IMPRINT: IMmunising PRegnant women and INfants neTwork
Lead Research Organisation:
London Sch of Hygiene and Trop Medicine
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Industrial Challenge Strategy Fund supplement is designed to bring diverse and flexible pump-priming activities to the Network with additional industrial involvement. This award will provide a support linkage, increasing UK Vaccine R&D activity around ‘proof of concept’ studies and can be used to support academic-industry partnerships and enhance academic and industry researchers' understanding of each other's needs and capabilities. This may be through people exchanges, creation of tecnology demonstrators, showcase events, workshops and pump-priming of grant activities.
Organisations
- London Sch of Hygiene and Trop Medicine, United Kingdom (Collaboration, Lead Research Organisation)
- University of Oxford, United Kingdom (Collaboration)
- University College London, United Kingdom (Collaboration)
- University of Edinburgh, United Kingdom (Collaboration)
- Public Health England, United Kingdom (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- Medical Research Council (Collaboration)
- University of Birmingham, United Kingdom (Collaboration)
- University of Liverpool, United Kingdom (Collaboration)
- PATH (Collaboration)
- University of British Columbia, Canada (Collaboration)
- Boston Children's Hospital (Collaboration)
- University of the Witwatersrand, South Africa (Collaboration)
- National Health Service (Collaboration)
- Johns Hopkins University, United States (Collaboration)
Publications
Le Doare K
(2019)
Serocorrelates of protection against infant group B streptococcus disease.
in The Lancet. Infectious diseases
Rice TF
(2019)
Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy - a prospective, observational cohort study from the United Kingdom.
in Clinical and experimental immunology
Wilcox CR
(2018)
Beyond Passive Immunity: Is There Priming of the Fetal Immune System Following Vaccination in Pregnancy and What Are the Potential Clinical Implications?
in Frontiers in immunology
| Title | Videos about IMPRINT - our passion, global network, our innovative approach and impact on the life of mothers and infants |
| Description | We taped videos during our IMPRINT full network meeting (for more details, please refer to the Engagement activity section). We let two people have conversations on why they joined the network, the benefits of our network, our innovative approach and the impact on the life of mothers and infants. the half an hour interviews/conversations were cut together to approx one minute clips and are presented on our website. We aim to show our passion for our network, why it is important and why more people should join. |
| Type Of Art | Film/Video/Animation |
| Year Produced | 2018 |
| Impact | After the meeting, we received new membership applications and feedback from the meeting participants that the videos caught perfectly the spirit of the network. |
| URL | http://www.imprint-network.co.uk |
| Description | Advisory Board Maternal Immunisation |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Influenced training of practitioners or researchers |
| Impact | Via setting up immunisation services in antenatal clinics we have improved uptake |
| Description | The Advancing Maternal Immunization collaboration (AMI) analysis report on respiratory syncytial virus (RSV) maternal immunization |
| Geographic Reach | Multiple continents/international |
| Policy Influence Type | Participation in a advisory committee |
| Impact | Beate Kampmann, our IMPRINT network PI, and Naor Bar-Zeev, our challenge 6 co-lead, joined 58 other individuals across 25 organizations in 14 countries to publish the AMI gap analysis report on respiratory syncytial virus (RSV) maternal immunization . The Advancing Maternal Immunization collaboration (AMI), coordinated by PATH in collaboration with the WHO, brings together diverse stakeholders from around the world and across immunization and maternal, newborn, and child health programs to identify a pathway to enable informed decision-making and introduction of maternal RSV vaccines, particularly in LMICs, and to provide tools to help decision-makers, implementers, researchers, and others navigate that pathway successfully. |
| URL | https://www.path.org/resources/advancing-rsv-maternal-immunization-gap-analysis-report/ |
| Description | British Columbia University |
| Organisation | University of British Columbia |
| Department | Department of Pediatrics |
| Country | Canada |
| Sector | Academic/University |
| PI Contribution | provided support for field sample collections and vaccinations, plus laboratory facilities |
| Collaborator Contribution | access to protocols |
| Impact | publication, presentation at international meeting, visibility |
| Start Year | 2014 |
| Description | Collaboration with MRC/GCRF funded International Veterinary Vaccinology Network, University of Edinburgh, UK |
| Organisation | University of Edinburgh |
| Department | The Roslin Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details). |
| Collaborator Contribution | The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details). |
| Impact | Joint meeting attendance. Exchange of knowledge on reporting to funders and administrative matters. |
| Start Year | 2017 |
| Description | Collaboration with MRC/GCRF funded network Hic-Vac, Imperial College, UK |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | the MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details). |
| Collaborator Contribution | the MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details). |
| Impact | Joint meetings and exchange of knowledge on reporting and administrative issues. |
| Start Year | 2017 |
| Description | Collaboration with the MRC/GCRF funded network BactiVac, University of Birmingham, UK |
| Organisation | University of Birmingham |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details). |
| Collaborator Contribution | The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details). |
| Impact | Joint meeting attendance. Exchange of knowledge on reporting to funders and administrative matters. |
| Start Year | 2017 |
| Description | Collaboration with the MRC/GCRF funded network Validate , University of Oxford, UK |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details). |
| Collaborator Contribution | The MRC/GCRF funded sister "Networks in Vaccine R&D" Hic-Vac, BactiVac, IntVetVacc, Validate and IMPRINT support each other by exchange of knowledge, administrative issues, the network PIs supporting network meeting by presenting their own networks and joint presentation of the networks during the BSI meeting 2017 (please refer to Engagement activities for more details). |
| Impact | Joint meeting attendance, exchange of knowledge on reporting to funders and administrative matters. |
| Start Year | 2017 |
| Description | Harvard Levy lab |
| Organisation | Boston Children's Hospital |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | exchange of staff and technology |
| Collaborator Contribution | contributed research samples |
| Impact | publication by Burl et al |
| Start Year | 2010 |
| Description | Harvard Levy lab |
| Organisation | University College London |
| Department | Institute of Child Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | exchange of staff and technology |
| Collaborator Contribution | contributed research samples |
| Impact | publication by Burl et al |
| Start Year | 2010 |
| Description | ICH London Goldblatt lab |
| Organisation | University College London |
| Department | Institute of Child Health |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | scientific exchange re pneumococcal immunisation policies, practice and research, sharing of reagents and assay development |
| Collaborator Contribution | scientific exchange re pneumococcal immunisation policies, practice and research, sharing of reagents and assay development |
| Impact | 1 shared PhD studentship, scientific workshop at MRC The Gambia input into senior appointments |
| Start Year | 2012 |
| Description | Imperial College London, UK; Dr Holder |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Dr Holder is member of our network Steering Committee |
| Collaborator Contribution | Dr. Beth Holder is a Lecturer in Maternal and Fetal Health in the Institute of Reproductive Biology (IRDB) and our IMPRINT challenge 1 "Mechanism of production and transfer of maternal antibody via the placenta and breast milk" co-lead. She supports the network with her expertise. |
| Impact | IMPRINT joint events (e.g. London Midwifery Festival, please refer to the section Engagement Activities) and publications. MatImms App for pregnant women (please refer to Engagement Activities). |
| Start Year | 2017 |
| Description | Johns Hopkins Bloomberg School of Public Health, USA; Dr Bar-Zeev |
| Organisation | Johns Hopkins University |
| Department | Johns Hopkins Bloomberg School of Public Health |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Narr Bar-Zeev is one of our IMPRINT Steering Committee members |
| Collaborator Contribution | Dr Naor Bar-Zeev is a pediatric infectious diseases physician and statistical epidemiologist. His research interest is in understanding how to maximise the benefit of existing and future vaccines in low-resourced high mortality settings, how best to protect vulnerable groups like newborns and pregnant women and how to optimise methods to evaluate vaccine impact and effectiveness. He is part of our IMPRINT Steering Committee and challenge 6 "Development of comparable methodologies for assessing efficacy in clinical trials" co-lead. |
| Impact | Joint IMPRINT events. |
| Start Year | 2017 |
| Description | Levy Lab |
| Organisation | Boston Children's Hospital |
| Department | Levy Laboratory |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | set up of systems vaccinology research for studies of EPI vaccines |
| Collaborator Contribution | bioinformatics support |
| Impact | several publications and a grant submission to the nIH |
| Start Year | 2014 |
| Description | London School of Hygiene and Tropical Medicine and the Vaccine Confidence Project, UK, Prof. Larson |
| Organisation | London School of Hygiene and Tropical Medicine (LSHTM) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Heidi Larson is a member of our IMPRINT Steering Committee. |
| Collaborator Contribution | Prof. Heidi J. Larson is an anthropologist and Director of The Vaccine Confidence Project™ (VCP); Professor of Anthropology, Risk and Decision Science, Dept. Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine; Clinical Professor, Institute of Health Metrics & Evaluation, University of Washington; and Chatham House Centre on Global Health Security Fellow. She is a member of our IMPRINT Steering Committee and one of our challenge 4 "Vaccine acceptancy and preparedness for maternal immunisation, including in emergencies" co-leads. IMPRINT is featured as a partner on the vaccine confidence.org website (please refer to Engagement activities for more details). |
| Impact | Joint IMPRINT events. |
| Start Year | 2017 |
| Description | MRC Unit The Gambia |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Unit, The Gambia |
| Country | Gambia |
| Sector | Public |
| PI Contribution | cross-fertilisation between nIHR funding and my role at the MRC Unit in The Gambia, where I hold a TB related program grant |
| Collaborator Contribution | program grant on childhood TB embedded within the MRC Unit |
| Impact | several publications and program grant award |
| Start Year | 2010 |
| Description | National Health Services, UK; Dr Mehring-Le Doare |
| Organisation | National Health Service |
| PI Contribution | Dr Kirsty Mehring-le Doare is one of our IMPRINT Steering Committee members. |
| Collaborator Contribution | Dr Mehring is consultant in Paediatric Infectious Diseases and Immunology, CSAC Training Advisor (PIID). She also functions as one of our IMPRINT Steering Committee members and co-lead of our challenge "Mechanism of production and transfer of maternal antibody via the placenta and breast milk". |
| Impact | Joint IMPRINT events and publications. |
| Start Year | 2017 |
| Description | Oxford Vaccine Group |
| Organisation | University of Oxford |
| Department | Oxford Vaccine Group |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | mutual engagement in Vaccinology research |
| Collaborator Contribution | joint supervision of PhD student |
| Impact | new collaboration |
| Start Year | 2014 |
| Description | PATH |
| Organisation | PATH |
| Country | Global |
| Sector | Private |
| PI Contribution | Path vaccine roadmap work |
| Collaborator Contribution | scientific advice |
| Impact | funding |
| Start Year | 2016 |
| Description | Public Health England |
| Organisation | Public Health England |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | a database was developed by my team, funded from the NIHR award, to capture household contacts, which is now used by PHE as the contact tracing module within the national TB notifications |
| Collaborator Contribution | PHE supported the database developer who was based at Colindale during the time of database development |
| Impact | is now used by PHE as the contact tracing module within the national TB notifications |
| Start Year | 2010 |
| Description | University of Liverpool, Prof. French |
| Organisation | University of Liverpool |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Neil French is member of our IMPRINT Steering Committee |
| Collaborator Contribution | Neil French is Professor of Infectious Diseases and Global Health and Hon Consultant Infectious Diseases Royal Liverpool & Broadgreen University Hospitals Trust. He is a member of our IMPRINT Steering Committee and challenge 6 "Development of comparable methodologies for assessing efficacy in clinical trials" co-lead. |
| Impact | Joint IMPRINT events and publications. |
| Start Year | 2017 |
| Description | University of Oxford, UK; Dr Drakesmith |
| Organisation | University of Oxford |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Alexander Drakesmith is member of our IMPRINT Steering Committee |
| Collaborator Contribution | Dr Drakesmith´s lab is at the Weatherall Institute of Molecular of Medicine where he studies the role of iron in infectious diseases and the immune response. He is member of our IMPRINT Steering Committee and challenge 3 "Impact of globally important co-factors on maternal and neonatal immunity" co-lead. |
| Impact | Joint IMPRINT events. |
| Start Year | 2017 |
| Description | University of the Witwatersrand, South Africa; Dr Clare Cutland |
| Organisation | University of the Witwatersrand |
| Department | Respiratory And Meningeal Pathogens Unit |
| Country | South Africa |
| Sector | Academic/University |
| PI Contribution | Clare Cutland is one of our network Executive Committee members. |
| Collaborator Contribution | Dr. Clare Cutland is the Deputy Director at the Respiratory and Meningeal Pathogens Research Unit (RMPRU) based at Chris Hani Baragwanath Academic Hospital (CHBAH), Soweto, South Africa. She has been a sub-investigator/ senior doctor on numerous phase I, II and III paediatric vaccine trials and principal investigator on a phase II paediatric measles vaccine trial and a phase III quadrivalent influenza vaccine trial in children. She is part of our IMPRINT Steering committee group and co-lead of our challenge "Vaccine Safety and Monitorgin in LMIC". |
| Impact | Joint events related to IMPRINT. Publications are currently in preparation. |
| Start Year | 2017 |
| Description | Blog feature MatIMMS project, Patient Experience Research Center Imperial College London |
| Form Of Engagement Activity | Engagement focused website, blog or social media channel |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | The MatImms project consists of a multi-disciplinary research team of midwives, doctors and scientists that investigates vaccination in pregnancy. The project is led by Prof. Beate Kampmann. MatImms encourages vaccination in pregnancy to protect newborn babies from preventable infections. In the laboratory, MatImms studies the impact of vaccines on immunity in mothers and babies. In order to connect with pregnant women, the MatImms Smartphone App has been developed to improve vaccine information available, enabling pregnant women and their support networks to make informed choices. Our challenge 1 co-lead Beth Holder co-developed the App and its contents. IMPRINT is mentioned on the blog news. |
| Year(s) Of Engagement Activity | 2019 |
| URL | http://wwwf.imperial.ac.uk/blog/perc/2019/02/11/case-study-15-matimms-involve-women-in-research-addr... |
| Description | Impact Science Report 2018 |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | IMPRINT was featured in the latest Impact Science Report. Our network PIs Beate Kampmann and Chrissie Jones talked about the "value of vaccination in pregnancy". They discussed our innovative and game-changing network activities as well as the network´s long-term global impact. Our IMPRINT fellow Alansana Darboe is also featured and shares how the IMPRINT fellowship will foster his research career. The article aimed at increasing our visibility and attract new members. |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://impact.pub/December2018-2digitaledition/ |
| Description | RE:Action 2017, Magazin of the University of Southampton |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | Chrissie Jones and IMPRINT were featured in the The RE:Action Magazine of the University of Southampton, Re:action is the University of Southampton's bi-annual Research and Enterprise newsletter offering insight into public policy related research conducted at the University as well as public engagement and business activities. the article aimed to increase our visibility and attract potential new members to the network. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://e.issuu.com/anonymous-embed.html?u=university_of_southampton&d=web_version_reaction_magazine... |