The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource

Lead Research Organisation: University of Bristol

Abstract

Between April 1991 and December 1992 we enrolled >14000 pregnant women in ALSPAC resulting in 14062 live births. Mothers, fathers, children and now children of the children from this recruitment have been followed up at multiple timepoints and a wide variety of samples, exposure and outcome measures collected.
Our mission is to ensure ALSPAC remains the premier multi-generational birth cohort offering unrivalled access to data and samples. We will look after the existing samples and data, improve visibility and access to the existing resource, maximise the connection of administrative data and continue collecting new data and samples.
Maintaining such a valuable UK resource will enable research uniquely equipped to follow changes in health and well-being across the lifespan, what affects this, how certain factors work across generations, and how changes in society affect the health and well-being of families going through similar events 30 years apart."

Technical Summary

ALSPAC is a multi-generation (G0/G1/G2), prospective cohort based in the UK [1-4] (supplementary information, Figure 1). This proposal seeks support to:
- Maintain the existing samples and data resources.
- Enhance visibility and access to data and samples.
- Maximise linkage opportunities through broad and innovative use of administrative records.
- Expand the resource by maximising recruitment and retention, and collecting new data and
samples on original parents (G0), index participants (G1) and the next generation (G2).
Work will be delivered via an efficient operational and governance infrastructure. We will deploy a combination of face-to-face assessment, biosample collection and analysis, remote data collection and administrative record linkage where the value of this activity is substantially enhanced by existing resources. All proposed work has been designed according to the overarching principles of (i) scientific utility and (ii) engagement/recruitment/retention. Study activities draw on experience from previous ALSPAC activity and consultation with participants and academics through bespoke workshops. Scientific focus reflects ALSPAC strengths and our target science areas, namely: The antecedents of cardiometabolic/cognitive/mental health, cross-generation contributions to health and era specific contributions to health, well-being and society."

Organisations

Publications

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Zhu X (2021) Factors influencing peak bone mass gain. in Frontiers of medicine

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Yilmaz Z (2019) Developmental Premorbid Body Mass Index Trajectories of Adolescents With Eating Disorders in a Longitudinal Population Cohort. in Journal of the American Academy of Child and Adolescent Psychiatry

 
Description A longitudinal study of gambling in late adolescence and early adulthood: Follow-up assessment at 24 years
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact This report describes a longitudinal study of young peoples' gambling between 17 and 24 years, using a contemporary UK cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). The aims of the ALSPAC Gambling Study were to describe gambling behaviour in youth aged 17-24 years, investigate the antecedents of regular and problem gambling, and explore the associations with other addictive behaviours and mental health.
URL https://www.begambleaware.org/media/2058/alspac-gambling-study_-report-for-gamble-aware_-july-2019.p...
 
Description COVID-19 mental health and wellbeing surveillance report (series)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://www.gov.uk/government/publications/covid-19-mental-health-and-wellbeing-surveillance-report/...
 
Description HDRUK - regular updates for SAGE, National Core Studies & UKRI/DHSC (ALSPAC have contribute to 7 of these)
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
URL https://www.hdruk.ac.uk/wp-content/uploads/2021/02/2021-02-23-Health-Data-Research-UK-SAGE-report.pd...
 
Description Internet use and suicide
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
Impact Work has highlighted the importance of internet use for understanding the architecture of suicidal behaviour. It has been specifically supported by a Department of Health Policy Research Programme and an ESRC Impact Accelerator Account and has already fed into the All Party Parliamentary Group (APPG) on suicide, the APPG on Social Media and Young People's Mental Health, a report by the House of Commons Health Select Committee on Suicide Prevention https://publications.parliament.uk/pa/cm201617/cmselect/cmhealth/1087/1087.pdf, a Royal College of Psychiatrist Patient Safety report and reviews of industry practice (e.g. advising YouTube).
 
Description Maternal depression increases generation on generation.
Geographic Reach National 
Policy Influence Type Citation in other policy documents
Impact Pearson RM, et al. Prevalence of Prenatal Depression Symptoms Among 2 Generations of Pregnant Mothers. JAMA Network Open 2018, 1:e180725 KEY IMPACT - The findings have had global media attention including live tv and radio and the results have been commented on by the Royal College of Midwives and the Maternal Mental Health Alliance. The work is new and has not yet delivered measurable policy change, but highlights the need for increased support for young pregnant women in the current enviro-socio-economic climate. The research has already supported national campaigns to facilitate universal screening for depression (and anxiety) by midwives, for the prioritisation of pregnant women for free psychological therapies and for provision of specialist perinatal mental health community mental health teams across the UK.
 
Description Maternal iodine status in early pregnancy
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
Impact Sarah Bath - University of Surrey- able to look back in time to maternal iodine status in early pregnancy so that we could explore the relationship with child cognition. Using ALSPAC was cost-effective as cognitive measures were available in the child, and samples were available from the mother which we could use for the measurement of maternal iodine status. ALSPAC, unlike many other biobanks had urine samples from very early in pregnancy - which was the time that we were interested in. Iodine and thyroid hormones are required from conception and during the first half of pregnancy the mother is the sole source of thyroid hormone and so adequate iodine is critical; we therefore wanted to measure iodine status as early as possible. ALSPAC also had dietary information, via the food frequency questionnaire completed in pregnancy, which we have been able to use in our follow-on project (EUthyroid - a Horizon 2020 project). Published our research paper in the Lancet in May 2013. Work cited as an example in Medical Research Council document "Outputs, outcomes and impact of MRC research: 2013/14 report". Publication of a fact sheet on iodine for the general public/health practitioners via the British Dietetic Association. Iodine now included in fact sheets for pregnant women by the Infant and Toddler Forum. Work cited in Dairy Council's new publication on iodine. Work cited in iodine review by the Scientific Advisory Committee on Nutrition (gov). Work cited by EFSA in document on Dietary Reference Value for iodine: European Food Safety Authority (2014) Scientific Opinion on Dietary Reference Values for iodine. EFSA Journal 12, 3660. Paper featured in NICE "Eyes on Evidence" February 2014. Further grant funding for follow-on project: European Commission Horizon 2020 EUthyroid: towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europe. Grant agreement No 634453
 
Description Participation in Department for Education's Childrenofthe2020s Cohort Technical Advisory Group
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description Quick findings on age distributions of grandparents and parents of primary school aged children - .gov (asset - Centre for Ageing and Demography)
Geographic Reach National 
Policy Influence Type Citation in other policy documents
URL https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/8934...
 
Description Where's the daddy? Fathers and father-figures in UK datasets - The Fatherhood Institute
Geographic Reach National 
Policy Influence Type Citation in systematic reviews
Impact Review aims - Firstly, for funders and providers of large-scale quantitative datasets, a documentation of questions and fieldwork practices which enable researchers to identify specific categories of fathers and collect data directly from fathers. Secondly, for researchers planning secondary analyses to study fathers, an assessment of whether different categories of fathers can be identified in the data. ALSPAC forms a key part of the evidence contained within this review.
 
Description (LONGITOOLS) - Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases
Amount € 11,997,449 (EUR)
Funding ID 874739 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 01/2020 
End 12/2024
 
Description A Recall by Genotype Study to investigate the role of common TRPA1 variants on acute pain perception
Amount £39,813 (GBP)
Organisation University Hospitals Bristol NHS Foundation Trust 
Department Above and Beyond Grants
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 11/2021
 
Description A UK underpinning platform to study immunology and immunopathology of COVID-19:The UK Coronavirus Immunology Consortium
Amount £6,552,119 (GBP)
Funding ID MR/V028448/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2020 
End 08/2021
 
Description Accumulative processes in health inequalities: the socioeconomic causes and consequences of mental and physical health comorbidity in adolescence
Amount £229,631 (GBP)
Funding ID ES/T013923/1 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 11/2020 
End 01/2023
 
Description COVID-19 Longitudinal Health and Wellbeing - National Core Study (LWH-NCS)
Amount £9,862,000 (GBP)
Funding ID MC_PC_20030 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 10/2020 
End 03/2021
 
Description COVID-19 Questionnaire support
Amount £6,598 (GBP)
Organisation University of Bristol 
Sector Academic/University
Country United Kingdom
Start 04/2020 
End 07/2020
 
Description Defining 'clinically actionable' genetic mechanisms in atopic eczema risk and resolution
Amount £2,258,810 (GBP)
Funding ID 220875/Z/20/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 11/2020 
End 10/2025
 
Description Development and evaluation of a pathway from 'universal screening' to online intervention for children with anxiety problems
Amount £2,547,794 (GBP)
Funding ID RP-PG-0218-20010 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 07/2019 
End 06/2024
 
Description Emotional dysregulation, self-harm and eating disorders: a mechanistic investigation
Amount £251,713 (GBP)
Funding ID MR/S020292/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 09/2019 
End 09/2021
 
Description Investigating five large population-based cohort studies to understand for the precursors of multimorbidity risk.
Amount £74,159 (GBP)
Funding ID MR/V004905/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2020 
End 02/2021
 
Description Molecular Genetic and Lifecourse Epidemiology
Amount £5,153,712 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 09/2021 
End 09/2025
 
Description Religious belief, health and disease: a family perspective
Amount £7,986,970 (GBP)
Organisation The John Templeton Foundation 
Sector Academic/University
Country United States
Start 09/2021 
End 08/2026
 
Description Research into the longer term effects of COVID-19 in non-hospitalised individuals
Amount £9,593,946 (GBP)
Funding ID COV-LT-0009 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 04/2021 
End 04/2024
 
Description The long term impact of COVID-19 on mental health: comparisons between health record linkage and observed longitudinal data
Amount £11,020 (GBP)
Funding ID R105121-249 
Organisation University of Bristol 
Department Elizabeth Blackwell Institute for Health Research
Sector Academic/University
Country United Kingdom
Start 09/2020 
End 08/2021
 
Description TwinsUK (2019-2023) - An Epidemiological and Genomic Resource
Amount £3,000,000 (GBP)
Funding ID 212904/Z/18/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2019 
End 06/2022
 
Description Understanding the mechanisms linking cities to psychotic experiences across the lifespan
Amount £300,000 (GBP)
Funding ID 218632/Z/19/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2020 
End 04/2024
 
Description Wellcome Longitudinal Population Study COVID-19 Steering Group and Secretariat
Amount £120,585 (GBP)
Funding ID 221574/Z/20/Z 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 07/2020 
End 07/2021
 
Title ALSPAC Biosamples and DNA resources 
Description Over 1.2 million aliquots biosamples taken at various timepoints from ALSPAC participants. The bioresource is available to the scientific community for research. Although the resource was initiated in 1991 it is an active collection with new samples being collected and made available constantly. 
Type Of Material Biological samples 
Provided To Others? Yes  
Impact Samples have been made available for numerous ALSPAC projects. The resource received the UK Biobank of the Year award in 2018 reflecting the impact of studies utalising the samples. 
URL http://www.bristol.ac.uk/alspac/researchers/our-data/biological-resources/
 
Title Deep freeze of ALSPAC datasets 
Description A regular snapshot of our current data is now backed up annually off site. This is in addition to central IT regular back up systems 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? No  
Impact Imperative for disaster recovery 
 
Title Development of ALSPAC Explore 
Description ALSPAC Explore is our public facing data catalogue. This is a component of the Obiba Open Source project suite and is hosted by University of Bristol IT services. 
Type Of Material Improvements to research infrastructure 
Year Produced 2021 
Provided To Others? Yes  
Impact Ultimately this tool will improve the discoverability and accessibility of ALSPAC data. The tool has been launched internally and is undergoing testing for external researchers to use as their primary tool for identifying ALSPAC variables. 
URL https://alspac-explore.bristol.ac.uk/mica-web/
 
Title Development of online consent procedures 
Description In order to facilitate virtual clinics the systems team have successfully tested and implemented the collection of online consent for remote measures. 
Type Of Material Improvements to research infrastructure 
Year Produced 2020 
Provided To Others? No  
Impact Consent is vital for all 'face to face' measures we would normally collect. As we have moved to remote data collection the method for obtaining consent has had to change. 
 
Title MRI images data pipeline 
Description Streamlined release of re-indexed MRI images on request. 
Type Of Material Improvements to research infrastructure 
Year Produced 2020 
Provided To Others? Yes  
Impact Data note listed below details the data available through the pipeline. This has resulted in reduced cost recovery charges for this data. 
URL https://wellcomeopenresearch.org/articles/5-203
 
Title Wellcome LPS COVID Questionnaire bank 
Description The ALSPAC team has led the development of the Wellcome funded Longitudinal Population Studies COVID questionnaire bank. This facilitates comparable research across longitudinal studies. Together with Generation Scotland, ALSPAC form the secretariat for the Wellcome LPS COVID group. ALSPAC has provided the questionnaire in REDCap format on demand 
Type Of Material Improvements to research infrastructure 
Year Produced 2020 
Provided To Others? Yes  
Impact The questionnaire bank facilitates research across multiple studies about the COVID pandemic. The questions were designed to help researchers explore changes using the same validated questions to the lives of cohort participants the UK and elsewhere. 
URL https://www.bristol.ac.uk/alspac/researchers/wellcome-covid-19/
 
Title ARIES-Explorer 
Description ARIES-Explorer provides an openly accessible web interface to explore epigenome-wide methylation data from the Accessible Resource for Integrated Epigenomics Studies 
Type Of Material Database/Collection of data 
Year Produced 2013 
Provided To Others? Yes  
Impact Cited in a key review in the field (Mill et al, Nature Reviews Genetics, VOLUME 14 | AUGUST 2013 | 585). 419 unique visitors to the site in its first month of operation. 
URL http://ariesepigenomics.org.uk/ariesexplorer
 
Title COVID Questionnaire 1 G0 and G1 dataset 
Description Dataset containing Q1 results for G1 and G0 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Contribution to our understanding of the impact of the pandemic, particularly mental health 
URL https://wellcomeopenresearch.org/articles/5-127
 
Title COVID Questionnaire 3 and serology results on G0 and G1 
Description Dataset containing Q3 results and results for home antibody testing for G1 and G0 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Contribution to our understanding of the impact of the pandemic, based for identifying cases for further study on recuperation and longevity of infection. A data note has just been submitted to Wellcome Open 
 
Title COVID questionnaire 2 G0 and G1 dataset 
Description Dataset containing Q2 results for G1 and G0 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Contribution to our understanding of the impact of the pandemic, particularly mental health 
URL https://wellcomeopenresearch.org/articles/5-210
 
Title Datasets containing indices of Multiple Deprivation (IMD) and other geocoded measures 
Description IMD data has been linked to multiple time points, both on an annual basis (e.g., January 2008, Jan 2009, Jan 2010, etc.), as well as at the time point each child-based ALSPAC questionnaire or clinic was completed/conducted. This has been released all mother and child based data collections 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Data to enable research using geocoded SES measures 
 
Title Linkage to ALSPAC participants Twitter Social Media Posts 
Description ALSPAC have linked to participants social media posts held on the Twitter Platform. These posts have been downloaded to ALSPAC servers where they have been processed and used with Natural Language Processing algorithms to generate derived variables relating to Mental Health status (e.g. mood, anxiety, depression) and COVID-19 status. These derived variables are now informing applied research projects and will be accessible through the ALSPAC resource. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact This dataset is now informing applied research investigations. 
 
Title Linkage to Avon & Wiltshire Partnership Community Mental Health Care records 
Description Linkage to the regional, detailed, community mental health care records of ALSPAC G1 index participants through collaboration with NHS AWP Trust and UK CRIS (University of Oxford). 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Supporting a research programme and new funding looking at Mental Health during COVID-19 Pandemic: Linking observed mental health data with record linkage in ALSPAC (ALSPAC Ref: B3602), PI: Alex Kwong, University of Edinburgh. URL: https://proposals.epi.bristol.ac.uk/?q=node/130189 
URL https://www.bristol.ac.uk/alspac/researchers/our-data/linkage/
 
Title Parents' Questionnaire 2018 - Your children and grandchildren; Dataset from questionnaire completed by G0 Mothers 
Description Data collected from the 'Your children and grandchildren' Questionnaire. Infrastructure funded by this award and supplemented with external funding. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Data collected enabling ongoing research into: child behaviour, personality, communication skills, and attention/activity 
 
Title UK10K - population based whole genome sequencing 
Description This is the collection of raw data and results from the UK10K study. By studying and comparing the DNA of 4,000 people whose physical characteristics are well documented, the project aims to identify those changes that have no discernible effect and those that may be linked to a particular disease; by studying the changes within protein-coding areas of DNA that tell the body how to make proteins of 6,000 people with extreme health problems and comparing them with the first group, it is hoped to find only those changes in DNA that are responsible for the particular health problems observed. 
Type Of Material Database/Collection of data 
Year Produced 2012 
Provided To Others? Yes  
Impact This work has been published: Nature. 2015 Oct 1;526(7571):82-90. doi: 10.1038/nature14962. Epub 2015 Sep 14. The UK10K project identifies rare variants in health and disease. UK10K Consortium, Walter K, Min JL, Huang J, Crooks L, Memari Y, McCarthy S, Perry JR, Xu C, Futema M, Lawson D, Iotchkova V, Schiffels S, Hendricks AE,Danecek P, Li R, Floyd J, Wain LV, Barroso I, Humphries SE, Hurles ME, Zeggini E, Barrett JC, Plagnol V, Richards JB, Greenwood CM, Timpson NJ, Durbin R,Soranzo N. 
URL http://www.uk10k.org
 
Title Update to Focusing on You Fathers Questionnaire; Dataset from questionnaire completed by G0 fathers/partners 
Description Data collected from the 'Focusing on You Fathers' Questionnaire. Infrastructure funded by this award and supplemented with external funding. Substantial update with the addition of 483 cases to the dataset. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Data collected enabling ongoing research into: - Home life, neighbourhood, friends and family, employment and finances, mental and physical health, physical activity, gambling behaviour, smoking and alcohol consumption 
 
Title Update to Life@25+; Dataset from questionnaire completed by G1 
Description Data collected at from the 25 year Questionnaire. Infrastructure funded by this award and supplemented with external funding. 
Type Of Material Database/Collection of data 
Year Produced 2020 
Provided To Others? Yes  
Impact Data enabling ongoing research into mental health, personality, behaviour, life events, Eating behaviours & food preferences. Updates: Section B - Strengths and Difficulties; Section C - Anxiety; Question D4 - ADHD medications; Section E - Behaviour; Questions F1 to F7 - Depression and self-harm; Section H - Personality; Section K - Life at Home; and the Friend/Partner Questionnaire 
URL https://alspac-explore.bristol.ac.uk/mica-web/mica/collected-dataset/ype
 
Description 3D whole body scans, B3495 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description A Consolidator Grant to Study the Developmental Trajectories of Physical and Mental Health Multimorbidity in Genetic High-Risk C (B3439) 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description A Negative Control Analysis Investigating Maternal Smoking, Alcohol consumption and BMI on Molar-Incisor Hypomineralisation, B3679 
Organisation University Hospitals Bristol NHS Foundation Trust
Country United Kingdom 
Sector Hospitals 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2021
 
Description A UK underpinning platform to study immunology and immunopathology of COVID-19: The UK Coronavirus Immunology Consortium, B3547 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description A robust micro-assay to determine the prevalence of COVID-19 antibodies in the general population using capillary sample collect, B3508 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description ALSPAC (University of Bristol) - Twins UK (KCL) collaboration on developing linkage methodologies 
Organisation St Thomas' Hospital
Department Twins Research Cohorts from St Thomas' Hospital
Country United Kingdom 
Sector Academic/University 
PI Contribution ALSPAC are providing strategic support to develop the TwinsUK record linkage programme based on the established and generalisable approaches developed by the 'PEARL' record linkage team. ALSPAC are specifically 1) supporting the development of the TwinsUK governance approvals based on the precedents of ALSPAC approaches; 2) supporting the development of the TwinsUK data access requests based on the precedents of ALSPAC approaches; 3) will lead the programme to secure GP assent to release copies of patients primary care records to the studies & to develop the technical mechanisms by which this will occur with practice software companies. Further to this, ALSPAC and TwinsUK will collaborate on development of aligned data processing and infrastructure and documentation/discovery developments.
Collaborator Contribution Regular working meetings to develop policy and materials and to share insights.
Impact In December 2019 TwinsUK received a conditional approval from the HRA Confidentiality Advisory Group to access identifiable patient information without explicit patient consent. This was based on ALSPAC's existing approvals.
Start Year 2019
 
Description ALSPAC families (B3370) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description ALSPAC linkage team collaboration with Dr Beng Choon-Ho, University of Iowa Carver College of Medicine. 
Organisation University of Iowa
Department Carver College of Medicine
Country United States 
Sector Academic/University 
PI Contribution The ALSPAC Data Linkage Team are collaborating with Dr Choon-Ho to develop funding applications to support research investigating the neurobiological mechanisms in Adolescent Marijuana Exposure and subsequent Schizophrenia Risk. This will reuse MRI data collected by ALSPAC and Collaborators Professor David and Professor Linden, it will also utilise new data management infrastructure developed by the ALSPAC MRC MH Pathfinder award.
Collaborator Contribution Contributing expertise to grant applications led by Dr Choo-Ho.
Impact 1) Grant application to NIHR (Not supported) "Adolescent Impulsivity, Reward Brain Networks & Schizophrenia Risk" 2) Grant application to NIHR (in progress) "Neurobiological Mechanisms in Adolescent Marijuana Exposure and Schizophrenia Risk"
Start Year 2019
 
Description ALSPAC response to COVID-19 pandemic, B3487 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Acceptability to participants of novel data linkages, ethical issues, and the practicalities of obtaining consent: Evidence from (B3406) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Adolescent anxiety and depressive symptoms and subsequent intimate partner violence: the impact of mental health support, B3654 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Adolescent insufficient sleep: epigenetic changes and the risk of developing AUD and neuropsychiatric comorbidities, B3641 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Adult peak Circulatory capacity; Mechanisms and Exposures (ACME), B3502 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Air pollution and childhood asthma: potential role of common allergies as mediators, B3632 
Organisation Bradford Institute for Health Research (BIHR)
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Air pollution exposure and childhood obesity, B3647 
Organisation Barcelona Institute for Global Health
Country Spain 
Sector Multiple 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Alcohol 18 to 30, B3507 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Alcohol use in the late 20's, B3501 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description An individual participant data meta-analysis examining the associations between mode of delivery and respiratory outcomes, B3689 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description An investigation of the environmental effect of parental genotypes on offspring behavioural problems (B3389) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Analysing the association between inflammation and scoliosis in a population-based birth cohort's a proof of concept study (B3404) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Analyst and writing group member for the MAGIC 'Trans-ethnic meta-analysis and fine-mapping for fasting glucose, fasting insulin, 2hr glucose and HbA1c using data imputed to the 1000 Genomes reference panel 
Organisation MAGIC (The Meta-Analyses of Glucose and Insulin-related traits Consortium)
Country Global 
Sector Charity/Non Profit 
PI Contribution I have contributed results from the analysis of ALSPAC (Avon Longitudinal Study of Parents and Children) data to the meta-analysis. I have acted as a central analyst which has involved conducting quality control checks and reformatting of data contributed by other analysts. I have a led a side project looking at the variance explained by new markers for glycaemic traits. I have contributed to the drafting of the manuscript that will hopefully be submitted shortly.
Collaborator Contribution The other investigators in the collaboration have also contributed results from analyses run within their own cohorts and similarly although variable contributed to side projects and manuscript writing.
Impact A manuscript is in progress but not yet published.
Start Year 2014
 
Description Anorexia and subsequent smoking: cause or correlation (B3355) 
Organisation University of Bristol
Department School for Policy Studies
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Anxiety and mood disorders in young people: a multivariate approach using the ALSPAC cohort, B3464 
Organisation University of Birmingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Are knee DXA biomarkers related to lower limb biomechanics and gait in women with and without knee osteoarthritis?, B3472 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Assessing the contribution of polygenic risk to pediatric lipid levels and longitudinal trends, B3595 
Organisation Stanford University
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Assessment of lung function decline in young adults; identifying and characterising early expressions of COPD (B3400) 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Association between childhood trauma, cognitive styles and depression, B3533 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Association between maternal thyroid dysfunction during pregnancy and thyroid dysfunction in offspring, B3609 
Organisation Hong Kong Polytechnic University
Country Hong Kong 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Association of Maternal education with DNA-methylation (B3431) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Association of maternal hypothyroidism with bone health in offspring, B3611 
Organisation Hong Kong Polytechnic University
Country Hong Kong 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Association of maternal thyroid dysfunction with cardiometabolic traits in offspring, B3617 
Organisation Hong Kong Polytechnic University
Country Hong Kong 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Associations between eating behaviours and body mass index in the ALSPAC cohort at 25, B3483 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Associations between experience of sexual violence, birth experience and perinatal mental health outcomes (B3401) 
Organisation University of Leeds
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Associations between physical activity, risk of alcohol-related harm in adolescence: cross-sectional and longitudinal analysis, B3556 
Organisation University of Hull
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Associations between sedentary time and physical activity with arterial function and structure from childhood to adulthood, B3622 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Associations of COVID-19 Risk Perceptions with Mental Health, Wellbeing, and Risk Behaviours, B3579 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Asthma and COVID-19, B3554 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description At the intersection of autism and psychosis: An investigation of causal pathways, developmental trajectories and phenotypic outc, B3477 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Atopic dermatitis, filaggrin null mutations and COVID-119, B3535 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Big data for reproductive health and wellbeing (B3379) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Birth mode impact on social behavior, B3653 
Organisation University of Delaware
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Body muscle and metabolism in middle age, B3498 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Bradford Institute for Health Research and the Born in Bradford Study 
Organisation Bradford Institute for Health Research (BIHR)
Department Born in Bradford
Country United Kingdom 
Sector Public 
PI Contribution Strategic alignment.
Collaborator Contribution Strategic alignment.
Impact na
Start Year 2012
 
Description Brain signatures of adolescent depression and depression risk (B3421) 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Bristol Health Intelligence Partnership 
Organisation NHS South, Central and West Commissioning Support Unit
Country United Kingdom 
Sector Public 
PI Contribution ALSPAC with NIHR Arc West are collaborating with the NHS South, Central West Commissioning Support Unit (NHS SCW CSU) to identify the governance and technical pathways to integrate ALSPAC data into regional health and social care data managed within the Bristol, North Somerset and South Gloucestershire Commissioning Support Unit. The objective is enable applied health research with feedback loops into local NHS care provisioning.
Collaborator Contribution NHS SCW CSU have provided governance and technical expertise to help inform the governance structure and methodologies needed to realise this objective.
Impact The insights from this have been distilled into a 'Blueprint' technical report.
Start Year 2019
 
Description Broad Antisocial Behavior Consortium (BroadABC) - meta-analysis of antisocial phenotypes (B3351) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description CLOSER Data Linkage Network 
Organisation Bradford Institute for Health Research (BIHR)
Department Born in Bradford
Country United Kingdom 
Sector Public 
PI Contribution CLOSER have established a Data Linkage working group for data managers and governance leads. The aim of the working group is to share insights into best practice, discuss emerging opportunities, to share useful materials (precedents, software scripts, data processing protocols) and to work together to help address shared barriers. The working group comprises representatives of the eight CLOSER studies and (to date) the collaborative partners listed above. The need for the group was identified at the 'Preparing for the Future' longitudinal research conference held in 2018.
Collaborator Contribution Contributing insights, precedents and examples of good practice. Knowledge exchange.
Impact 1. Promotion of CLOSER/NHS Digital work led to the Centre for Longitudinal studies changing their approach to onward sharing arrangements with NHS Digital and leading to a successful ammendment to their data sharing contracts. 2. Established contact with the Department for Education to discuss linkage to the Longitudinal Educational Outcome (LEO) dataset. This is furthering understanding of how a linkage arrangements can be designed and implemented.
Start Year 2019
 
Description CLOSER Data Linkage Network 
Organisation Million Women Study
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution CLOSER have established a Data Linkage working group for data managers and governance leads. The aim of the working group is to share insights into best practice, discuss emerging opportunities, to share useful materials (precedents, software scripts, data processing protocols) and to work together to help address shared barriers. The working group comprises representatives of the eight CLOSER studies and (to date) the collaborative partners listed above. The need for the group was identified at the 'Preparing for the Future' longitudinal research conference held in 2018.
Collaborator Contribution Contributing insights, precedents and examples of good practice. Knowledge exchange.
Impact 1. Promotion of CLOSER/NHS Digital work led to the Centre for Longitudinal studies changing their approach to onward sharing arrangements with NHS Digital and leading to a successful ammendment to their data sharing contracts. 2. Established contact with the Department for Education to discuss linkage to the Longitudinal Educational Outcome (LEO) dataset. This is furthering understanding of how a linkage arrangements can be designed and implemented.
Start Year 2019
 
Description CLOSER Data Linkage Network 
Organisation St Thomas' Hospital
Department Twins Research Cohorts from St Thomas' Hospital
Country United Kingdom 
Sector Academic/University 
PI Contribution CLOSER have established a Data Linkage working group for data managers and governance leads. The aim of the working group is to share insights into best practice, discuss emerging opportunities, to share useful materials (precedents, software scripts, data processing protocols) and to work together to help address shared barriers. The working group comprises representatives of the eight CLOSER studies and (to date) the collaborative partners listed above. The need for the group was identified at the 'Preparing for the Future' longitudinal research conference held in 2018.
Collaborator Contribution Contributing insights, precedents and examples of good practice. Knowledge exchange.
Impact 1. Promotion of CLOSER/NHS Digital work led to the Centre for Longitudinal studies changing their approach to onward sharing arrangements with NHS Digital and leading to a successful ammendment to their data sharing contracts. 2. Established contact with the Department for Education to discuss linkage to the Longitudinal Educational Outcome (LEO) dataset. This is furthering understanding of how a linkage arrangements can be designed and implemented.
Start Year 2019
 
Description COVID-19- Pregnancy, Cardiometabolic health and selection bias, B3543 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Cardiorespiratory fitness, adiposity, and lean mass in relation to arterial structure and function from childhood to adulthood, B3455 
Organisation University of Eastern Finland
Country Finland 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Causes of Chronic Pain in ALSPAC, B3574 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Cell type-specific DNA methylation meta-analysis for ADHD symptoms, B3639 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Changes in metabolomic measures attributable to body composition during puberty and young adulthood (B3372) 
Organisation Leiden University
Country Netherlands 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Changing causes and consequences of underweight, overweight, and obesity: a historical comparison of the UK and Norway, 1984-202 (B3441) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Characterisation, determinants, mechanisms and consequences of long COVID - providing the evidence base for health care services, B3666 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Characterising the ALSPAC mothers who are also UKBiobank participants (B3423) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Characterising trajectories and transitions in tobacco, nicotine and cannabinoid use, and their relationship to mental health, B3499 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Childcare attendance and age of introductions on respiratory infections, allergy and asthma, B3674 
Organisation Telethon Kids Institute
Country Australia 
Sector Charity/Non Profit 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Children's daycare attendance and trajectories of emotional and behavioural symptoms, B3628 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Chronic Airway Diseases Early Stratification (CADSET) (B3446) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Clinical Director Designate/ Clinical Co-Director West of England Clinical Research Network 
Organisation National Institute for Health Research
Department NIHR Clinical Research Network (CRN)
Country United Kingdom 
Sector Academic/University 
PI Contribution ALSPAC provides important opportunities for NIHR CRN to contribute to clinically relevant research at a population level. Working with the clinical director of CRN West ALSPAC is able to optimise a contribution to clinical research and to make this viable through support.
Collaborator Contribution The CRN West of England will work with ALSPAC to include studies in the NIHR CRN Portfolio. Inclusion in the portfolio will ensure that studies are supported in their delivery by the CRN West of England clinical research infrastructure in Bristol and across the West of England, including use of the CRN's network of research-active GP practices. Portfolio inclusion will also ensure that the important work of ALSPAC is recognised by the Department of Health and Social Care in regional measures of success in Clinical Research. Support costs funding allocation received: 23/11/2018 Contingency Funding 2018-19 £8,092 21/01/2019 Contingency Funding 2018-19 £9,500 01/04/2019 2019-2020 allocation £32,651
Impact na
Start Year 2018
 
Description Cognitive ability measures in ALSPAC @ 30 clinic (B3420) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Collaboration with Stephen O'Rahilly and his team at the Wellcome-MRC Institute of Metabolic Science at the University of Cambridge. 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution As part of a wider collaboration to understand the rare genetics of adiposity, we have been working closely with Stephen's group to firstly identify, functionally characterise and describe the downstream adiposity effects of rare genetic variants in the MC4R and MC3R gene regions within the ALSPAC cohort study.
Collaborator Contribution Stephen's group sequenced the MC4R and MC3R gene regions of ~6000 randomly selected ALSPAC participants, of which we have lead the downstream analyses to characterise the relationships between adiposity and related traits.
Impact Two papers have come from this (one that's been accepted in Nature Medicine and one that has been resubmitted to Nature)
Start Year 2019
 
Description Collaboration with the Fatherhood Institute 
Organisation Fatherhood Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Focused research on men and fathers represents a target area for ALSPAC and also a challenge. With little research in this area and the rates of study interaction lower for Men, this collaboration provides focus and an opportunity to expand in this area with the Fatherhood Institute.
Collaborator Contribution The Fatherhood Institute is focused on the gathering of best evidence and research around the role of fathers in the family (and more broadly) and the impact of life course events on the health of fathers. An important relationship between ALSPAC and the Fatherhood Institute has been initiated in order to seek all possible routes to engage with and attract fathers (and men more generally) into the study.
Impact na
Start Year 2018
 
Description Computational approaches to modelling parent -infant behavioural data, B3646 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Consortium Against Pain InEquality (CAPE) - The impact of adverse childhood experiences on chronic pain & responses to treatment, B3678 
Organisation University of Aberdeen
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Correlating whooping cough susceptibility and pertussis vaccine immune responses through HLA diversity (B3362) 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Curating UK COVID-19 diagnostics data to catalyse research and innovation 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution The UK has rich, globally important COVID-19 datasets, including large serology cohort studies funded by UKRI, Wellcome, DHSC/NHS, NIHR and the devolved administrations. However, this breadth of data creates a risk of fragmentation, inconsistent structure and access processes, severely limiting utility, timeliness and impact. "CoCONNECT" is a collaboration looking to transform UK COVID-19 diagnostic datasets to be Findable, Accessible, Interoperable and Reusable (FAIR) and couple this with expert data engineering, enabled by Health Data Research (HDR) UK, to catalyse responsible and trustworthy use of the data for research and innovation. This collaborative work is looking to support the visibility and utility of COVID-19 specific data and resources - such as that contained within ALSPAC. This longitudinal linkage is vital to derive new scientific insights and deliver informed decisions about how best to control the spread of SARS-CoV-2. This follows the realisation in 2020 that there were >30 independent studies with no streamlined approach to linkage to other health and non-health related datasets, lack of data standardisation, and no strategic approach to synthesise analyses across studies.
Collaborator Contribution The key contribution here is two-fold. Firstly the development and implementation of standard data description approaches to ALSPAC COVID-19 data and resources. Secondly, there is the completion of aligned approaches for ALSPAC re. HDRUK Alliance membership and Gateway display. This is a key development which is - at this time - based on COVID-19 data, but which will go on to be relevant for ALSPAC data made accessible through the HDRUK Gateway.
Impact NA
Start Year 2020
 
Description Curating UK COVID-19 diagnostics data to catalyse research and innovation, B3634 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description DNA methylation indices of cancer risk factors, B3660 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description DNA methylation signatures of aggressive behavior (B3405) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description DPUK and Cambridge Cognition data collection (cognition) as part of remote data collection (ALSPAC) and DPUK 
Organisation Cambridge Cognition Ltd
Country United Kingdom 
Sector Private 
PI Contribution A relationship between Ian Penton-Voak, Marcus Munafo, ALSPAC and Jenny Barnett - Cambridge Cognition using ALSPAC to generate cognitive data remotely for DPK.
Collaborator Contribution Cambridge Cognition is a Cambridge-based SME that is the leading global provider of cognitive assessment software for clinical trials, academic research and healthcare provision. It has recently funded a Research Hub at the University of Bristol. This will facilitate data collection planned with DPUK as part of the remote data collection initiative over the next funding window in ALSPAC.
Impact na
Start Year 2018
 
Description Deep phenotyping of cardiovascular systems physiology in adults born to hypertensive pregnancies, B3613 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Dementias Platform UK - John Gallacher 
Organisation University of Oxford
Department Department of Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution Strategic alignment with DPUK in order to (i) test the use of DPUK/UKSeRP data release pathways (for all data rather than just linkage) and to work collaboratively on the use of Cambridge Cognition remote cognitive testing barrage; (ii) examine and extend the application of federated linkage across studies contained within the UKSeRP infrastructure.
Collaborator Contribution The collection of cognition data (remotely) through the deployment of Cambridge Cognition based cognitive testing. Data collection is provided by the collaboration along with the automatic "piping" of data to DPUK secure repositories within the UKSeRP framework (SAIL).
Impact na
Start Year 2018
 
Description Depositing data with DPUK: a trial dataset, B3619 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Depressive symptoms from childhood to adulthood, B3663 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Depressogenic thinking in adolescence and depressive mood across early adulthood, B3534 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Developing a olfactory-like biosensor for urine diagnostics (B3422) 
Organisation Rosa Biotech Limited
Country United Kingdom 
Sector Private 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Developmental Origins of Health and Disease as mediated and moderated by social determinants within the family, B3510 
Organisation Syracuse University
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Diagnostic prediction model for coeliac disease, B3685 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Dietary intake throughout childhood and adolescence with cardiometabolic health in later life (B3388) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Discovering the person behind the data: Assembling and validating vulnerable children's life histories from quantitative data, B3492 
Organisation University of Sussex
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Dissect the interaction of age at first marriage and associated sociological traits with a genetic approach (B3380) 
Organisation University of Wisconsin-Madison
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Dissecting PCOS Physiology by Defining Phenotypes Associated with PCOS Genetic Risk Factors in Children, B3581 
Organisation Boston Children's Hospital
Country United States 
Sector Hospitals 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Do asthma and ADHD have shared developmental origins? B3569 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Do poverty-reduction fiscal policies reduce childhood obesity? A study based on microsimulations and scenario evaluations, B3608 
Organisation University of Turin
Country Italy 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Do women's expectations impact their birth experience and health outcomes? (B3364) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Does attachment style in childhood predict mental health difficulties in early adulthood? B3572 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Does following a vegetarian/vegan/plant-based diet during pregnancy causally affect the health of offspring? B3626 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Does opting in or out affect the take up of incentives in a long running population-based cohort study: A nested randomised trial, B3662 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Does sleep quality and quantity during the early years having lasting effects on educational outcomes? B3677 
Organisation Centre for Applied Education Research
Sector Charity/Non Profit 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Does socioeconomic position modify associations between grandparental body composition and that of the grandchildren? (B3425) 
Organisation Aarhus University
Country Denmark 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Does the Timing of Menarche Affect the Development of Eating Disordered Behaviour, B3559 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description EWAS of Green Spaces - LifeCycle, B3549 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Early Childhood Shyness, Psychosocial Experiences, and Trajectories of Cardiovascular Risk Factors across the Life-Course (B3381) 
Organisation University of Maryland
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Early life exposure to cardiovascular risk factors and cerebral structure and function in young adults, B3665 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Early metabolic features of adiposity-related cancer susceptibility, B3538 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Early signs and predictors of ADHD. A population cohort study, B3590 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Early-life determinants of peak muscle function in adulthood (B3387) 
Organisation Manchester Metropolitan University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Eating disorders and anxiety: Mapping developmental trajectories and their genetic underpinnings (B3382) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Eating disorders and anxiety: Mapping developmental trajectories and their genetic underpinnings (B3382) 
Organisation University of Geneva
Country Switzerland 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Effect of adverse childhood experiences on adolescent depression, anxiety and self harm: An analysis in the ALSPAC cohort, B3536 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Effects of adolescent physical activity on physical and mental health in adulthood: novel multivariate pattern analysis approach, B3659 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Effects of feeding practice on children's eating behavior and weight growth, B3509 
Organisation Peking University
Country China 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Egton Medical Informatics Systems (EMIS) - Development of a harmonised standard and extraction tool for primary care data into longitudinal studies. 
Organisation EMIS Group
Country United Kingdom 
Sector Private 
PI Contribution ALSPAC with Born In Bradford and UK Biobank have established a harmonised standard for primary care data extracts optimised for longitudinal studies. EMIS Ltd are working to develop this into a clinical software grade software standard and to operationalise it in the EMIS primary care system platform (>50% market share within English GP practices).
Collaborator Contribution EMIS are bringing their considerable experience of managing primary care records and developing software extraction processes and data transformations. This experience will bring technical and data quality insights to the proposed standard. EMIS will also facilitate the collection of GP assents for data collection and extraction by longitudinal studies.
Impact The extraction software standard and mechanism are currently in development.
Start Year 2018
 
Description Emotional dysregulation, self-harm and eating disorders: a mechanistic investigation (B3395) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Engagement, recruitment and monitoring of participation - Qualitative Research Integrated within Trials (QuinteT) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution ALSPAC will work with QuinteT to deploy qualitative methods used to monitor and maximise recruitment in randomised controlled trials in ALSPAC.
Collaborator Contribution This will be focused on the recruitment activity around ALSPAC_30 clinic visits and will be run both before and during the recruitment process given the nature of the open clinic.
Impact na
Start Year 2018
 
Description Environment, DNA methylation and risk of childhood acute lymphoblastic leukaemia: a novel two-sample MR study, B3511 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Environment-wide association study for adiposity in ALSPAC (B3383) 
Organisation University of Hong Kong
Country Hong Kong 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Environmental exposures in pregnancy and early life influencing cognitive and cardio-respiratory development (B3412) 
Organisation University of Leicester
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description EpiTIME: Solving the 'time puzzle' of epigenetic effects on child mental health (B3361) 
Organisation King's College London
Department Department of Child & Adolescent Psychiatry
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Epigenetic prediction of pubertal timing, B3690 
Organisation University of Texas at Austin
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Epigenetic trajectories of mental health (B3428) 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Epigenome-wide association study of handedness, B3694 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2021
 
Description Evaluating diet at age 30 (ALSPAC-G1) (B3376) 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Evaluating longitudinal invariance in measures of child and adolescent mental health and wellbeing across development, B3658 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Evaluating longitudinal invariance in measures of child and adolescent mental health and wellbeing across development, B3658 
Organisation University of Edinburgh
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Examining patterns and predictors of mental health during and in response to COVID-19, B3506 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Examining the association between alcohol use, cognitive functioning and self-harm (B3437) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Examining the association between childhood bilingualism and cognitive functioning in adulthood, B3500 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exome sequencing of ALSPAC children and parents, B3565 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploration of the relationship between social cognition and PTSD within the ALSPAC cohort, B3474 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploring candidate gene mechanisms in atopic eczema (B3453) 
Organisation University of Dundee
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploring causal effects of health behaviours on mental health and wellbeing, B3456 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploring epigenetic and phenotypic associations with genetic liability to juvenile idiopathic arthritis, B3669 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploring how much complex trait variation is captured by DNA methylation in epigenome-wide association studies, B3561 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploring self-harm and disordered eating as risk factors for poorer mental health during the COVID-19 pandemic, B3562 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploring shared genetic associations between risk behaviours and educational attainment, B3557 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploring the associations between paternal postnatal depression, aspects of involvement and parenting and child development , B3516 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploring the effects of twin birth and prematurity on school readiness and early academic outcomes (B3454) 
Organisation Bradford Institute for Health Research (BIHR)
Department Born in Bradford
Country United Kingdom 
Sector Public 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploring the progression of mental illness: Identifying predictors of recovery, B3591 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exploring the text data provided by participants completing the COVID Q, B3529 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exposure to carbon monoxide in pregnancy and postnatally and neurocognitive effects on the child - a secondary data analysis, B3629 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Exposure to urban natural environments and birth outcomes, B3648 
Organisation Barcelona Institute for Global Health
Country Spain 
Sector Multiple 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Factors associated with third molar pathology and treatment in a representative population, B3482 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Family background and the intergenerational transmission of educational attainment: A multi-cohort analysis, B3539 
Organisation Duke University
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Fasting insulin GWAS, B3491 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Fine-mapping of vascular reactivity loci using human artery multi-omics analyses, B3523 
Organisation University of Virginia (UVa)
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description From Social Cognitive Deficits to Later Emotional and Behavioural Problems: The Roles of Cortisol and Inflammatory Cytokines, B3681 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description G1 Addition of lung function to G1 clinic @30 (B3393) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description G1 Substance Use questions for the next sweep, B3599 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description GWAS of age of peak velocity of depressive symptoms and investigation of associated variables, B3657 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description GWAS of breast density (B3356) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description GWAS on longitudinal pubertal traits in Chilean adolescents, B3633 
Organisation Adolfo Ibáñez University
Country Chile 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Genetic and Environmental Components of Parental Effects on Child Physical and Mental Health, B3465 
Organisation University of Hong Kong
Country Hong Kong 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Genetic and non-genetic influences on the development of psychiatric outcomes in children born with cleft lip and/or palate, B3578 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Genetic determinants of neonatal hyperbilirubinemia, B3606 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Genetic impact on youth vaping: extending known genetic risk factors in smoking to vaping, B3593 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Genetic influences on infant and childhood growth, B3605 
Organisation University of Bergen
Country Norway 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Genetic risk for Alzheimers disease and the metabolome across the life course, B3695 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2021
 
Description Genetics of Stuttering, B3620 
Organisation Max Planck Society
Department Max Planck Institute for Psycholinguistics
Country Germany 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Genetics, Adverse Childhood Experiences (ACEs), and Developmental and Behavioral Outcomes, B3652 
Organisation University of Cincinnati
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Genome-wide association studies of prenatal depression in ALSPAC (B3448) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Genome-wide meta-analysis of infant developmental milestones and temperament (B3360) 
Organisation Birkbeck, University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Genomic determinants of Multiple Sclerosis susceptibility in an ethnically diverse population, B3571 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Green Spaces and Multiple Child Health Outcomes /Air pollution exposure and childhood obesity/Nature and birth outcomes, B3625 
Organisation Barcelona Institute for Global Health
Country Spain 
Sector Multiple 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Green Spaces and Multiple Child Health Outcomes, B3625 
Organisation Barcelona Institute for Global Health
Country Spain 
Sector Multiple 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description HDR-UK South West Better Care Partnership, B3521 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Harnessing genetics to understand the role of DNA methylation in healthy aging, B3603 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Health and wellbeing in surviving congenital heart disease patients, B3530 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Home Biome project (DUsty SecreTs - DUST), B3588 
Organisation Northumbria University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Host genetic effects on COVID-19 susceptibility and outcomes, B3520 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Hypertensive disorders of pregnancy and cognition, B3614 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Hypothesis-free and pQTL analysis of deep vein thrombosis aetiology: a Mendelian randomization study (B3432) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Identification of genetic determinants of dietary intakes by prioritizing obesity-related variants highly expressed in the brain, B3636 
Organisation Harvard University
Department Harvard T.H. Chan School of Public Health
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Identifying genetic variants predisposing to overeating behaviour (B3407) 
Organisation Brunel University London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Identifying genetic variants predisposing to overeating behaviour (B3407) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Impact of immune sex differences in the first 1000 days of life, B3696 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2021
 
Description Impact of parenthood on maternal and paternal neurobiology and subsequent child development (B3386) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Implications of COVID-19 lockdown for inequalities in health student mini project, B3616 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Implications of covid-19 lockdown for inequalities in health, B3564 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Inclusion of ALSPAC samples in Psychiatric Genomics Consortium (PGC) for ED, B3253 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Inclusion of ALSPAC samples in Psychiatric Genomics Consortium (PGC) for ED, B3253 
Organisation University of Geneva
Country Switzerland 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Indoor and outdoor tanning determinants in British young adults, B3458 
Organisation Universidade de São Paulo
Country Brazil 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Infection during childhood and cognitive function, B3644 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Influence of early-life pet exposure on the risk of allergic sensitisation and asthma in childhood, B3462 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Influence of the month of birth on persistence of ADHD in prospective studies: an individual patient data meta-analysis, B3691 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Integrating longitudinal and cross-national evaluations of increased community alcohol availability and the health and economic (B3399) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description International Cannabis Consortium - GWAMA of quantity/frequency of cannabis use (B3408) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Investigating Resilience Mechanisms in Neurodevelopmental Conditions, B3558 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Investigating a DNA methylation signature of e-cigarette use (B3416) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Investigating genetic influences on ASD, autistic traits and trajectories of autistic traits, B3640 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Investigating maternal cannabis exposure during pregnancy and epigenetic alterations in offspring, B3466 
Organisation Sinai Health System
Country United States 
Sector Hospitals 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Investigating predictors of risk behaviours in adolescence and early adulthood, B3697 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2021
 
Description Investigating the Activity of Transposon-Derived Regulatory Sequences in the Human Placenta, B3580 
Organisation Queen Mary University of London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Investigating the Genetic Architecture and Risk Factors of Epilepsy, B3497 
Organisation Broad Institute
Department Stanley Center for Psychiatric Research
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Investigating the effect of maternal and paternal phenotypes on offspring cardiometabolic risk factors, B3544 
Organisation University of Queensland
Country Australia 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Investigating the effects of autism related exposures on BMI and disordered eating behaviours in adulthood, B3600 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Investigating the influence of natural selection on metabolites, B3548 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Investigating the role of genetics in the obese-asthma phenotype in children (B3415) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Is genetic predisposition to osteoarthritis associated with musculoskeletal pain in adolescents? (B3377) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Is normal variation in brain activity during sleep related to liability for schizophrenia? (B3424) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Is the association between maternal pre-pregnancy BMI and breastfeeding outcome mediated by changes in maternal DNA methylation?, B3459 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Is the polygenic risk score for Alzheimer's disease and cognitive function manifest in childhood/adolescent brain structures? (B3374) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Is there a causal association between insulin signalling and myopia pathogenesis? B3645 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Kings College London and Twins UK 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Strategic alignment
Collaborator Contribution Strategic alignment
Impact na
Start Year 2011
 
Description LATERALCOG - Typical and atypical development of laterality, B3650 
Organisation University of Strasbourg
Country France 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Large-Scale Evaluation of the Effect of Rare Genetic Variants on Psychiatric Symptoms and Cognitive Ability (B3363) 
Organisation Boston Children's Hospital
Country United States 
Sector Hospitals 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia Onset, B3594 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Laura Corbin-Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: An adaptive recall by genotype study in ALSPAC 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Based on my previous experience in setting up and running recall-by-genotype studies in ALSPAC, I contributed to the design of the study and the initial set up, e.g. obtaining ethics approval. The study is now in the recruitment phase. I have contributed to the writing of a protocol article that will shortly be submitted to BMC Genomics.
Collaborator Contribution James Dunham (https://research-information.bris.ac.uk/en/persons/jim-dunham) is the lead clinician on the project with Tony Pickering (https://research-information.bris.ac.uk/en/persons/anthony-edward-pickering) as his Sponsor. Both are experienced in pain management. James is leading the study and carrying out the data collection (i.e. participant facing). Tony is providing supervisory support. Aidan Nickerson is a PhD student joint between UoB and Eli Lilly. He is particularly contributing to the statistical aspects of the project.
Impact N/A
Start Year 2019
 
Description Lectin Histochemistry and Glycocalyx Measurement of the ALSPAC Placentas - A Feasibility Study (B3378) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Life course and transgenerational patterns of mental ageing, B3553 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description LifeCycle: How do early years risk factors mediate inequalities in child mental health and cognitive development? B3686 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2021
 
Description LifeCycle: How do early years risk factors mediate inequalities in child mental health and cognitive development? B3686 
Organisation University of Liverpool
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2021
 
Description Lifecycle paper, WP3.1.4: Multi-behavioral patterns in European preschoolers, B3637 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Linking observed mental health data with record linkage in ALSPAC, B3602 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Linking research and routine data to explore childhood asthma, eczema and allergic rhinitis in the Born in Bradford birth cohort, B3526 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Liver measures in F@30 clinic (B3430) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Long-term outcomes of antidepressant use, a machine learning approach, B3550 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Longitudinal association between sleep at age 3 and behavior and cognition from ages 4 to 6 years in Lifecycle cohorts (B3433) 
Organisation National Institute of Health and Medical Research (INSERM)
Country France 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Longitudinal prevalence of COVID-19 symptoms in the ALSPAC cohorts, B3517 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Lung development genes and adult lung function: replication in ALSPAC (B3444) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Mapping Neurodevelopmental Trajectories for Adult Psychiatric Disorder: A focus on Autism and Psychosis, B3688 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Mapping the shared genetic architecture of human blood multi-omics phenotypes at cardiovascular disease risk loci (B3436) 
Organisation University of Bristol
Department MRC Integrative Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Markers of infection within Twins (B3451) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Maternal exposure to urban environmental stressors and depression in the postnatal period, B3673 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Maternal iodine status in pregnancy and association with social/behavioural disorders in offspring, B3505 
Organisation University of Surrey
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Maternal nutritional status in pregnancy and offspring Autism Spectrum Disorder: a social perspective (B3367) 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Maternal postnatal stress and pathways to childhood growth (B3368) 
Organisation University at Albany
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Maths achievement over the primary-secondary school transition: the role of psychological, biological and social factors (B3045), B3461 
Organisation University of Sussex
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Mendelian randomisation analysis of the relationship between body composition (BMI and related variables) and Metabolon data, B3486 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Menstruation and women's health, B3469 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Mental health and educational outcomes in high-risk children, B3488 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Metabolic Health and Obesity-Relevant Diseases, B3642 
Organisation International Agency for Research on Cancer (IARC)
Country France 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Metabolomic association studies of cortical thickness and microstructural properties of the brain in children and adolescents, B3494 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Metabolomic quality control and association analyses, B3473 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Metabolon metabolomics data collection - strategic sample deployment. 
Organisation Metabolon Inc
Country United States 
Sector Private 
PI Contribution As part of a new relationship with Metabolon will collect metabolome-wide GC-LC mass spectrometry for 3000 participants at 3 life course time points. Samples and data brought forward for this from ALSPAC.
Collaborator Contribution Work will be completed well within the first year of proposed core support (2019-24) and will generate an accessible longitudinal metabolomic data set (likely the first of its kind on this scale). This will be coordinated by a Metabolon and University of Bristol co-supported research associate who will lead on analysis and public-private collaboration. Metabolon will contribute the analysis of samples.
Impact na
Start Year 2018
 
Description Methods of recruitment and retention of fathers in cohort and longitudinal studies, B3552 
Organisation National Centre for Social Research
Department Scottish Centre for Social Research (ScotCen)
Country United Kingdom 
Sector Public 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Methylation of the glucocorticoid receptor gene in the development of child psychopathology (B3434) 
Organisation University of Amsterdam
Country Netherlands 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Microbiome transfer and intergenerational transmission of mental health, B3651 
Organisation University of Sussex
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Moving from self-harm or violence towards others to dual harm: predictors of transition in early adulthood (B3449) 
Organisation University of Manchester
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Myopia in Young Adults, B3675 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description NCS ARQ6: Identifying cases of COVID-19 in the ALSPAC cohort, B3676 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description NCS Cohort Project, ARQ1, COVID-19 and Mental Health Outcomes, B3680 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description NIHR Non-hospitalised long_COVID 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution This is a collaboration which is built up around a specific call from UKRI and NIHR and which was met (and supported) by a proposed looking to undertake work focusing on the characterisation, determinants of, mechanisms of and consequences of the long-term effects of COVID-19. This work has established a consortium of experts and platforms uniting linked national primary care registries and population cohorts - including ALSPAC. This effort brings together work from the analysis of electronic health records data and cohorts in order to address longCOVID - this is a direct read-out of the current collaborative National Core Studies. We have an established consortium of experts and platforms uniting linked national primary care registries and population cohorts. The national coverage of primary care registries captures all individuals presenting to their GP, with linked prescribing, consulting, referral and outcome data. Alongside this and within this coordinated work, questionnaires will identify long-COVID cases across cohorts. A subgroup of 200 cases will be matched to three sets of controls (C-19 +, long-COVID-), (C-19-, long-COVID+), and (C-19-, long-COVID-). They will wear a device capturing exercise capacity, heart rate and respiration, and complete regular online questionnaires on mental health and cognition. They will attend clinic for imaging to assess target organ damage. Qualitative work with people with long-COVID will inform diagnostic criteria and understanding of the lived experience. Parallel analysis of cohorts and registries will address each question. With NICE, we will quantify adherence to diagnostic and management guidelines in GP records, and pilot a pop-up intervention to enhance adherence. Our findings will enhance diagnostic criteria, identify pathways for bespoke sub-phenotype intervention, and inform plans for health service delivery.
Collaborator Contribution The main contributions to this work include the deployment of new questionnaire data collection efforts alongside the undertaking of focused analyses of cases and controls. This is supported work, but importantly recognises the collaborative approach to the analysis of COVID-19 across electronic health record linkage and cohort data retrospectively and prospectively.
Impact NA - this work is underway.
Start Year 2020
 
Description National Core Studies - Longitudinal Health and Wellbeing 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution The UK Chief Scientific Advisor has established a programme of National Core Studies (NCS) for SARS-CoV-2 (C-19) research as a coordinated, long-term, national research initiative. Work in the NCS includes the deployment of large-scale electronic health record linkage across cohorts like ALSPAC, the support of research analysts and antibody testing for COVID-19. Work considers COVID-19 in terms of the properties of infection (including issues of determining caseness, transmission, symptoms and outcomes) and in terms of the health and social impacts of behavioural restrictions designed to mitigate the harms of the pandemic. The NCS has six different subprogrammes, of which one is designed to use Longitudinal Study data with linked health and administrative record. The Longitudinal Health & Wellbeing NCS (LH&W NCS - from which the current proposal is derived) is designed to conduct a programme of research and which is responsive to emerging research priorities as determined by the UK Scientific Advisory Group for Emergencies. The LH&W NCS research model is based on the joint analysis of multiple longitudinal studies rather than using any one study in isolation. Through using multiple studies, the LH&W NCS will increase statistical power, particularly of low prevalence symptoms/outcomes such as "Long COVID" and will also increase the heterogeneity of the sample in order to allow adequately powered sub-group analysis (for example considering outcomes of different ethnic groups or those with different socioeconomic position or in different occupation groups).
Collaborator Contribution This is a joint activity. The research lead for NCS LHW is at UCL, but there is an executive group, analyst group and sub-sections of the activity which work together in a collaborative framework to deliver main activity within NCS LHW.
Impact Outputs are interdisciplinary. Example outputs include: MENTAL HEALTH The proportion of young people experiencing anxiety at the beginning of the pandemic almost doubled, at 24% (95% CI 23-26%) compared with a pre-pandemic level of 13% (95% CI 12-14%). These effects were still present when restrictions were eased in the summer of 2020 with 24% (95% CI 22-25%) still experiencing anxiety. In ALSPAC and Generation Scotland, anxiety and depression during the pandemic was greater in younger members, women, those with pre-existing mental/physical health conditions and individuals in socioeconomic adversity, even when controlling for pre-pandemic anxiety and depression. Kwong, A et al. Mental health before and during COVID-19 in two longitudinal UK population cohorts. The British Journal of Psychiatry, 1-27. doi:10.1192/bjp.2020.242 Kwong, A et al. Longitudinal evidence for persistent anxiety in young adults through COVID-19 restrictions. Wellcome Open Research, 5-195. doi.org/10.12688/wellcomeopenres.16206.1 NEW - The number of individuals with anxiety has also risen throughout the pandemic in older populations (ages 40-90), with 9% (95% CI 8-10%) of individuals reporting anxiety at the beginning of the pandemic compared to 14% (95% CI 13-15%) at the beginning of 2021. The number of individuals with anxiety at the beginning of 2021 is highest for those aged 40-49, at 30% (95% CI 20-40%) and lowest for those aged 70+, at 9% (95% CI 5-16%). Children's emotional and behavioural difficulties increased during infancy peak at around the age of 2. Compared to pre-pandemic data the expected decline in emotional and behavioural problems after 2 years was much slower. The overall rate of decline in difficulty scores was 0.5 points per month after age 2, but this rate of decline was approximately one third less in post pandemic trajectories (with an average of 0.195 points per month difference in pre vs during pandemic rates of decline after age 2 [95 % CI 0.113 to 0.277, p<0.001]).This lower decline in scores over the years translated to older children having pandemic difficulty scores much higher than would expected from pre-pandemic trajectories (for example an estimated 10 point higher score by age 8.5). Paul, E et al - in review Jama Paediatrics CONTACT Essential workers, specifically those in healthcare, had 4.5 times as many contacts as non-essential workers [incident rate ratio = 4.42 (CI95%: 3.88-5.04)], whilst essential workers in other sectors, mainly teaching and the police force had three times as many contacts [IRR = 2.84 (2.58-3.13)]. The number of individuals in a household, which is conflated by number of children, increases essential social contacts by 40%. Self-isolation effectively reduces numbers of contacts outside of the home, but not entirely. Thomas, A et al - Limits of lockdown: characterising essential contacts during strict physical distancing - in submission Nature Human Behaviour There is some evidence that transmission is associated with nurseries being open, though nurseries workers are as likely to have been identified with COVID-19 compared to other types of teachers and other participants. Parents are more likely than non-parents to be a COVID case and nursery workers report higher numbers of non-household contacts than an average participants. Parents with children at nursery and school report higher numbers of contacts than parents whose children are not at nursery or school. Compared to schools, nurseries appear likely to contribute less to transmission than primary schools and secondary schools. Parents of nursery school children are less likely to be a COVID case than parents of school-aged children. Parents of nursery school aged children report fewer contacts than non-parents and parents of school-aged children in contrast to the highest numbers of contacts as reported by parents who are essential workers. Nurseries (evidence submitted to SPI-M) CASENESS In order to assess outcomes of COVID infection - including longCOVID - is it imperative to recognise cases within cohort/population-based resources. This can be achieved through access to questionnaire and symptom data (e.g. Menni, C et al Nature 2020), through to pillar linkage data and via study based antibody testing. Ealy analysis of the efficacy of self-report/questionnaire collected symptom data suggests that a combination of data sources if critical to the successful assignment of case status. Assessment via symptoms alone can mis-allocate cases (in favour of case status) - biasing analyses and potentially leading to over conservative or erroneous behavioural change. It is important to note that self-report can be transient and variable and below are some statistics on the performance of this data across NCS resources. However, from new data (limited at present) there is a suggestion that it is definitely is possible to have symptomatic covid with a positive PCR and still no detectable antibodies at 8 weeks. Compound measurement - in the population, but also in key studies of COVID-19 - is needed and is the concentration of NCS studies. Data from the summer of 2020 suggested that 48% of those who had predicted COVID-19 using symptom-based, algorithm defined, case status were antibody negative. www.journalofinfection.com/article/S0163-4453(20)30653-8/fulltext In agreement with this, data from TwinsUK shows that half of those who had predicted COVD-19 between Feb-July 2020 were antibody negative in July/August 2020. This was a similar situation in ALSPAC where 57% of those who had predicted COVID-19 between Feb-Oct 2020 were antibody negative in Oct 2020. This is likely both to be a reflection of antibody waning (seen to be of a similar magnitude, but over longer time periods elsewhere), but also the over-calling of cases by self-report. Northstone, K et al. The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Home-based antibody testing results, October 2020. Wellcome Open 2020 Restricting to a tighter timeframe apparently magnifies this issue. A third wave of questionnaire data collection in ALSPAC (October 2020) collected retrospective symptoms data from March to October 2020 against antibody status. These data suggest that of who had predicted COVID-19 only 23% were antibody positive. Further addressing the issue of possible waning, but limited to a greater reliance on symptomatic disease, Pillar linkage data also highlights the trend that assessment by symptoms alone can be misleading. In ALSPAC again, of those with predicted COVID-19 only 8% tested positive. This pattern was similar in Scotland where the vast majority of recorded cases in The Generation Scotland initiative were self-reported (e.g. more than 10-fold difference). In combination, in order to be able to examine COVID-19 and its outcomes well, a mixed approach to case assignment is crucial. Questionnaire data/symptoms offer broad insight, but are too generous; antibody testing is valuable to examine asymptomatic and mild disease, but is subject to timing; Pillar linkage is secure, but subject to obvious presentation and testing. In isolation, each of these approaches will lead to flawed results, but taken together it is possible to generate meaningful representations of case load in cohorts with deep retrospective and continuing prospective data/samples.
Start Year 2020
 
Description National Core Studies ARQ7: Investigating the socio-economic impact of COVID-19, B3670 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description National Core Studies: Longitudinal Health and Wealth (Research Capability), B3643 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Neurobiological Mechanisms in Adolescent Marijuana Exposure and Schizophrenia Risk (B3418) 
Organisation University of Iowa
Department Carver College of Medicine
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Neurodevelopmental Disorders and Cardiometabolic Risk in ALSPAC Cohort, B3490 
Organisation University of Glasgow
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Non-alcoholic fatty liver disease and cardiac function in young adults (B3366) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Non-invasive Characterisation (Diagnosis & Prognosis) of COVID-19 Respiratory Infection, B3515 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Novel statistical methods for the analysis of high-dimensional epigenetic data (B3438) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Nuffield Department of Population Health, University of Oxford, Big Data Institute (Li Ka Shing Centre for Health Information and Discovery) GAMECHANGER 
Organisation University of Oxford
Department Big Data Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution The GAMECHANGER project is a University of Oxford led and Alzheimer's Society supported initiative to use remote data collection to harvest information on cognitive health in the general population: www.alzheimers.org.uk/research/play-your-part/gamechanger. ALSPAC is making an important contribution to the effective enhancement of recruitment in cohorts and will roll out the use of this data collection mode as a test ground for integrating data collection into the ALSPAC participant web portal.
Collaborator Contribution This collaboration will also enable ALSPAC to assess the porting of data direct from mobile device to secure storage. This will also generate cognitive data complementary to that generated by our Cambridge Cognition and DPUK collaboration.
Impact na
Start Year 2018
 
Description Nutritional biomarker in adolescence and adulthood and associations with socioeconomic trajectories and cardiometabolic outcomes (B3371) 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description OLink Proteomics collaboration for data generation in ALSPAC 
Organisation Olink AB
Country Sweden 
Sector Private 
PI Contribution Collaboration with OLink proteomics includes expert assistance with proteomic study design, sample analysis, data processing and quality control. ALSPAC will bring a collection of researchers and samples for this in efforts to generate new project specific and strategic data sets.
Collaborator Contribution As a result of the collaboration, OLink have reduced analysis and support costs from £92 to £40 per sample on any panel for 2 years.
Impact na
Start Year 2019
 
Description Obesity and Inflammation (B3429) 
Organisation Dartmouth–Hitchcock Medical Center
Country United States 
Sector Hospitals 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Onset of menarche and depressive symptoms from adolescence to adulthood (B3394) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Optimising Adult Mental Health Outcomes in Children with Neurodevelopmental Problems: Interplay of Social and Genetic Factors, B3587 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description PLACENTA (B3440) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Pathways to eating disorders and self-harm: the role of memory and self-esteem, B3638 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Pervasive vs. Situational ADHD: Mechanisms, Trajectories, Comorbidity, Gender Differences, and Long-Term Outcome, B3493 
Organisation Uppsala University
Country Sweden 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Physical activity and mental health among adolescents and young adults: A novel approach using multivariate pattern analysis (B3443) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Physical activity and prediabetes in adolescents and young adults (B3452) 
Organisation Ann & Robert H. Lurie Children's Hospital of Chicago
Country United States 
Sector Hospitals 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Placentas and health across the life-course of two generations (B3445) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Polygenic predictions of blood pressure traits (B3447) 
Organisation Norwegian University of Science and Technology (NTNU)
Country Norway 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Polygenic risk score prediction of BMI/adiposity/obesity in ALPSAC and longitudinal outcome data, B3485 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Positive and adverse childhood experiences and cardiovascular disease risk , B3604 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Predicting Childhood Language Disorder and Ability using Genome-Wide Polygenic Scores (B3398) 
Organisation University of York
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Predicting adult height among children with idiopathic short stature using a polygenic risk score (B3359) 
Organisation McGill University
Country Canada 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Predicting asthma beyond childhood , B3470 
Organisation University of Southampton
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Predicting comprehensive smoking behaviours using epigenetic risk scores (B3450) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Predicting pubertal timing in boys and girls using clinical data and polygenic risk scores, B3667 
Organisation University of Montreal
Country Canada 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Predictors and patterns of self-harm thoughts and behaviours (B3390) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Pregnancy complications, menopausal symptoms and cardiovascular health, B3692 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Prenatal Hg exposure and DNA methylation consortium analysis (B3373) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Prenatal and early-life exposure to heavy metals and childhood neurodevelopment, B3630 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Prescriptive drug use during pregnancy: a pharmacoepidemiological study of the risks and benefits to mothers and offspring, B3635 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Profiling the occupational and educational trajectories of individuals with special educational needs and disabilities, B3468 
Organisation Coventry University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Protective factors in the association between exposure to domestic violence in childhood and internalising symptoms (B3352) 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Psychosocial mechanisms of persistent pain: Expression of Interest, B3598 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Pubertal development and psychobiological health, B3596 
Organisation University College Cork
Country Ireland 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Pubertal development and the gender gap in education: A study using the ALSPAC birth cohort (B3357) 
Organisation Norwegian Institute of Public Health
Country Norway 
Sector Public 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Public engagement development within the City of Bristol with We The Curious 
Organisation We The Curious
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution ALSPAC outreach and engagement in Bristol.
Collaborator Contribution We The Curious is a part Wellcome supported, Bristol city based, science and communications organisation with a focus on dissemination, engagement, recruitment and the delivery of science. They will act as city of Bristol engagement partners - activity which includes the development of initiatives to engage those hard to reach through a combination of local activity and outreach.
Impact n
Start Year 2018
 
Description QR8 MyHealth Platform deployment for cognitive testing in ALSPAC clinic (@30) 
Organisation QR8 Health
Country United States 
Sector Private 
PI Contribution Qr8 Health's MyHealth Platform is a mobile device-based cognitive assessment tool intended for use in clinical and at-home settings. This will be run in the ALSPAC clinics @30 years.
Collaborator Contribution The self-administered nature of the QR8 platform lends itself perfectly to the collection of validated information during inevitable "downtime" in the ALSPAC face-to-face clinics. Qr8 will provide all infrastructure needed to allow data collection for a Processing Speed Test, Verbal Memory Test, and Set Switching Test.
Impact na
Start Year 2019
 
Description Qualitative review of ALSPAC recruitment and virtual visits by QuinteT (Qualitative Research Integrated within Trials), B3585 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Qualitative review of ALSPAC recruitment and virtual visits by QuinteT (Qualitative Research Integrated within Trials), B3585 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Quantifying social contact patterns during the COVID-19 epidemic, B3514 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Quantitative triangulation in aetiological epidemiology (B3402) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description RADAR CNS (Remote Assessment of Disease and Relapse - Central Nervous System) 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution RADAR CNS is a substantial, European, research project focused on the use of mobile phone and wearable device-based measurement for the assessment of central nervous system related health outcomes. ALSPAC will work with RADAR CNS to advance the use of existing and open source measurement solutions for the passive collection of normative data.
Collaborator Contribution Collaboration re. the deployment of remote detection.
Impact na
Start Year 2018
 
Description Record Linkage to support Covid-19 Research in ALSPAC & Immediate COVID-19 research objectives, B3513 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Relationship between early school experiences and adolescent self harm: an analysis using the ALSPAC birth cohort, B3537 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Relationship between serum sclerostin and cardiovascular disease, B3560 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Religious belief and reaction to COVID-19 pandemic , B3576 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Religious belief, health and disease: a family perspective (B3397) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2019
 
Description Research-on-research: Blinded data analysis to improve the robustness and reproducibility of health research, B3615 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Resilience and Susceptibility to Chronic Pain in ALSPAC, B3597 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Risky Business: Understanding intergenerational persistence in entrepreneurship, B3551 
Organisation University of Bath
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Role of inflammation and psychosocial variables in the associations between prenatal maternal stress and offspring mental health, B3570 
Organisation University of Ottawa
Country Canada 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description School starting age: the role of gene-environment interactions, B3545 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Sensation-Seeking Related DNA Methylation and the Development of Delinquency: A Longitudinal Epigenome-Wide Study, B3687 
Organisation King's College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Sensory Sensitivity: Misophonia, Hyperacusis and Tinnitus, B3542 
Organisation University of Sussex
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Serological testing for COVID-19 in ALPSAC (G0/G1), B3566 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description Serological testing for COVID19, B3527 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Sex differences in the association of socioeconomic position with cardiovascular health across the life course (B3435) 
Organisation University College Cork
Country Ireland 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Sibling Structure, Gender-Nonconformity, and Prosocial Behaviour: A Comparison of Only- & Non-Only, Queer and Heterosexual Child (B3396) 
Organisation Pompeu Fabra University
Country Spain 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Simulated ALSPAC data as a resource for longitudinal research and teaching (B3349) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Social Reserve as buffer against psychosis development: a psychological and molecular investigation (SCORE), B3467 
Organisation Icahn School of Medicine at Mount Sinai
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Social causes and consequences of depressive symptom and high BMI comorbidity (B3369) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Socioeconomic disparity, placental pathology, and child development, B3575 
Organisation Northwestern University
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Socioeconomic inequalities in mental health and cognitive trajectories, B3531 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Spatial Analytics to Prevent Population Health Inequalities in Residential Environments: The SAPPHIRE study (B3385) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Specifying Risk for Driven Exercise in Eating Disorders (B3365) 
Organisation University of Wisconsin-Madison
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description Strategic collaboration with the Norwegian MoBa cohort study 
Organisation Norwegian Institute of Public Health
Country Norway 
Sector Public 
PI Contribution Strategic alignment.
Collaborator Contribution Strategic alignment.
Impact na
 
Description Super Cohort for COVID Research, B3586 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Tackling genetic and phenotypic heterogeneity of neurodevelopmental disorders, B3541 
Organisation Pasteur Institute, Paris
Country France 
Sector Charity/Non Profit 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Teachers' psychological processes, B3475 
Organisation University of York
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description Testing the role of relative age within school year on mental health in children with neurodevelopmental vulnerability (B3410) 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description The Association between the Natural Environment and Emotional, Social and Behavioural Development (B3414) 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description The EU Child Cohort Network's core variables: establishing a set of findable, accessible, interoperable and reusable (FAIR) data, B3555 
Organisation University of Copenhagen
Country Denmark 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The Healthier Together Population Data Platform , B3522 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The Heart-Brain Connection in ALSPAC@30: Cardioaggression or Neuroselection? (B3350) 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description The Maternal Diet Diversity Index during Pregnancy and Allergy outcomes in the child, B3480 
Organisation University of Colorado
Country United States 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The Millennium Cohort Study (Centre for Longitudinal Studies - UCL 
Organisation Millennium Cohort Study (MCS)
Country United Kingdom 
Sector Academic/University 
PI Contribution Strategic Alignment - and genetic data generation.
Collaborator Contribution Strategic Alignment
Impact na
Start Year 2018
 
Description The Reading Model (Thames Valley Police & Public Health England Data Intelligence Network) 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Thames Valley Police (Superintendent Stan Gilmour: Head of Violence Reduction, Thames Valley Police) and Public Health England (Dr Éamonn O'Moore: National lead health and justice team, PHE) have established a national data intelligence network called 'The Reading Model'. ALSPAC have contributed in order to provide research and data resource insights; to promote the ALSPAC database as a resource for studying criminal justice outcomes; and the interaction between criminality and mental health; and to further our research program to collect criminal justice self-report and linked records.
Collaborator Contribution Attendance and contributions to workshops and working groups.
Impact 1) Thames Valley Police and PHE supported ALSPAC led application to ESRC for funding to support criminal justice (particularly violent crime) research programme (under review) 2) Thames Valley Police and PHE supported ALSPAC work to engage Avon & Somerset Constabulary to develop a data sharing agreement for linking cohort data to their police outcomes data (project underway) 3) We have developed a working relationship with the Edinburgh Study of Youth Transition and Crime considering how to develop prospectively harmonised data collection and cross-cohort analysis.
Start Year 2018
 
Description The Reading Model (Thames Valley Police & Public Health England Data Intelligence Network) 
Organisation Thames Valley Police
Country United Kingdom 
Sector Public 
PI Contribution Thames Valley Police (Superintendent Stan Gilmour: Head of Violence Reduction, Thames Valley Police) and Public Health England (Dr Éamonn O'Moore: National lead health and justice team, PHE) have established a national data intelligence network called 'The Reading Model'. ALSPAC have contributed in order to provide research and data resource insights; to promote the ALSPAC database as a resource for studying criminal justice outcomes; and the interaction between criminality and mental health; and to further our research program to collect criminal justice self-report and linked records.
Collaborator Contribution Attendance and contributions to workshops and working groups.
Impact 1) Thames Valley Police and PHE supported ALSPAC led application to ESRC for funding to support criminal justice (particularly violent crime) research programme (under review) 2) Thames Valley Police and PHE supported ALSPAC work to engage Avon & Somerset Constabulary to develop a data sharing agreement for linking cohort data to their police outcomes data (project underway) 3) We have developed a working relationship with the Edinburgh Study of Youth Transition and Crime considering how to develop prospectively harmonised data collection and cross-cohort analysis.
Start Year 2018
 
Description The Reading Model (Thames Valley Police & Public Health England Data Intelligence Network) 
Organisation University of Edinburgh
Department Edinburgh Study of Youth Transitions and Crime
Country United Kingdom 
Sector Academic/University 
PI Contribution Thames Valley Police (Superintendent Stan Gilmour: Head of Violence Reduction, Thames Valley Police) and Public Health England (Dr Éamonn O'Moore: National lead health and justice team, PHE) have established a national data intelligence network called 'The Reading Model'. ALSPAC have contributed in order to provide research and data resource insights; to promote the ALSPAC database as a resource for studying criminal justice outcomes; and the interaction between criminality and mental health; and to further our research program to collect criminal justice self-report and linked records.
Collaborator Contribution Attendance and contributions to workshops and working groups.
Impact 1) Thames Valley Police and PHE supported ALSPAC led application to ESRC for funding to support criminal justice (particularly violent crime) research programme (under review) 2) Thames Valley Police and PHE supported ALSPAC work to engage Avon & Somerset Constabulary to develop a data sharing agreement for linking cohort data to their police outcomes data (project underway) 3) We have developed a working relationship with the Edinburgh Study of Youth Transition and Crime considering how to develop prospectively harmonised data collection and cross-cohort analysis.
Start Year 2018
 
Description The UK Biobank Study (Oxford University, Big Data Institute - Oxford, UK Biobank - Manchester) 
Organisation UK Biobank
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Strategic alignment
Collaborator Contribution Strategic alignment
Impact na
Start Year 2018
 
Description The association between different modes of delivery for childbirth and sexual health: a studying using ALSPAC data, B3524 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The association between traumatic brain injury and emotion recognition, B3457 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The biological background of attention-deficit/hyperactivity disorder (B3442) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The course of autistic traits in the population from childhood to adolescence and educational attainment, B3583 
Organisation University Medical Center Gronigen
Country Netherlands 
Sector Hospitals 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The determinants and burden of gastrointestinal infection: a tale of two generations? B3479 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The effect of adverse childhood experiences on multiple functional domains, B3624 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The effect of early life exposures on body mass index from early childhood to early adulthood (B3409) 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description The effect of historic digit sucking on facial shape at 15 years of age (B3427) 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description The effect of the perceived environmental surroundings on face shape at 15 years of age (B3417) 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2019
 
Description The effectiveness of public health advice about healthy eating on dietary change and associations with cardiovascular profiles i, B3563 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The genetic basis of acne vulgaris, B3601 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The genetics of speech sound disorder, B3568 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The impact of Adverse Childhood Experiences on social and health inequalities: a life course perspective, B3623 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The impact of COVID-19 Lockdown on family interactions and infant behaviours, B3519 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution New Data and Secondary Analysis
Impact None yet
Start Year 2020
 
Description The impact of loneliness in young adults, B3573 
Organisation University of Exeter
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020
 
Description The impact of public health measures adopted to control the COVID-19 pandemic on mental health of parents and children, risk and, B3503 
Organisation University of Bristol
Country United Kingdom 
Sector Academic/University 
PI Contribution Data Provision
Collaborator Contribution Secondary Analysis
Impact None yet
Start Year 2020