Placing Discovery Science at the heart of Big Data

Lead Research Organisation: University of Birmingham

Abstract

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Technical Summary

Clinical informatics is emerging as a powerful academic discipline and one in which the MRC
has recently invested over £100 million. A national ambition is to develop a network that can
leverage the unique opportunities available from UK science and the NHS to deliver novel
insights for improving health. Meta-analysis of clinical data is already showing considerable
value within healthcare delivery but for the MRC the challenge is to utilize this information for
research and there is an urgent need to place discovery science at the heart of clinical „Big
Data?. Within this application we seek to exploit unique expertise on the Birmingham campus
to address this challenge. Specifically we will utilize our excellence within genomics,
phenomics and immunomics as a platform to develop a series of research programmes
focused on novel interdisciplinary working and close alignment with patient informatics. A
particular focus is to utilize additional opportunities that can arise from the award of the
£7.3M MRC Clinical Research Infrastructure Initiative in 2014 and to place this investment at
the heart of a series of innovative research studies funded by the MRC Discovery Award. The
aim is to deliver a range of interdisciplinary early phase basic research awards which can be
subsequently be developed to support the UK ambition to be an international leader within
the exploitation of clinical data.

Publications

10 25 50

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Caleyachetty R (2017) Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women in Journal of the American College of Cardiology

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Liu Z (2018) Ninety day mortality following pancreatoduodenectomy in England: has the optimum centre volume been identified? in HPB : the official journal of the International Hepato Pancreato Biliary Association

 
Description Health Data Research UK Award
Amount £5,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 06/2018 
End 05/2023
 
Description Rutherford Fellowship
Amount £600,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2018 
End 01/2023
 
Description Study of early immune reconstitution following stem cell transplantation :biological significance and therapeutic opportunities
Amount £298,487 (GBP)
Funding ID 17009 
Organisation Bloodwise 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2019 
End 03/2022
 
Description University Hospitals Birmingham NHS Foundation Trust (UHBFT) 
Organisation University Hospitals Birmingham NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Clinical data that are utilised in this study are obtained from UHBFT who are a key partner.
Collaborator Contribution Data collection and appropriate monitoring are from UHBFT. Our contribution helps to support research outputs.
Impact Work in progress
Start Year 2016