Liverpool – Confidence in Concept 2019
Lead Research Organisation:
University of Liverpool
Department Name: UNLISTED
Abstract
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Technical Summary
The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.
People |
ORCID iD |
| Description | Biochemical Toolkit for Discovery and Optimisation of Fungal Thioredoxin Reductase Inhibitors (University of Liverpool - University of Exeter) |
| Organisation | University of Exeter |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Tao You will construct an in vitro PK/PD model to recapitulate the relationships among PK - target engagement - disease modulation (cell cycle distribution / apoptosis biomarkers). Tao You will qualify and refine PK/PD modelling. Based on the PK/PD modelling work, Xiao-Ling Cockcroft and Tao You will optimise. Tao You will perform PK/PD modelling to support human dose selection. |
| Collaborator Contribution | Steven Bates will help produce and purify thioredoxin reductase protein (Trr1 protein) from medically important fungal pathogens, including Aspergillus fumigatus, Candida auris, Candida albicans and Candida glabrata. |
| Impact | To follow when outputs and outcomes of the work have been reported on. |
| Start Year | 2022 |