tenovus PhD Studentship
Amount £90,000 (GBP)
Organisation Tenovus 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2015 
End 09/2018
 
Title Assays for complement biomarkers 
Description Immunoassays for complement-mediated pathologies 
Type Of Material Antibody 
Provided To Others? No  
Impact New assays available 
 
Title Cell therapy 
Description Cellular immunotherapy reagent 
Type Of Material Cell line 
Provided To Others? No  
Impact Intervention in pathologies reliant on gamma delta T cells 
 
Title miR detection in wound fluid 
Description Collection of wound fluid and demonstration of presence of miR biomarkers 
Type Of Material Technology assay or reagent 
Provided To Others? No  
Impact Stratification of non-healing wounds 
 
Title urine miRs 
Description Method for detecting microRNAs in urine to measurement in organ perfusate 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Development of methods for early detection of nephropathy 
 
Description Fraser/Ploeg 
Organisation University of Oxford
Department Quality in Organ Donation
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of knowledge and data
Collaborator Contribution Exchange of knowledge and data. Biobank samples.
Impact Availability of samples
Start Year 2014
 
Description Morgan/Lambie 
Organisation Keele University
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of knowledge and data
Collaborator Contribution Exchange of knowledge and data
Impact Data analysis
Start Year 2014
 
Description Morgan/Mizuno 
Organisation Nagoya University
Country Japan 
Sector Academic/University 
PI Contribution Exchange of knowledge and data
Collaborator Contribution Exchange of knowledge and data
Impact Replication sets
Start Year 2014
 
Description Moser/Curbishley 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of knowledge and data
Collaborator Contribution Exchange of knowledge and data
Impact Manufacture of clinical grade cells
Start Year 2014
 
Description Moser/Steven 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of knowledge and data
Collaborator Contribution Exchange of knowledge and data
Impact Manufacture of clinical grade cells
Start Year 2014
 
Description Stevens/Hughes 
Organisation University of Edinburgh
Department MRC Centre for Inflammation Research
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of knowledge and data
Collaborator Contribution Exchange of knowledge and data
Impact N/A
Start Year 2014
 
Description Weeks/GE 
Organisation GE Healthcare Limited
Country United Kingdom 
Sector Academic/University 
PI Contribution Exchange of knowledge and data
Collaborator Contribution Exchange of knowledge and data. Availability of sampling materials.
Impact Sampling methods
Start Year 2014
 
Title CHRONIC KIDNEY DISEASE DIAGNOSTIC 
Description The invention relates to a diagnostic method for determining at least one of, or a combination of, the following: has-miR-155-5p, hsa-miR-126-3p and has-miR-29b-3p in a urine sample for determining the existence of, or progression of, chronic kidney disease in a subject; and a kit of parts for undertaking said method 
IP Reference WO2017129977 
Protection Patent application published
Year Protection Granted
Licensed No
Impact n/a
 
Title Kidney Disease Diagnostic 
Description Detection of micro RNA biomarkers in urine as an early marker of nephropathy 
IP Reference  
Protection Patent application published
Year Protection Granted
Licensed Commercial In Confidence
Impact None yet
 
Title Non-invasive test for bladder cancer 
Description Urine test for the detection and monitoring of bladder cancer. Used to test >100 urine samples with clinical correlation. Recently funded by external investment presently negotiating renewal of funding 
Type Diagnostic Tool - Non-Imaging
Current Stage Of Development Initial development
Year Development Stage Completed 2014
Development Status Actively seeking support
Impact Potential for use in other diagnostic tests 
 
Description Public lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Public Lecture for the Welsh Livery Guild
Year(s) Of Engagement Activity 2016
 
Description Public lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Public lecture for Welsh Livery Guild
Year(s) Of Engagement Activity 2015