University of Birmingham MRC Proximity to Discovery: Open Innovation Through Local Integration
Lead Research Organisation:
University of Birmingham
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The MRC Proximity to Discovery scheme awards universities funds to help develop new collaborations, and ways of exchanging knowledge and skills. The awards can be used to support activities that promote the value of academic-industry partnership, and enhance academic and industry researchers’ understanding of each other’s needs and capabilities. This may be through people exchanges, creation of technology demonstrators, showcase events, commercialisation workshops and ‘entrepreneurs in residence’ schemes. Such exchanges of knowledge and skills will boost the most fruitful collaborations between UK universities and life science companies.
People |
ORCID iD |
Publications
Wang J
(2021)
Protocol for analysis of G2/M DNA synthesis in human cells.
in STAR protocols
Patten DA
(2017)
SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress.
in Scientific reports
De S
(2022)
Genome-wide chromosomal association of Upf1 is linked to Pol II transcription in Schizosaccharomyces pombe.
in Nucleic acids research
Malehmir M
(2019)
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer.
in Nature medicine
Dufton NP
(2017)
Dynamic regulation of canonical TGFß signalling by endothelial transcription factor ERG protects from liver fibrogenesis.
in Nature communications
Saponaro M
(2022)
Transcription-Replication Coordination.
in Life (Basel, Switzerland)
Resheq YJ
(2017)
Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13.
in Journal of immunology (Baltimore, Md. : 1950)
Jeffery HC
(2019)
Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases.
in Journal of immunology (Baltimore, Md. : 1950)
| Description | Dissecting Androgen excess and metabolic dysfunction - an Integrated SYstems approach to PolyCystic Ovary Syndrome (DAISY-PCOS) |
| Amount | £2,389,852 (GBP) |
| Funding ID | 209492/Z/17/Z |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2018 |
| End | 04/2023 |
| Description | Large-scale screening for membrane protein interactions involved in platelet-monocyte interactions |
| Amount | £296,751 (GBP) |
| Funding ID | PG/16/53/32242 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 01/2020 |
| Description | Mechanistic Insights Into Aberrant Transcriptional Programming In Acute Myeloid Leukaemia |
| Amount | £1,543,859 (GBP) |
| Organisation | Bloodwise |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2015 |
| End | 12/2020 |
| Description | NIHR Biomedical Research Centre |
| Amount | £12,120,962 (GBP) |
| Organisation | Government of Catalonia |
| Department | Department of Health |
| Sector | Public |
| Country | Spain |
| Start | 04/2017 |
| End | 03/2022 |
| Description | Royal Academy of Engineering Fellowship |
| Amount | £60,000 (GBP) |
| Funding ID | EF1617/6/5 |
| Organisation | Royal Academy of Engineering |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 02/2018 |
| Description | Themed Scientific Meeting grant from the Society of Endocrinology |
| Amount | £10,000 (GBP) |
| Organisation | Society for Endocrinology |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 11/2016 |
| End | 11/2017 |
| Description | BCTI |
| Organisation | Bio-Cancer Treatment International |
| Country | Hong Kong |
| Sector | Private |
| PI Contribution | Scientific rationale for preclinical studies and clinical trials Processing of samples from clinical trials Biology |
| Collaborator Contribution | Gift of BCT-100 drug Sponsorship / participation/ provision of drug for patients in US FDA Solid Tumour Phase I trial, LI1 AML Phase II trial, PARC Phase II trial |
| Impact | US FDA Solid Tumour Phase I trial LI1 AML Phase II trial PARC Phase II trial Fultang et al. Can Res 2019 Mussai et al. Int J Cancer 2019 De Santo et al. Int J Cancer 2018 Vardon et al. Oncotarget 2017 |
| Start Year | 2016 |
| Description | Communicate novel UoB purification methodology and its applications for membrane protein research/drug discovery |
| Organisation | Sanofi |
| Country | Global |
| Sector | Private |
| PI Contribution | Established good working relationships with three research groups within Sanofi Genzyme (including proof-of-principle experiments) Successfully co-applied for EPSRC/HEIF funding to dedicate 6 months of post-doctoral time to these efforts (£65k) Findings were presented at internal North American Sanofi Genzyme conference (Sept '16) |
| Collaborator Contribution | Agreement-in-principle to apply jointly for a MIBTP iCASE PhD studentship |
| Impact | Established good working relationships with three research groups within Sanofi Genzyme (including proof-of-principle experiments) Successfully co-applied for EPSRC/HEIF funding to dedicate 6 months of post-doctoral time to these efforts (£65k) Findings were presented at internal North American Sanofi Genzyme conference (Sept '16) |
| Start Year | 2015 |
| Description | Research fellowship |
| Organisation | Albert Ludwig University of Freiburg |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | EU funded research fellowship for Nico Buettner to visit our laboratory for 2 years |
| Collaborator Contribution | Funded research fellow |
| Impact | Conference presentation Publications in preparation |
| Start Year | 2014 |
| Title | FUNCTIONALIZED SURFACE |
| Description | Provided is a nitrided metal surface functionalized with molecules, each molecule comprising at least one binding group and an antimicrobial moiety. The molecules are immobilized on the surface by only covalent interactions between the binding groups of the molecules and nitrogen atoms within the nitrided metal surface. Articles comprising the functionalized nitrided surface find use in inhibiting or reducing the growth of microorganisms on surfaces that are frequently touched. A method for preparing the functionalized nitrided surface comprises contacting a nitrided metal surface with molecules so as to form covalent bonds between the binding groups of the molecules and the nitrogen atoms in the surface, thereby immobilising the molecules on the metal surface. |
| IP Reference | WO2017006139 |
| Protection | Patent application published |
| Year Protection Granted | 2017 |
| Licensed | Commercial In Confidence |
| Impact | Discussions taking place with industrial collaborator around formation of spin out company. Enterprise Fellowship awarded. |