The Innovative Targets Portfolio: Basic Life Sciences Research to Novel Therapies, through a Portfolio of Small Molecule Translational Projects
Lead Research Organisation:
University of Dundee
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.
People |
ORCID iD |
Publications
Armstrong LA
(2021)
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.
in PloS one
Barker S
(2021)
Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species.
in PloS one
Pearson LA
(2021)
Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry.
in SLAS discovery : advancing life sciences R & D
| Description | Fellowship |
| Amount | £1,500,000 (GBP) |
| Organisation | UK Dementia Research Institute |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 02/2020 |
| End | 01/2025 |
| Description | Human PPM1H activators for the treatment of Parkinson's Disease |
| Amount | $290,000 (USD) |
| Organisation | Michael J Fox Foundation |
| Sector | Charity/Non Profit |
| Country | United States |
| Start | 08/2019 |
| End | 07/2020 |
| Description | Pro-senescence therapies for basal-like breast cancer: A novel therapeutic innov |
| Amount | £242,221 (GBP) |
| Funding ID | MGU0537 |
| Organisation | Barts Charity |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2020 |
| End | 10/2023 |
| Description | Proof of concept award |
| Amount | £50,000 (GBP) |
| Organisation | Queen Mary University of London |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 12/2021 |
| Description | Wellcoem Investigator award - Cowling |
| Amount | £1,300,000 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2020 |
| End | 12/2024 |
| Description | Collaboration with Beactica |
| Organisation | Beactica |
| Country | Sweden |
| Sector | Private |
| PI Contribution | We have contributed platform technology and detailed knowledge of the target and associated chemical matter |
| Collaborator Contribution | Beactica have contributed key biophysical expertise that is enabling for the projects concerned |
| Impact | Multi-disciplinary - chemistry, biology, biophysical and computational methods |
| Start Year | 2021 |