Biomedical Catalyst – Cadmium-free quantum dots for cancer diagnostics using fluorescence imaging

Lead Research Organisation: University of London

Abstract

Quantum dot (QDs) are semiconducting nanocrystals with unique optical properties which have stimulated wide interest in their use for biomedical diagnostic applications. In this project we will investigate QDs for Sentinel Lymph Node (SLN) mapping which is a key technique in cancer treatment.
A further objective is mapping of QD fluorescence in metastases using targeted vs. untargeted QDs. Mapping of potentially malignant lymph nodes adjacent to tumours (ie sentinel nodes) followed by surgical excision of the nodes can lead to improved survival. However current SLN mapping techniques using blue dyes and radioactive colloids have several disadvantages. Fluorescence imaging offers improved detection sensitivity for SLN mapping. Nanoco has unique patented technology to synthesize heavy metal-free water soluble fluorescent quantum dots (QDs) in large quantities. This project aims to demonstrate the use and functionalisation of QDs with red/NIR fluorescence developed by Nanoco for application in SLN/metastasis mapping using clinically relevant models at UCL.

Technical Summary

Quantum dot (QDs) are semiconducting nanocrystals with unique optical properties which have stimulated wide interest in their use for biomedical diagnostic applications. In this project we will investigate QDs for Sentinel Lymph Node (SLN) mapping which is a key technique in cancer treatment.
A further objective is mapping of QD fluorescence in metastases using targeted vs. untargeted QDs. Mapping of potentially malignant lymph nodes adjacent to tumours (ie sentinel nodes) followed by surgical excision of the nodes can lead to improved survival. However current SLN mapping techniques using blue dyes and radioactive colloids have several disadvantages. Fluorescence imaging offers improved detection sensitivity for SLN mapping. Nanoco has unique patented technology to synthesize heavy metal-free water soluble fluorescent quantum dots (QDs) in large quantities. This project aims to demonstrate the use and functionalisation of QDs with red/NIR fluorescence developed by Nanoco for application in SLN/metastasis mapping using clinically relevant models at UCL.

Publications

10 25 50
 
Description Nanoparticles for enhancement of colorectal cancer treatment 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Industry/Business
Results and Impact This was a workshop organised by our department and held at UCL from October 26-27, 2017, to discuss the latest developments in using nanoparticles to enhance radiotherapy of colorectal cancer and detect colorectal tumours. The attendees (22) were drawn from academia, industry and patient-representatives groups. The workshop was a great success and a report on its conclusions is being prepared for publication in Br. J. Radiology.
Year(s) Of Engagement Activity 2017
 
Description Royal Society Summer Exhibition, July 2017 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact We participated in the annual Royal Society Summer Exhibition which was held over 6 days in July 2017. Our stand under the title of 'Smart Surfaces' presented our research in collaboration with UCL Chemistry and Engineering using nanoparticles for preparing self-sterilising surfaces for minimising the spread of infections. The exhibition attendance was about 15,000. Our exhibit was well attended and the visitors asked our staff many questions and were impressed with our achievements
Year(s) Of Engagement Activity 2017
URL https://royalsociety.org/science-events-and-lectures/2017/summer-science-exhibition/exhibits/smart-s...