University College London – Confidence in Concept 2019
Lead Research Organisation:
University College London
Department Name: UNLISTED
Abstract
Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.
Technical Summary
The Confidence in Concept (CIC) scheme is a key part of MRC’s translational research strategy and provides annual awards to institutions to flexibly support a portfolio of early stage translational research projects. CIC is designed to accelerate the transition from discovery research to viable translational projects by supporting preliminary studies to establish proof-of-concept so that the approach will then become competitive for more substantial translational funding.
Organisations
People |
ORCID iD |
Publications
Kozielski F
(2022)
Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16.
in RSC chemical biology
Rogstam A
(2020)
Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2.
in International journal of molecular sciences
| Description | DREADDs for clinical translation |
| Amount | £477,361 (GBP) |
| Funding ID | MR/W005204/1 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 01/2022 |
| End | 06/2024 |
| Description | MRC DPFS - Kolzieski - SARS-CoV2 DD |
| Amount | £525,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 09/2023 |
| End | 09/2025 |
| Description | UCL Technology Fund - Pule - ExoAMP CAR-T |
| Amount | £247,297 (GBP) |
| Organisation | UCL Business |
| Sector | Private |
| Country | United Kingdom |
| Start | 09/2022 |
| End | 09/2024 |
| Description | UCL technology Fund - Phillips - Nervewrap |
| Amount | £223,193 (GBP) |
| Organisation | UCL Business |
| Sector | Private |
| Country | United Kingdom |
| Start | 01/2021 |
| End | 01/2023 |
| Description | WT TPA - TIN PDS award - Phillips - Nerve wrap |
| Amount | £12,143 (GBP) |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 09/2021 |
| End | 09/2022 |
| Title | CHIMERIC ANTIGEN RECEPTOR CELL |
| Description | The present invention relates to a cell which comprises a chimeric antigen receptor (CAR) comprising a binding domain which binds a first epitope of a tumour antigen; and a polynucleotide which encodes a bi-specific protein which comprises a first binding domain which binds a second epitope of said tumour antigen; and a second binding domain which binds a cell surface antigen. The present invention also provides CAR systems, nucleic acids, vectors, pharmaceutical compositions and pharmaceutical compositions for use in the treatment and/or prevention of disease. |
| IP Reference | WO2021250405 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2021 |
| Licensed | No |
| Impact | None as yet |
| Title | DRUG ELUTING BIOMATERIALS |
| Description | The invention relates to a nanofibrous material comprising a drug for treating a peripheral nerve injury by delivering the drug locally to a damaged or injured nerve. The drug may be such a Non Steroidal Anti Inflammatory Drug or a PPAR agonist. In particular, the invention relates to a drug eluting nerve wrap or bandage that can be wrapped around an injured peripheral nerve. The invention also relates to a nanofibrous drug delivery system or device for delivering a drug locally to a peripheral nerve, a treatment for a peripheral nerve injury comprising contacting a damaged nerve with the drug eluting nanofibrous material or drug delivery system, kits and methods for making the nanofibrous materials, and uses of the nanofibrous materials. |
| IP Reference | WO2021144592 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2021 |
| Licensed | No |
| Impact | None as yet |
| Title | NERVE LABEL |
| Description | The invention relates to a method of visualising a peripheral nerve, the method comprising contacting the nerve with a 5-aminolevulinate or a derivative thereof. |
| IP Reference | WO2023285839 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2023 |
| Licensed | No |
| Impact | none as yet |
| Title | SYNTHETIC RECEPTORS |
| Description | The invention relates to modified G-protein coupled receptors (GPCRs) which (i) have decreased responsiveness to an endogenous activating ligand, and (ii) may be activated by exogenous agonists, which may be relatively benign over the counter drugs such as antihistamines. The modifications comprise mutations at particular amino acid positions, relative to the unmodified GPCRs. The invention also provides methods of use comprising administration of the modified GPCRs, for example in treating a neurological circuit disorder. |
| IP Reference | WO2022238513 |
| Protection | Patent / Patent application |
| Year Protection Granted | 2022 |
| Licensed | No |
| Impact | None as yet |