ICT Solutions for Real-Time Electronic Monitoring of Antimicrobial Use & Resistance in the One Health Approach
Lead Research Organisation:
Public Health England
Department Name: UNLISTED
Abstract
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Technical Summary
Adopting a ""One Health"" approach, this project will explore information and communication technology (ICT) solutions to create an electronic platform to holistically monitor antimicrobialuse and resistance in real time using ""big data"" from a range of surveillance systems on antimicrobial use and resistance in the human,(food) animal and environmental sectors in the UMgungundlovu district in KwaZulu-Natal, South Africa. The project will compare and contrast different surveillance systems in terms oftechnical feasibility and cost effective delineation of robust,representative surveillance data in addition to creating the electronic platform. The ""big data"" generated from the three sectors will be triangulated by adapting one or more of the open source software solutions: (1) WHONET and (2) ""Suite for Automated Global Electronic bioSurveillance"" (SAGES} which will allow analysis and visualization within and between sectors at district level. The real-time data on phenotypic trends in antimicrobial resistance (AMR) in correlation with antimicrobial use/exposure are expected to:
1. Assess the reliability, representivity and financial and technical feasibility of generating
antimicrobial use and resistance data from:
a. Point prevalence surveys,passive,laboratory-based,sentinel surveillance,and, active,disease-based, comprehensive surveillance in human health,
b. The implementation of integrated,""farm-to-fork"" surveillance in animal health, and,
c. Water-based surveillance systems in environmental health.
2. Allow early identification of emerging/escalating resistance within and between sectors,
3. Establish a database for evidence-based treatment guidelines and associated essential medicines lists for the optimal management of infections in humans and (food) animals,
4. Ascertain whether the surveillance of AMR in human sludge,animal manure-based
fertilizers and water sources could serve as suitable proxies for AMR in human,animal and environmental health using Escherichia coli and Enterococcus spp. as indicator organisms,and,
5. Provide ""information for action"" by the various sectors and their regulatory authorities.
1. Assess the reliability, representivity and financial and technical feasibility of generating
antimicrobial use and resistance data from:
a. Point prevalence surveys,passive,laboratory-based,sentinel surveillance,and, active,disease-based, comprehensive surveillance in human health,
b. The implementation of integrated,""farm-to-fork"" surveillance in animal health, and,
c. Water-based surveillance systems in environmental health.
2. Allow early identification of emerging/escalating resistance within and between sectors,
3. Establish a database for evidence-based treatment guidelines and associated essential medicines lists for the optimal management of infections in humans and (food) animals,
4. Ascertain whether the surveillance of AMR in human sludge,animal manure-based
fertilizers and water sources could serve as suitable proxies for AMR in human,animal and environmental health using Escherichia coli and Enterococcus spp. as indicator organisms,and,
5. Provide ""information for action"" by the various sectors and their regulatory authorities.
Organisations
People |
ORCID iD |
| Description | 1. Essack, S.Y. Antibiotic Resistance and One Health. Presented at the 9th Annual Coalition of Universities for Global Health Conference, New York, USA, March 2018. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 1. Essack, S.Y. Antibiotic Resistance and One Health. Presented at the 9th Annual Coalition of Universities for Global Health Conference, New York, USA, March 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | 2. Essack S.Y., Abia-Akebe, L.K., Amoako, D., McIver, K., Molechan, C., Pillay, S. & Ramtahal, M. Triangulation of Antibiotic Resistance from Humans, the Food Chain and Associated Environments - A One Health Project. Presented at 8th Meeting of the Advisory Group of Integrated Surveillance of Antimicrobial Resistance Utrecht, The Netherlands, November 2018. |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Essack S.Y., Abia-Akebe, L.K., Amoako, D., McIver, K., Molechan, C., Pillay, S. & Ramtahal, M. Triangulation of Antibiotic Resistance from Humans, the Food Chain and Associated Environments - A One Health Project. Presented at 8th Meeting of the Advisory Group of Integrated Surveillance of Antimicrobial Resistance Utrecht, The Netherlands, November 2018. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Guest invited seminar |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Invited guest lecture (1h) delivered by Neil Woodford at the Westville Campus of University of KwaZulu Natal. Global aspects of AMR |
| Year(s) Of Engagement Activity | 2018 |
| Description | Interactive tutorial with research group |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | 2 h interactive session with students from Prof Essack's AMR team, discussing their research. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Site visit to Bruntville Community Health Centre |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I visited Bruntville with Prof Sabiha Essack and members of her team from University of KwaZulu Natal. I spoke for 30 minutes on International aspects of AMR, and Sabiha spoke about the specifics of the project. There was excellent engagement and willingness from the practitioners in this community health centre to participate in our project. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Site visit to Edendale Hospital |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | I visited Edendale with Prof Sabiha Essack and members of her team from University of KwaZulu Natal. I spoke for 30 minutes on International aspects of AMR, and Sabiha spoke about the specifics of the project. There was excellent engagement and willingness from the practitioners in this hospital to participate in our project. |
| Year(s) Of Engagement Activity | 2018 |