King’s College London Confidence in Concept
Lead Research Organisation:
King's College London
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
- King's College London (Lead Research Organisation)
- University of Milan (Collaboration)
- Jagiellonian University (Collaboration)
- Mayo Clinic Hospital (Collaboration)
- University of Groningen (Collaboration)
- Karolinska Institute (Collaboration)
- Erasmus MC (Collaboration)
- Swiss Institute of Allergy and Asthma Research (Collaboration)
- QUEEN'S UNIVERSITY BELFAST (Collaboration)
- University of Vienna (Collaboration)
- UNIVERSITY OF OXFORD (Collaboration)
- UNIVERSITY OF EDINBURGH (Collaboration)
- National Institutes of Health (NIH) (Collaboration)
- KING'S COLLEGE LONDON (Collaboration)
People |
ORCID iD |
Publications
Reading E
(2020)
Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB.
in Nature communications
Roccia E
(2019)
Accelerated 3D T2 mapping with dictionary-based matching for prostate imaging.
in Magnetic resonance in medicine
Roccia E
(2018)
Accelerated 3D T 2 mapping with dictionary-based matching for prostate imaging
in Magnetic Resonance in Medicine
Rowley M
(2017)
A latent class model for competing risks.
in Statistics in medicine
Sheikh M
(2019)
Analysis of overfitting in the regularized Cox model
in Journal of Physics A: Mathematical and Theoretical
Shiu KY
(2020)
Effect of Optimized Immunosuppression (Including Rituximab) on Anti-Donor Alloresponses in Patients With Chronically Rejecting Renal Allografts.
in Frontiers in immunology
| Description | Co-opted onto BTS council to represent Basic Science |
| Geographic Reach | National |
| Policy Influence Type | Membership of a guideline committee |
| Description | European Academy of Allergy and Clinical Immunology (EAACI) Task Force |
| Geographic Reach | Europe |
| Policy Influence Type | Membership of a guideline committee |
| URL | https://www.eaaci.org/science/task-forces.html#category-anchor-1236 |
| Description | BBSRC research grant |
| Amount | £442,305 (GBP) |
| Funding ID | BB/S005560/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 12/2021 |
| Description | BHF Translational Award (First-phase ejection fraction as a diagnostic marker and therapeutic target in cardiac disease) |
| Amount | £146,961 (GBP) |
| Funding ID | TG/17/2/33054 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2017 |
| End | 07/2019 |
| Description | CAR T-cell mediated co-targeting of MUC1 and HER2 to achieve precision immunotherapy of breast cancer |
| Amount | £229,844 (GBP) |
| Organisation | Breast Cancer Now |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 01/2022 |
| Description | CDT student |
| Amount | £96,000 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2016 |
| End | 09/2020 |
| Description | Chemistry and medicinal chemistry of tris(hydroxypyridinone) (THP) and derivatives thereof |
| Amount | £50,000 (GBP) |
| Organisation | Theragnostics Limited |
| Sector | Private |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 05/2019 |
| Description | Clinical Research Training Fellowship (Hannah Wilkinson) |
| Amount | £270,889 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| Description | Enabling clinical translation of a novel activation-repolarisation time metric for improved identification of optimal catheter ablation sites |
| Amount | £287,947 (GBP) |
| Funding ID | PG/16/81/32441 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 04/2020 |
| Description | Exploring the Links Between Regulatory T cell Populations and Development of HLA Antibodies in Renal Patients Awaiting Transplantation. |
| Amount | £274,253 (GBP) |
| Funding ID | MR/T006560/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2020 |
| End | 05/2023 |
| Description | First-phase ejection fraction guided management of aortic stenosis |
| Amount | £266,800 (GBP) |
| Organisation | National Institute for Health Research |
| Sector | Public |
| Country | United Kingdom |
| Start | 07/2019 |
| End | 06/2022 |
| Description | First-phase ejection fraction to guide elective aortic valve replacement in asymptomatic aortic stenosis |
| Amount | £228,515 (GBP) |
| Funding ID | PG/19/23/34259 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2019 |
| End | 09/2022 |
| Description | How do membranes communicate with their molecular partners? |
| Amount | £292,249 (GBP) |
| Organisation | The Leverhulme Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 10/2022 |
| Description | Improving beta cell function by mesenchymal stromal cells: novel mechanisms and cell-free translational potential MR/WOO22876/1 |
| Amount | £370,000 (GBP) |
| Funding ID | MR/WOO22876/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2022 |
| End | 08/2024 |
| Description | MRC DPFS: Regulatory T cells in Highly Sensitised Renal Patients to Improve Outcomes after HLA-Ab Incompatible Transplantation |
| Amount | £3,107,704 (GBP) |
| Funding ID | MR/T025573/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2020 |
| End | 12/2023 |
| Description | Multidisciplinary project award |
| Amount | £501,608 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2016 |
| End | 03/2019 |
| Description | New quantitative tools for precision medicine: overfitting correction in multivariate Cox analysis |
| Amount | £84,726 (GBP) |
| Funding ID | NS/A000071/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 06/2020 |
| Description | Research Grants |
| Amount | £5,180,000 (GBP) |
| Funding ID | MR/R014043/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2018 |
| End | 05/2022 |
| Description | UKRI Future Leaders Fellowship |
| Amount | £1,134,103 (GBP) |
| Funding ID | MR/S031995/1 |
| Organisation | United Kingdom Research and Innovation |
| Department | Future Leaders Research Fellowship |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2020 |
| End | 11/2024 |
| Description | Analysis of Swedish national cancer data |
| Organisation | Karolinska Institute |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | My research team contribute innovative statistical methodology and know-how, implemented in software. |
| Collaborator Contribution | My partner contributed large scale Swedish national epidemiological cancer data. |
| Impact | There are no outcomes yet. Outcomes will take the form of research publications and possibly joint grant applications. |
| Start Year | 2017 |
| Description | Analysis of complex epidemiological data from AMD patients |
| Organisation | Erasmus MC |
| Country | Netherlands |
| Sector | Hospitals |
| PI Contribution | My research team contribute innovative statistical methodology and know-how, implemented in software. |
| Collaborator Contribution | My partner provided clinical and epidemiological data from AMD patients (the Rotterdam Study and the EU network Eye-Risk) |
| Impact | There are no outcomes yes. Outcomes will take the form of joint publications and possible joint grant applications. |
| Start Year | 2017 |
| Description | Els |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Perform experiments |
| Collaborator Contribution | Provides expert advice |
| Impact | Provides expert advice on genetic manipulation of stem cells |
| Start Year | 2017 |
| Description | Interdisciplinary research collaboration towards clinical implementation |
| Organisation | King's College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The MRI research sequence for fast 3D T2 mapping is implemented on several MRI scanners at the Guy's and St Thomas Hospital Trust to be used in collaborative research projects towards clinical implementation. To extend the research to application in radiotherapy, diagnostic multi-parametric cancer imaging. |
| Collaborator Contribution | Use the new research sequence as an add on in their clinical research studies, compare to standard imaging methods towards clinical implementation. Give feedback on image quality, robustness measures. |
| Impact | Conference proceedings published, journal publications and grant proposals in preparation |
| Start Year | 2016 |
| Description | JB (klebsiella) |
| Organisation | Queen's University Belfast |
| Department | School of Medicine, Dentistry and Biomedical Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Perform experiments |
| Collaborator Contribution | Provision of transgenic bacteria |
| Impact | We are using the reagents provided for our experiments |
| Start Year | 2019 |
| Description | Latent class analysis of data from colorectal cancer trials |
| Organisation | Mayo Clinic Hospital |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | My research team contribute innovative statistical methodology and know-how, implemented in software. |
| Collaborator Contribution | My partners contribute data from clinical trials. |
| Impact | This is a multidisciplinary collaboration. Outputs will take the form of clinical research papers and possible joint grant applications. |
| Start Year | 2017 |
| Description | PK (MAIT) |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Performing experiments |
| Collaborator Contribution | Provision of transgenic mice |
| Impact | We are currently using the mice for experiments |
| Start Year | 2019 |
| Description | Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology |
| Organisation | Jagiellonian University |
| Country | Poland |
| Sector | Academic/University |
| PI Contribution | Organiser and chair of the Task Force |
| Collaborator Contribution | Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report. |
| Impact | n/a |
| Start Year | 2017 |
| Description | Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology |
| Organisation | Karolinska Institute |
| Country | Sweden |
| Sector | Academic/University |
| PI Contribution | Organiser and chair of the Task Force |
| Collaborator Contribution | Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report. |
| Impact | n/a |
| Start Year | 2017 |
| Description | Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology |
| Organisation | Swiss Institute of Allergy and Asthma Research |
| Country | Switzerland |
| Sector | Charity/Non Profit |
| PI Contribution | Organiser and chair of the Task Force |
| Collaborator Contribution | Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report. |
| Impact | n/a |
| Start Year | 2017 |
| Description | Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology |
| Organisation | University of Edinburgh |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Organiser and chair of the Task Force |
| Collaborator Contribution | Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report. |
| Impact | n/a |
| Start Year | 2017 |
| Description | Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology |
| Organisation | University of Groningen |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Organiser and chair of the Task Force |
| Collaborator Contribution | Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report. |
| Impact | n/a |
| Start Year | 2017 |
| Description | Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology |
| Organisation | University of Milan |
| Country | Italy |
| Sector | Academic/University |
| PI Contribution | Organiser and chair of the Task Force |
| Collaborator Contribution | Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report. |
| Impact | n/a |
| Start Year | 2017 |
| Description | Task Force on eicosanoids in asthma and allergy, European Academy of Allergy and Clinical Immunology |
| Organisation | University of Vienna |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Organiser and chair of the Task Force |
| Collaborator Contribution | Starting the collaboration on eicosanoids in asthma and allergy. Working on a consensus report. |
| Impact | n/a |
| Start Year | 2017 |
| Description | Tetramer |
| Organisation | National Institutes of Health (NIH) |
| Country | United States |
| Sector | Public |
| PI Contribution | We will use the reagents provided for the development of the research project |
| Collaborator Contribution | Provide unique reagents required for the project |
| Impact | The reagents provided by NIH are necessary for the progress and development of the research project |
| Start Year | 2014 |
| Title | Bur with Bioactive Materials |
| Description | 'Biobur': a new instrument for minimum intervention dentistry |
| IP Reference | GB1713166.5 |
| Protection | Patent application published |
| Year Protection Granted | |
| Licensed | No |
| Impact | pending |
| Title | DENTAL TREATMENT |
| Description | A pharmaceutically acceptable small molecule which inhibits GSK-3 activity, such as BIO, CHIR99021 or tideglusib; are used in the repair or regeneration of dentine. Combinations with matrix materials forming dental implants are also described and claimed. |
| IP Reference | WO2018073599 |
| Protection | Patent granted |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | NA |
| Title | Measurement of cardiac first phase ejection fraction |
| Description | detection of early stage heart failure |
| IP Reference | GB1603216.1 |
| Protection | Patent application published |
| Year Protection Granted | |
| Licensed | No |
| Impact | None yet |
| Title | Accelerated 3D 1 mm isotropic T2w-Imaging of the Prostate in less than 3 min |
| Description | T2-weighted imaging is a key contrast in magnetic resonance imaging (MRI) for prostate cancer diagnostics and stratification. Three dimensional (3D), isotropic T2-weighted imaging of the prostate requires a long acquisition time. We have developed a 3D T2-prepared multi- shot bSSFP acquisition with a variable density undersampled trajectory and TV-SENSE reconstruction. We have published results from a healthy volunteer study and demonstrated that 3D 1 mm isotropic resolution T2-weighted images of the prostate can be acquired in 2 min 45 s, with image quality that is comparable to the clinical standard turbo spin echo sequences but only takes 1/3 of the acquisition time. |
| Type | Diagnostic Tool - Imaging |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2018 |
| Development Status | Under active development/distribution |
| Impact | This sequence is currently implemented at the hospital and tested in a pilot patient study. |
| URL | https://www.ismrm.org/18/program_files/Tu03.htm |
| Title | Accelerated 3D and quantitative T2-mapping with dictionary-based matching for prostate cancer imaging |
| Description | Prostate cancer (PCa) is one of the most frequent types of cancer in men. Multiparametric MRI (mpMRI) of the prostate, which consists of the acquisition of 2D T2-weighted (T2w), dif- fusion-weighted and gadolinium-based dynamic contrast- enhanced images, has shown great potential for diagnosis of PCa and has been shown to correlate with pathological Gleason score. Whereas 2D T2w images are evaluated in a qualitative manner, quantitative MRI directly relates the MR signals to quantitative tissue features enabling consistent and reproducible assessment and thus more reliable treatment decisions. However, the scan time is too long. We have developed an imaging approach for 3D quantitative T2 mapping using undersampled acquisition and dictionary-based fitting. We have shown in an initial healthy volunteer pilot study that accurate and rapid 3D T2-mapping of the prostate is feasible in under 3 minutes and can be used in an mpMRI protocol for PCa detection and characterization. |
| Type | Diagnostic Tool - Imaging |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2019 |
| Development Status | Under active development/distribution |
| Impact | We have published results from an initial healthy volunteer pilot study that accurate and rapid 3D T2-mapping of the prostate is feasible in under 3 minutes and can be used in an mpMRI protocol for PCa detection and characterization. We have implemented the sequence on clinical scanners throughout the hospital to acquire pilot patient data towards clinical translation. |
| URL | https://onlinelibrary.wiley.com/doi/10.1002/mrm.27540 |
| Description | Debate at National British Society for Histocompatibility and Immunogenetics meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited speaker at Keynote debate |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.bshi.org.uk/html/bshi_2017.html |
| Description | Frontiers in Transplantation Course |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | workshop facilitator |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | A course for clinicians and scientists interested in translational transplantation research. Attended by more than 80 people in 2014. I was highest rated speaker in 2015 and 2017 Second URL relating to 2013 course: https://www.youtube.com/watch?v=ZlzUAzOj47A Extremely good feedback scores form participants has ensured we will make this an annual event |
| Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015,2016,2017 |
| URL | https://www.youtube.com/watch?v=dRnOEYs9hCQ |
| Description | Give me six hours to chop down a tree ... statistical tools to meet the challenges of modern medical data |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited seminar at the Mayo Clinic (Rochester, USA) |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://nms.kcl.ac.uk/ton.coolen/seminars/Mayo2016.pdf |
| Description | Heterogeneity and competing risks in cancer survival |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | I was invited by the University of Umea in Sweden to give a seminar. |
| Year(s) Of Engagement Activity | 2017 |
| Description | How can we bond and repair carious dentine? |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Keynote presentation at the International Association for Dental Research General Session in San Francisco |
| Year(s) Of Engagement Activity | 2017 |
| Description | Interview |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with a Spanish news agency. The interview later appeared in a national Spanish newspaper and online |
| Year(s) Of Engagement Activity | 2019 |
| Description | Interview for German radio |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interview with a national German radio. |
| Year(s) Of Engagement Activity | 2020 |
| Description | School children engagement |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Engagement activity with school children (6-12 years old) explaining the functions of the Immune System |
| Year(s) Of Engagement Activity | 2019 |
| Description | Systems biomedicine graduate programme |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | An annual series of lectures on a wide variety of biomedical topics, for a multidisciplinary audience of postgraduate students. The aim is to break down barriers between the biomedical and the mathematical/physical sciences, and encourage young scientists to engage in multidisciplinary research. |
| Year(s) Of Engagement Activity | 2012,2013,2014,2015,2016 |
| Description | Theory of overfitting in Cox regression |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Postgraduate students |
| Results and Impact | I was speaking at a conference organised at King's College London. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Theragnostics Annual Update |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Industry/Business |
| Results and Impact | Postgraduate students, postdocs and PIs met at Theragnostics LTD headquarter in Bracknell (February 2018) to discuss outcomes of the KCL/Theragnostics collaborative research. The full day consisted of open debates and powerpoint presentations from various participants. This was the first annual update and it was decided to run the event annually. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Towards a theory of overfitting in proportional hazards regression for survival data |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited research seminar at the Department of Statistics of Columbia University (New York, USA) |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://nms.kcl.ac.uk/ton.coolen/seminars/NYC2016.pdf |
| Description | Undergraduate event talk |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | Presentation in a career-event for undergraduate students from KCL and the Crick Institute |
| Year(s) Of Engagement Activity | 2018 |
| Description | What data bases and statistics do we need? Meeting the challenges of data-driven precision medicine |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Invited talk for the annual meeting of the German Opthamological Society (Berlin) |
| Year(s) Of Engagement Activity | 2016 |
| Description | Workshop lectures Havana |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | International Workshop `Statistical Approaches to Systems Biology' in Havana, for young researchers mainly from Latin America and Europe. I gave a series of lectures on mathematical and statistical topics in survival analysis, and their application to cancer data analytics. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://www.fisica.uh.cu/statphys/ |