The MRC Confidence in Concepts at UCL Fund 2015
Lead Research Organisation:
University College London
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
Organisations
People |
ORCID iD |
Publications
Panpisut P
(2016)
Dental Composites with Calcium / Strontium Phosphates and Polylysine.
in PloS one
Fernando O
(2018)
Development of Targeted siRNA Nanocomplexes to Prevent Fibrosis in Experimental Glaucoma Filtration Surgery.
in Molecular therapy : the journal of the American Society of Gene Therapy
Subramaniam S
(2018)
Perinatal Stem Cells
Tagalakis AD
(2018)
In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis.
in Journal of nanobiotechnology
Mazzon M
(2019)
Targeting viral entry as a strategy for broad-spectrum antivirals.
in F1000Research
Mazzon M
(2019)
Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry
in Viruses
Patel N
(2020)
Free urinary glycosylated hydroxylysine as an indicator of altered collagen degradation in the mucopolysaccharidoses.
in Journal of inherited metabolic disease
Yaghmoor RB
(2020)
Effect of Novel Antibacterial Composites on Bacterial Biofilms.
in Journal of functional biomaterials
Lygidakis NN
(2020)
Early Polylysine Release from Dental Composites and Its Effects on Planktonic Streptococcus mutans Growth.
in Journal of functional biomaterials
Doykov ID
(2020)
Rapid, proteomic urine assay for monitoring progressive organ disease in Fabry disease.
in Journal of medical genetics
Delgado A
(2021)
Modelling ATR-FTIR Spectra of Dental Bonding Systems to Investigate Composition and Polymerisation Kinetics
in Materials
Delgado AHS
(2021)
Scoping review of trials evaluating adhesive strategies in pediatric dentistry: where do simplified strategies lie?
in BMC oral health
Jamal H
(2022)
Impact of Dentine Pretreatment with Matrix Metalloproteinase Inhibitors on Bond Strength of Coronal Composite Restorations: A Systematic Review and Meta-analysis of In Vitro Studies.
in European journal of dentistry
Alkhouri N
(2022)
Renewal MI Dental Composite Etch and Seal Properties.
in Materials (Basel, Switzerland)
Yaghmoor RB
(2022)
Incorporation of MMP inhibitors into dental adhesive systems and bond strength of coronal composite restorations: A systematic review and meta-analysis of in vitro studies.
in The Japanese dental science review
Main K
(2023)
Evaluation of modified dental composites as an alternative to Poly(methyl methacrylate) bone cement
in Polymer Bulletin
Singhatanadgit W
(2023)
ICAM-1-mediated osteoblast-T lymphocyte direct interaction increases mineralization through TGF-ß1 suppression
in Journal of Cellular Physiology
| Description | BRC - Anne Young |
| Amount | £59,130 (GBP) |
| Organisation | University College Hospital |
| Sector | Hospitals |
| Country | United Kingdom |
| Start | |
| Description | BRC Feasibility - Heywood |
| Amount | £15,150 (GBP) |
| Organisation | Great Ormond Street Hospital (GOSH) |
| Sector | Hospitals |
| Country | United Kingdom |
| Start | |
| Description | EPSRC First Grant, Matt Clarckson |
| Amount | £99,906 (GBP) |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2016 |
| End | 07/2017 |
| Description | Moorfields Eye Charity, Cynthia Yu-Wai-Man |
| Amount | £82,402 (GBP) |
| Organisation | Moorfields Eye Charity |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2017 |
| End | 12/2017 |
| Description | NIHR Fellowship award, Mahdad Noursadeghi |
| Amount | £1,200,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR Fellowship Programme |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2017 |
| End | 03/2022 |
| Description | NIHR i4i Product Development Award, Matt Clarkson |
| Amount | £1,470,000 (GBP) |
| Organisation | National Institute for Health Research |
| Department | NIHR i4i Invention for Innovation (i4i) Programme |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2021 |
| Description | Newton Fund Fellowship, Anne Young |
| Amount | £108,000 (GBP) |
| Organisation | Newton Fund |
| Sector | Public |
| Country | United Kingdom |
| Start | 05/2017 |
| End | 04/2019 |
| Description | Real-Time Ultrasound Guided Abdominal Interventions Without a Tracking Device |
| Amount | £1,015,268 (GBP) |
| Funding ID | EP/T029404/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 06/2020 |
| End | 06/2023 |
| Description | UCL TAS fund, Sam Janes |
| Amount | £73,057 (GBP) |
| Organisation | University College London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2018 |
| End | 12/2018 |
| Title | CELL DEATH BIOMARKER |
| Description | The invention relates to cell death of cancer cells, and in particular to biomarkers that may be used to identify cancer cells that are sensitive to death receptor ligand (DRL)- induced cell death. The invention also extends to prognostic methods and kits for identifying cancer cells that are sensitive to DRL-induced cell death. The invention further extends to novel compositions and therapeutic methods using such compositions for treating cancer. |
| IP Reference | WO2018051110 |
| Protection | Patent application published |
| Year Protection Granted | 2018 |
| Licensed | No |
| Impact | Still in development |
| Title | Nanoparticles for Cancer Therapy and Diagnosis |
| Description | The present invention relates generally to methods and materials for use in photothermal or sonodynamic therapy. The invention novel nanoparticles for use in delivering sensitizers to solid tumour target, wherein the nanoparticles are composed of a polymers or co-polymer of monomers linked by peptide bonds, wherein the polymer or co-polymer comprises one or both of glutamate or derivatised glutatamic acid, and optionally a further, different, monomer which is a naturally occurring amino acid or synthetic monomer having a side chain group, wherein the polymer or co-polymer is not composed only of glutamate. The pendant groups and/or side chains of the polymer or co-polymer interact non-covalently with the sensitizer. |
| IP Reference | US2020330598 |
| Protection | Patent application published |
| Year Protection Granted | 2020 |
| Licensed | No |
| Impact | In further development |
| Title | ULTRASOUND REGISTRATION |
| Description | A computer implemented method is disclosed for identifying a pose of a probe by registering an ultrasound image from with volumetric scan data. The volumetric scan data is processed (31) to determine simulated ultrasound images corresponding with a plurality of different poses of the probe. A feature vector is extracted (32) from each of the simulated ultrasound images and from the ultrasound image. The feature vector from the ultrasound image is compared (33) with each feature vector of the simulated ultrasound images to determine a distance or similarity for each simulated ultrasound image. At least one candidate image is selected (34), the at least one candidate image comprising a subset of the simulated ultrasound images that best matches the ultrasound image, based on the distance or similarity. The pose of the probe is identified (35) from the at least one candidate image. |
| IP Reference | WO2021019217 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2021 |
| Licensed | No |
| Impact | none as yet, |