University of Birmingham Confidence in Concept
Lead Research Organisation:
University of Birmingham
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
People |
ORCID iD |
Publications
Di Pasquale A
(2020)
Cooperative Multipoint Recognition of Sialic Acid by Benzoboroxole-Based Receptors Bearing Cationic Hydrogen-Bond Donors.
in The Journal of organic chemistry
Elhassan YS
(2019)
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
in Cell reports
Fromont C
(2020)
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
in Journal of medicinal chemistry
Hosie L
(2017)
Cytomegalovirus-Specific T Cells Restricted by HLA-Cw*0702 Increase Markedly with Age and Dominate the CD8+ T-Cell Repertoire in Older People.
in Frontiers in immunology
Rosenthal O
(2019)
Boosting robot-assisted rehabilitation of stroke hemiparesis by individualized selection of upper limb movements - a pilot study.
in Journal of neuroengineering and rehabilitation
Rosenthal O
(2017)
Mapping upper-limb motor performance after stroke - a novel method with utility for individualized motor training
in Journal of NeuroEngineering and Rehabilitation
Simm C
(2018)
Targeting of BRD4 with JQ1, combined with mitomycin C as a novel combination therapy for non-muscle invasive bladder cancer
in European Urology Supplements
Tommasone S
(2020)
Targeting Oligosaccharides and Glycoconjugates Using Superselective Binding Scaffolds.
in Advanced functional materials
| Description | CRUK/16/030 AmpseqUr Amplicon deep sequencing of Urinary DNA for the detection of bladder cancer |
| Amount | £282,155 (GBP) |
| Funding ID | 23590 |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2017 |
| End | 07/2020 |
| Description | DARO |
| Amount | £150,000 (GBP) |
| Organisation | University of Birmingham |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 04/2022 |
| Description | Development and validation of a synthetic sugar recognition technology for prostate cancer risk stratification |
| Amount | £274,945 (GBP) |
| Funding ID | RIA17-ST2-020 |
| Organisation | Prostate Cancer UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 03/2021 |
| Description | Development of an accurate, early diagnostic tool for ovarian cancer |
| Amount | £150,000 (GBP) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 01/2021 |
| End | 06/2022 |
| Description | Identification Of New Adjunctive Treatments For Bladder Cancer |
| Amount | £7,500 (GBP) |
| Organisation | Action Bladder Cancer UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2017 |
| End | 03/2018 |
| Description | Innovate UK- Advanced Therapy Treatment Centres |
| Amount | £7,300,000 (GBP) |
| Organisation | University of Birmingham |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2018 |
| Description | Investigating GPCR:RAMP interactions using nanobodies |
| Amount | £404,022 (GBP) |
| Funding ID | BB/R016615/1 |
| Organisation | Biotechnology and Biological Sciences Research Council (BBSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 05/2022 |
| Description | MRC Confidence in Concept |
| Amount | £97,433 (GBP) |
| Funding ID | CiC 6.1 Lalor |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2019 |
| End | 04/2021 |
| Description | MRC Stratified Medicine Initiative- Minimising mortality in alcoholic hepatitis |
| Amount | £5,000,000 (GBP) |
| Organisation | University of Birmingham |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2017 |
| Description | Wellcome ISSF |
| Amount | £25,000 (GBP) |
| Funding ID | WT ISSF 3 Lalor |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2019 |
| End | 04/2021 |
| Description | Wellcome ISSF |
| Amount | £28,862 (GBP) |
| Funding ID | ISSF3 959744 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 03/2020 |
| End | 02/2021 |
| Description | working with Harwell Diamond light source |
| Organisation | MRC Harwell |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | £57,564 (in kind) of synchrotron beam time (beam line B23) at Diamond has been secured to address academic questions pertaining to the peptides structure and their interaction with collagen. |
| Collaborator Contribution | allowing use of facility |
| Impact | n/a |
| Start Year | 2017 |
| Title | MOLECULAR SENSOR PREPARATIONS AND USES THEREOF |
| Description | The present invention relates to a method of preparing a molecular sensor that is specific for a target molecule having a saccharide or peptide region. The method comprises using the target molecule as a template and incubating the template with a receptor to form a template-receptor complex. A molecular scaffold is formed on a surface around the template-receptor complex such that the receptor and at least a portion of the template are embedded in the scaffold, and the template is removed to produce a cavity defined by the scaffold, such that the cavity is complementary to at least a portion of the saccharide or peptide region of the target molecule. |
| IP Reference | WO2015118294 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2015 |
| Licensed | No |
| Impact | No licence yet, still developing the technology |
| Title | TREATMENT OF ACUTE LIVER FAILURE |
| Description | The present invention relates to the treatment or prophylaxis of acute liver failure. More particularly, the invention relates to use of an agent that modulates the podoplanin pathway, such as by inhibiting an interaction of podoplanin with CLEC-2 or inhibiting the activity of Src and/or Syk family kinases for the treatment or prophylaxis of acute liver failure, as well as a method for determining the efficacy of treatment of acute liver failure. |
| IP Reference | WO2018046877 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | n/a |
| Title | TREATMENT OF CHRONIC INFLAMMATORY DISEASE |
| Description | The present invention relates to the treatment or prevention of a chronic inflammatory disease, condition or related pathology. More particularly, the invention relates to use of an agent that modulates the podoplanin pathway, such as by inhibiting an interaction of podoplanin with CLEC-2 or inhibits the activity of Src and/or Syk family kinases for use in a method of treating and/or preventing a chronic inflammatory disease, condition or related pathology in a subject. |
| IP Reference | WO2018046876 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | n/a |