Advancing early stage healthcare research in Sheffield
Lead Research Organisation:
University of Sheffield
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding
People |
ORCID iD |
Publications
Varney AM
(2021)
Transcriptomic Analysis of the Activity and Mechanism of Action of a Ruthenium(II)-Based Antimicrobial That Induces Minimal Evolution of Pathogen Resistance.
in ACS pharmacology & translational science
Abdulqader T
(2021)
Respiration Measurement in a Simulated Setting Incorporating the Internet of Things
in Technologies
| Description | Long-term consequences of silencing pain pathways with novel Botulinum constructs. |
| Amount | £560,318 (GBP) |
| Funding ID | MR/S025847/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2019 |
| End | 09/2022 |
| Description | MRC Confidence in Concept Sheffield Consortium |
| Organisation | Sheffield Children's Hospital |
| Country | United Kingdom |
| Sector | Hospitals |
| PI Contribution | Sheffield provides an excellent translational environment for healthcare research with close collaboration between scientists and clinicians at the University of Sheffield, Sheffield Hallam University, Sheffield Teaching Hospitals NHS Foundation Trust and Sheffield Children's NHS Foundation Trust. The University of Sheffield leads the established Sheffield consortium application to the MRC Confidence in Confidence scheme. The receipt of MRC CiC monies in 2016-2018 has facilitated new collaborations in common areas of research including neuroscience, pain, infection control and medical technologies and all partners involved in projects contributed either financially or in-kind. There is continued strong demand across the partners for funds to accelerate the development of early stage healthcare projects. The Sheffield CiC consortium has established robust and successful processes using external industry experts to rapidly distribute funding and support translation of projects into impact. |
| Collaborator Contribution | Institutional contributions to add value to the funding provided: Reflecting the importance of the MRC CiC scheme to Sheffield, financial contributions to a CiC award was made by TUOS (£80K) and SHU (£30K). Both NHS Foundation Trusts also contribute financially or in-kind up to 10% of the cost of their research activity to projects that they are involved in. TUOS maintains overall administrative responsibility for any potential award, utilises the good practice established in previous CiC rounds and provides significant operational support, overseeing CiC processes, IP arrangements, eligibility, partner contributions, reporting etc which are all captured by formal agreement. This CiC support is augmented by University of Sheffield Knowledge Exchange Commercialisation business managers, many of whom are funded by the Higher Education and Innovation Fund. Our partner institutions similarly support projects they lead on. |
| Impact | All as the full ResearchFish return for this award. |
| Start Year | 2014 |
| Description | MRC Confidence in Concept Sheffield Consortium |
| Organisation | Sheffield Hallam University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Sheffield provides an excellent translational environment for healthcare research with close collaboration between scientists and clinicians at the University of Sheffield, Sheffield Hallam University, Sheffield Teaching Hospitals NHS Foundation Trust and Sheffield Children's NHS Foundation Trust. The University of Sheffield leads the established Sheffield consortium application to the MRC Confidence in Confidence scheme. The receipt of MRC CiC monies in 2016-2018 has facilitated new collaborations in common areas of research including neuroscience, pain, infection control and medical technologies and all partners involved in projects contributed either financially or in-kind. There is continued strong demand across the partners for funds to accelerate the development of early stage healthcare projects. The Sheffield CiC consortium has established robust and successful processes using external industry experts to rapidly distribute funding and support translation of projects into impact. |
| Collaborator Contribution | Institutional contributions to add value to the funding provided: Reflecting the importance of the MRC CiC scheme to Sheffield, financial contributions to a CiC award was made by TUOS (£80K) and SHU (£30K). Both NHS Foundation Trusts also contribute financially or in-kind up to 10% of the cost of their research activity to projects that they are involved in. TUOS maintains overall administrative responsibility for any potential award, utilises the good practice established in previous CiC rounds and provides significant operational support, overseeing CiC processes, IP arrangements, eligibility, partner contributions, reporting etc which are all captured by formal agreement. This CiC support is augmented by University of Sheffield Knowledge Exchange Commercialisation business managers, many of whom are funded by the Higher Education and Innovation Fund. Our partner institutions similarly support projects they lead on. |
| Impact | All as the full ResearchFish return for this award. |
| Start Year | 2014 |
| Description | MRC Confidence in Concept Sheffield Consortium |
| Organisation | Sheffield Teaching Hospitals NHS Foundation Trust |
| Country | United Kingdom |
| Sector | Public |
| PI Contribution | Sheffield provides an excellent translational environment for healthcare research with close collaboration between scientists and clinicians at the University of Sheffield, Sheffield Hallam University, Sheffield Teaching Hospitals NHS Foundation Trust and Sheffield Children's NHS Foundation Trust. The University of Sheffield leads the established Sheffield consortium application to the MRC Confidence in Confidence scheme. The receipt of MRC CiC monies in 2016-2018 has facilitated new collaborations in common areas of research including neuroscience, pain, infection control and medical technologies and all partners involved in projects contributed either financially or in-kind. There is continued strong demand across the partners for funds to accelerate the development of early stage healthcare projects. The Sheffield CiC consortium has established robust and successful processes using external industry experts to rapidly distribute funding and support translation of projects into impact. |
| Collaborator Contribution | Institutional contributions to add value to the funding provided: Reflecting the importance of the MRC CiC scheme to Sheffield, financial contributions to a CiC award was made by TUOS (£80K) and SHU (£30K). Both NHS Foundation Trusts also contribute financially or in-kind up to 10% of the cost of their research activity to projects that they are involved in. TUOS maintains overall administrative responsibility for any potential award, utilises the good practice established in previous CiC rounds and provides significant operational support, overseeing CiC processes, IP arrangements, eligibility, partner contributions, reporting etc which are all captured by formal agreement. This CiC support is augmented by University of Sheffield Knowledge Exchange Commercialisation business managers, many of whom are funded by the Higher Education and Innovation Fund. Our partner institutions similarly support projects they lead on. |
| Impact | All as the full ResearchFish return for this award. |
| Start Year | 2014 |
| Title | ANTIMICROBIAL AGENT |
| Description | A compound according to formula (I) or formula (la), and a composition comprising the compound for use as an antimicrobial: wherein, X1, X2, X3 and X4 are each independently selected from: N, O, S; Y1 and Y2 are each independently selected from: N, O, S, C(Ra); M1 and M2 are each a metal centre; R1, R2, R3, R4 and Ra are each independently selected from: hydrogen, alkyl, alkenyl, aryl, halogen, haloalkyl, haloalkenyl, haloaryl, hydroxy, alkoxy, carboxylic acid, amino, amido, nitro or combination thereof; A1, A2, A3 and A4 are each bidentate ligands; and rings D1 and D2 are each independently comprise one or more heteroatoms selected from N, O, S, C(Ra); wherein said compound is for use as an antimicrobial. |
| IP Reference | WO2020201754 |
| Protection | Patent granted |
| Year Protection Granted | 2020 |
| Licensed | Commercial In Confidence |
| Impact | Commercial In Confidence |
| Title | BONDED NEUROTOXINS |
| Description | The present invention provides novel neurotoxins and compositions comprising the same. The neurotoxins are useful in therapy, particularly for preventing, regulating or reducing neuropathic pain or sweating. Methods and kits for producing the neurotoxins are also provided. |
| IP Reference | WO2021105664 |
| Protection | Patent granted |
| Year Protection Granted | 2021 |
| Licensed | Commercial In Confidence |
| Impact | Commercial In Confidence |
| Company Name | NEURESTA INC |
| Description | Commercial In Confidence |
| Year Established | 2020 |
| Impact | Commercial In Confidence |
| Company Name | METALLOBIO LIMITED |
| Description | Commercial in Confidence |
| Year Established | 2021 |
| Impact | Commercial in Confidence |
| Website | https://www.metallobio.com/ |
| Description | Channel 4 News - Lower Limb |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The project sought to develop interactive Virtual Reality play scenarios for children post-surgery to reduce anxiety and pain when performing physiotherapy exercises with a view to building a prototype VR system for scale-up and clinical demonstration. Channel 4 News ran a piece about the study, highlighting the benefits to patients of using the technology in practice. The video was released on YouTube, available at the address below. The news coverage highlighted the importance and impact of the work to the general public, which is being upscaled through, for example, UKRI funding applications and discussions with potential commercial partners. |
| Year(s) Of Engagement Activity | 2020,2021 |
| URL | https://www.youtube.com/watch?v=30zBDXcBt0Q |