Accelerating translational research through Cardiff University’s Clinical Innovation pipeline
Lead Research Organisation:
Cardiff University
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.
People |
ORCID iD |
Publications
Elvers K
(2021)
Structures of the Human SPAK and OSR1 Conserved C -Terminal (CCT) Domains**
in ChemBioChem
Collaborative Group On Duodenal Polyposis In MAP
(2021)
Duodenal Adenomas and Cancer in MUTYH-associated Polyposis: An International Cohort Study.
in Gastroenterology
| Description | Development of an oral drug delivery platform |
| Amount | £20,000 (GBP) |
| Organisation | Higher Education Innovation Funding (HEIF) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2020 |
| End | 08/2020 |
| Description | BIA Pulse 2021 |
| Organisation | BioIndustry Association |
| Country | United Kingdom |
| Sector | Charity/Non Profit |
| PI Contribution | Dr. Foley has been invited to participate in BIA Pulse 2021 in March, a leadership and entrepreneurship training programme developed by the BIA and the Francis Crick Institute. |
| Collaborator Contribution | The programme is for aspiring entrepreneurs and new CEOs looking for advanced practical advice, support and feedback from leading entrepreneurs, renowned professionals and CEOs. |
| Impact | ongoing |
| Start Year | 2021 |
| Description | Collaboration Agreement |
| Organisation | Cellesce Ltd |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Collaboration agreement between Cellesce Ltd and Cardiff University for scale up and commercial use of organoids. |
| Collaborator Contribution | Collaboration agreement between Cellesce Ltd and Cardiff University for scale up and commercial use of organoids. Cellesce are continuing to provide their knowledge and expertise in organoid culture. |
| Impact | Permanent academic lectureship post for original PI, Dr Laura Thomas at Swansea university. |
| Start Year | 2020 |
| Description | Commitment for future collaboration |
| Organisation | PTC Therapeutics |
| Country | United States |
| Sector | Private |
| PI Contribution | This study used a novel model of disease (the first FAP associated duodenal tumours). It also focused on a novel approach to treatment, a genetically targeted therapy for a specific disease mechanism (nonsense mediated FAP). |
| Collaborator Contribution | Written support from PTC Therapeutics (developer and marketing authorisation holder for ataluren) for studies trialling ataluren in FAP. |
| Impact | Written support from PTC Therapeutics (developer and marketing authorisation holder for ataluren) for studies trialling ataluren in FAP. |
| Start Year | 2020 |
| Description | University of Manchester Discovery and Development of SPAK and OSR1 Kinase Inhibitors as Novel Treatments for Ischemic Strokes |
| Organisation | University of Manchester |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Discovery and Development of SPAK and OSR1 Kinase Inhibitors as Novel Treatments for Ischemic Strokes |
| Collaborator Contribution | Discovery and Development of SPAK and OSR1 Kinase Inhibitors as Novel Treatments for Ischemic Strokes |
| Impact | N/A |
| Start Year | 2022 |