Cambridge Confidence in Concepts: translating pathophysiological insights for patient benefit

Lead Research Organisation: University of Cambridge

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

10 25 50
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Albuquerque IS (2015) An artificial CO-releasing metalloprotein built by histidine-selective metallation. in Chemical communications (Cambridge, England)

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Chaves-Ferreira M (2015) Spontaneous CO release from Ru(II)(CO)2-protein complexes in aqueous solution, cells, and mice. in Angewandte Chemie (International ed. in English)

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De Sciscio P (2017) TCT-322 In Vitro Optimisation of a Transcatheter Polymeric Aortic Valve in Journal of the American College of Cardiology

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Fitzpatrick AWP (2017) Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump. in Nature microbiology

 
Description (SilkFUSION) - Genetically engineered human pluripotent stem cells, functionalized silk-fibroin platforms and bio-inks: a novel solution for large-scale ex-vivo platelet production, transfusion and drug research
Amount € 2,998,500 (EUR)
Funding ID 767309 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 11/2017 
End 10/2021
 
Description BBSRC DTP PhD studentship
Amount £120,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 06/2017 
 
Description BHF Translational Award
Amount £248,018 (GBP)
Funding ID TG/15/4/31891 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2016 
End 03/2017
 
Description Blood and Transplant Grant
Amount £900,000 (GBP)
Organisation NHS England 
Sector Public
Country United Kingdom
Start 10/2015 
End 10/2020
 
Description CRUK Multidisciplinary Project award
Amount £483,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description CRUK Pioneer award
Amount £200,000 (GBP)
Organisation Cancer Research UK 
Department CRUK Centre for Cancer Therapeutics
Sector Private
Country United Kingdom
Start  
 
Description CiC-Development of a Transcatheter Mitral Repair System for patients with Mitral Regurgitation
Amount £69,978 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2017 
End 11/2017
 
Description Clinical Research Training Fellowship
Amount £116,678 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2016 
End 08/2019
 
Description Combined biomechanical modelling and imaging to predict human atherosclerotic plaque rupture and growth
Amount £109,776 (GBP)
Funding ID RG2638 
Organisation Heart Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2015 
End 12/2016
 
Description Development of 3D finite element analysis and imaging to predict human atherosclerotic plaque instability
Amount £249,185 (GBP)
Funding ID PG/18/14/33562 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 03/2021
 
Description NIHR i4i
Amount £537,000 (GBP)
Funding ID II-C5-0715-20005 
Organisation National Institute for Health Research 
Department NIHR i4i Invention for Innovation (i4i) Programme
Sector Public
Country United Kingdom
Start 04/2016 
End 04/2019
 
Description PhD studentship
Amount £128,000 (GBP)
Organisation AstraZeneca 
Sector Private
Country United Kingdom
Start  
 
Description Production of HLA-null universal platelets from GMP banked human pluripotent stem cell lines
Amount £208,259 (GBP)
Funding ID MR/P007813/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2017
 
Description SBC Grant
Amount £154,000 (GBP)
Organisation Higher Education Funding Council for England 
Sector Public
Country United Kingdom
Start  
 
Description Supercharging Platelets to Prevent Blood Loss after Trauma and Regenerate Hearts after Heart Attacks
Amount £59,450 (GBP)
Funding ID M724 
Organisation Rosetrees Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 10/2020
 
Description Targeting latent human cytomegalovirus (HCMV) infection by novel chemo and immunotherapeutic strategies to prevent virus reactivation in transplant settings
Amount £448,865 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 08/2017 
End 07/2020
 
Description Understanding human cytomegalovirus latency as a means to target the latent reservoir
Amount £1,864,411 (GBP)
Funding ID MR/S00081X/1 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 11/2018 
End 10/2023
 
Description Collaborative support in the form of a USB snapshot camera package 
Organisation XIMEA GmbH
PI Contribution Further development of a novel video-rate near-infrared endoscope
Collaborator Contribution Collaborative support of the research
Impact Publications: 1) doi: 10.1117/1.JBO.21.8.084001 ; 2) https://doi.org/10.1088/2040-8986/aa6176
Start Year 2015
 
Title DEVICE FOR INSERTION INTO HUMAN OR ANIMAL BODY AND ASSOCIATED METHODS 
Description An implant device for insertion in a human or animal body comprises a frame, wherein at least a portion of the frame is capable of reversibly transitioning between a solid state rigid mode and a liquid state flexible mode, thereby allowing the device to change its shape. 
IP Reference WO2016181138 
Protection Patent application published
Year Protection Granted 2016
Licensed Commercial In Confidence
Impact Not yet
 
Description 'Imaging your Insides: Stroke and Heart Attack Prevention' 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Dr Teng participated in Homerton 250-- Future visions of healthcare, Homerton College, by giving 'Imaging your Insides: Stroke and Heart Attack Prevention' at 10 Feb 2018 to the general audience. Dr Teng introduced vascular imaging and its application in stroke and heart attack prevention to the audiences from the local community.
Year(s) Of Engagement Activity 2018
 
Description Development of a Removable Transcatheter Valve as an Alternative to Surgical Valve Replacement for Aortic Stenosis 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Article in Heart Matters, the BHF magazine: Development of a Removable Transcatheter Valve as an Alternative to Surgical Valve Replacement for Aortic Stenosis
Year(s) Of Engagement Activity 2017
 
Description Development of microdialysis online-sensor technology for use in the neurocritical care of patients with acute brain injury 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact Our outreach activities on critical care of acute brain trauma patients (the field to which our CiC work relates) include the following presentations:
1) Cambridge Science Festival (20.3.2016);
2) Women in Science Festival for 6th form students (Robinson College, 22.9.2016);
3)Celebrating Success in Access to HE Diploma Science (Royal Society of Chemistry, London, 4.10.2016).
Year(s) Of Engagement Activity 2016
 
Description Pint of Science is an annual science festival that takes place every May and brings researchers to your local pub to show you the latest happenings in the world of science. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Pint of Science (2016): Delivered a lecture paired with optics demonstrations to illustrate novel endoscopic imaging to the public
Year(s) Of Engagement Activity 2016
URL https://pintofscience.co.uk/
 
Description Pint of Science presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Development of a Removable Transcatheter Valve as an Alternative to Surgical Valve Replacement for Aortic Stenosis
Year(s) Of Engagement Activity 2017
 
Description Soapbox Science (2016): Stood on a soapbox in Cambridge Market Square 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Other audiences
Results and Impact Stood on a soapbox in Cambridge Market Square explaining the concepts of wavelength and polarization, illustrating how they might be used in diagnosis of cancer.
Year(s) Of Engagement Activity 2016
URL http://soapboxscience.org/soapbox-science-2016-cambridge/
 
Description Targeted delivery of CO using artificial metalloproteins: CO's immunomodulatory properties for cancer therapy 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact "Targeted delivery of CO using artificial metalloproteins: CO's immunomodulatory properties for cancer therapy". Presentation about the technology "artificial metalloproteins for targeted delivery of CO in cancer therapy" at the RSC Emerging Technologies Competition 2015 (awarded the 2nd prize in Healthcare)
Year(s) Of Engagement Activity 2015
 
Description Workshop for the Institute of Physics, CamAWiSE, and Schlumberger Gould Research Center 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact Novel Imaging for Cancer
Year(s) Of Engagement Activity 2015
URL https://camawise.org.uk/2015/10/16/novel-imaging-for-cancer-dr-sarah-bohndiek-by-raheela-rehman/