UoGlasgow Confidence in Concept 2013

Lead Research Organisation: University of Glasgow
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

People

ORCID iD

Publications

10 25 50
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Abraham SA (2016) Casting a NETwork instead of shooting magic bullets. in Cell cycle (Georgetown, Tex.)

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Cuschieri K (2021) Penile cancer and the HPV attributable fraction in Scotland; A retrospective cohort study. in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

 
Description New technique training to research technician
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Influenced training of practitioners or researchers
Impact The work has fed into development of a clinical trial grant application to CRUK-EMP
 
Description BHF Project Grant
Amount £251,755 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 08/2020
 
Description Biomedical Catalyst Feasibility
Amount £70,000 (GBP)
Funding ID Application Number: 81103-511295 
Organisation MRC Biomedical Catalyst Developmental Pathway Funding Scheme (DPFS) 
Sector Academic/University
Country United Kingdom
Start 05/2017 
End 04/2018
 
Description Biomedical Catalyst: Developmental Pathway Funding Scheme (DPFS)
Amount £1,258,477 (GBP)
Funding ID MR/N018958/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2016 
End 04/2019
 
Description Collaborative Award
Amount £2,151,302 (GBP)
Funding ID 201505/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 07/2021
 
Description Collaborative research funding.
Amount £6,000 (GBP)
Organisation Constellation Pharmaceuticals 
Sector Private
Country United States
Start 11/2014 
End 10/2015
 
Description Collaborative research grant
Amount £32,000 (GBP)
Organisation Roche Pharmaceuticals 
Sector Private
Country Global
Start 11/2014 
End 10/2015
 
Description ERC Advanced Grant
Amount € 3,093,480 (EUR)
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 09/2017 
End 08/2022
 
Description Grant - Research
Amount £307,675 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 02/2016 
End 01/2019
 
Description Grant - Research
Amount £115,988 (GBP)
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2015 
End 03/2018
 
Description High-Growth Spinout Programme
Amount £394,000 (GBP)
Organisation Scottish Enterprise 
Sector Public
Country United Kingdom
Start 05/2017 
End 11/2018
 
Description MRC iCASE
Amount £112,164 (GBP)
Funding ID MR/N018230/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 09/2020
 
Description MRC project grant
Amount £595,086 (GBP)
Funding ID MR/N011112/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2016 
End 04/2019
 
Description MRC/CiC
Amount £23,540 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2014 
End 09/2015
 
Description MRS studentship
Amount £125,000 (GBP)
Funding ID PhD-890-2015 
Organisation Medical Research Scotland 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
End 09/2020
 
Description Medical Research Scotland PhD studentship
Amount £116,308 (GBP)
Funding ID PhD-789-2014 
Organisation Medical Research Scotland 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2015 
End 09/2019
 
Description Programme grant
Amount £1,700,000 (GBP)
Funding ID Award No. 14033 
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2015 
End 05/2020
 
Description Researcher Initiated Grant Scheme
Amount £279,195 (GBP)
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 02/2018 
End 02/2021
 
Description SULSA Hi-Throughput assay development fund.
Amount £3,000 (GBP)
Organisation Scottish Universities Life Sciences Alliance 
Sector Academic/University
Country United Kingdom
Start 05/2015 
 
Description UK Biomedical Catalyst
Amount £198,000 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 07/2017 
End 07/2018
 
Title 3D model 
Description We have been developing a 3D culture system that will be further developed as a model system for human joints in arthritis by MAP in his ARUK-CDF 
Type Of Material Model of mechanisms or symptoms - in vitro 
Provided To Others? No  
Impact By developing an in vitro model of mouse and human arthritic joints, this will allow us to screen a large number of SMAs in vitro, obviating the need for a large number of the animal models that we require at present 
 
Title New in-vivo approaches in xenograft mouse model 
Description Ability to administrate small molecules to sub-lethally irradiated NSG mice 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2016 
Provided To Others? Yes  
Impact Set a new level of optimisation for CML in NSG mice 
 
Title stemformatics 
Description stem cell data including leukaemia stem cells 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact Publication in Nature and Cancer Discovery and lots of press release around this 
 
Description Clinical consortium 
Organisation NHS Greater Glasgow and Clyde (NHSGGC)
Department Beatson West of Scotland Cancer Centre
Country United Kingdom 
Sector Public 
PI Contribution In 2021 we forged a new clinical consortium consisting of oncologists, pathologists, epidemiologists, clinical scientists and statisticians to take forward clinical HPV research in the West of Scotland. It is led by Dr Kathryn Graham, Consultant Oncologist, Beatson cancer Centre, NHS GGC. I am the basic scientist on this consortium.
Collaborator Contribution The partners offer different expertise to the project, oncology, pathology, clinical testing, surgery.
Impact University of Glasgow MRC Confidence in Concept award £80,000 "BioMARSC: RNA Biomarker Matrix for Risk Stratification of Cervical Disease".
Start Year 2021
 
Description SHINe 
Organisation University of Edinburgh
Department Scottish HPV Investigators Network (SHINe)
Country United Kingdom 
Sector Academic/University 
PI Contribution I am a member of this consortium
Collaborator Contribution Discussions, clinical material, new projects initiated
Impact Funding for an MRC Clinical Training Fellow. Two papers in submission. A grant application in preparation
Start Year 2009
 
Description miR96 and pulmonary hypertension 
Organisation United Therapeutics
Country United States 
Sector Academic/University 
PI Contribution Building on our success with the MRC CiC award and the PhD studentship we were awarded a MRC project grant to further our studies into miR96 and PAH. This created discussions with United Therapeutics who supplemented tis study.
Collaborator Contribution Provision of £79000 to cover costs of a patent and RNAseq
Impact Too early
Start Year 2016
 
Title ???????????????? 
Description The invention relates to the use of microRNA 96 and precursors and mimics thereof for the inhibition of vascular cell proliferation and/or vascular remodelling, and for the treatment of associated medical conditions such as pulmonary arterial hypertension (PAH). 
IP Reference CN106029887 
Protection Patent application published
Year Protection Granted 2016
Licensed Commercial In Confidence
Impact In development
 
Title ????????????????????? 
Description ?????????????/?????????????????????????????????????????(PAH)????????????RNA96??????????????????????????? 
IP Reference JP2016540049 
Protection Patent application published
Year Protection Granted 2016
Licensed Commercial In Confidence
Impact In development
 
Title COLICINS FOR TREATING BACTERIAL INFECTIONS 
Description The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli infections, including Crohns' disease. In particular, the invention relates to the use of colicins and bacteria producing colicins, for the treatment of such conditions. 
IP Reference GB20120012588 
Protection Patent application published
Year Protection Granted 2013
Licensed Commercial In Confidence
Impact In development
 
Title COLICINS FOR TREATING BACTERIAL INFECTIONS 
Description The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli infections, including Crohns' disease. In particular, the invention relates to the use of colicins and bacteria producing colicins, for the treatment of such conditions. 
IP Reference US2019151408 
Protection Patent application published
Year Protection Granted 2019
Licensed Commercial In Confidence
Impact In development
 
Title COLICINS FOR TREATING BACTERIAL INFECTIONS 
Description The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli infections, including Crohns' disease. In particular,, the invention relates to the use of colicins and bacteria producing colicins, for the treatment of such conditions. 
IP Reference CA2878890 
Protection Patent application published
Year Protection Granted 2014
Licensed Commercial In Confidence
Impact In development
 
Title COLICINS FOR TREATING BACTERIAL INFECTIONS 
Description The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli infections, including Crohns' disease. In particular,, the invention relates to the use of colicins and bacteria producing colicins, for the treatment of such conditions. 
IP Reference EP2872162 
Protection Patent granted
Year Protection Granted 2015
Licensed Commercial In Confidence
Impact In development
 
Title Colicins for treating bacterial infections 
Description The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli infections, including Crohns' disease. In particular,, the invention relates to the use of colicins and bacteria producing colicins, for the treatment of such conditions. 
IP Reference AU2013288416 
Protection Patent application published
Year Protection Granted 2015
Licensed Commercial In Confidence
Impact In development
 
Title IMMUNOMODULATORY COMPOUNDS 
Description This invention relates to compounds and uses thereof in the treatment or prophylaxis of diseases associated with inflammation 
IP Reference GB1214106.5 
Protection Patent application published
Year Protection Granted 2014
Licensed No
Impact In development
 
Title IMMUNOMODULATORY COMPOUNDS 
Description This invention relates to compounds and uses thereof in the treatment or prophylaxis of diseases associated with inflammation. 
IP Reference EP2882727 
Protection Patent application published
Year Protection Granted 2015
Licensed No
Impact In development
 
Title IMMUNOMODULATORY COMPOUNDS 
Description This invention relates to compounds and uses thereof in the treatment or prophylaxis of diseases associated with inflammation. 
IP Reference WO2014023934 
Protection Patent application published
Year Protection Granted 2014
Licensed No
Impact This has now been published in the European (17.06.2015) and USA patent offices (06.08.2015) allowing the therapeutic potential of our SMAs to be evaluated in several indications in partnership with Industry: in particular with Jubilant- India (matched funding from the University of Strathclyde) in Lung Fibrosis, AstraZeneca in Alopecia and Leopharma in Psoriasis.
 
Title Immunomodulatory Compounds 
Description This invention relates to compounds and uses thereof in the treatment or prophylaxis of diseases associated with inflammation. 
IP Reference US2015218116 
Protection Patent granted
Year Protection Granted 2015
Licensed No
Impact In development
 
Title MATERIALS AND METHODS FOR TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 
Description The invention relates to the use of microRNA 96 and precursors and mimics thereof for the inhibition of vascular cell proliferation and/or vascular remodelling, and for the treatment of associated medical conditions such as pulmonary arterial hypertension (PAH). 
IP Reference GB20140016570 
Protection Patent application published
Year Protection Granted 2014
Licensed Commercial In Confidence
Impact In development
 
Title MATERIALS AND METHODS FOR TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 
Description The invention relates to the use of microRNA 96 and precursors and mimics thereof for the inhibition of vascular cell proliferation and/or vascular remodelling, and for the treatment of associated medical conditions such as pulmonary arterial hypertension (PAH). 
IP Reference CA2932035 
Protection Patent application published
Year Protection Granted 2015
Licensed Commercial In Confidence
Impact In development
 
Title MATERIALS AND METHODS FOR TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 
Description The invention relates to the use of microRNA 96 and precursors and mimics thereof for the inhibition of vascular cell proliferation and/or vascular remodelling, and for the treatment of associated medical conditions such as pulmonary arterial hypertension (PAH). 
IP Reference EP3077509 
Protection Patent application published
Year Protection Granted 2016
Licensed Commercial In Confidence
Impact In development
 
Title MATERIALS AND METHODS FOR TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 
Description The invention relates to the use of microRNA 96 and precursors and mimics thereof for the inhibition of vascular cell proliferation and/or vascular remodelling, and for the treatment of associated medical conditions such as pulmonary arterial hypertension (PAH). 
IP Reference GB20130021237 
Protection Patent application published
Year Protection Granted 2013
Licensed Commercial In Confidence
Impact In development
 
Title MATERIALS AND METHODS FOR TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 
Description The invention relates to the use of microRNA 96 and precursors and mimics thereof for the inhibition of vascular cell proliferation and/or vascular remodelling, and for the treatment of associated medical conditions such as pulmonary arterial hypertension (PAH). 
IP Reference WO2015082896 
Protection Patent application published
Year Protection Granted 2015
Licensed Commercial In Confidence
Impact In development
 
Title Materials and Methods for Treatment of Pulmonary Arterial Hypertension 
Description The invention relates to the use of microRNA 96 and precursors and mimics thereof for the inhibition of vascular cell proliferation and/or vascular remodelling, and for the treatment of associated medical conditions such as pulmonary arterial hypertension (PAH). 
IP Reference US2016304869 
Protection Patent application published
Year Protection Granted 2016
Licensed No
Impact too early
 
Title PULMONARY ADMINISTRATION OF PYOCINS FOR TREATING BACTERIAL RESPIRATORY INFECTIONS 
Description The invention relates to the treatment of bacterial respiratory infections using the bacterially-originating antibiotics known as pyocins. In particular, the invention provides the use of S-type pyocins, administered by pulmonary administration, for the treatment of such infections. 
IP Reference WO2016046218 
Protection Patent application published
Year Protection Granted 2016
Licensed No
Impact Also published as: GB20140016788 (UK), CA2962117 (Canada), CN107073073 (China), EP3200813 (Europe), JP2017529398 (Japan), US2017240602 (UsS
 
Title Idasanutlin 
Description submitting clinical trIal grant CRUK EMP 20 March 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2017
Development Status Actively seeking support
Impact NOT YET 
 
Company Name PROTOBIOTIX LIMITED 
Description for development of novel therapeutics 
Year Established 2018 
Impact none yet
 
Description British Heart Foundation Rock up in Red Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Supporters
Results and Impact As part of Rock up in Red events the Institute hosted an open day for BHF fundraisers and shop workers. We hosted a coffee morning to chat to them about research and show them where the money from fund raising is invested and gave them tours of the building.
Year(s) Of Engagement Activity 2015
 
Description EHA, Vienna 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Speaking at European Haematology Association Meeting in Vienna
Year(s) Of Engagement Activity 2015
 
Description ESH Portugal 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Health professionals
Results and Impact Talk with discussion

improved collaborations
Year(s) Of Engagement Activity 2013
 
Description ESH, Estoril 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Keynote Lecturer at the European Society of Haematology, Estoril, Portugal
Year(s) Of Engagement Activity 2015
 
Description Hinterzarten Circle on Cancer Research, Italy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Speaking at annual meeting of the Hinterzarten Circle on Cancer Research of the DFG (German Research Foundation
Year(s) Of Engagement Activity 2015
 
Description Hosting local BHF Fundraising team 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Supporters
Results and Impact Hosted visits to the Institute of local BHF fundraising team, patients/ donors
Year(s) Of Engagement Activity 2017
 
Description Institute Open Day 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Our Institute hosted an open day to showcase ongoing research. I also took part in round table debates with pupils on different aspects of research and judged the "best scientific question" competiion
Year(s) Of Engagement Activity 2015
 
Description Keynote lecture 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Keynote lecture - Course on Molecular Aspects of Haematological Disorders
Year(s) Of Engagement Activity 2016
 
Description MP and MSP Visit to Research Institute 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Policymakers/politicians
Results and Impact Invited to take part in an informal discussion/ presentation hosted by the British Heart Foundation in Scotland with local MPs and MSPs regarding current funding and types of research being done in Glasgow.
Year(s) Of Engagement Activity 2015
 
Description Medical Research Scotland Meet the Researcher Events in Dundee & Glasgow Science Centres 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact Members of our group including the PDRA (JC) on the award participated in interactive workshops at the Dundee and Glasgow Science Centres for 5th and 6th secondary school pupils focusing on the Hygiene Hypothesis and therapeutic potential of parasitic worm products, and drugs based on these, in inflammatory disease and potentially on life/healthspan.
Year(s) Of Engagement Activity 2017
 
Description Public engagement 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact We and our group members have been involved in Explorathon events and organised interactive workshops during "Science Weeks", for example at SU and the Glasgow Science Centre, the latter focusing on a 'Drugs from Bugs, ask Dr. Worm' event, designed to involve both children and parents in our research. Relating to this, further interaction with the public is encouraged by our ES-62 website (ES62.webstarts.com) and Facebook page ("Drugs from Bugs"), which focus on educational and translational aspects of research employing parasitic worms and we are scheduled to provide our interactive workshop to local primary 4/5 school children in April 2016.
Year(s) Of Engagement Activity 2014,2015
URL http://ES62.webstarts.com
 
Description STEM Week activity at local primary school 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact I attend a local primary school during national STEM week to talk about my work and career with pupils and to run science activities related to our research
Year(s) Of Engagement Activity 2016,2017,2018
 
Description School workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact We and our group members are active in interacting with the public via our ES-62 website (ES62.webstarts.com), Facebook page ("Drugs from Bugs") and @HarnettLabsTwitter account, all of which focus on educational and translational aspects of research employing parasitic worms in inflammatory disease. Moreover, we presented our interactive workshop 'Drugs from Bugs, ask Dr. Worm' to >50 local primary 4/5 school children (May 2016)
Year(s) Of Engagement Activity 2016
 
Description South East Scotland Blood Club meeting 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Health professionals
Results and Impact talk

opened up discussion
Year(s) Of Engagement Activity 2014
 
Description Stem cell symposium Cambridge 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other academic audiences (collaborators, peers etc.)
Results and Impact talk and discussion

improved collaboration
Year(s) Of Engagement Activity 2014
 
Description Talk - MD Anderson Centre, Houston, USA 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Lecture as part of the Haematology Grand Round at the MD Anderson Centre, Houston
Year(s) Of Engagement Activity 2016
 
Description Till and McCulloch meeting, Toronto 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Guest speaker at the Till and McCulloch meeting, Toronto, Canada
Year(s) Of Engagement Activity 2015