Imperial Confidence in Concept: ICiC3
Lead Research Organisation:
Imperial College London
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
- Imperial College London (Lead Research Organisation)
- Canterbury Christ Church University (Collaboration)
- Norwegian University of Science and Technology (NTNU) (Collaboration)
- Université Catholique de Louvain (Collaboration)
- IMPERIAL COLLEGE LONDON (Collaboration)
- DNA Electronics (Collaboration)
- University Clinic Golnik (Collaboration)
- Institute of Cancer Research UK (Collaboration)
- Glenfield Hospital (Collaboration)
- St Mary's Hospital, London (Collaboration)
- Ludwig Maximilian University of Munich (LMU Munich) (Collaboration)
- European Molecular Biology Laboratory (Collaboration)
- GlaxoSmithKline (GSK) (Collaboration)
People |
ORCID iD |
Publications
Broichhagen J
(2015)
A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function.
in Chemical communications (Cambridge, England)
Broichhagen J
(2016)
Allosteric Optical Control of a Class B G-Protein-Coupled Receptor.
in Angewandte Chemie (International ed. in English)
Broichhagen J
(2015)
Optical Control of Insulin Secretion Using an Incretin Switch.
in Angewandte Chemie (International ed. in English)
Cunnea P
(2018)
Clinical value of bioelectrical properties of cancerous tissue in advanced epithelial ovarian cancer patients.
in Scientific reports
Cunnea P
(2017)
Review article: Novel technologies in the treatment and monitoring of advanced and relapsed epithelial ovarian cancer.
in Convergent science physical oncology
Eggebø TM
(2015)
A model to predict vaginal delivery in nulliparous women based on maternal characteristics and intrapartum ultrasound.
in American journal of obstetrics and gynecology
Eggebø TM
(2015)
Prediction of delivery mode by ultrasound-assessed fetal position in nulliparous women with prolonged first stage of labor.
in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
Fine NHF
(2018)
Glucocorticoids Reprogram ß-Cell Signaling to Preserve Insulin Secretion.
in Diabetes
Frank JA
(2016)
Photoswitchable diacylglycerols enable optical control of protein kinase C.
in Nature chemical biology
| Description | ICiC 3 - Bentley - Application of Gaming in New Media Marketing 2019. Eds: Mishra, Dham |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Citation in systematic reviews |
| Impact | The publication is an international review of Apps cites Gripable as an example of cost-efficient innovation for rehabilitation. A Gripable prototype is being used in ~10 rehabilitation centres worldwide currently and a total of 33 centres have placed orders for the final commercial product due in late 2019. |
| URL | http://www.irma-international.org/book/application-gaming-new-media-marketing/195956/ |
| Description | Turner - ICiC3 - Expert adviser to Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT), Dept of Health |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Membership of a guideline committee |
| Description | BBSRC DTP studentships |
| Amount | £77,600 (GBP) |
| Organisation | University of Cambridge |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2016 |
| End | 09/2020 |
| Description | BHF PhD Studentship |
| Amount | £98,000 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 08/2019 |
| Description | BHF Project Grant |
| Amount | £300,000 (GBP) |
| Funding ID | PG/14/46/3091 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2015 |
| End | 08/2018 |
| Description | British Heart Foundation Intermediate Basic Science Research Fellowship |
| Amount | £395,949 (GBP) |
| Funding ID | FS-15-59-31839 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2016 |
| End | 12/2019 |
| Description | COMPARE Primer Grant |
| Amount | £48,000 (GBP) |
| Organisation | Centre of Membrane and Protein Receptors |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2018 |
| Description | CRUK Small Molecule Drug Discovery Project Award |
| Amount | £251,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2015 |
| End | 12/2016 |
| Description | Confidence in Concept |
| Amount | £944,000 (GBP) |
| Funding ID | MC_PC_17162 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2018 |
| End | 02/2020 |
| Description | Confidence in Concept |
| Amount | £840,000 (GBP) |
| Funding ID | MC_PC_16046 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 02/2019 |
| Description | Confidence in Concept 4 |
| Amount | £900,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2016 |
| End | 02/2018 |
| Description | Development Pathway Funding Scheme (DPFS) |
| Amount | £1,160,000 (GBP) |
| Funding ID | EESA_P65433 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 10/2020 |
| Description | Development of a Novel Angioplasty Catheter for Treatment of Calcified Arteries |
| Amount | £946,294 (GBP) |
| Funding ID | MR/P026850/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 04/2021 |
| Description | ERC Starting Grant |
| Amount | € 1,650,000 (EUR) |
| Funding ID | 715884 |
| Organisation | European Commission |
| Department | Horizon 2020 |
| Sector | Public |
| Country | European Union (EU) |
| Start | 06/2017 |
| End | 06/2022 |
| Description | Efficacy and Mechanism Evaluation (EME) Programme |
| Amount | £1,700,000 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | European Foundation for the Study of Diabetes (EFSD)/Novo Nordisk Rising Star Fellowship |
| Amount | £22,302 (GBP) |
| Organisation | European Association for the Study of Diabetes (EASD) |
| Department | European Foundation for the Study of Diabetes (EFSD) |
| Sector | Academic/University |
| Country | Germany |
| Start | |
| Description | FP7 iFAAM collaboration |
| Amount | € 12,244,563 (EUR) |
| Funding ID | 312147 |
| Organisation | European Commission |
| Department | Seventh Framework Programme (FP7) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 09/2015 |
| End | 02/2017 |
| Description | Facility Network of Excellence |
| Amount | £75,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | ICiC 3 - Brand - BHF ICB/CD Centre of Research Excellence PhD studentship |
| Amount | £127,314 (GBP) |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 09/2021 |
| Description | ICiC 3 - Cooke - DNA Electronics Ltd (commercial) |
| Amount | £500,000 (GBP) |
| Organisation | DNA Electronics Ltd |
| Sector | Private |
| Country | United Kingdom |
| Start | 12/2018 |
| End | 12/2020 |
| Description | ICiC 3 - Cota - CRUK Small Molecule Drug Discovery Project Award |
| Amount | £313,000 (GBP) |
| Funding ID | C29637/A27311 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 12/2020 |
| Description | ICiC 3 - Long - EPSRC DTP Studentships TC |
| Amount | £65,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2017 |
| End | 09/2020 |
| Description | ICiC 3 - MAndic - DRI Care and Technology Programme, Dementia Research Centre |
| Amount | £20,000,000 (GBP) |
| Organisation | UK Dementia Research Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2019 |
| End | 05/2025 |
| Description | ICiC 3 - Mandic - The Racing Foundation |
| Amount | £241,000 (GBP) |
| Organisation | The Racing Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2018 |
| End | 09/2020 |
| Description | ICiC 3_Long_EPSRC DTP Studentship (EC) |
| Amount | £65,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2015 |
| End | 09/2020 |
| Description | Imperial College Healthcare Charities Project Grant |
| Amount | £60,500 (GBP) |
| Organisation | Imperial College Healthcare NHS Trust |
| Department | Imperial College Healthcare NHS Charity |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2016 |
| Description | Innovate Award |
| Amount | £450,000 (GBP) |
| Organisation | Lloyds Bank |
| Sector | Private |
| Country | United Kingdom |
| Start | |
| Description | Innovation Challenge Prize |
| Amount | £10,000 (GBP) |
| Organisation | NHS England |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | MRC Project Grant |
| Amount | £460,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Orion Corporation Collaboration Research Funding |
| Amount | € 92,162 (EUR) |
| Organisation | Orion Corporation |
| Sector | Private |
| Country | Finland |
| Start | 04/2017 |
| End | 02/2018 |
| Description | Ovarian Cancer Action Research Centre - Director's Discretionary Funding |
| Amount | £55,000 (GBP) |
| Funding ID | PS5826_WSCC |
| Organisation | Ovarian Cancer Action |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| End | 07/2017 |
| Description | Proof of Concept Award |
| Amount | £47,000 (GBP) |
| Organisation | Higher Education Funding Council for England |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Title | Brand - ICiC3 - Compounds selectively binding to the Popeye domain |
| Description | A compound screen has led to the identification of seven putative small molecules which bind with high specificity and selectivity to the Popeye domain of POPDC1. |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | In the longer term it will be possible to activate and block POPDC1 selectively which maybe of clinical interest but also as a research tool in basic science. |
| Title | Cooke - ICiC3 - Diagnostic |
| Description | A novel point of care semiconductor device capable of diagnosing viral infection (HIV,HCV) |
| Type Of Material | Technology assay or reagent |
| Provided To Others? | No |
| Impact | Development of novel technology for diagnosis |
| URL | https://www1.imperial.ac.uk/departmentofmedicine/divisions/infectiousdiseases/infectious_diseases/hi... |
| Title | Hodson - ICiC3 - JB253 |
| Description | JB253 and JB558 are light-activated sulfonylureas that allow optical control of KATP channels in the pancreas and elsewhere. LirAzo is a light-activated incretin-mimetic (based on liraglutide) that allows optical control of the GLP-1R in the pancreas and elsewhere. PhotoETP is a light-activated allosteric modulator of the GLP-1R that allows optical control of allosteric-orthosteric cooperativity. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2015 |
| Provided To Others? | Yes |
| Impact | 1. Broichhagen, J., Podewin, T., Meyer-Berg, H., von Ohlen, Y., Johnston, N.R., Jones, B.J., Bloom, S.R., Rutter, G.A., Hoffmann-Röder, A.*, Hodson, D.J.*, Trauner, D.* (2015). Optical control of insulin secretion using an incretin switch. Angew. Chem. Int. Ed. Accepted. *Corresponding authors. IF = 11.3. http://www.ncbi.nlm.nih.gov/pubmed/26585495 2. Broichhagen, J. Frank, J.R., Johnston, N.R., Mitchell, R.K., Šmid, K., Marchetti, P., Bugliani, M., Rutter, G.A., Trauner, D.*, Hodson, D.J.* (2015). A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function. Chem Commun. 51:6018-6021. *Corresponding authors. IF = 6.8. http://www.ncbi.nlm.nih.gov/pubmed/25744824 3. Broichhagen, J., Schönberger, M., Cork, S.C., Frank, J.A., Marchetti, P., Bugliani, M., Shapiro, A.M.J., Trapp, S., Rutter, G.A., Hodson, D.J.*, Trauner D.* (2014). Optical control of insulin release using a photoswitchable sulfonylurea. Nat Commun. 5:5116. *Corresponding authors. IF = 11.5. http://www.ncbi.nlm.nih.gov/pubmed/25311795 • http://tinyurl.com/l2ahooo • http://tinyurl.com/n3w6zw4 • http://tinyurl.com/oexz8o2 • http://tinyurl.com/qdbo9cn • http://tinyurl.com/oeqsj9u • http://tinyurl.com/oasecs2 |
| Description | Amis - ICiC3 - ProfAS |
| Organisation | Canterbury Christ Church University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We have done all of the inventive and technical work; Prof Shetty does not appear as a co-inventor on our patent application. |
| Collaborator Contribution | He has provided clinical advice and has done some trials with our early prototypes of the novel instrumentation. We hope that he will be an early cinical triallist when the instruments are ready for use in patients. This collaboration was established before the ICiC award but is important to Prof AMis' ICiC3 project. |
| Impact | None |
| Description | Bahmanyar - ICiC3 - DrDA |
| Organisation | Glenfield Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Proposed a novel potential solution for the angioplasty of arteries that are partially or fully occluded by calcification. Prototypes have been fabricated and are being tested to prove the concept. |
| Collaborator Contribution | DrDA at Glenfield Hospital is also a practicing interventionist. He expressed the need for a medical device to treat calcified arteries with less risk to patients compared to the existing devices. He has also been consulted for preparation of our joint patent draft. |
| Impact | The project is still at an early stage. It involves: physics, Electronics and mechanical engineering as well as MEMS from one side and cardiovascular sciences from the other. |
| Start Year | 2014 |
| Description | Cooke - ICiC3 - Imperial College - DNA Electronics Ltd |
| Organisation | DNA Electronics |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Development of novel assays to detect HIV and HCV within a point of care device |
| Collaborator Contribution | Provision of expertise in semiconductor technology. The collaboration began prior to the ICiC award but is important to Dr Cooke's ICiC3 project. |
| Impact | Outputs: development of prototypic diagnostic Presentation at national meetings (BHIVA) and preparation of manuscripts for publication |
| Start Year | 2011 |
| Description | Cota - ICiC3 - ICR (Sutton) |
| Organisation | Institute of Cancer Research UK |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Group at Imperial (Tate, Cota, Recchi) led application for funds from CRUK, awarded recently. Design and production of Rab27a constructs for screen with ligands using surface plasmon resonance (SPR). Currently developing enzymatic assays to test influence of ligands on Rab27a-effector complexes. |
| Collaborator Contribution | Provided expertise for design of in silico library of compounds for Rab27a (Dr Nathan Brown). Provided expertise and equipment to perform screen of such ligands against Rab27a using SPR (Drs Rob van Montfort and Rosemary Burke). Currently developing in vitro functional assays of cancer cell behaviour specific for Rab27a (Prof Sue Eccles). |
| Impact | Apart from the MRC-ICiC grant, we were successful in our application for a CRUK grant (Small Molecule Drug Discovery Project Award) for the project 'Rab27a: A novel drug target in drug resistant and metastatic cancer' (£251,430 for 2 years), with Prof Ed Tate as PI and Dr Ernesto Cota and Dr Chiara Recchi as Co-Is. |
| Start Year | 2015 |
| Description | Cota - ICiC3 - ICR (Sutton) |
| Organisation | Institute of Cancer Research UK |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Group at Imperial (Tate, Cota, Recchi) led application for funds from CRUK, awarded recently. Design and production of Rab27a constructs for screen with ligands using surface plasmon resonance (SPR). Currently developing enzymatic assays to test influence of ligands on Rab27a-effector complexes. |
| Collaborator Contribution | Provided expertise for design of in silico library of compounds for Rab27a (Dr Nathan Brown). Provided expertise and equipment to perform screen of such ligands against Rab27a using SPR (Drs Rob van Montfort and Rosemary Burke). Currently developing in vitro functional assays of cancer cell behaviour specific for Rab27a (Prof Sue Eccles). |
| Impact | Apart from the MRC-ICiC grant, we were successful in our application for a CRUK grant (Small Molecule Drug Discovery Project Award) for the project 'Rab27a: A novel drug target in drug resistant and metastatic cancer' (£251,430 for 2 years), with Prof Ed Tate as PI and Dr Ernesto Cota and Dr Chiara Recchi as Co-Is. |
| Start Year | 2015 |
| Description | Hodson - ICiC3 - ProfAHR |
| Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We contributed biological assays. |
| Collaborator Contribution | The Hoffmann-Röder lab, together with the Trauner lab, performed all peptide synthesis, as well as some biological assays. This collaboration began prior to the ICIC award but is important to Dr Hodson's ICiC 3 project. |
| Impact | 1. Broichhagen, J., Podewin, T., Meyer-Berg, H., von Ohlen, Y., Johnston, N.R., Jones, B.J., Bloom, S.R., Rutter, G.A., Hoffmann-Röder, A.*, Hodson, D.J.*, Trauner, D.* (2015). Optical control of insulin secretion using an incretin switch. Angew. Chem. Int. Ed. Accepted. *Corresponding authors. IF = 11.3. http://www.ncbi.nlm.nih.gov/pubmed/26585495 |
| Start Year | 2014 |
| Description | Hodson - ICiC3 - ProfCS |
| Organisation | European Molecular Biology Laboratory |
| Department | European Molecular Biology Laboratory Heidelberg |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We contributed biological assays. |
| Collaborator Contribution | The Carsten lab, together with the Trauner lab, performed chemical synthesis, as well as biological assays. |
| Impact | None as yet - too early |
| Start Year | 2015 |
| Description | Hodson - ICiC3 - ProfDT |
| Organisation | Ludwig Maximilian University of Munich (LMU Munich) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | We contributed biological assays. |
| Collaborator Contribution | The Trauner lab performed chemical synthesis, as well as biological assays. The collboration began prior to the ICiC award but is important in Dr Hodson's ICiC3 project. |
| Impact | 1. Broichhagen, J., Podewin, T., Meyer-Berg, H., von Ohlen, Y., Johnston, N.R., Jones, B.J., Bloom, S.R., Rutter, G.A., Hoffmann-Röder, A.*, Hodson, D.J.*, Trauner, D.* (2015). Optical control of insulin secretion using an incretin switch. Angew. Chem. Int. Ed. Accepted. *Corresponding authors. IF = 11.3. http://www.ncbi.nlm.nih.gov/pubmed/26585495 2. Broichhagen, J. Frank, J.R., Johnston, N.R., Mitchell, R.K., Šmid, K., Marchetti, P., Bugliani, M., Rutter, G.A., Trauner, D.*, Hodson, D.J.* (2015). A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function. Chem Commun. 51:6018-6021. *Corresponding authors. IF = 6.8. http://www.ncbi.nlm.nih.gov/pubmed/25744824 3. Broichhagen, J., Schönberger, M., Cork, S.C., Frank, J.A., Marchetti, P., Bugliani, M., Shapiro, A.M.J., Trapp, S., Rutter, G.A., Hodson, D.J.*, Trauner D.* (2014). Optical control of insulin release using a photoswitchable sulfonylurea. Nat Commun. 5:5116. *Corresponding authors. IF = 11.5. http://www.ncbi.nlm.nih.gov/pubmed/25311795 |
| Start Year | 2012 |
| Description | ICiC 3 - Mandic - We have established collaboration with StMary's hospital regarding simultaneous recording of maternal and foetal ECG, towards advanced methods of pre-natal care. |
| Organisation | St Mary's Hospital, London |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Data analysis tools |
| Collaborator Contribution | Know how on foetal and neonatal ECG |
| Impact | N/A |
| Start Year | 2018 |
| Description | Klug - ICiC3 - GlasoSmithKline |
| Organisation | GlaxoSmithKline (GSK) |
| Country | Global |
| Sector | Private |
| PI Contribution | Development of joint research plan of action. Availability of equipment and resources. |
| Collaborator Contribution | Provision of time from a team of researchers. Availability of equipment and resources. |
| Impact | Development of an action plan to develop an optical poration methodology. Creation of an optical poration rig, high content single cell analysis software packages and a highly complementary liquid handling system. |
| Start Year | 2015 |
| Description | Lees - ICiC3 - DrBVC |
| Organisation | Catholic University of Louvain |
| Country | Belgium |
| Sector | Academic/University |
| PI Contribution | Statistical advice and modelling |
| Collaborator Contribution | Developing the intrapartum model for predicting outcome of labour. Collaboration began prior to ICiC award but is important to Prof Lees ICiC3 project. |
| Impact | Not yet |
| Start Year | 2013 |
| Description | Lees - ICiC3 - DrCWB |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Statistical advice and methodology |
| Collaborator Contribution | Statistical advice and methodology in papers and grant applications. The collboration began prior to the ICiC award but is important to Prof Lees ICiC3 project. |
| Impact | Eggebo TM, Wilhelm-Benartzi C, Hassan WA, Usman S, Salvesen KA, Lees CC. A model to predict vaginal delivery in nulliparous women based on maternal characteristics and intrapartum ultrasound. Am J Obstet Gynecol. 2015 Sep;213(3):362.e1-6. doi: 10.1016/j.ajog.2015.05.044. Epub 2015 May 22 |
| Start Year | 2013 |
| Description | Lees - ICiC3 - ProfTME |
| Organisation | Norwegian University of Science and Technology (NTNU) |
| Department | Department of Laboratory Medicine, Children's and Women's Health (LBK) |
| Country | Norway |
| Sector | Academic/University |
| PI Contribution | Exchanging research ideas, design of studies |
| Collaborator Contribution | Developing the intrapartum model for predicting outcome of labour. Collaboration started before ICiC award but is important in the ICiC project. |
| Impact | Eggebo TM, Wilhelm-Benartzi C, Hassan WA, Usman S, Salvesen KA, Lees CC. A model to predict vaginal delivery in nulliparous women based on maternal characteristics and intrapartum ultrasound. Am J Obstet Gynecol. 2015 Sep;213(3):362.e1-6. doi: 10.1016/j.ajog.2015.05.044. Epub 2015 May 22 Eggebø TM, Hassan WA, Salvesen KÅ, Lindtjørn E, Lees CC. Sonographic prediction of vaginal delivery in prolonged labor: a two-center study. Ultrasound Obstet Gynecol. 2014 Feb;43(2):195-201. doi: 10.1002/uog.13210. Epub 2013 Dec 22 Eggebø TM, Hassan WA, Salvesen KÅ, Torkildsen EA, Østborg TB, Lees CC. Prediction of delivery mode by ultrasound-assessed fetal position in nulliparous women with prolonged first stage of labor.Ultrasound Obstet Gynecol. 2015 Nov;46(5):606-10. doi: 10.1002/uog.14773. Epub 2015 Sep 28. |
| Start Year | 2013 |
| Description | Turner - ICiC3 - University Clinic of Pulmonary and Allergic Diseases, Slovenia |
| Organisation | University Clinic Golnik |
| Department | Laboratory for Clinical Immunology and Molecular Genetics |
| Country | Slovenia |
| Sector | Academic/University |
| PI Contribution | Provision of samples and data from food challenges to peanut, to determine pathophysiological changes during allergic reactions. |
| Collaborator Contribution | Provision of samples and data from patients undergoing acute allergic reactions to venom, presenting to the emergency department, to determine pathophysiological changes during allergic reactions. |
| Impact | N/A |
| Start Year | 2016 |
| Title | Angioplasty of calcified arteries |
| Description | A device 1 for and method of breaking-up, disrupting or disintegrating calcified or other hardened material within vessels of the human or animal body, comprises the provision of a catheter 2 having a lumen 9 extending between a distal end 5 and a proximal end 6 of the catheter and a displaceable element 4 at the distal end of the catheter configured for axial and / or radial displacement relative to the catheter when driven by pressure fluctuations within the lumen (e.g. a balloon). In a first embodiment a pressure pump 11 and pressure modulation source 12 are coupled to the proximal end of the catheter and are configured to apply a baseline pressure to the catheter lumen and to modulate the baseline pressure in the catheter lumen with one or more pressure impulses (preferably with a series of pressure pulses) respectively. In a second embodiment the balloon has a flexible outer structure (e.g. a mesh sleeve 20, Fig 2) which localises the outward force of the balloon, when inflated, to only a portion of the balloons external surface. |
| IP Reference | GB2549081 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | No |
| Impact | N/A |
| Title | ULTRASONIC IMAGING |
| Description | Method of ultrasound imaging in which vibration-induced localised (LOVIT) displacements code the ultrasound signal at the place of origin, enabling clutter cancellation. The require displacements can be induced by an acoustic radiation force (ARF) generated by an ultrasonic focused beam. One possibility for ARF-LOVIT is to acquire one photoacoustic (PA) image prior to the ARF push, and a second image immediately after the push when the non-zero displacement transient at the focus region is present. A difference image then highlights the signal from optically absorbing structures located inside the displacement region. Direct clutter, in contrast, originates from outside the imaged region where no displacement occurs, and is thus estimated. Echo clutter from acoustic scattering at echogenic structures inside the displacement region also shows up on the difference image, but at a different depth from where it was generated owing to the additional acoustic round-trip time as compared to PA signals. |
| IP Reference | WO2014016600 |
| Protection | Patent granted |
| Year Protection Granted | 2014 |
| Licensed | No |
| Impact | None as yet. |
| Description | Bamber - ICiC 3 - E MSOT UM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | "Overview of optoacoustic research at the Institute of Cancer Research, London". EUROPEAN MSOT USER MEETING. Royal Marsden Conference Centre, Stewart's Grove, London, 16th November 2016 |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.ithera-medical.com/fileadmin/documents/iThera_User_Meeting2016_agenda.pdf |
| Description | Bamber - ICiC 3 - OIM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | We welcome users and scientists interested in the preclinical and clinical use of optoacoustic imaging to participate in a one-day meeting, held at the University Hospital Erlangen. The aim of the meeting is to stimulate informal and friendly discussion of the work being performed by MSOT and RSOM users and give the opportunity to meet other users and imaging-associated scientists. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.ithera-medical.com/events.html |
| Description | Bentley - ICiC 2 + 3 - ESC |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Presentation at conference |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://eurostroke.eu/esc-vienna-2015 |
| Description | Frost - ICiC3 - Imperial College Fringe Event: Food of Tomorrow |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | The purpose of the Fringe was to highlight our research to the general public. We had fantastic feedback on ongoing research and ideas for the future. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/eventssummary/event_8-12-2015-11-54-47 |
| Description | Hodson - ICiC3 - Diabetes UK |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Public engagement exercise on behalf of Diabetes UK, giving a presentation to a lay audience entitled: 'Smart anti-diabetics for the treatment of type 2 diabetes'. Diabetes UK London Volunteer Conference. Radisson Blu Portman Hotel, UK, 2015. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Hodson - ICiC3 - Life Sciences in Six |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Dr Hodson gave a Puecha Kuecha style presentation at a Life Sciences in Six event, showcasing the best life sciences research at the University of Birmingham. The presentations were filmed and put on YouTube. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.birmingham.ac.uk/university/colleges/mds/events/2016/11/life-sciences-6/index.aspx |
| Description | Hodson - ICiC3 - Pint of Science |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Presenting research to a lay audience as part of the Pint of Science scheme. 50 members of the lay public attended and were informed about the impact of the funded research on human health. |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://pintofscience.co.uk/event/how-does-our-environment-affect-our-wellbeing |
| Description | Hodson - ICiC3 - University of Birmingham Research Gala |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Dr Hodson was a Keynote Speaker at the postgraduate research gala at the University of Birmingham. Over 100 students attended. |
| Year(s) Of Engagement Activity | 2016 |
| Description | ICiC 3 - Long - Long and Rutter are part of the Imperial College Network of Excellence in Diabetes. This group meets regularly and is positioning itself for a large scale funding application to the MRC, for Centre status. |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | To share research ideas and innovations across the Imperial College diabetes researchers |
| Year(s) Of Engagement Activity | 2018,2019 |
| URL | http://www.imperial.ac.uk/diabetes-network/ |
| Description | ICiC3 - Fotopoulou - OCA Tribute wall events |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Supporters |
| Results and Impact | The OCA Tribute wall event, which commemorates supporters or charitable donor family members who have passed away from ovarian cancer, is held 2-3 times per year in the Ovarian Cancer Action Research Centre where the translational aspect of this research programme is carried out. On each occasion over the past 4 years Dr Paula Cunnea has led tours of supporters/charitable donors, patients and families around the centre and discussed in lay terms, the impact of measuring biopotential and metabolites ex vivo in ovarian tumours. |
| Year(s) Of Engagement Activity | 2014,2015,2016,2017,2018 |
| URL | https://ovarian.org.uk/get-involved/donate/give-memory/tribute-funds-and-tribute-wall/ |
| Description | Lees - ICiC3 - IUSE & BOUC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Both the intrapartum study evening and basic obstetric ultrasound course were an opportunity to discuss the use of ultrasound management in labour and use of biometry to aid management. The understanding and interest in this area increased from midwives, ultrasonographers, undergraduate and postgraduate doctors. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Lees - ICiC3 - International Society of Ultrasound in Obstetrics & Gynaecology (ISUOG) simulation workshop on intrapartum ultrasound |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Prof Lees group gave a simulation workshop at International Society of Ultrasound in Obstetrics & Gynaecology (ISUOG) on intrapartum ultrasound. Workshops were run alongside talks to complement the scientific program. The sessions were very didactic and include live scan demonstrations where appropriate. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.isuog.org/WorldCongress/2015/Scientific+program/Workshops/ |
| Description | Lees - ICiC3 - RCOG World Congress 2016 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Prof Lees group will attend the Royal College of Obstetricians & Gynaecologists Pre-Congress Workshop on Intrapartum Ultrasound in June 2016. The Congress once again will feature sessions from the UK's specialist societies with world renowned speakers from the UK and further afield to share their expertise and knowledge. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://rcog2016.com/wp-content/uploads/2015/05/RCOG-Main-Announcement.pdf |
| Description | Mandic - ICiC3 - CMHC |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote speeches at various international meetings which also presented the findings from our project |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.cardio-m-health.org/ |
| Description | Mandic - ICiC3 - CMHC |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote speeches at various international meetings which also presented the findings from our project |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.cardio-m-health.org/ |
| Description | Mandic - ICiC3 - IEEE ERCIM |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote speeches at various international meetings which also presented the findings from our project |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://iwcim.isep.fr/invited_speakers.html |
| Description | Mandic - ICiC3 - TMED7 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote speeches at various international meetings which also presented the findings from our project |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.c-tric.com/tmed7/programmespeakers |
| Description | Stevens - ICiC3 - AG |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Dr Anthony Gordon was invited to give a talk at The International Symposium on Intensive Care and Emergency Medicine entitled "Biomarkers in sepsis: Improved phenotyping". This is organized by the Departments of Intensive Care and Emergency Medicine of Erasme University Hospital, Université Libre de Bruxelles, in association with the Belgian Society of Intensive Care and Emergency Medicine (SIZ). The meeting is held every year in March. Started in 1980, this meeting has become established as one of the largest in its field, now attracting more than 6200 participants (including exhibitors and visitors) from countries worldwide. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.intensive.org/ |
| Description | Stevens - ICiC3 - MRS Fall Meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://www.mrs.org/fall2015/ |