The Avon Longitudinal Study of Parents and Children: An international resource for population genomics and lifecourse epidemiology. Core Programme Support 2011-2015 and Core programme support 2014-2019

Lead Research Organisation: The Wellcome Trust Ltd

Abstract

For over 20 years Children of the 90s (or ALSPAC) has charted the health of 14,500 parents and
children. Now in its third decade it has started to study the next generation, the children of the
Children of the 90s. The study is unequalled by other population studies because of the breadth
and depth of information it holds on participants from before birth over 20 years ago through to the
present day. It is internationally renowned and used by researchers worldwide. The data allow
researchers to study key periods of development, how certain conditions develop and change over
time and are passed (or not) from one generation to the next, and how health is affected by the
interplay between genes and other factors like smoking, where people live and the job they do.
Our goals are to ensure the resource remains sustainable and open to researchers to use, and
that participants remain engaged. We will continue to gather information from the original children
through clinical assessments, questionnaires and record linkage, and will be recruiting and
gathering data on the children of the children as well as merging genetic data and enhancing research in the exciting new field of epigenomics.

Technical Summary

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective cohort study with
unprecedented scope and detail of information on thousands of people from before birth through
to early adulthood, on their parents and now on their children. It is an internationally valued
resource at the forefront of population-based research. ALSPAC allows the investigation of
developmental trajectories marking critical periods in human life, the genetic and epigenetic
factors contributing to health and disease and the environmental exposures which form the context
within which these processes act. As ALSPAC participants enter adulthood and start having
children, the study's potential to contribute to scientific discovery is expanding, giving a greater
capacity to explore links between current and future health and the intergenerational components
of health and disease. ALSPAC is unequivocally the richest open-access epidemiological resource
in the world. Our goals are to ensure that ALSPAC (i) is sustained, (ii) has participation maximised
and (iii) is enhanced. These goals will be delivered by follow-up of the original cohort through clinic
assessment, questionnaires and record linkage, data collection on their children, consolidation of
GWAS data on all participants and the development of epigenomics research.

Organisations

Publications

10 25 50
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Niarchou M (2014) Exploring the indirect effects of catechol-O-methyltransferase (COMT) genotype on psychotic experiences through cognitive function and anxiety disorders in a large birth cohort of children. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Richardson TG (2014) Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Niarchou M (2015) The clinical presentation of attention deficit-hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Coleman JRI (2017) Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

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Riglin L (2019) Identifying Novel Types of Irritability Using a Developmental Genetic Approach in American Journal of Psychiatry

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Mahmoud O (2018) Association of Height Growth in Puberty with Lung Function. A Longitudinal Study. in American journal of respiratory and critical care medicine

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Peralta GP (2019) Childhood Body Composition Trajectories and Adolescent Lung Function. Findings from the ALSPAC study. in American journal of respiratory and critical care medicine

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Cai Y (2020) Prenatal, Early-Life, and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort. in American journal of respiratory and critical care medicine

 
Title Creative Reactions 2018 
Description Creative Reactions is an art exhibition associated with the national Pint of Science festival. Approximately 20 researchers using ALSPAC data were paired with local Bristol artists who produced an artwork based upon their research. The exhibition was held from 11-22 May 2018. 
Type Of Art Artistic/Creative Exhibition 
Year Produced 2018 
Impact Artworks were viewed and seen by the general public as well as the scientific community. Local radio, online and print media covered the exhibition. 
URL https://pintofscience.co.uk/event/creative-reactions-bristol-launch
 
Title Creative Reactions- Kayleigh Easey 
Description Collaboration with an artist to produce a piece of artwork that summarises my research on the effects of maternal and paternal drinking in pregnancy on offspring depression. 
Type Of Art Artwork 
Year Produced 2018 
Impact The artwork is to be displayed in an exhibition in Bristol, involved with Pint of Science. There is to be an opening event that is widely advertised to the public. This work will allow scientists to share with the public their research and the implications it may have. 
URL https://pintofscience.co.uk/events/bristol
 
Title Researcher videos for social media & website 
Description A series of video interviews with researchers and collaborators using ALSPAC data. Designed to share the findings and nature of work conducted with a lay audience. 
Type Of Art Film/Video/Animation 
Year Produced 2018 
Impact Widening awareness of research impact among core audiences - public, participants, collaborators and charities/third parties. It also provides an opportunity for researchers to thank participants and engage them in future participation with the study. 
URL http://www.bristol.ac.uk/alspac/media/researcher-interviews/
 
Description "The one-way mirror: public attitudes to commercial access to health data"
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description ALSPAC information used in in 'Your Health Record Saves Lives' information booklet produced by UK Clinical Research Collaboration
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://www.nhs.uk/Conditions/Clinical-trials/Documents/Research1.pdf
 
Description ALSPAC obesity data cited in government's child obesity strategy
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/childhood-obesity-a-plan-for-action
 
Description ALSPAC research on bullying and maltreatment cited in EHRC race report
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.equalityhumanrights.com/en/race-report-healing-divided-britain
 
Description ALSPAC research on eczema and genes featured in the National Eczema Society's Exchange magazine (159, March 2016)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://www.eczema.org/products/154
 
Description ALSPAC research on premature babies quoted in Parliament by Stephen Hammond MP
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
URL https://hansard.parliament.uk/commons/2016-10-10/debates/5032D3A8-AA55-4388-BCE2-DE2ACAB8CDCC/School...
 
Description ALSPAC used as example of best practice by Health and Social Care Information Centre
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL http://systems.hscic.gov.uk/infogov/codes/cop
 
Description Adjournment debate on fetal alcohol spectrum disorder
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL https://hansard.parliament.uk/Commons/2019-01-17/debates/19011751000002/FoetalAlcoholSpectrumDisorde...
 
Description Bullying research included in textbook
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact The research features in 'Bullying', a textbook in the 'Issues' series by Independence Educational Publishers http://www.independence.co.uk/. It is in a format that is accessible to all levels but is aimed primarily at the 16-18 age group. According to the publisher, the book is used in a wide variety of courses including GCSE, A-level and further education, as well as by public libraries, prison education providers, government agencies and professional health and social care bodies.
URL http://www.independence.co.uk/shop/family-and-relationships/issues/bullying
 
Description Bullying research included in textbook
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact The research features in 'Bullying', a textbook in the 'Issues' series by Independence Educational Publishers http://www.independence.co.uk/. It is in a format that is accessible to all levels but is aimed primarily at the 16-18 age group. According to the publisher, the book is used in a wide variety of courses including GCSE, A-level and further education, as well as by public libraries, prison education providers, government agencies and professional health and social care bodies.
URL http://www.independence.co.uk/shop/family-and-relationships/issues/bullying
 
Description Change in Information Commissioner's Office code of practice guidance on data protection following the Data Protection Act 2018
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
Impact CLOSER work on the need for clearer and changed regulatory guidance regarding data retention (see Boyd et al. 2018, available from: https://wellcomeopenresearch.org/articles/3-112/v1) led to a change in official guidance from the Information Commissioner's Office (see https://ico.org.uk/for-organisations/guide-to-data-protection/guide-to-the-general-data-protection-regulation-gdpr/principles/storage-limitation/). This has the potential to help safeguard data which could be used as research resources of the future.
URL https://ico.org.uk/for-organisations/guide-to-data-protection/guide-to-the-general-data-protection-r...
 
Description Chapter on childhood asthma included in RCPCH air pollution report
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.rcplondon.ac.uk/projects/outputs/every-breath-we-take-lifelong-impact-air-pollution
 
Description Evidence included in Commons Health Select Committee report
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
URL http://www.publications.parliament.uk/pa/cm201415/cmselect/cmhealth/845/845.pdf
 
Description Evidence that little time outdoors contributes to the development of myopia in middle childhood
Geographic Reach National 
Policy Influence Type Citation in clinical reviews
 
Description Findings of research on dyslexia and vision recommended by Dyslexia Action
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
URL http://www.dyslexiaaction.org.uk/news/%E2%80%98dyslexia-and-sight-wider-view%E2%80%99-research-welco...
 
Description Guidance on iodine cited by Scientific Advisory Committee on Nutrition
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/sacn-statement-on-iodine-and-health-2014
 
Description Internet use and the impact of this on mental health and well-being
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description Involvement of ALSPAC in the formation of Joint Strategic Needs Assessment - Chlamydia prevalence
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Citation in other policy documents
 
Description Leading joint academic-NHS review on methods to onward share linked NHS records
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a advisory committee
Impact A joint piece of work between CLOSER (led by Andy Boyd & Alison Park) and NHS Digital (led by Garry Coleman & Estelle Spence) through the NHS Digital Research Advisory Group. The work included conducting a stakeholder needs analysis amongst the longitudinal studies community (two workshops held) and a report generated. The findings are leading to a clearer and more efficient mechanisms to maximise the research value of the secondary use of routine health records in order to develop and more effective and efficient NHS.
URL https://digital.nhs.uk/services/research-advisory-group
 
Description METADAC
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL https://www.metadac.ac.uk/data-access-committee/application-forms/
 
Description Maternal iodine status and child early and later life health outcomes.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status and child early and later life health outcomes.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status and early child health outcomes.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status and health of the child
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status in early pregnancy and child health
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status in early pregnancy and child health (2014)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Maternal iodine status in early pregnancy and child health (2014) (2014)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description New evidence on vitamin D supplementation in pregnancy from research showing that vitamin D status in pregnancy not associated with offspring bone mineral content
Geographic Reach National 
Policy Influence Type Citation in clinical reviews
 
Description New guidance on alcohol in pregnancy endorsed by Dr Simon Newell (RCOP), James Nicholls (Alcohol Research UK) and Professor David Nutt, Imperial.
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
 
Description New guidance on importance of iodine in pregnancy diet backed up by BDA factsheet http://www.bda.uk.com/foodfacts/Iodine.pdf
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.bda.uk.com/foodfacts/Iodine
 
Description Participation in All Party Parliamentary Group on Autism - building brighter futures for children with autism event (10 July 2018)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Questionnaire, linkage and interview data inform BIS report
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/progression-into-higher-education-for-disadvantaged-and-u...
 
Description Research on school outcomes for premature babies endorsed by Professor Sir Al Aynsley Green (first Children's Commissioner for England)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
 
Description Submitted evidence to Commons Health Select committee inquiry into suicide prevention
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
URL http://data.parliament.uk/WrittenEvidence/CommitteeEvidence.svc/EvidenceDocument/Health/Suicide%20Pr...
 
Description Submitted evidence to Commons Health Select committee inquiry into suicide prevention
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
URL http://data.parliament.uk/WrittenEvidence/CommitteeEvidence.svc/EvidenceDocument/Health/Suicide%20Pr...
 
Description 37356: Scourfield fellowship: Fathers, social interventions and children's wellbeing
Amount £8,482 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 09/2011 
End 08/2014
 
Description 38361: The determinants of measures of immune function in a wild mammal.
Amount £5,000 (GBP)
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 07/2011 
End 01/2015
 
Description 43249: NICE childhood obesity weight management
Amount £2,250 (GBP)
Funding ID F00003186 
Organisation National Institute for Health and Care Excellence (NICE) 
Sector Public
Country United Kingdom
Start 04/2012 
End 03/2014
 
Description 43992: POPPIE Predictors of Persistence & Psychological Impact of Childhood Eczema
Amount £800 (GBP)
Funding ID F00022685 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 06/2012 
End 11/2012
 
Description 47297: B1227 Biomarker study
Amount £2,593 (GBP)
Organisation Royal College of Surgeons in Ireland 
Sector Academic/University
Country Ireland
Start 03/2013 
End 02/2017
 
Description 59452: C.Williams Senior Research Fellowship
Amount £37,043 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2020
 
Description A Recall by Genotype Study to investigate the role of common TRPA1 variants on acute pain perception
Amount £39,813 (GBP)
Organisation University Hospitals Bristol NHS Foundation Trust 
Department Above and Beyond Grants
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 11/2021
 
Description A framework for linking and sharing social media data for high-resolution longitudinal measurement of mental health across CLOSER cohorts
Amount £149,971 (GBP)
Funding ID ES/R011583/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description ALSPAC Additional Funding from 01/04/2019 to 31/07/2019
Amount £283,265 (GBP)
Funding ID 102215/Z/13/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2019 
End 07/2019
 
Description ALSPAC Questionnaire - dietary preference
Amount £10,000 (GBP)
Organisation University of Edinburgh 
Sector Academic/University
Country United Kingdom
Start 06/2017 
End 12/2017
 
Description Adolescent and adult mental health outcomes of autism and autistic traits
Amount £74,096 (GBP)
Funding ID TRUST/VC/AC/SG/3747-6849 
Organisation Baily Thomas Charitable Fund 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2016 
End 03/2018
 
Description Adolescent and adult mental health outcomes of autism and autistic traits
Amount £226,152 (GBP)
Funding ID MR/R004889/1 
Organisation Medical Research Council (MRC) 
Department Medical Research Foundation
Sector Charity/Non Profit
Country United Kingdom
Start 06/2017 
End 05/2019
 
Description Adverse life events, inflammation, and trajectories of emotional and behavioural problems in childhood
Amount £161,295 (GBP)
Funding ID ES/P001742/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 04/2017 
End 05/2018
 
Description An investigation of the causal pathways from childhood conduct problems to poor health outcomes and criminal behaviour in adulthood
Amount £250,000 (GBP)
Funding ID 209138/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 03/2022
 
Description Are sleep difficulties in ADHD an index of neurodevelopmental severity?
Amount £57,539 (GBP)
Funding ID 918-3021 
Organisation The Waterloo Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 10/2020
 
Description Autism Speaks B954 RX9194 'Genetic Variation and Gene-Environment Influences in Autistic-like traits'
Amount £71,704 (GBP)
Funding ID 7132 
Organisation Autism Speaks 
Sector Charity/Non Profit
Country United States
Start 12/2011 
End 05/2014
 
Description B2390 Internal Locus of Control: Origins, Determinants, and Benefits
Amount £5,000 (GBP)
Funding ID 58223 
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 09/2015 
 
Description BIOSHARE Social Core - Qualatative Study
Amount £1,806 (GBP)
Funding ID Health-F4-2010-261433 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 07/2014 
End 01/2015
 
Description Behavioural and neurophysiological effects of schizophrenia risk genes
Amount £789,477 (GBP)
Funding ID MR/K004360/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Biomedical Research Centre (BRC) in Cardiovascular disease, mental health, nutrition, diet and lifestyle (including obesity), reproductive and perinatal health, surgical innovation.
Amount £20,000,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 04/2022
 
Description British Heart Foundation funded PhD programme in cardiovascular science. Interdisciplinary PhD studentship programme in integrative cardiovascular science. 5 students per year for 4 years.
Amount £2,500,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 10/2021
 
Description CLOSER AMENDMENT 4: CLOSER INNOVATION FUND
Amount £112,678 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2017
 
Description CLOSER Amendment 1: Cohort and Longitudinal Studies Enhancement Resources Grant
Amount £327,143 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2019
 
Description CLOSER Amendment 3: Cohort and longitudinal studies enhancement resources grant
Amount £149,136 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2019
 
Description CLOSER Amendment 5: Innovation Fund - Occupational and social class data coding and harmonisation
Amount £9,811 (GBP)
Funding ID ES/K000357/1 
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start 01/2016 
End 08/2017
 
Description CLOSER Ammendment 2: Cohort and longitudinal studies enhancement resources
Amount £95,684 (GBP)
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start  
End 09/2017
 
Description Can Hip DXA scans be used to identify genetic determinants of hip shape & osteoarthritis? Proposal for a proof-of-concept study B1372
Amount £11,429 (GBP)
Funding ID 20244 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2013 
End 01/2016
 
Description Characterising brain network differences during scene perception and memory in young adult APOE-e4 carriers: multi-modal imaging in ALSPAC
Amount £1,420,574 (GBP)
Funding ID MR/N01233X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2016 
End 04/2020
 
Description Childhood predictors of inadequate health literacy in young adults
Amount £28,568 (GBP)
Organisation Sir Halley Stewart Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2017 
End 02/2019
 
Description Clinical Research Training Fellowship (Simon Haworth)
Amount £167,384 (GBP)
Funding ID 201268/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2016 
End 05/2019
 
Description Cohorts as Platforms for Mental Health research (CaP:MH)
Amount £1,497,192 (GBP)
Funding ID MC_PC_17210 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description Cohorts as Platforms for Mental Health research (MRC MH Pathfinder)
Amount £1,497,192 (GBP)
Funding ID MC_PC_17210 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 03/2020
 
Description Computational Models for the Prediction and Prevention of Child Traumatic Stress
Amount $781,926 (USD)
Funding ID 1R01MH119114-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2019 
End 05/2023
 
Description Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA)
Amount £1,190,293 (GBP)
Funding ID MR/N000390/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2015 
End 09/2018
 
Description Creating a West African BioResource for Nutritional Genetics and Epigenetics
Amount £186,171 (GBP)
Funding ID MC_PC_MR/R020183/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2018
 
Description Creating a West African BioResource for Nutritional Genetics and Epigenetics
Amount £186,171 (GBP)
Funding ID MC_PC_MR/R020183/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description Cytoprotective defence mechanisms during tissue maintenance and repair - Helen Weaver
Amount £1,159,829 (GBP)
Funding ID 208762/Z/17/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2018 
End 07/2023
 
Description Deriving and validating a clinical prediction rule for the diagnosis of asthma in primary care
Amount £207,554 (GBP)
Funding ID CAF/17/01 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 09/2017 
End 06/2021
 
Description Describing habitual levels of physical activity (PA) in older people in terms of impact loads and how this relates to bone and other systems
Amount £58,433 (GBP)
Funding ID MR/K024973/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2013 
End 06/2016
 
Description Development of ALSPAC Industry Partner and Participant Portal
Amount £15,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 03/2018 
End 08/2018
 
Description Development of ALSPAC Industry Partner and Participant Portal (Timpson NJ, Skinner A.)
Amount £15,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2018 
End 05/2019
 
Description Diagnoptics - AGE readers for field use (Recall by Genotype) in the MRC IEU
Amount £50,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 02/2017 
End 05/2017
 
Description Do epigenetic markers contribute to the excess risk of diabetes and coronary heart disease in Indian Asians?
Amount £196,086 (GBP)
Funding ID 082464/Z/07/C 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Does epigenetic methylation explain the gender-switch in adolescent asthma?
Amount $153,747 (USD)
Funding ID 1R01A/121226-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 01/2016 
End 12/2016
 
Description Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases
Amount £8,327,295 (GBP)
Organisation European Commission H2020 
Sector Public
Country Belgium
Start 08/2019 
End 07/2024
 
Description Early adulthood education/employment transitions and the development of inequalities in diet quality and cardiovascular health
Amount £1,096,469 (GBP)
Funding ID MR/T010576/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2020 
End 03/2025
 
Description Early life adversity and life course health: an investigation of adversity clustering and associations with health
Amount £232,283 (GBP)
Funding ID ES/P010229/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2020
 
Description Eating Behaviour Measurement using the Mandometer - A Pilot Study In ALSPAC B1038
Amount £600 (GBP)
Organisation National Institute for Health Research 
Department NIHR Biomedical Research Centre
Sector Public
Country United Kingdom
Start 01/2012 
End 12/2012
 
Description Effect of different feeding methods and non-nutritive sucking behaviours on child speech development
Amount £52,438 (GBP)
Funding ID ICA-CDRF-2016-02-053 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2021
 
Description Efficient and transparent methods for linking and analysing longitudinal population studies and administrative data
Amount £301,055 (GBP)
Funding ID 212953/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 12/2021
 
Description Electronic Longitudinal Alcohol Study in Communities (ELAStiC)
Amount £978,102 (GBP)
Funding ID ES/L015471/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 10/2016 
End 09/2019
 
Description Elizabeth Blackwell Institute Extension Fellowship (Leila Thuma)
Amount £46,467 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 11/2016 
End 08/2017
 
Description Elizabeth Blackwell Institute Postgraduate Extension Scheme (Michelle Taylor)
Amount £32,817 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 06/2017
 
Description Enhancing Environmental data Resources in Cohort Studies: ALSPAC exemplar (ERICA)
Amount £99,899 (GBP)
Funding ID NE/P010830/1 
Organisation Natural Environment Research Council 
Sector Public
Country United Kingdom
Start 02/2017 
End 01/2018
 
Description Environmental risk factors of health-risk behaviours: Using DNA to strenghten causal inference
Amount £225,000 (GBP)
Organisation MQ Transforming Mental Health 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 01/2020
 
Description Epidemiological studies of human transgenerational responses (TGR) to paternal and ancestral exposures
Amount $25,000 (USD)
Funding ID 2016-165617 
Organisation Silicon Valley Community Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2017 
End 12/2017
 
Description Ethical aspects of epidemiological research on young people involving linkage to routine individual data B1089
Amount £860 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2012 
End 10/2012
 
Description Excessive drinking and alcohol related harms in Adulthood: ALSPAC at 24
Amount £1,378,535 (GBP)
Funding ID MR/L022206/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2015 
End 05/2019
 
Description Faculty capital bid for portable OCT machine (Alexandra Creavin)
Amount £60,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 10/2015 
 
Description Father involvement and child development in the context of maternal postnatal depression
Amount £301,101 (GBP)
Funding ID 212664/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2019 
End 04/2022
 
Description Fellowship B1088 SSCM.RJ5562 'Molecular and life-course aspects of APOE and TOMM40 in cognition'
Amount £35,305 (GBP)
Funding ID WT096114/Z/11/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2012 
End 12/2015
 
Description Fellowship Bath B1423 SSCM.RD1832 ' Iodine status in pregnancy & child neurodevelopment'
Amount £11,707 (GBP)
Funding ID MR/K02132X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2013 
End 05/2016
 
Description Gene-Environment Interplay in the Comorbity of PTSD and Disordered Eating
Amount £10,909 (GBP)
Organisation National Institutes of Health Clinical Center 
Sector Hospitals
Country United States
Start 01/2013 
End 12/2016
 
Description Genetic, behavioural and cognitive mechanisms underpinning the association between mother and offspring mental health problems: mental health intergenerational transmission (MHINT)
Amount € 1,499,611 (EUR)
Funding ID 758813 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 12/2017 
End 11/2022
 
Description Genetics of wound healing - BCG scar study
Amount £46,467 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 11/2016 
End 08/2017
 
Description HDHL-Biomarkers: Early life programming of childhood health: a nutritional and epigenetic investigation (ALPHABET)
Amount £101,222 (GBP)
Funding ID BB/P028187/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 04/2017 
End 09/2019
 
Description How early stress gets under the skin: The role of DNA methylation in the development of youth conduct problems and comorbid symptoms
Amount £250,543 (GBP)
Funding ID ES/N001273/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description Informing educational interventions using genome-wide data: causal evidence from 573,586 participants of eight cohort studies
Amount £222,571 (GBP)
Funding ID ES/N000757/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2016 
End 12/2018
 
Description Integrative Cancer Epidemiology Programme: Towards improved causal evidence and enhanced prediction of cancer risk and survival
Amount £7,715,113 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2020 
End 05/2025
 
Description Interplay between Peer-based Processes and Alcohol Metabolism Genes on Trajectories of Alcohol Use across Adolescence
Amount $68,657 (USD)
Funding ID 1F31AA025833-01 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 04/2017 
End 03/2019
 
Description Investigating the Epidemiology of CFS/ME in children using the ALSPAC cohort B1425 RD1805
Amount £21,391 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2013 
End 09/2015
 
Description Investigation of the causal effects of atopic eczema on other health outcomes
Amount £89,968 (GBP)
Organisation British Skin Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2016 
End 10/2018
 
Description Ipsos Mori: Qualitative research on attitudes around commercial access to health, biomedical and genetic data
Amount £2,195 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2015 
End 11/2015
 
Description Klarman Family Foundation B1190 'Epigentics of Eating Disorders : A Lifespan Approach'
Amount $132,590 (USD)
Organisation The Klarman Family Foundation 
Sector Charity/Non Profit
Country United States
Start 06/2012 
End 05/2014
 
Description LONGITUDINAL ADMINISTRATIVE DATA SPINE SCOPING PROJECT GRANT FOR THE SPF UK POPULATION LAB WAVE I
Amount £236,901 (GBP)
Funding ID ES/S016732/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 12/2018 
End 03/2019
 
Description Life course aetiology of dementia and cognitive decline: improving causal inference
Amount £315,800 (GBP)
Funding ID MR/P014437/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 03/2017 
End 02/2020
 
Description Lifecourse epidemiology of female reproductive health and its relation to chronic disease
Amount £70,205 (GBP)
Funding ID MR/M009351/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 12/2014 
End 11/2019
 
Description MRC Mental Health Pathfinder Award
Amount £1,400,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 04/2020
 
Description MRC Proximity to Discovery Industry Engagement Fund (Tom Richardson)
Amount £12,225 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2016 
End 05/2017
 
Description MRC Proximity to Discovery Industry Engagement Fund: Development of ALSPAC Industry Partner and Participant Portal
Amount £15,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2018 
End 09/2018
 
Description MRC Public Engagement Seed Fund- Matthew Lee
Amount £5,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2018 
End 12/2019
 
Description Mapping Neurodevelopmental Trajectories for Adult Psychiatric Disorder: ALSPAC-MRI-II
Amount £1,791,731 (GBP)
Funding ID MR/S003436/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 12/2018 
End 11/2022
 
Description Mapping phenotypic to genetic variability in the High Bone Mass Study
Amount £355,425 (GBP)
Funding ID 20000 
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2013 
End 12/2018
 
Description Mental health and educational achievement in UK adolescents
Amount £131,721 (GBP)
Funding ID ES/P00881X/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 07/2017 
End 12/2018
 
Description Mitochondrial DNA copy number as a phenotypic trait for human diseases in genetic epidemiological studies
Amount £384,038 (GBP)
Funding ID MR/K002767/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Molecular Genetic and Lifecourse Epidemiology
Amount £5,153,712 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2021 
End 09/2025
 
Description Molecular, Genetic and Lifecourse Epidemiology
Amount £1,350,000 (GBP)
Funding ID 108902/B/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
End 10/2019
 
Description Molecular, Genetic and Lifecourse Epidemiology - PhD programme (original programme funding and extension - awarded in 2015, extended by one year in 2017)
Amount £1,820,000 (GBP)
Funding ID 108902/Z/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2016 
End 10/2024
 
Description Molecular, Genetic and Lifecourse Epidemiology. PhD programme to provide 3 PhD students per year (on 4-year PhD programmes) for the intake years 2016/17, 2017/18, 2018/19, 2019/2020. (108902/Z/15/Z).
Amount £1,820,000 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2016 
End 01/2016
 
Description Multidimensional Phenotyping in Eczema
Amount £89,991 (GBP)
Organisation British Skin Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description NIHR Biomedical Research Centre Bristol
Amount £20,858,545 (GBP)
Funding ID BRC-1215-20011 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2017 
End 03/2022
 
Description NMHB Research Grant SSCM.RD1796 'Behavioral & neurophysicological effects of schizophrenia risk genes'
Amount £112,078 (GBP)
Funding ID MR/K004360/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2013 
End 03/2017
 
Description Neurodevelopmental disorders: What happens when children grow up and why?
Amount £893,353 (GBP)
Funding ID 204895/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2017 
End 01/2021
 
Description Non-genetic inheritance in human development
Amount £995,516 (GBP)
Funding ID ID#60828 
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 01/2018 
End 09/2020
 
Description Novel epidemiological methods to infer the causal effects of risk factors on neuropsychiatric and cardiovascular disorders
Amount $358,957 (AUD)
Funding ID APP1079583 
Organisation National Health and Medical Research Council 
Sector Public
Country Australia
Start 01/2015 
End 12/2017
 
Description Our Menopauses: an event for sharing experiences and information about menopause in Bristol
Amount £2,619 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 06/2017 
End 11/2017
 
Description Oxytocin-Related Predictors of Postpartum Maternal Mood and Mothering B1167
Amount £4,628 (GBP)
Organisation National Institutes of Health Clinical Center 
Sector Hospitals
Country United States
Start 04/2012 
End 03/2014
 
Description PAR-13-109 Mechanistic Insights from Birth Cohorts (R01)
Amount £110,613 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 09/2014 
End 08/2019
 
Description Pathogenic mechanisms in post-bereavement psychopathology: Contributions of gene-environment interplay, psychosocial factors, and cognitive ability in two population-based cohorts
Amount $190,011 (USD)
Funding ID 1K23MH117278-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 03/2019 
End 02/2024
 
Description Pathways to peak lung function: Genetic, Environmental and lifestyle influences on maximally attainable lung function in young adults
Amount £482,295 (GBP)
Funding ID MR/M022501/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 05/2015 
End 08/2018
 
Description Pathways to psychosis: investigating environmental, cognitive and genetic mechanisms underlying development of psychotic experiences in young adults
Amount £455,151 (GBP)
Funding ID MR/M006727/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 06/2014 
End 06/2018
 
Description PhD Studentship - B910 SSCM.RJ5158 'Biological Differences in Smoking Behaviour'
Amount £38,715 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2012 
End 06/2012
 
Description Picky Eating in the ALSPAC cohort: Determinants and related health outcomes
Amount £1,230 (GBP)
Organisation Nestlé Research Center 
Sector Private
Country Switzerland
Start 05/2014 
End 03/2016
 
Description Population Research Committee - Programme Award Reducing the burden of cancer: causal risk factors, mechanistic targets and predictive biomarkers
Amount £4,100,000 (GBP)
Funding ID 19169 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2015 
End 05/2020
 
Description Population Research Committee - Project Award B911 SSCM.RJ5681'Breast tissue composition in young women and its pre-natal and early life determinant: a study nested within the ALSPAC'
Amount £90,345 (GBP)
Funding ID C405/A12730 
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2011 
End 12/2012
 
Description Predictors and consequences of being a Child in Need or Looked After: data linkage study based on ALSPAC
Amount £50,931 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 10/2016 
End 09/2018
 
Description Programme B798 SSCM.RJ5447 'The relationship of the menopausal transition to healthy aging and chronic disease risk'
Amount £774,825 (GBP)
Funding ID 092830/Z/10/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2011 
End 06/2016
 
Description Psychosocial factors and cancer incidence: a pre-planned meta-analysis of the Psychosocial factors and Cancer
Amount € 1,328,435 (EUR)
Funding ID VU 20l7-8288 
Organisation Dutch Cancer Society (KWF) 
Sector Charity/Non Profit
Country Netherlands
Start 04/2018 
End 09/2021
 
Description Psychosocial resilience in children of mothers with depression B1112
Amount £702 (GBP)
Funding ID ES/J011657/1 
Organisation Economic and Social Research Council 
Department ESRC Seminar Series
Sector Academic/University
Country United Kingdom
Start 10/2012 
End 09/2014
 
Description Publication Metadata Augmentation
Amount £112,678 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2016 
End 11/2017
 
Description Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma?
Amount £2,560,571 (GBP)
Funding ID 108818/Z/15/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2016 
End 12/2018
 
Description Religious belief, health and disease: a family perspective.
Amount $234,800 (USD)
Funding ID 61356 
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 08/2019 
End 07/2021
 
Description Research - B1173 SSCM.RD1795 'Study Team for early life Asthma Research (STELAR)
Amount £38,406 (GBP)
Funding ID MR/K002449/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2013 
End 12/2016
 
Description Research B998 SSCM.RD1782Cussens 'A graphical model approach to pedigree construction using constrained optimisation'
Amount £4,602 (GBP)
Funding ID G1002312 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2011 
End 10/2014
 
Description Research Grant - B836 SSCM.RK7212 'Maternal thyroid status and offspring development'.
Amount £14,529 (GBP)
Funding ID ETM/97 
Organisation Chief Scientist Office 
Sector Public
Country United Kingdom
Start 04/2011 
End 03/2013
 
Description Research Grant BBR Scheme (BBSRC)- B1074 SSCM.RA0543 'A multigenerational prospective resource for integrating genetic, epigenetic and dense phenotypic measures from birth to 18.'
Amount £1,186,455 (GBP)
Funding ID BB/I025751/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 09/2011 
End 08/2013
 
Description RoSPA: Evaluation of Lifeskills using the ALSPAC Cohort - LASER Safety Education Schemes
Amount £19,733 (GBP)
Organisation Royal Society for the Prevention of Accidents 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2014 
End 10/2014
 
Description S1P1R genetic profiles in endothelial function and disease
Amount € 204,537 (EUR)
Funding ID 166002 - CW388001 
Organisation Sanofi 
Department Sanofi Research Division
Sector Private
Country France
Start 03/2016 
End 07/2019
 
Description Seeing is believing in ALSPAC
Amount £199,387 (GBP)
Funding ID 102215/Z/13/B 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2016 
End 10/2016
 
Description Seventh Framework Programme - B1301 SSCM.RQ8840 'Collaborative Projects & Networks of Excellence EXPOsOMICS'
Amount € 56,704 (EUR)
Funding ID 308610 
Organisation European Commission 
Department Seventh Framework Programme (FP7)
Sector Public
Country European Union (EU)
Start 10/2012 
End 09/2016
 
Description Study of Emerging Adulthood and Cardiomatic Health in ALSPAC: The Influence and of growth and other exposures
Amount £999,049 (GBP)
Funding ID CS/15/6/31468 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2015 
End 06/2020
 
Description TENOVUS - Da Silva Focus Group
Amount £804 (GBP)
Organisation University of Dundee 
Sector Academic/University
Country United Kingdom
Start 10/2015 
End 11/2015
 
Description Testing cortisol dysregulation as a mediator between early stress and adolescent cardiovascular health
Amount $140,054 (USD)
Funding ID 1K01HL143159-01A1 
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start 07/2019 
End 06/2024
 
Description Testing evolutionary hypotheses of social development in the ALSPAC cohort
Amount £1,559 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2014 
End 09/2015
 
Description Testing the feasibility and user acceptability of integrating wearable air pollution monitors into population based studies
Amount £24,769 (GBP)
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 07/2016 
End 08/2017
 
Description The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019
Amount £7,903,667 (GBP)
Funding ID 102215/Z/13/Z 
Organisation Wellcome Trust 
Department Wellcome - MRC Cambridge Stem Cell Institute
Sector Academic/University
Country United Kingdom
Start 04/2014 
End 03/2019
 
Description The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being.
Amount £8,327,295 (GBP)
Funding ID 217065/Z/19/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2019 
End 08/2024
 
Description The Genetic Basis of Urinary Incontinence in Women B956
Amount £44,664 (GBP)
Organisation International Urogynecological Association (IUGA) 
Sector Academic/University
Country Global
Start 10/2011 
End 09/2014
 
Description The Millennium Cohort Study Sweep 6 (Age 14) Survey (GWAS data collection).
Amount £1,000,000 (GBP)
Organisation ESRC Impact Acceleration Account Cambridge 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 02/2019
 
Description The Millennium Cohort Study Sweep 6 (Age 14) Survey - extension (GWAS data collection and analysis)
Amount £1,052,503 (GBP)
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2017 
End 03/2018
 
Description The causal map of the human phenome
Amount £809,240 (GBP)
Funding ID 208806 
Organisation Sir Henry Dale Fellowships 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2018 
End 03/2023
 
Description The developmental role of metabolism, appetite and growth in eating disorders: exploring novel longitudinal risk pathways
Amount £215,430 (GBP)
Funding ID MR/R004803/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 07/2017 
End 09/2020
 
Description The genetic epidemiology of High Bone Mass: skeletal geometry, turnover and fat metabolism, and implications for the wider population
Amount £3,322 (GBP)
Organisation Versus Arthritis 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2013 
End 01/2018
 
Description TwinsUK (2019-2023) - An Epidemiological and Genomic Resource
Amount £3,000,000 (GBP)
Funding ID 212904/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 06/2022
 
Description Type 2 Diabetes and Cancer: RD Lawrence Fellowship - Emma Vincent
Amount £587,237 (GBP)
Funding ID 17/0005587 
Organisation Diabetes UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2017 
End 09/2022
 
Description UK Department for Business Innovation & Skills (BIS) B931 RK7220 'Further education data linkage projects'
Amount £55,000 (GBP)
Funding ID BIS/RBU/008/2011 
Organisation Department for Business, Energy & Industrial Strategy 
Sector Public
Country United Kingdom
Start 02/2011 
End 12/2012
 
Description UK Dept for Business Innovation and Skills B2057 SSCM.RK 'Data Linkage Proposal 2013'
Amount £30,000 (GBP)
Funding ID BIS/RBU/011/2013 
Organisation Department for Business, Energy & Industrial Strategy 
Sector Public
Country United Kingdom
Start 10/2013 
End 09/2015
 
Description UK MenCar4
Amount £4,483 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2015 
End 09/2015
 
Description Understanding Asthma Phenotypes
Amount £181,852 (GBP)
Funding ID 668954 
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 01/2016 
End 12/2020
 
Description Understanding successful progression to higher education for the white working class and minority ethnic groups (B2215)
Amount £14,081 (GBP)
Organisation Department for Business, Energy & Industrial Strategy 
Sector Public
Country United Kingdom
Start 02/2014 
End 07/2015
 
Description Understanding the Antecedents and Outcomes of Frequent Adolescent Cannabis Use
Amount £250,000 (GBP)
Funding ID 209158 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2018 
End 05/2022
 
Description Unique research opportunities in the genetics and epidemiology of disordered gambling
Amount $396,559 (USD)
Organisation National Center for Responsible Gaming 
Sector Charity/Non Profit
Country United States
Start 07/2017 
End 06/2020
 
Description University of Bristol Widening Participation Grant- Matthew Lee
Amount £1,000 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 10/2018 
End 12/2018
 
Description Using Mendelian Randomisation to Establish the Causal Role of Cigarette Smoking in Anxiety and Depression
Amount £110,594 (GBP)
Funding ID MR/J01351X/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start  
 
Description Using birth cohorts to understand the impact of urban green space on child health and wellbeing
Amount £79,929 (GBP)
Funding ID 2081026 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2018 
End 03/2022
 
Description Using genetic and environmental risks to understand variation in social emotional, and educational outcomes in individuals with language impairments
Amount £161,348 (GBP)
Funding ID ES/P001955/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 04/2017 
End 09/2019
 
Description Using linked electronic health data to improve eczema diagnosis and outcomes
Amount £1,305,851 (GBP)
Funding ID 205039/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2017 
End 02/2019
 
Description WT Biomedical Resource - B1234 SSCM.RD1793 'The 1958 Birth Cohort Biomedical Resource - facilitating access to data and samples and enhancing future utility'
Amount £668,124 (GBP)
Funding ID G1001799 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2011 
End 12/2014
 
Description WT Project award - B1118 'Dopamine Function, Cognitive Flexibility and Emotion Regulation'
Amount £4,816 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2011 
End 01/2012
 
Description Wellcome Trust Helen Weavers Sir Henry Dale Wellcome: Cytoprotective defence mechanisms during tissue maintenance and repair.
Amount £150,829 (GBP)
Funding ID 208762 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2018 
End 01/2023
 
Description Wellcome Trust Research Training Fellowship (Tom Dudding)
Amount £187,327 (GBP)
Funding ID 201237/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 09/2019
 
Description What lies behind the causal impact of body mass index (BMI) level and change on human health? Added value from complementary study design and deep metabolomic phenotyping.
Amount £1,850,000 (GBP)
Funding ID 202802/Z/16/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2016 
End 08/2022
 
Title A Privacy-Preserving Data Management system for MRI and other Large Image Data 
Description ALSPAC are collecting large volumes of image data through scanning individuals at assessment clinics and also work underway as part of ALSPAC's MRC MH Pathfinder award, through linkage to images held in social media accounts. These images are individually relatively small size, but are being accessed in huge volumes - e.g. a single participants MRI scan can comprise ~12,000 separate image files. Furthermore, many images have embedded identifier values (e.g. NHS ID or name embedded in an MRI scan) or have inherently identifiable components (e.g. an individuals MRI head scan can be used to show a 3D topographic map of a persons face). This leaves study databanks with a challenge to archive large volumes of data, efficiently process them for reuse, and to de-identify them in complex ways. Through MRC MH Pathfinder, the ALSPAC Data Team and Data Linkage Team have developed an image management server with capabilities for archiving, processing and de-identification. This is built on a suite of 'open source' software packages and tuned to the needs of a longitudinal study. This new infrastructure is now operational and facilitating new research in ALSPAC. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? Yes  
Impact The tool has enabled ALSPAC to lower the charges for the processing of data for reuse from £750 per project to £300 per project. The use of the tool is supporting multiple grant applications, both in the UK and USA. The tool reduces the cost of the grant compared to previous approaches as it impacts on collection and archiving as well as reuse. E.g. Elanor Hinton application to support assessment of the impact of parenthood on maternal and paternal neurobiology and subsequent child development (ALSPAC Reference: B3386, https://proposals.epi.bristol.ac.uk/?q=node/129988). The tool is supporting the MRC funded grant led by Professor Anthony David (UCL) (ALSPAC Reference: B3035, https://proposals.epi.bristol.ac.uk/?q=node/127353). 
 
Title ALSPAC Biosamples and DNA resources 
Description Over 1.2 million aliquots biosamples taken at various timepoints from ALSPAC participants. The bioresource is available to the scientific community for research. Although the resource was initiated in 1991 it is an active collection with new samples being collected and made available constantly. 
Type Of Material Biological samples 
Provided To Others? Yes  
Impact Samples have been made available for numerous ALSPAC projects. The resource received the UK Biobank of the Year award in 2018 reflecting the impact of studies utalising the samples. 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/biological-resources/
 
Title Data Access Agreement (DAA) data sharing contract 
Description The data access agreement is a new data sharing contract which is compatible with contemporary legislative (e.g. General Data Protection Regulations) and research governance expectations. It aligns with ALSPAC's Online Proposal System for efficient generation of specified and controlled data requests. Importantly, the DAA enables the replication of third-party data owner requirements and the addition of particular governance controls for specific datasets (e.g. geo-spatial datasets), and as such is an important element in ALSPAC's process to allow onward sharing of linked health, geo-spatial and social records. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? Yes  
Impact The DAA is a central component in ALSPAC's negotiations with NHS Digital to enable onward sharing of linked records. 
URL http://www.bristol.ac.uk/alspac/researchers/access/
 
Title Data Privacy Impact Assessment Process 
Description A new privacy assessment tool for ALSPAC which enables the assessment of data flows (i.e. new record linkages or new data sharing with research users) in line with EU General Data Protection Regulation requirements. The tool allows the assessment of diverse risks and particular research scenarios (e.g. the use of geocoded data in the research process, the additional sensitivities of using mental or sexual health records in research investigations. 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? No  
Impact Ensuring ALSPAC data sharing is legally compliant. 
 
Title Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference 
Description Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. We have described the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We have considered the efficacy and practicality of the RbG approach, provide a catalogue of UK-based resources for such studies and present an online RbG study planner. 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? Yes  
Impact Recent development. notably described here: https://www.nature.com/articles/s41467-018-03109-y - with related software - see the link below. 
URL http://www.bristol.ac.uk/integrative-epidemiology/faciliitiesresources/software/
 
Title Handling ethical queries and feedback within studies of genetic sequence data. 
Description This work provides a discussion and framework for the handling of incident and pertinent findings in the analysis of sequence data. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact NA 
URL http://www.nature.com/ejhg/journal/v22/n9/full/ejhg2013290a.html
 
Title Implementation of DataSHIELD for the InterConnect project 
Description Prof Paul Burton worked with Professor Nick Wareham's MRC-Epidemiology Unit led, Interconnect Project which is funded by the European Union to implement DataSHIELD on a consortium of eight cohorts/biobanks (seven European, one North American) including ALSPAC. This required a standard implementation of the DataSHIELD structure for remote federated analysis of "horizontally partitioned" data (different sources hold the same variables on different individuals). 
Type Of Material Improvements to research infrastructure 
Year Produced 2017 
Provided To Others? Yes  
Impact The implementation of DataSHIELD has been successfully led by Tom Bishop who is the lead DataSHIELD development team member based in Cambridge. Prof Burton's team have provided ongoing support of both the technology and statistical methods. This work was successful and a paper is currently under review at the International Journal of Epidemiology: 
URL http://www.interconnect-diabetes.eu/
 
Title Implementation of new data warehouse and external data catalogue 
Description We are in the process of moving all data access to Opal (data warehouse) and to add Mica (public catalogue) as a data discovery option. This will be known externally as ALSPAC Explore. Opal and Mica are both components of the Obiba Open Source project suite and are hosted by University of BRistol IT services. 
Type Of Material Improvements to research infrastructure 
Year Produced 2019 
Provided To Others? Yes  
Impact Mica and Opal talk to each other; a researcher can compile their data list as they search and it can be imported directly into Opal, reducing work for both researchers and data buddies - Realtime frequencies of data in Opal will be displayed in Explore; this drastically reduces the amount of work going into the data dictionary. - Explore much more efficient searching system which should enhance data discoverability - Future developments may include the use of Datashield for federated analyses, networking with other studies using the same software - Enables the use of Ontologies (currently CLOSER topics and Maelstrom classification). 
URL https://alspac-data.bristol.ac.uk/mica-web/
 
Title Improved access policy 
Description A much improved Access Policy has been written and made available via the website 
Type Of Material Improvements to research infrastructure 
Year Produced 2014 
Provided To Others? Yes  
Impact Ensures rules regarding data access are clear and transparent 
URL http://www.bristol.ac.uk/alspac/researchers/data-access/
 
Title Imputed Genome Wide (GWAS) single nucleotide polymorhism (SNP) dataset 
Description Imputation of 526,688 SNPs post quality control to the HapMap CEU population, release 22 for subjects in ALSPAC with GWAS data. 
Type Of Material Biological samples 
Year Produced 2013 
Provided To Others? Yes  
Impact The data have been used in several high impact publications including: Anttila, V. et al. 2013. Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet. 2013 Aug;45(8):912-7 Hinds, D.A. et al. (In press). A meta-analysis of self-reported allergy identifes shared and allergy-specifc susceptibility loci Nat Genet. 2013 Aug;45(8):907-11 Evans, D.M. et al. 2013. Genome-Wide Association Study Identifies Loci Affecting Blood Copper, Selenium and Zinc. Hum Mol Genet. 2013 Oct 1;22(19):3998-4006 
 
Title Introduction of REDCap as a data collection tool 
Description REDCap has been successfuly introduced as the data collection tool used in clinic based data collection. It is also about to be used for the first time for online questionnaire data collection 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Streamlines data collection; minimising errors 
URL http://www.project-redcap.org/
 
Title Introduction of cost recovery, replacing data buddy fee 
Description At the request of the funders a number of salaries related to data provision are now recovered directly from external researchers who pay a variable amount (depending on the amount and type of data) to access ALSPAC data 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Cost recovery income is monitored very closely - currently the model is not bringing in sufficient income. It will be reassessed at the end of year 1. 
 
Title Management of a whole genome sequencing project and data 
Description This work presents lessons learnt from the management of a whole genome sequence data project. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This work has been published: Genome Med. 2013 Nov 15;5(11):100. doi: 10.1186/gm504. eCollection 2013. Implementing a successful data-management framework: the UK10K managed access model. Muddyman D1, Smee C1, Griffin H2, Kaye J2. 
 
Title Management of clinical information within a whole genome sequence project 
Description This work considers and advises on how to handle data which is clinically important within the context of a whole genome sequence project. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This work has been published: Eur J Hum Genet. 2014 Sep;22(9):1100-4. doi: 10.1038/ejhg.2013.290. Epub 2014 Jan 15. Managing clinically significant findings in research: the UK10K example. Kaye J1, Hurles M2, Griffin H1, Grewal J3, Bobrow M4, Timpson N5, Smee C2, Bolton P6, Durbin R2, Dyke S2, Fitzpatrick D7, Kennedy K2, Kent A8, Muddyman D2, Muntoni F9, Raymond LF4, Semple R4, Spector T10; UK 10K. 
 
Title Metadata: Variable catalogue 
Description Improved metadata provision - a simple list of variables available so that researchers can simply copy and paste in order to provide lists of variables as part of their data request under cost recovery 
Type Of Material Improvements to research infrastructure 
Year Produced 2014 
Provided To Others? Yes  
Impact Improves accessibility/discoverability of data 
URL http://www.bristol.ac.uk/alspac/researchers/data-access/data-dictionary/
 
Title Online booking system 
Description Bespoke software development allowing study participants to book appointments online to attend the clinical assessment 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Improved participant experience 
 
Title Online proposal for data access system 
Description Bespoke software development where researchers can enter details of new proposals to access ALSPAC data, system processes these and logs all relevant supporting information and agreements together (see https://proposals.epi.bristol.ac.uk/) 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Improved system providing speedier access to ALSPAC data. We have been approached by other research groups interested in using this system and we are exploring options around how we might make this available to others. 
URL https://proposals.epi.bristol.ac.uk/
 
Title Online questionnaire system 
Description Successful development of an effective online questionnaire system used by participants to complete ALSPAC questionnaires via the study website 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact More efficient and cost effective collection of data from research particpants 
 
Title Power calculations for the undertaking of genetic sequence analysis of rare variants. 
Description This work provides a framework within which power calculations for the analysis of rare variants from genetic sequence data can be undertaken. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact NA 
URL http://onlinelibrary.wiley.com/doi/10.1002/gepi.21797/abstract
 
Title Protocol for genetic annotation and characterization 
Description We have developed a tool which annotates all genetic variants within a user specified region of the human genome. These annotations are collated from various databases, including information such as (but not limited to) predicted consequence, predicted deleterious impact, trait associations, quantitative trait loci (i.e. expression, methylation, chromatin, metabolomics, proteomics), regulatory information, biological pathways and druggable/trials info. 
Type Of Material Model of mechanisms or symptoms - in vitro 
Provided To Others? No  
Impact As the tool is unreleased there has been no impact yet. However, we intend to share the tool with the French pharmaceutical company Sanofi once it is ready as part of our on-going collaboration. 
 
Title Protocol for recall by genotype study - sleep 
Description This work provides a framework within which recall by genotype studies can be undertaken. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This description is now published: BMC Med Genet. 2015 Oct 24;16:96. doi: 10.1186/s12881-015-0244-4. Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology. 
URL http://www.biomedcentral.com/1471-2350/15/13
 
Title Protocol for recall by genotype study - smoking 
Description This work provides a written protocol for the undertaking of recall by genotype studies. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This work is now published: BMC Med Genet. 2014 Jan 22;15:13. doi: 10.1186/1471-2350-15-13. A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography: study protocol. Ware JJ1, Timpson N, Davey Smith G, Munafò MR. 
 
Title Providing a genomic teaching resource 
Description Teaching the methods and approaches used in genetic epidemiology is most effective when realistic data is available for students to use. We have scrambled the ALSPAC genetic data in order to preserve the genetic characteristics of the dataset whilst making the data non-disclosive of the participants. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This scrambled dataset has been used in at least six short courses on genetic epidemiology to date, and is continually used to teach students. 
 
Title Recall by Genotype Study Planner - app 
Description This is an online "shiny app" which is designed to accompany a position paper describing the principal and application of Recall by Genotype as a research method. It allows the calculation of statistical power and study cost (in comparison to other more conventional designs) in a series of study formats. 
Type Of Material Improvements to research infrastructure 
Year Produced 2016 
Provided To Others? Yes  
Impact This research tool will be released in full form with the publication of the Recall by Genotype position paper. 
 
Title Statistical methods for approaching lifecourse methods 
Description A number of groups are working on methods for analysing longitudinal data from the study producing both novel methods and building on existing methods to make best use of the repeat measures ALSPAC has. This area of work has a particular focus on lifecourse models. 
Type Of Material Improvements to research infrastructure 
Year Produced 2015 
Provided To Others? Yes  
Impact A number of papers have been published including: Smith AD, Hardy R, Heron J, Joinson CJ, Lawlor DA, Macdonald-Wallis C, Tilling K. A structured approach to hypotheses involving continuous exposures over the life course. Int J Epidemiol. 2016 Aug;45(4):1271-1279. Epub 2016 Jul 1. Howe LD, Smith AD, Macdonald-Wallis C, Anderson EL, Galobardes B, Lawlor DA, Ben-Shlomo Y, Hardy R, Cooper R, Tilling K, Fraser A. Relationship between mediation analysis and the structured life course approach. Int J Epidemiol. 2016 Aug;45(4):1280-1294. Epub 2016 Sep 27. Smith AD, Heron J, Mishra G, Gilthorpe MS, 
 
Title Statistical methods for dealing with repeat measures 
Description A number of groups are working on methods for analysing longitudinal data from the study producing both novel methods and building on existing methods to make best use of the repeat measures ALSPAC has. This covers a variety of different types of data and areas of research including growth, risky behaviours, diet and health outcomes 
Type Of Material Improvements to research infrastructure 
Year Produced 2010 
Provided To Others? Yes  
Impact A number of papers have been published. A few relevant examples are provided below: Anderson EL, Tilling K, Fraser A, Macdonald-Wallis C, Emmett P, Cribb V, Northstone K, Lawlor DA, Howe LD. Estimating Trajectories of Energy Intake Through Childhood and Adolescence Using Linear-Spline Multilevel Models. Epidemiology. Epub 2013 May 21. PMID: 23698751 Howe LD, Tilling K, Galobardes B, Davey Smith G, Gunnell D, Lawlor DA. Socioeconomic differences in childhood growth trajectories: at what age do height inequalities emerge? J Epidemiol Community Health. 2012;66(2):143-8. PMID:20724285. Heron J, Macleod J, Munafo MR, Melotti R, Lewis G, Tilling K, Hickman M. Patterns of Alcohol Use in Early Adolescence Predict Problem Use at Age 16. Alcohol Alcohol. 2012;47(2):169-77. PMID:22215001. Macdonald-Wallis C, Lawlor D, Palmer T, Tilling K. Multivariate multilevel spline models for parallel growth processes: application to weight and mean arterial pressure in pregnancy. Stat Med. 2012;31(26):3147-6. PMID:22733701. 
 
Title Statistical methods for examining missing data/misclassification 
Description A number of statisticians are working on methods using linkage data to investigate missing data and/or misclassification of exposures/outcomes. This covers a number of different data sources and areas of research including education, mental health and wellbeing 
Type Of Material Improvements to research infrastructure 
Year Produced 2015 
Provided To Others? Yes  
Impact A number of papers have been published including: Cornish R, Tilling K, Boyd A, Macleod J, Van Staa T. Using linkage to electronic primary care records to evaluate recruitment and nonresponse bias in the Avon Longitudinal Study of Parents and Children. Epidemiology. 2015 Jul;26(4):e41-2. doi: 10.1097/EDE.0000000000000288. Cornish RP, Tilling K, Boyd A, Davies A, Macleod J. Using linked educational attainment data to reduce bias due to missing outcome data in estimates of the association between the duration of breastfeeding and IQ at 15 years. Int J Epidemiol. 2015 Jun;44(3):937-45. doi: 10.1093/ije/dyv035. Mars B, Cornish R, Heron J, Boyd A, Crane C, Hawton K, Lewis G, Tilling K, Macleod J, Gunnell D. Using Data Linkage to Investigate Inconsistent Reporting of Self-Harm and Questionnaire Non-Response. Arch Suicide Res. 2016;20(2):113-41. doi: 10.1080/13811118.2015.1033121. Epub 2016 Jan 20. Cornish RP, John A, Boyd A, Tilling K, Macleod J. Defining adolescent common mental disorders using electronic primary care data: a comparison with outcomes measured using the CIS-R. BMJ Open. 2016 Dec 1;6(12):e013167. doi: 10.1136/bmjopen-2016-013167. 
 
Title Statistical thresholds for the analysis of whole genome sequence data. 
Description This work provides guidelines for the setting of statistical thresholds when analysing whole genome sequence data. 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact This work has been published: Genet Epidemiol. 2014 May;38(4):281-90. doi: 10.1002/gepi.21797. Epub 2014 Feb 14. Estimating genome-wide significance for whole-genome sequencing studies. Xu C1, Tachmazidou I, Walter K, Ciampi A, Zeggini E, Greenwood CM; UK10K Consortium. 
 
Title UK10K Project Dalliance Genome Browser 
Description The UK10K Genome Browser is based on the Biodalliance platform (Down et al., Bioinformatics 2011), designed to facilitate the retrieval of genotype-phenotype association results from the UK10K Cohorts Project (Walter et al, Nature 2015), and their visualisation in the context of different annotation features. 
Type Of Material Physiological assessment or outcome measure 
Provided To Others? No  
Impact Allows researchers to easily access key results from the cohort arm of the UK10K and generate new hypothesis based on this dataset 
URL http://www.uk10k.org/dalliance.html
 
Title Variable Search Tool 
Description A web application has been developed which performs rapid searching of all variables that are readily accessible in the resource. Using this in conjunction with the detailed data dictionary eases discoverability of the ALSPAC data for potential users. This web based app was formally released in May 2018 
Type Of Material Improvements to research infrastructure 
Year Produced 2018 
Provided To Others? Yes  
Impact The release of the tool has facilicated easy searching for variables and is used widely by both internal and external researchers 
URL http://variables.alspac.bris.ac.uk/
 
Title Web resource for the provision of UK10K sequence data, the display of results, related information and ethical documentation. 
Description This resource provides a collection of material from the UK10K project which involved the sequencing of over 4000 population based human genomes. Resources include: (i) access to raw data (ii) results from association study analysis (rare and common genetic variants) through an integrated browser (iii) ethical documentation (iv) related publications and management information 
Type Of Material Improvements to research infrastructure 
Year Produced 2013 
Provided To Others? Yes  
Impact NA 
URL http://www.uk10k.org
 
Title ALSPAC 'GP' dataset of linked primary care records (1991-2018) 
Description These data are the coded values - relating to participant symptoms, diagnoses, treatments, care - extracted from GP primary care records of ALSPAC participants receiving care in England. The records are linked from EMIS Ltd (a GP software system company) and are managed by the ALSPAC data linkage team. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact The data are being used projects led by: 1) Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 2) Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 3) Dr Rosie Cornish as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 4) Professor Dheeraj Rai to study Adolescent and adult mental health outcomes of autism and autistic traits (ALSPAC Reference: B2622, https://proposals.epi.bristol.ac.uk/?q=node/127702) 5) Professor Hilary Pinnock for the derivation of a clinical prediction rule for the diagnosis of asthma (ALSPAC Reference: B2830, https://proposals.epi.bristol.ac.uk/?q=node/127536) 6) Professor Sinead Langan as part of a program to establish efficient methods to understand medical and social outcomes associated with eczema (ALSPAC Reference: B2606, https://proposals.epi.bristol.ac.uk/?q=node/127717). 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC 'HES' Hospital Episode Statistics records 
Description These are minimum returns of Hospital Episode Statistics secondary care records of ALSPAC participants receiving care in England. The records are linked from NHS Digital and accessed under a NHS Digital - University of Bristol Data Sharing Agreement (managed by the ALSPAC data linkage team). 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact The data are being used projects led by: 1) Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 2) Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 3) Dr Rosie Cornish as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC 'Looked After' and 'Children In Need' linked social care records 
Description These are records of children taken into state care and children classifed as 'in Need'. The records are linked from Department for Education National Pupil Database and accessed under a DfE - University of Bristol Data Sharing Agreement (managed by the ALSPAC data linkage team). While access is currently restricted to the project team, we are exploring mechanisms to widen access using the new powers of the Digital Economy Act and in partnership with the Administrative Data Research-UK. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? No  
Impact The data are being used in a project led by Professor John Macleod and Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). This research has resulted in an academic paper: Teyhan A, Boyd A, Wijedasa D, Macleod J. Early life adversity, contact with children's social care services and educational outcomes at age 16 years: UK birth cohort study with linkage to national administrative records. BMJ open. 2019 Oct 1;9(10):e030213. We have also published a blog article emphasising the value of the novel methodologies in this research: https://www.closer.ac.uk/news-opinion/blog/filling-gaps-boosts-evidence-vulnerable-children/ 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC 'MHSDS' Data Set of Mental Health & Learning Difficulties Community Care Interactions 
Description These are minimum returns of Mental Health community care records of ALSPAC participants receiving care in England. The records are linked from NHS Digital and accessed under a NHS Digital - University of Bristol Data Sharing Agreement (managed by the ALSPAC data linkage team). 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact The data are being used in a project led by Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC 'STORK' dataset of linked maternity records (1990-1992) 
Description The ALSPAC Data Linkage team have recently (2019-2020) cleaned and documented the STORK dataset of midwifery and birth delivery records for those index participants born in either of the two main maternity hospitals in Bristol (approx. 85% of enrolled participants). These data are available for access to the bona-fide research community via the ALSPAC access mechanism. A 'Data Note' publication is being prepared to contribute documentation and to aid the discoverability of the new dataset. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact The data are being used by Dr Katie Harron (UCL) as part of her Wellcome Trust LPS (Aim 2) Award (ALSPAC reference B3002, https://proposals.epi.bristol.ac.uk/?q=node/127384). The data are being used by Dr Alison Teyhan (University of Bristol) as part of the ALSPAC Born-in-Bradford MRC MH Pathfinder award (ALSPAC reference B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ALSPAC - genomewide genetic data resources 
Description Currently I am responsible for the delivery of genomewide data from the ALSPAC collection. With over 18000 mother and child samples, this is being increased to include partners/fathers and to make best use of newly available deep imputation panels. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact The resource is fully described online and is available to the academic community. 
URL http://www.bris.ac.uk/alspac/
 
Title ALSPAC UK Secure eResearch Platform for the secure analysis of sensitive data 
Description The ALSPAC data linkage team have worked with the UK Secure eResearch Platform team (University of Swansea) to establish an 'ALSPAC UKSeRP' secure research server and for the secure analysis of sensitive data, particularly linked routine records accessed under contract. The ALSPAC UKSeRP has been embedded in ALSPAC's linkage ethics and data sharing agreements. It has also been embedded in the study's ISO27001 certified Information Security Management System (ISMS). This is now providing the infrastructure for sharing data with bona fide users, subject to ALSPAC's project approvals process. The management of the system is governed by Standard Operating Procedures and is subject to internal and external audit assessments. We are currently in a 'Beta User' phase, once the mechanisms are fully established the resource will be promoted more widely. 
Type Of Material Data handling & control 
Year Produced 2019 
Provided To Others? Yes  
Impact The ALSPAC UKSeRP 'Beta User' phase is currently being used for 6 research programmes, 4 based at the University of Bristol, 1 at the University of Edinburgh and 1 at LSHTM. It is the key infrastructure for enabling the ALSPAC Born In Bradford MRC MH Pathfinder deliverables. The infrastructure is being used projects led by: 1) Professor Stan Zammit as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 2) Dr Alison Teyhan as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 3) Dr Rosie Cornish as part of the ALSPAC - Born in Bradford MRC MH Pathfinder Award (ALSPAC Reference: B3060, https://proposals.epi.bristol.ac.uk/?q=node/129688). 4) Professor Dheeraj Rai to study Adolescent and adult mental health outcomes of autism and autistic traits (ALSPAC Reference: B2622, https://proposals.epi.bristol.ac.uk/?q=node/127702) 5) Professor Hilary Pinnock for the derivation of a clinical prediction rule for the diagnosis of asthma (ALSPAC Reference: B2830, https://proposals.epi.bristol.ac.uk/?q=node/127536) 6) Professor Sinead Langan as part of a program to establish efficient methods to understand medical and social outcomes associated with eczema (ALSPAC Reference: B2606, https://proposals.epi.bristol.ac.uk/?q=node/127717). 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title ARIES-Explorer 
Description ARIES-Explorer provides an openly accessible web interface to explore epigenome-wide methylation data from the Accessible Resource for Integrated Epigenomics Studies 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact Cited in a key review in the field (Mill et al, Nature Reviews Genetics, VOLUME 14 | AUGUST 2013 | 585). 419 unique visitors to the site in its first month of operation. 
URL http://ariesepigenomics.org.uk/ariesexplorer
 
Title Bristol region NOx modelled Air Pollution Dataset 
Description NOx air pollution data was modelled for the ALSPAC catchment area from 1990 to 2018. In conjunction with ALSPAC participant residential and school geocoding database this enables air pollution data exposure to be estimated and linked to participants. Using the ALGAE software ALSPAC can estimate the exposure with critical development periods (e.g. pregnancy trimesters). Directly measured air pollution records have been collected (from local authority deployed air pollution sensors) and these sensor data will be used to calibrate the modelled data. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact The data will be used in an ALSPAC based epidemiological assessment of the impact of in utero NOx exposure and lung-function outcomes. It is also being shared with collaborators at Imperial (London) for use in an assessment of the impact of availability of greenspace on mental health outcomes. 
 
Title Browser for the UK10K whole genome sequencing project 
Description This work represents the need for a way to present both whole genome sequence data and the results obtained from the analysis of those data (for phenotypic associations in principle). This browser is an existing solution to the need to display genomewide results for sequencing data. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact This work has been published: Bioinformatics. 2015 Dec 15;31(24):4029-31. doi: 10.1093/bioinformatics/btv491. Epub 2015 Aug 26. An interactive genome browser of association results from the UK10K cohorts project. Geihs M1, Yan Y1, Walter K1, Huang J1, Memari Y1, Min JL2, Mead D1; UK10K Consortium, Hubbard TJ3, Timpson NJ2, Down TA4, Soranzo N5. 
 
Title CLOSER harmonised BMI dataset 
Description ALSPAC has contributed to a harmonised dataset through CLOSER which has harmonised data on height, weight and BMI at ages 7, 8, 9, 10, 11 and 17. The data has been lodged with the UK Data Service and can be accessed through a Special License 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact Has contributed to our understanding of how rates of obesity have changed over the generations and the impact of social inequalities. See here: https://www.closer.ac.uk/research-fund-2/data-harmonisation/harmonising-measures-body-size-body-composition/ for a summary. 
URL http://doi.org/10.5255/UKDA-SN-8208-1
 
Title Creation of synthetic datasets for the Big Data VR Project 
Description Three synthetic datasets were created containing 15,000, 155,000 and 1,555,000 participants. These synthetic datasets retained similar data properties to the original study data they were simulated from. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact The data was used in a Wellcome funded project to develop visualisation methods in virtual reality (VR) using big biomedical datasets. As the generated data has no ethical-legal constraints associated with it the synthetic datasets can be used for teaching and training purposes without restriction. 
URL https://wellcomeopenresearch.org/articles/2-74/v1
 
Title Deep imputation from reference panels derived from whole genome sequence data. 
Description This work describes the value added from deep imputation given new reference panels derived from whole genome sequencing - as we undertook with the UK10K project. 
Type Of Material Data analysis technique 
Provided To Others? No  
Impact This work is published: Nat Commun. 2015 Sep 14;6:8111. doi: 10.1038/ncomms9111. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Huang J, Howie B, McCarthy S, Memari Y, Walter K, Min JL, Danecek P, Malerba G, Trabetti E, Zheng HF; UK10K Consortium, Gambaro G, Richards JB, Durbin R, Timpson NJ, Marchini J, Soranzo N. 
 
Title Focus 24+; G1 clinic visit dataset 
Description Data collected at from the 24 year clinic. Infrastructure funded by this award and supplemented with external funding. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact Substantial datasets enabling ongoing research in the areas of cardiovascular disease, mental health, body composition, physical activity, liver and lung health 
URL https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/f24
 
Title Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference 
Description Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. We have described the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We presented two broad scenarios for the application of RbG: studies using single variants and those using multiple variants. We also considered the efficacy and practicality of the RbG approach, provide a catalogue of UK-based resources for such studies and present an online RbG study planner. 
Type Of Material Data analysis technique 
Year Produced 2017 
Provided To Others? Yes  
Impact First described here:https://www.biorxiv.org/content/early/2017/04/12/124586, then formally here: https://www.nature.com/articles/s41467-018-03109-y 
URL http://www.bristol.ac.uk/integrative-epidemiology/faciliitiesresources/software/
 
Title Geocoded School History dataset for ALSPAC index participants 
Description We have collated information on the schools ALSPAC participants attended from reception (Age 4-5) through to leaving schooling (Age 16-18). We have addressed issues such as schools changing over time (changing name, moving location etc). We have then geo-coded the school address information and assigned this back into the ALSPAC research database. This now allows ALSPAC staff to map environmental exposure data (e.g. air pollution, proximity to fast-food outlets) to individuals based on which school they attended. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact The schools geo-coding was used to assign NO2 exposure to ALSPAC participants in a more accurate manner as the model was then able to weight exposure based on residential geocoding and schools geocoding. This dataset can be used in future for similar purposes with different envrionmental exposures. 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/environment-data/
 
Title Haplotype reference consortium - deep imputation reference panel 
Description This is a collection of >25000 whole human genomes which has been brought together, called, phased and made available as an imputation reference panel to the academic community. 
Type Of Material Database/Collection of data 
Provided To Others? No  
Impact This resource currently has a service provision element where collaborative servers can be used for the imputation of existing GWAS data sets. This is currently the most effective imputation resource available (ahead of 1000 genomes or HAPMAP). 
URL http://www.haplotype-reference-consortium.org/data-access
 
Title Life@22+; Dataset from questionnaire completed by G1 
Description Data collected at from the 22 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact - Health - Physical activity - Vision Data collected enabling ongoing research into: - Substance use - Moods and feelings - Life events - Being a parent - Childhood experiences - Education and employment - Voting intentions 
URL https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ypb
 
Title Life@23+; Dataset from questionnaire completed by G1 
Description Data collected at from the 23 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. 
Type Of Material Database/Collection of data 
Year Produced 2017 
Provided To Others? Yes  
Impact - Sexual experiences - Wellbeing - Eating behaviour Data collected enabling ongoing research into: - Being a parent - Brothers and sisters - Smoking and e-cigarette use - Mental health & traumatic experiences - Dental health - Life events - Education and employment 
URL https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ypc
 
Title Life@24+; Dataset from questionnaire completed by G1 
Description Data collected at from the 24 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact Data collected enabling ongoing research into: - Life events - Being a parent - Communication skills - Monetary choice - behaivour - Deliberate self-harm - Smoking and e-cigarette use - Eating, weight & exercise - Gambling - Social media use 
URL https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ypd
 
Title Life@25+; Dataset from questionnaire completed by G1 
Description Data collected at from the 25 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact Data enabling ongoing research into mental health, personality, behaviour, life events, Eating behaviours & food preferences 
URL https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ype
 
Title Life@26+; Dataset from questionnaire completed by G1 
Description Data collected at from the 26 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact Data to enable research into various aspects of health, wellbeing, physical activity, education, life events and attitudes to data sharing 
URL https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ypf
 
Title Major research database re-structure - OPAL interface 
Description The whole of ALSPAC data migrated into a mongoDB database fronted by OPAL/mica in order to develop and make more efficient browsing and the formation of new data sets for sharing / research generation. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact This will be tested against existing methods to ensure that ALSPAC resources are visible and can be released more efficiently than before. 
 
Title Synthetic dataset created for MAPS project 
Description KN to add more detail 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact KN to add more detail 
URL https://osf.io/buqk8/
 
Title The European Genome-phenome Archive of human data consented for biomedical research 
Description The 4000 sequences including 2000 sequences generated from ALSPAC participants are deposited in EGA. After an application procedure, every researcher has access to the sequences generated for the UK10k project. 
Type Of Material Database/Collection of data 
Year Produced 2015 
Provided To Others? Yes  
Impact n/a 
URL https://www.ebi.ac.uk/ega/home
 
Title Training dataset for Mendelian Randomisation 
Description Training materials for a Mendelian Randomisation Course using simulated ALSPAC data has been developed by Nic Timpson and Colleagues. The data and all training materials are available for download fro data.bris. The course has been taught around the world 
Type Of Material Database/Collection of data 
Year Produced 2018 
Provided To Others? Yes  
Impact Enables education and facilitates data use without disclosure risk 
URL https://data.bris.ac.uk/data/dataset/2e8d53bcg2yhp26r79zu425cyg
 
Title UK10K - population based whole genome sequencing 
Description This is the collection of raw data and results from the UK10K study. By studying and comparing the DNA of 4,000 people whose physical characteristics are well documented, the project aims to identify those changes that have no discernible effect and those that may be linked to a particular disease; by studying the changes within protein-coding areas of DNA that tell the body how to make proteins of 6,000 people with extreme health problems and comparing them with the first group, it is hoped to find only those changes in DNA that are responsible for the particular health problems observed. 
Type Of Material Database/Collection of data 
Year Produced 2012 
Provided To Others? Yes  
Impact This work has been published: Nature. 2015 Oct 1;526(7571):82-90. doi: 10.1038/nature14962. Epub 2015 Sep 14. The UK10K project identifies rare variants in health and disease. UK10K Consortium, Walter K, Min JL, Huang J, Crooks L, Memari Y, McCarthy S, Perry JR, Xu C, Futema M, Lawson D, Iotchkova V, Schiffels S, Hendricks AE,Danecek P, Li R, Floyd J, Wain LV, Barroso I, Humphries SE, Hurles ME, Zeggini E, Barrett JC, Plagnol V, Richards JB, Greenwood CM, Timpson NJ, Durbin R,Soranzo N. 
URL http://www.uk10k.org
 
Title Your life in 2013; Dataset from questionnaire completed by G0 Mothers 
Description Data collected at from the 'Your life in 2013' Questionnaire. Infrastructure funded by this award and supplemented with external funding. 
Type Of Material Database/Collection of data 
Year Produced 2019 
Provided To Others? Yes  
Impact Data collected enabling ongoing research into: - Family and home life - Employment - Finances - Physical, sexual and reproductive health - Mental health - Substance Use - Physical activity 
 
Title mQTLdb 
Description mQTLdb is a database of methylation QTL, initially set up for methylation QTL from the ALSPAC-ARIES project 
Type Of Material Database/Collection of data 
Year Produced 2016 
Provided To Others? Yes  
Impact The database is being used by researchers to identify methylation QTL for Mendelian randomization analyses 
URL http://www.mqtldb.org/
 
Description (Epi)Genetics of Puberty and Risky Sexual Behavior (B3077) 
Organisation University at Albany
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description (Epi)Genetics of Puberty and Risky Sexual Behavior (B3077) 
Organisation University at Albany
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description 10,000 hours: Children, Childcare and Developmental Opportunity (2335) 
Organisation Queensland University of Technology (QUT)
Country Australia 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2014
 
Description 2 Sample MR Lung function and Cognition (B3294) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2019
 
Description 24-hour ambulatory measures of blood pressure and their association with cardiac structure and function in adolescents (B2858) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description A Bayesian mixture framework for epigenetics (2441) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description A Consolidator Grant to Study the Developmental Trajectories of Physical and Mental Health Multimorbidity in Genetic High-Risk C (B3439) 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description A GWAS of child's ability to cope as measured by SDQ (B2823) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description A Longitudinal Study on the Impact of Stressful Life Events on Obsessive-Compulsive Disorder Symptomatology (2424) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description A Mendelian Randomisation Study of IL-6, Depression and Psychosis in the ALSPAC Birth Cohort (2323) 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary analysis
Impact None Yet
Start Year 2014
 
Description A Mendelian Randomisation study of Skin tone and Vitamin D (2406) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description A Recall by Genotype Study to investigate the role of common TRPA1 variants in acute pain perception. (B3236) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution New Data collection and secondary analysis
Impact None yet
Start Year 2019
 
Description A comprehensive literature review of the genetic variants identified in Cleft Lip with/without Palate (continued title) (B2814) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description A genetic underpinning of Optimism (2539) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description A hypothesis-free approach to identify DNA sequences regulating gene environment interaction (GxE) in programming adult response (B3203) 
Organisation Manchester Metropolitan University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description A meta-analysis of maternal smoking GFI1-CpGs and cardio-metabolic phenotypes in adults (B3097) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description A methylation-based biomarker for alcohol intake in the general population (B2818) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description A methylation-based biomarker for alcohol intake in the general population (B2818) 
Organisation University of California, San Francisco
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description A molecular genetic study of Theory of Mind (2528) 
Organisation McMaster University
Country Canada 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description A molecular test of the Nature of Nurture in the psychosis pathway (B3171) 
Organisation Icahn School of Medicine at Mount Sinai
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description A multi-cohort GWAS of income using ALSPAC (B3307) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2019
 
Description A multi-omics investigation into the metabolic and epigenetic effects of childhood glycemic profile (2370) 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description A novel genetic instrument for lifetime smoking indicates that smoking is a casual risk factor for depression and schizophrenia (B3094) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description A polygenic approach to understanding resilience to peer victimisation (B3331) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description A prospective examination of the influence of ultra-processed food consumption on measures of adiposity and CVD (B3052) 
Organisation University of Sao Paulo
Country Brazil 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description A study of origins, correlates and determinants of locus of control (2390) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description ADHD and DNA methylation: a repeated measures EWAS (B2749) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description ALSPAC & DataSHIELD in the InterConnect Project. Subproject1: Physical Activity in Pregnancy & Anthropometric Outcomes (B2660) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description ALSPAC (University of Bristol) - Twins UK (KCL) collaboration on developing linkage methodologies 
Organisation St Thomas' Hospital
Department Twins Research Cohorts from St Thomas' Hospital
Country United Kingdom 
Sector Academic/University 
PI Contribution ALSPAC are providing strategic support to develop the TwinsUK record linkage programme based on the established and generalisable approaches developed by the 'PEARL' record linkage team. ALSPAC are specifically 1) supporting the development of the TwinsUK governance approvals based on the precedents of ALSPAC approaches; 2) supporting the development of the TwinsUK data access requests based on the precedents of ALSPAC approaches; 3) will lead the programme to secure GP assent to release copies of patients primary care records to the studies & to develop the technical mechanisms by which this will occur with practice software companies. Further to this, ALSPAC and TwinsUK will collaborate on development of aligned data processing and infrastructure and documentation/discovery developments.
Collaborator Contribution Regular working meetings to develop policy and materials and to share insights.
Impact In December 2019 TwinsUK received a conditional approval from the HRA Confidentiality Advisory Group to access identifiable patient information without explicit patient consent. This was based on ALSPAC's existing approvals.
Start Year 2019
 
Description ALSPAC MRI-II (B3035) 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution New data collection and secondary analysis
Impact None yet
Start Year 2018
 
Description ALSPAC Proposal - Education and Myopia: A Bi-directional Mendelian Randomisation Study (B2715) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description ALSPAC analysis for ExomeBP consortium (2615) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact none yet
Start Year 2016
 
Description ALSPAC analysis for YGen consortium (2623) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact none yet
Start Year 2016
 
Description ALSPAC and ELSPAC: Pre-birth cohorts with longitudinal data on childhood obesity, respiratory development and neurocognitive abi (B2650) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution New data and secondary analysis
Impact None yet
Start Year 2016
 
Description ALSPAC cohorts National Chlamydia Screening Programme testing patterns (2594) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analyiss
Impact None yet
Start Year 2015
 
Description ALSPAC exome generation (2605) 
Organisation Massachusetts General Hospital
Country United States 
Sector Hospitals 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description ALSPAC exome generation (B2680) 
Organisation Massachusetts General Hospital
Country United States 
Sector Hospitals 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description ALSPAC families (B3370) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description ALSPAC iPSC bank - (2489) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description ALSPAC in the Digital Age (2588) 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution secondary ANALYSIS
Impact None yet
Start Year 2015
 
Description ALSPAC linkage team collaboration with Dr Beng Choon-Ho, University of Iowa Carver College of Medicine. 
Organisation University of Iowa
Department Carver College of Medicine
Country United States 
Sector Academic/University 
PI Contribution The ALSPAC Data Linkage Team are collaborating with Dr Choon-Ho to develop funding applications to support research investigating the neurobiological mechanisms in Adolescent Marijuana Exposure and subsequent Schizophrenia Risk. This will reuse MRI data collected by ALSPAC and Collaborators Professor David and Professor Linden, it will also utilise new data management infrastructure developed by the ALSPAC MRC MH Pathfinder award.
Collaborator Contribution Contributing expertise to grant applications led by Dr Choo-Ho.
Impact 1) Grant application to NIHR (Not supported) "Adolescent Impulsivity, Reward Brain Networks & Schizophrenia Risk" 2) Grant application to NIHR (in progress) "Neurobiological Mechanisms in Adolescent Marijuana Exposure and Schizophrenia Risk"
Start Year 2019
 
Description ALSPAC mGWAS (B2813) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Abnormal metabolic measures in adolescents with pyschotic experiences (2532) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description Acceptability to participants of novel data linkages, ethical issues, and the practicalities of obtaining consent: Evidence from (B3406) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Accuracy of clinical characteristics, biochemical and ultrasound markers in the prediction of pre-eclampsia: an IPD 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Acetaminophen (paracetamol) use during pregnancy and behaviour problems and autism spectrum symptoms in childhood (B2763) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Acetaminophen Exposure in Utero and Subsequent Impact on Female Reproductive Function (B3225) 
Organisation University of Pennsylvania
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Adaptations to Inequality and the Perpetuation of Disadvantages: An Evolutionary Developmental Approach (B3082) 
Organisation University of Washington
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Adolescent and adult mental health outcomes of autism and autistic traits (2622) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact none yet
Start Year 2016
 
Description Adolescent diet and cardiometabolic health (B2798) 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Adult Eating Behaviour Questionnaire in ALSPAC (2496) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution New data collection via questionnaire - subject to funding by collaborator
Collaborator Contribution Seeking funding to collect new data
Impact None yet
Start Year 2015
 
Description Adverse childhood experiences and body composition in adolescence: a cross-cohort comparison (2598) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description Adverse childhood experiences and psychopathology: A genetically informative approach (B3218) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Adverse childhood experiences and psychopathology: A propensity score matching approach (B3219) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Adverse life events, inflammation, and trajectories of emotional and behavioural problems in childhood (B2645) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Prevision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2016
 
Description Aetiology of increased birthweight for gestation (2360) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2014
 
Description Age at menarche and lung function: A Mendelian randomisation analysis (2461) 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Age specific BMI SNP effects (SNP effect look up) (B2998) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Ageing Lungs in European Cohorts Project- EWAS on Lung Function (B2909) 
Organisation University of Basel
Country Switzerland 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Agreement in alcohol reporting (as part of ELAStiC) (B2726) 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Air Pollution Risk and Genetic Liability for Autism and ADHD (2538) 
Organisation University of Wisconsin-Madison
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Air pollution data in ALSPAC - documentation (2600) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Alcohol Misuse: Electronic Longitudinal Alcohol Study in Communities (2501) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description Alcohol use, breastfeeding and offspring neurodevelopment (B3248) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2019
 
Description Amendment to STELAR Collaboration - Asthma Trajectories From Childhood to Adulthood (B3149) 
Organisation University Hospital Southampton NHS Foundation Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description An EWAS of Anti-Mullerian Hormone (2454) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description An adult eating questionnaire to measure disinhibition and restraint (B2872) 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution New data collection and secondary analysis
Impact None yet
Start Year 2017
 
Description An analysis of the environments which promote the development of early speech and language skills (2465) 
Organisation North Bristol NHS Trust
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description An atlas of phenotypic correlations and a correction of multiple testing across human traits and diseases using GWAS summary sta (B2739) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description An ethical and technical framework for linking social media data in UK cohorts (B2934) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description An examination of the association between school engagement at 10-11 yrs and sexual health and behaviours at 21 yrs (2402) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description An integrative analysis of biological and environmental risks for mental ill-health in young adulthood to precision psychiatry (B3303) 
Organisation Royal College of Surgeons in Ireland
Country Ireland 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2019
 
Description An investigation into the determinants of fatigue in a population-based cohort of young adults (2408) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description An investigation of maternal risk factors for the development of paediatric obsessive-compulsive disorder (2330) 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2014
 
Description An investigation of the association between substance use in adolescence and mental health using linked data (B3112) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description An investigation of the environmental effect of parental genotypes on offspring behavioural problems (B3389) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Analysing the association between inflammation and scoliosis in a population-based birth cohort's a proof of concept study (B3404) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Analysis for Global Lipids Genetics / The Genetic Investigation of Anthropometric Traits (GLG/GIANT) consortia (B2861) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Analysis of DNA Methylation for family trios (B2724) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis and new data
Impact None yet
Start Year 2016
 
Description Analysis of SNP-heritability and co-heritability of adolescent psychotic experiences (2321) 
Organisation Birkbeck, University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2014
 
Description Analysis of SNP-heritability and co-heritability of adolescent psychotic experiences (2321) 
Organisation Birkbeck, University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2014
 
Description Analysis of copy number variation in relation to age at menarche and age at natural menopause (B2978) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Analyst and writing group member for the MAGIC 'Trans-ethnic meta-analysis and fine-mapping for fasting glucose, fasting insulin, 2hr glucose and HbA1c using data imputed to the 1000 Genomes reference panel 
Organisation MAGIC (The Meta-Analyses of Glucose and Insulin-related traits Consortium)
Country Global 
Sector Charity/Non Profit 
PI Contribution I have contributed results from the analysis of ALSPAC (Avon Longitudinal Study of Parents and Children) data to the meta-analysis. I have acted as a central analyst which has involved conducting quality control checks and reformatting of data contributed by other analysts. I have a led a side project looking at the variance explained by new markers for glycaemic traits. I have contributed to the drafting of the manuscript that will hopefully be submitted shortly.
Collaborator Contribution The other investigators in the collaboration have also contributed results from analyses run within their own cohorts and similarly although variable contributed to side projects and manuscript writing.
Impact A manuscript is in progress but not yet published.
Start Year 2014
 
Description Anorexia and subsequent smoking: cause or correlation (B3355) 
Organisation University of Bristol
Department School for Policy Studies
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Antecedents of Trait Psychological Functioning (2514) 
Organisation Florida State University
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Antecedents of obesity in the ALSPAC cohort: the role of early diet (sugar and fibre), antibiotics and gut bacteria (B2753) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Antenatal Selection Gradients (B2915) 
Organisation Princeton University
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Antenatal Selection and the Parent-Child Gene Environment: Challenging the Nurture/Nature Dichotomy (B2931) 
Organisation Princeton University
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Antibodies to Infectious Agents and Psychiatric Disorders (B3033) 
Organisation Johns Hopkins Medicine
Country United States 
Sector Hospitals 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Anxiety and mood disorders in young people: a multivariate approach using the ALSPAC cohort, B3464 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Apgar scores and long term growth, health ann development (2495) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Application of the joint linear mixed effect IOU model:accounting for autocorrelation and informative dropout (B2747) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Applied epidemiology and the human gut microbiome: evidence for causal effects versus confounded companionship (B3043) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Applying Mendelian randomization to predicting the overall effects of interventions targeting sclerostin (B2646) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Applying causal inference methods to investigate the impact of adverse childhood experiences on psychopathology (B3219) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Applying genetic risk scores for one-carbon micronutrients to Mendelian randomization and epigenome-wide association analyses (B3140) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Appropriate statistical models for multivariate epigenetic data, with focus on prenatal alcohol exposure. (B2745) 
Organisation University College Dublin
Country Ireland 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Are Children with Impaired Vision or Hearing at Greater or Differential Risk of Unintentional Injury? (2348) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2014
 
Description Are Different Face Shapes Related to Different Levels of Blood Pressure? (B3244) 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2019
 
Description Are associations between maternal risk factors and non-syndromic cleft lip and/or palate mediated by cord blood methylation? (B2681) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Are dietary patterns in childhood associated with later alcohol use (B3280) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2019
 
Description Are effects of early-life oxidant exposures on asthma risk modified by TRPA1 variants and mediated by TRPA1 methylation? (B2800) 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Are knee DXA biomarkers related to lower limb biomechanics and gait in women with and without knee osteoarthritis?, B3472 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Are prenatal metabolites, nutrients, and toxins linked to lung function in adolescence via DNA methylation? (2440) 
Organisation University of Memphis
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Are women who experience domestic violence and abuse more likely to seek emergency contraception? (B2770) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Ascertaining direction of causality in associations between smoking, cognition and schizophrenia (2338) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2014
 
Description Assessing Methylome changes across adolescence in gender-related switch of asthma. (B2687) 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis and new data
Impact None yet
Start Year 2016
 
Description Assessing Misreporting of Smoking Behavior Using DNA Methylation (2614) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Assessing causality in associations between cannabis & tobacco use and poor social cognition: A Mendelian randomization study (B2734) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Assessing causality in metabolic systems (B2880) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Assessing causality in the association between maternal pre-pregnancy obesity and child neurodevelopment: observational and mendelian randomization analyses (2534) 
Organisation Center for Research in Environmental Epidemiology
Country Spain 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Assessing epigenetic changes in relation to night shift work (B3300) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2019
 
Description Assessing the association between screen time and anxiety in UK adolescents: a prospective longitudinal study using the ALSPAC cohort (2551) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Assessing the extent to which disclosure control techniques impact on data utility (2361) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2014
 
Description Assessing the impact of parental smoking on DNA methylation in offspring sex chromosomes (B2833) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Assessing the impact of parental smoking on genetic variation in offspring Y chromosome (B2847) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Assessing the role of martial status on sexual timing, and the association between breast development and sports participation (B3055) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Assessing trajectories of e-cigarette use and smoking and their risk factors (B3322) 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution New data collection and secondary analysis
Impact None yet
Start Year 2019
 
Description Assessment and harmonisation of cognitive measures in Britsih Cohort Studies (B3185) 
Organisation University College London
Department Centre for Longitudinal Studies
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Assessment of Telomere Length Measurement in ALSPAC DNA 
Organisation University of Leicester
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description Assessment of lung function decline in young adults; identifying and characterising early expressions of COPD (B3400) 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Association between arterial stiffness of ALSPAC fathers, mothers and blood pressure trajectories of their offspring (2307) 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2014
 
Description Association between asthma/allergies and depression/anxiety/self harm 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2014
 
Description Association between brain anatomy and genetic risk for mental disorders in healthy volunteers (2399) 
Organisation Medical Research Council (MRC)
Department MRC Centre for Neuropsychiatric Genetics and Genomics
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Association between dietary measures and later development of psychotic symptoms in the ALSPAC cohort (2482) 
Organisation University of Warwick
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Association between oxytocin genetic variants and mood, personality and addictive behaviour (B2685) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Association between paternal depressogenic cognitive style during pregnancy and offspring cognitive style 18 years later (B2678) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Association between the complexity of written language in childhood and adolescent mental health (B3101) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Association of Maternal education with DNA-methylation (B3431) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Association of adolescent physical activity profiles with hip strength at age 25 (B3235) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2019
 
Description Association of atopic illness and raised inflammatory markers in childhood with manic symptoms in young adult life (2345) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None Yet
Start Year 2014
 
Description Association of childhood mental health with adolescent substance abuse (2621) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution secondary analysis
Impact none yet
Start Year 2016
 
Description Association of dietary factors with cardiometabolic health: Possible mediating role of DNA methylation and metabolome (B2769) 
Organisation Korea University
Country Korea, Republic of 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Association of dietary fat intake in infancy and early childhood with serum leptin concentrations and body fat in later life (B3178) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2018
 
Description Association of disease genetic risk scores with DNA methylation (2562) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2015
 
Description Association of maternal and child BMI with cardio-metabolic health in adolescence via DNA methylation (B2901) 
Organisation Columbia University
Country United States 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2017
 
Description Association of mitochondrial copy number with phenotypes in the UK10K cohort samples (B2662) 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Association of mtDNA SNPs with anthropometric and glycemic traits: integration with the CHARGEmtDNA+ consortium (2442) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2015
 
Description Associations between Adolescent Anxiety and Alcohol Use in Young Adulthood (B2799) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data prevision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Associations between body composition and lung function development up to 16 years of age (B2722) 
Organisation Barcelona Institute for Global Health
Country Spain 
Sector Multiple 
PI Contribution Data provision
Collaborator Contribution Secondary analysis
Impact None yet
Start Year 2016
 
Description Associations between childhood diet and subsequent puberty timing (B3208) 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Data provision