Transforming Translational Research at the University of Bristol

Lead Research Organisation: University of Bristol

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

10 25 50
 
Description Innovate UK Investment Accelerator (Julian Paton)
Amount £150,000 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 02/2017 
End 01/2018
 
Description Innovate UK Investment Accelerator (Massimo Antognozzi)
Amount £150,000 (GBP)
Organisation Innovate UK 
Sector Public
Country United Kingdom
Start 01/2018 
End 02/2019
 
Description MRC Proximity to Discovery Market Assessment Award (Cathy Williams)
Amount £7,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 07/2017 
End 08/2017
 
Description NIHR RFPB A new urinary catheter to improve bladder drainage: first-in-human testing of the Flume catheter (Marcus Drake)
Amount £300,000 (GBP)
Funding ID PB-PG-0317-20026 
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 01/2019 
End 01/2020
 
Description Royal Academy of Engineering Fellowship in Soft Robotics (Jonathan Rossiter)
Amount £1,300,000 (GBP)
Organisation Royal Academy of Engineering 
Sector Learned Society
Country United Kingdom
Start 01/2018 
End 01/2028
 
Description Collaboration with Semefab (Jaap Velthuis) 
Organisation Semefab (Scotland) Ltd
Country United Kingdom 
Sector Private 
PI Contribution The academics involved have more than a decade experience in testing sensors, designing readout PCBs and writing firmware, DAQ and analysis software
Collaborator Contribution Semefab will then manufacture several devices for testing. Semefab has 15 years experience of producing sensors for the MEMS market based on thin membranes. These devices are used in very high volumes in industrial, medical and automotive applications. The basis of the technology is the production of membranes of thicknesses down to <5 micron on both silicon and stress compensated dielectrics.
Impact Project not yet complete
Start Year 2017
 
Description MRC Confidence in Concept Collaboration with UCB (Matt Crump) 
Organisation UCB Pharma
Country United Kingdom 
Sector Private 
PI Contribution Leading MRC Confidence in Concept project, "IGF2-TRAP development; preparation for funding applications for a first in man trial"
Collaborator Contribution IGF2-TRAP bulk production
Impact N/A
Start Year 2017
 
Description MRC Confidence in Concept collaboration with Flume Catheter Company (Marcus Drake) 
Organisation Flume Catheter Company Limited
PI Contribution Leading MRC Confidence in Concept project in partnership with the Company
Collaborator Contribution The Flume Catheter Company would in parallel fund the work and filings necessary to secure worldwide IP protection
Impact UK patent application submitted no. 1701027.3; Applied for an NIHR RFPB grant of £1.2M - accepted through to stage 2
Start Year 2017
 
Description Partnership in MRC Confidence in Concept project (Julian Paton) 
Organisation Ceryx Medical Ltd
PI Contribution This proposal will have three major objectives: (i) Tuning of the CPG for biofeedback, (ii) Adapting the silicon-graphite pressure device for connection to the blood vessel with output to the CPG and (iii) Testing the CPG to demonstrate feasibility and efficacy of biofeedback. The current CPG needs to be modified to incorporate biofeedback and integrate this signal to allow activation of one of two outputs. We need to show that activation of the outputs is proportional to the incoming signal in order that set point/homeostasis can be achieved.
Collaborator Contribution Development, optimisation and maintenance of biofeedback CPG and BP monitor.
Impact • Awarded £150,000 from Innovate UK's Investment Accelerator scheme (with £45,000 from IP Group) specifically to undertake development of the Blood Pressure management device that CiC funded • Project partner Ceryx have raised £150K from IP Group via convertible loan (although this is primarily for pacemaking technology)
Start Year 2017
 
Description Partnership with LifeArc 
Organisation LifeArc
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution The in vitro PoC studies will be conducted at the University of Bristol where the applicant, RL, has a strong track record of translation for patient benefit (100% research impact score in their UoB Unit of Assessment for the 2014 REF). This environment is where the in vitro platform development for antibody-drug conjugate evaluation was untaken, and the proposed functional T cell experiments will be performed.
Collaborator Contribution LifeArc will supply the resources, expertise and material to generate the CCR6 antibodies and provide access to their laboratories and generally to assist in the generation of the monoclonal antibody. LifeArc have 17 years' experience in therapeutic antibody development and dedicated laboratories for the generation of monoclonal therapeutic antibodies. They have a variety of robotic systems and assay systems to aid the development and engineering of antibodies and substantial protein chemistry and protein production facilities. LifeArc also have a dedicated antibody-drug conjugate team and X-ray crystallography in place plus a broad spectrum of assays and capabilities to assist in the project if necessary.
Impact Project selected as Bristol's application to Jules Thorne Biomedical Award 2018
Start Year 2017
 
Title Method and Apparatus for Bacterial Analysis (Massimo Antognozzi) 
Description A first aspect of the invention provides an apparatus comprising: a light source arranged to cast light toward a substrate defining a bacteria binding volume to create an evanescent field and the bacteria binding volume is within the evanescent field; a detector arranged to receive light from the bacteria binding volume and output data; and a processor arranged to determine a level of vibration of bacteria within the bacteria binding volume in three-dimensions from the data. 
IP Reference P123064GB 
Protection Patent application published
Year Protection Granted
Licensed No
Impact • Awarded £13,000 Longitude Discovery Prize • £25,000 applied for through clinical partner for more data • Awarded £150,000 Innovate UK Investment Accelerator
 
Title Urinary catheter redesign to reduce complications and improve tolerability 
Description Urinary catheter redesign to reduce complications and improve tolerability 
IP Reference GB1701027.3 
Protection Patent application published
Year Protection Granted
Licensed No
Impact • Successful application for an NIHR RFPB grant of £300k • Project conducted in partnership with SME, Flume Catheter Company