Cambridge Confidence in Concepts: translating pathophysiological insights for patient benefit

Lead Research Organisation: University of Cambridge
Department Name: UNLISTED

Abstract

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

Technical Summary

The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding.  It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.

Publications

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Thackray AM (2021) A new model for sensitive detection of zoonotic prions by PrP transgenic Drosophila. in The Journal of biological chemistry

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Swaddiwudhipong N (2021) Investigating the Electrical Properties of Different Cochlear Implants. in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

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Popescu DM (2019) Decoding human fetal liver haematopoiesis. in Nature

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Lyne AM (2018) A track of the clones: new developments in cellular barcoding. in Experimental hematology

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Jiang C (2021) An Instrumented Cochlea Model for the Evaluation of Cochlear Implant Electrical Stimulus Spread. in IEEE transactions on bio-medical engineering

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Garcia C (2021) The Panoramic ECAP Method: Estimating Patient-Specific Patterns of Current Spread and Neural Health in Cochlear Implant Users. in Journal of the Association for Research in Otolaryngology : JARO

 
Description 4th year extension for Serena Belluschi's PhD Cambridge Cancer Centre fellowship
Amount £24,521 (GBP)
Funding ID RG81381 
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 09/2018 
End 09/2019
 
Description 779822 BioMagMat - Functional magnetic materials for biomedical applications
Amount € 149,997 (EUR)
Funding ID 779822 BioMagMat 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2017 
End 05/2019
 
Description A preclinical PET-CT scanner for advancing dementia research
Amount £150,000 (GBP)
Organisation Alzheimer's Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2018 
End 02/2019
 
Description ACF 25% protected time for clinical trainees for research
Amount £60,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 05/2018 
End 05/2021
 
Description Adaptive Molecular Diagnostics
Amount £750,858 (GBP)
Funding ID 218453/Z/19/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 12/2020 
End 11/2024
 
Description Amendment PhD studentship: Impact of cell & gene therapy on the function and molecular regulation of haematopoietic stem cells
Amount £64,766 (GBP)
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 09/2018 
End 09/2019
 
Description Bioassay of cervid prions in Drosophila
Amount £476,000 (GBP)
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start  
 
Description CRUK small grant
Amount £50,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2017 
End 01/2018
 
Description Cambridge Enterprise Seed Funds: Pathfinder Grant
Amount £20,000 (GBP)
Organisation University of Cambridge 
Department Cambridge Enterprise
Sector Academic/University
Country United Kingdom
Start 09/2017 
 
Description DEVELOPMENT OF A PERSONALISED RISK PREDICTION TOOL TO INFORM TREATMENT SELECTION AND IMPROVE OUTCOMES IN MEN WITH NEWLY DIAGNOSED PRIMARY NON-METASTATIC PROSTATE CANCER
Amount £42,376 (GBP)
Organisation The Evelyn Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2017 
End 01/2018
 
Description DEVELOPMENT OF A PERSONALISED RISK PREDICTION TOOL TO INFORM TREATMENT SELECTION AND IMPROVE OUTCOMES IN MEN WITH NEWLY DIAGNOSED PRIMARY NON-METASTATIC PROSTATE CANCER
Amount £42,376 (GBP)
Organisation The Evelyn Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 02/2017 
End 01/2018
 
Description Detection of blood-borne prions
Amount £1,280,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start  
 
Description EPSRC Project grant
Amount £783,024 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 07/2020 
 
Description Host-TB: Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis
Amount € 2,160,926 (EUR)
Organisation European Research Council (ERC) 
Sector Public
Country Belgium
Start 05/2019 
End 05/2024
 
Description Improving Localisation, Diagnosis and Quantification in Clinical and Medical PET Imaging with Randomised
Amount £1,013,321 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 08/2019 
 
Description Improving outcomes of cochlear implants using an integrated engineering, basic science and clinical research team approach
Amount £167,000 (GBP)
Organisation The Evelyn Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2018 
End 08/2021
 
Description NIH Programme Grant - Detection of blood-borne prions
Amount £1,000,200 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start  
 
Description Platform for next generation of cochlear implants
Amount £187,000 (GBP)
Organisation William Demant Foundation 
Sector Charity/Non Profit
Country Denmark
Start  
 
Description Quantitative Analysis of Clonality in Haematopoiesis - Concepts, methods and potential
Amount £9,073 (GBP)
Funding ID BB/R021465/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 08/2018 
End 10/2018
 
Description Rapid Multi-antigen COVID-19 Point-of-Care Antibody Test from a Pin-Prick Blood Sample
Amount £256,000 (GBP)
Funding ID EP/V043277/1 
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Public
Country United Kingdom
Start 09/2020 
End 04/2022
 
Description Rapid bioassay of cervid prions in PrP transgenic Drosophila: addressing the threat to animal and human health from Chronic Wasting Disease
Amount £475,660 (GBP)
Funding ID BB/T00343X/1 
Organisation Biotechnology and Biological Sciences Research Council (BBSRC) 
Sector Public
Country United Kingdom
Start 01/2020 
End 12/2023
 
Description Serena Belluschi's PhD Cambridge Cancer Centre fellowship
Amount £64,766 (GBP)
Funding ID • RG91305 
Organisation GlaxoSmithKline (GSK) 
Sector Private
Country Global
Start 09/2017 
End 09/2021
 
Description The use of PrP transgenic Drosophila to replace and reduce mice in the bioassay of mammalian prions
Amount £75,608 (GBP)
Funding ID NC/R00093X/1 
Organisation National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) 
Sector Public
Country United Kingdom
Start 11/2017 
End 06/2019
 
Description Wellcome Trust Innovator Award - for further testing the diagnostic system
Amount £750,858 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description cochlear implants
Amount £62,099 (GBP)
Organisation University of Cambridge 
Department Trinity College Cambridge
Sector Academic/University
Country United Kingdom
Start 11/2017 
End 10/2021
 
Description funding for clinician-scientist
Amount £210,000 (GBP)
Organisation Oticon Medical 
Sector Private
Country France
Start  
 
Title A novel split mode TFBAR device for quantitative measurements of prostate specific antigen in a small sample of whole blood 
Description The project brought together research into biomarkers for prostate cancer with the novel FBAR sensing technology with a particular focus on demonstrating operation with whole blood samples for the first time. 
Type Of Material Biological samples 
Year Produced 2020 
Provided To Others? Yes  
Impact But important milestones are completed: 1 and 2 completed. 3 and 4 partially completed as problem with getting PSA isoform antibody, but it has been shown that measurement of total PSA can be performed in whole blood samples without significant preparation with both the sensitivity and selectivity required for clinical applications. This was the key proof of concept that was required 
 
Description Measuring electrical spread outside the cochlea 
Organisation Advanced Bionics Inc. (AB)
Department Advanced Bionics UK
Country United Kingdom 
Sector Private 
PI Contribution We have developed methods to measure electrical potentials in cadavers at sites distant to the cochlea
Collaborator Contribution They have provided several fully functioning electrodes
Impact ongoing
Start Year 2019
 
Company Name Sorex Sensors 
Description Sorex Sensors develops very small sensors designed to detect small masses. 
Year Established 2017 
Impact Sorex Sensors has now produced a stand-alone box of electronics which connects via USB to a computer and an associated app to drive the box. This allows the sensors to be driven without the need for an expensive Network Analyser and LabVIEW. The company has also transferred production of the sensor devices to a foundry.
Website http://sorexsensors.com
 
Company Name Spliceor Therapeutics 
Description Spliceor Therapeutics develops medical therapies, specialising in cancer treatments. 
Year Established 2020 
Impact N/A
 
Company Name Cambridge Medical Innovation Ltd 
Description  
Year Established 2020 
Impact CMI Ltd has been awarded an Innovate UK grant to pilot the technology in NHS Scotland. An NIHR i4i grant application was submitted in December 2020 to cover development and pilot of an integrated platform to enable DigiVis and other digital tests to work within NHS clinician and patient workflows. Cambridge Enterprise has enabled Free of Charge use of DigiVis during the Covid crisis to support remote consultations at CUH and catch up vision screening by CCS.
 
Description A novel split mode TFBAR device for quantitative measurements of prostate specific antigen in a small sample of whole blood 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Appearance on
- BBC Look East
- BBC Breakfast
Year(s) Of Engagement Activity 2020
 
Description Abstract selected for short-talk at Single Cell Biology Conference (Wellcome Sanger Institute) virtual edition. 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Abstract selected for short talk Virtual edition presented by Carys Johnson, PhD Student at the Wellcome Sanger Institute.
Year(s) Of Engagement Activity 2020
 
Description Engaging Public Health for Development and Deployment of Adaptive Molecular Diagnostics 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The test and strategy was presented to the WHO and it was very well received. They wanted speedy progress but that has been stalled due to absence of dedicated funds for the project since the closure of MRC-CiC award.
Year(s) Of Engagement Activity 2018,2019
 
Description Great Ormond Street Hospital Academic Teaching - Activated PI3 kinase Delta Syndrome (APDS): from genetics to therapy and beyond 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact N/A
Year(s) Of Engagement Activity 2021
 
Description Invited Speaker at MRC Centre for Regenerative Medicine, Edinburgh 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Requests for further information
Year(s) Of Engagement Activity 2020
 
Description Invited speaker at Columbia, Genetics and Development Seminar Series, New York 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Invited speaker at Columbia, Genetics and Development Seminar Series, New York, United States. (Virtual seminar) Requests for further information.
Year(s) Of Engagement Activity 2021
 
Description Invited speaker at IBSC virtual seminar, University of Exeter 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Invited speaker at IBSC virtual seminar, University of Exeter - Requests for further information
Year(s) Of Engagement Activity 2012,2021
 
Description Virtual reality can spot navigation problems in early Alzheimer's disease 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Virtual reality (VR) can identify early Alzheimer's disease more accurately than 'gold standard' cognitive tests currently in use, suggests new research from the University of Cambridge.
We've wanted to do this for years, but it's only now that virtual reality technology has evolved to the point that we can readily undertake this research in patients
Year(s) Of Engagement Activity 2019
URL https://www.cam.ac.uk/research/news/virtual-reality-can-spot-navigation-problems-in-early-alzheimers...