Accelerating Translation at UCL – “UCL Confidence in Concept (CiC6) 2017”
Lead Research Organisation:
University College London
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions, to be used flexibly to support the earliest stages of multiple translational research projects. The award can be used by the institution to support a number of preliminary-stage translational projects. The projects supported should aim to provide sufficient preliminary data to establish the viability of an approach –– before seeking more substantive funding. It is intended to accelerate the transition from discovery research to translational development projects by supporting preliminary work or feasibility studies to establish the viability of an approach.
People |
ORCID iD |
Publications
Rau A
(2019)
Implicit domain adaptation with conditional generative adversarial networks for depth prediction in endoscopy.
in International journal of computer assisted radiology and surgery
Everson M
(2019)
Artificial intelligence for the real-time classification of intrapapillary capillary loop patterns in the endoscopic diagnosis of early oesophageal squamous cell carcinoma: A proof-of-concept study.
in United European gastroenterology journal
Campinoti S
(2020)
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds.
in Nature communications
Simitzi C
(2020)
Promotion of Proangiogenic Secretome from Mesenchymal Stromal Cells via Hierarchically Structured Biodegradable Microcarriers.
in Advanced biosystems
Whitehead K
(2020)
Long-range temporal organisation of limb movement kinematics in human neonates.
in Clinical neurophysiology practice
Chiu YJ
(2020)
The Effect of Solvent Vapor Annealing on Drug-Loaded Electrospun Polymer Fibers.
in Pharmaceutics
García-Peraza-Herrera LC
(2020)
Intrapapillary capillary loop classification in magnification endoscopy: open dataset and baseline methodology.
in International journal of computer assisted radiology and surgery
Mackle EC
(2020)
Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning.
in Journal of visualized experiments : JoVE
| Description | A Network Approach to Gene Therapy for Refractory Epilepsies |
| Amount | £2,640,411 (GBP) |
| Funding ID | MR/V034758/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2026 |
| Description | Bowel and Cancer Research -Delivering multimodal treatment in colorectal cancer using sonodynamic therapy in combination with nanotechnology |
| Amount | £50,000 (GBP) |
| Organisation | Bowel & Cancer Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 12/2021 |
| End | 11/2022 |
| Description | Brain injuries acquired during the neonatal period: investigating mechanisms which can correct depressed cortical electrical activity |
| Amount | £298,114 (GBP) |
| Funding ID | 201819-23 |
| Organisation | Brain Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 08/2023 |
| Description | CRUK grant (RadNet) - awarded. A stimulus-responsive formulation for optimising sonodynamic therapy in the treatment of pancreatic cancer |
| Amount | £108,000 (GBP) |
| Organisation | Cancer Research UK |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 07/2022 |
| End | 06/2023 |
| Description | Crick idea to innovation scheme - Bonfanti - Engineered Thymus |
| Amount | £75,000 (GBP) |
| Organisation | Francis Crick Institute |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 01/2023 |
| Description | DTP 2018-19 University College London |
| Amount | £15,585,724 (GBP) |
| Funding ID | EP/R513143/1 |
| Organisation | Engineering and Physical Sciences Research Council (EPSRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2018 |
| End | 09/2023 |
| Description | ERC proof-of-concept - Bonfanti - Engineered Thymus |
| Amount | £135,000 (GBP) |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 01/2023 |
| End | 01/2024 |
| Description | EU SICM - Mervyn Singer - sepsis, membrane cholesterol levels |
| Amount | € 20,000 (EUR) |
| Organisation | European Society of Intensive Care Medicine (ESICM) |
| Sector | Charity/Non Profit |
| Country | Belgium |
| Start | 01/2020 |
| End | 01/2022 |
| Description | Generation of a novel pre-clinical model for the treatment of congenital athymia using a tissue-engineered thymus: Innovate UK Smart grant in partnership with Videregen |
| Amount | £500,000 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 01/2023 |
| Description | Improving cardiac performance and vascular hyporeactivity in sepsis through elevation of membrane cholesterol levels - UCL TF |
| Amount | £250,000 (GBP) |
| Organisation | University College London |
| Department | Technology Fund |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 01/2023 |
| Description | Innovate UK Smart Grant - Bonfanti - thymus engineering |
| Amount | £500,000 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 01/2024 |
| Description | Innovate UK- Laurence Lovatt - Caddie study |
| Amount | £341,320 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2019 |
| End | 04/2020 |
| Description | Innovate UK: RESECT-AI: Reliable Estimations for Safer Endoscopic Cancer Therapy with Artificial Intelligence |
| Amount | £216,505 (GBP) |
| Organisation | Innovate UK |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 01/2023 |
| Description | Medcity C2I ATMPs - Paola Bonfanti - engineered thymus |
| Amount | £178,000 (GBP) |
| Organisation | MedCity |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 01/2023 |
| Description | Medtronic ERP grant ERP-2019-11996 - Robert Brownstone - multimodality imaging |
| Amount | £146,884 (GBP) |
| Organisation | Medtronic |
| Sector | Private |
| Country | United States |
| Start | 01/2020 |
| End | 01/2022 |
| Description | RCP - Student stipend - Nikolitsa Nomikou - sonodynalic therapy in the treatment of pancreatic cancer |
| Amount | £5,000 (GBP) |
| Organisation | Royal College of Physicians of London |
| Sector | Learned Society |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 01/2021 |
| Description | RCS - Student stipend - Nikolitsa Nomikou - sonodynamic therapy in the treatment of pancreatic cancer |
| Amount | £5,000 (GBP) |
| Organisation | Royal College of Surgeons of England |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 01/2021 |
| Description | Sentinell - Mariya Moosajee - PAX6-related aniridia |
| Amount | £15,000 (GBP) |
| Organisation | Sentinel Oncology |
| Sector | Private |
| Country | United Kingdom |
| Start | 05/2020 |
| End | 12/2021 |
| Description | UK Space Agency - Lovatt (Odin Vision) - AI in colonoscopy |
| Amount | £1,000,000 (GBP) |
| Organisation | UK Space Agency |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2019 |
| End | 09/2022 |
| Description | Robert Brownstone: BK Medical Novel multimodality imaging techniques |
| Organisation | BK Medical |
| Country | Denmark |
| Sector | Private |
| PI Contribution | BK Medical supporting and sponsoring future study using research software |
| Collaborator Contribution | BK Medical supporting and sponsoring future study using research software |
| Impact | too early |
| Start Year | 2022 |
| Title | METHODS FOR TISSUE DECELLULARIZATION |
| Description | The present invention provides A method of producing a decellularised extracellular matrix (ECM) scaffold of at least a portion of a lobular organ with no common artery, the method comprising: a) closing afferent blood vessels to substantially seal a target lobular organ or portion thereof with no common and/or major artery within a non-human donor or a dead/brain dead human donor; b) optionally: (i) cleaning coagulum and/or blood from at least a portion of the closed afferent blood vessels; and/or (ii) perfusing the organ or portion thereof to confirm closure of the afferent blood vessels; c) removing the sealed organ or portion thereof from the donor; and d) perfusing the sealed organ or portion thereof with detergent and enzymatic solutions to obtain the decellularised ECM scaffold. Methods for producing an artificial organ, and artificial organs produced by the methods are also provided. |
| IP Reference | WO2019220091 |
| Protection | Patent application published |
| Year Protection Granted | 2019 |
| Licensed | No |
| Impact | Still in development |
| Title | Nanoparticles for Cancer Therapy and Diagnosis |
| Description | The present invention relates generally to methods and materials for use in photothermal or sonodynamic therapy. The invention novel nanoparticles for use in delivering sensitizers to solid tumour target, wherein the nanoparticles are composed of a polymers or co-polymer of monomers linked by peptide bonds, wherein the polymer or co-polymer comprises one or both of glutamate or derivatised glutatamic acid, and optionally a further, different, monomer which is a naturally occurring amino acid or synthetic monomer having a side chain group, wherein the polymer or co-polymer is not composed only of glutamate. The pendant groups and/or side chains of the polymer or co-polymer interact non-covalently with the sensitizer. |
| IP Reference | US2020330598 |
| Protection | Patent application published |
| Year Protection Granted | 2020 |
| Licensed | No |
| Impact | In further development |
| Company Name | Odin Vision |
| Description | Odin Vision, founded by a team of clinicians, medical imaging and artificial intelligence (AI) experts, is developing the next generation of AI enabled applications for endoscopic procedures. We believe that AI will create a new era of healthcare by supporting doctors to deliver higher quality care leading to improved patient outcomes and better value for healthcare payers. |
| Year Established | 2019 |
| Impact | too early (- start-up) |
| Website | https://odin-vision.com/ |