MICA: Application for a Mental Health Data Pathfinder award (Oxford)

Lead Research Organisation: University of Oxford

Abstract

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Technical Summary

Making data findable and interoperable, adding value to existing datasets and enriching data collection from person-centric and patient reported measures represents the most valuable opportunity to accelerate understanding and improved treatment of mental health conditions.
Building on our experience of leading national and international programmes enabling access, interoperability and reuse of data for mental health - including the platform enabling use of Electronic Medical Records for mental health across England (CRIS), the platform for data aggregation for dementia (DPUK) and the pan-European platform to enable data interoperability from cohort and real-world data (EMIF) we propose here a programme of work including
underpinning themes and four indicative projects. These projects will gain from the linkage we propose to establish between routine care data and primary, secondary, schools and cohort data and will use devices to collect data remotely ranging from patient reported outcome measures to cognition, sleep and behaviour. To these enormous volumes of data, including the full mental health medical records from 10k people we have already linked to UK Biobank and the generation of 10k proteomes linked to mental health records, plus the streaming data from connected devices, we will bring advanced analytics from the Mathematics Institute and Natural Language Processing from computer scientists using neural networks. All our work will be enveloped in a governance and ethics stream with patient and public involvement. We leverage more than £40m in existing grant funding plus new cash and in-kind contribution from industry partners of over £12m. The outcome will be an informatics supported platform for experimental
medicine, increased understanding and development of novel therapeutics for depression and a bold drive to determine the relationship between intervention and outcome in mental wellbeing in young people. These themes and proposed projects will work with our proposed partners to establish the preparatory work for a platform for Mental Health Data capitalising on the unique opportunities presented by the NHS, by strengths in mental health research and by outstanding
digital sciences in the UK and in Oxford.

Publications

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