Membrane protein sorting
Lead Research Organisation:
MRC Laboratory of Molecular Biology
Abstract
Cellular growth and differentiation is often regulated by the abundance of particular proteins, which in turn is determined both by the rate of their synthesis and the rate and timing of their degradation. Proteins often have to be degraded either because they are no longer needed or, importantly, when they are defective and a potential hazard to the cell. We are trying to understand how this is controlled.
Defective or unwanted proteins are marked for destruction by the attachment of a specific tag called ubiquitin. We are trying to identify, understand and control the machinery that recognises the proteins and carries out this protective tagging and subsequent destruction. A full understanding will allow us to devise ways to promote or inhibit these processes, to preserve genetically defective but beneficial proteins or to control the growth of cancer cells.
Defective or unwanted proteins are marked for destruction by the attachment of a specific tag called ubiquitin. We are trying to identify, understand and control the machinery that recognises the proteins and carries out this protective tagging and subsequent destruction. A full understanding will allow us to devise ways to promote or inhibit these processes, to preserve genetically defective but beneficial proteins or to control the growth of cancer cells.
Technical Summary
Proteins in cells are regulated in their abundance, and sometimes need to be removed entirely. A major challenge for cell biology is to understand how these processes are controlled.
Proteins are also subject to quality control, with abnormal or misfolded proteins being degraded. Such mechanisms protect cells from the damage caused by misfolded proteins, and are closely related to those used for specific regulatory purposes where proteins need to be removed, such as the downregulation of signalling receptors. We wish to understand how proteins are recognised and destroyed, and how these processes can be regulated.
The key event is ubiquitination, and we have focussed on the HECT family of ubiquitin ligases in mammalian cells.
We have shown that aggregation or polymerisation of proteins can greatly enhance their ubiquitination by HECT ligases, and this may be used as a regulatory mechanism during signal transduction, notably through the polymerisation of the Dvl proteins in the Wnt pathway. It may also be used as a way of detecting defective proteins, which may aggregate following a heat shock, for example. The presence of many weak binding sites in close proximity has a dramatic effect on attracting and activating the ligases. We have previously shown that multiple binding sites are a common and necessary feature of natural activators of these enzymes, even though a single PPxY motif is sufficient for interaction.
Alpha synuclein, the causative agent of Parkinson’s disease, forms pathogenic beta sheet filaments. We have found that these, but not the monomeric protein, are ubiquitinated by the Nedd4 family of HECT ligases, apparently by direct recognition of the beta sheet form. Subsequent degradation may limit toxicity. A point mutation in alpha synuclein that leads to early onset of disease largely abolishes ubiquitination, which may contribute to its damaging effects.
Proteins are also subject to quality control, with abnormal or misfolded proteins being degraded. Such mechanisms protect cells from the damage caused by misfolded proteins, and are closely related to those used for specific regulatory purposes where proteins need to be removed, such as the downregulation of signalling receptors. We wish to understand how proteins are recognised and destroyed, and how these processes can be regulated.
The key event is ubiquitination, and we have focussed on the HECT family of ubiquitin ligases in mammalian cells.
We have shown that aggregation or polymerisation of proteins can greatly enhance their ubiquitination by HECT ligases, and this may be used as a regulatory mechanism during signal transduction, notably through the polymerisation of the Dvl proteins in the Wnt pathway. It may also be used as a way of detecting defective proteins, which may aggregate following a heat shock, for example. The presence of many weak binding sites in close proximity has a dramatic effect on attracting and activating the ligases. We have previously shown that multiple binding sites are a common and necessary feature of natural activators of these enzymes, even though a single PPxY motif is sufficient for interaction.
Alpha synuclein, the causative agent of Parkinson’s disease, forms pathogenic beta sheet filaments. We have found that these, but not the monomeric protein, are ubiquitinated by the Nedd4 family of HECT ligases, apparently by direct recognition of the beta sheet form. Subsequent degradation may limit toxicity. A point mutation in alpha synuclein that leads to early onset of disease largely abolishes ubiquitination, which may contribute to its damaging effects.
Organisations
- MRC Laboratory of Molecular Biology, United Kingdom (Lead Research Organisation)
- University College London, United Kingdom (Collaboration)
- Curie Institute Paris (Institut Curie) (Collaboration)
- National Centre for Meteorological Research (CNRS) (Collaboration)
- University of Birmingham, United Kingdom (Collaboration)
- Medical Research Council (Collaboration)
- Indian Institute of Technology Patna (Collaboration)
- University of Cambridge (Collaboration)
- AstraZeneca plc (Collaboration)
- Nikon (Collaboration)
- Artios Pharma Limited (Collaboration)
- University of Sheffield, United Kingdom (Collaboration)
- Cochin Institute (Collaboration)
- University of Leicester, United Kingdom (Collaboration)
People |
ORCID iD |
| Hugh Pelham (Principal Investigator) |
Publications
Bandara M
(2016)
Composition and Activity of the Non-canonical Gram-positive SecY2 Complex.
in The Journal of biological chemistry
Bandara M
(2017)
The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation.
in Microbes and infection
Bao L
(2017)
A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS.
in Scientific reports
Barone G
(2016)
Human CDK18 promotes replication stress signaling and genome stability.
in Nucleic acids research
Basset A
(2017)
An extended model of vesicle fusion at the plasma membrane to estimate protein lateral diffusion from TIRF microscopy images.
in BMC bioinformatics
Bretscher MS
(2007)
Using single loxP sites to enhance homologous recombination: ts mutants in Sec1 of Dictyostelium discoideum.
in PloS one
Byrne R
(2017)
Activity-Based Probes for HECT E3 Ubiquitin Ligases.
in Chembiochem : a European journal of chemical biology
Clarke TL
(2017)
PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.
in Molecular cell
Fiedorczuk K
(2016)
Atomic structure of the entire mammalian mitochondrial complex I.
in Nature
Fridmann-Sirkis Y
(2006)
Structural analysis of the interaction between the SNARE Tlg1 and Vps51.
in Traffic (Copenhagen, Denmark)
| Title | Artist's in Residence structure |
| Description | Large structure built in LMB atrium by Artist's in Residence as focal point for 'Home in the Service of Science' |
| Type Of Art | Artwork |
| Year Produced | 2016 |
| Impact | Structure used to display LMB staff art exhibition. Structure used as platform for dancers during artists performance events. |
| URL | http://www2.mrc-lmb.cam.ac.uk/homeinsci/construction/ |
| Title | Home in the Service of Science' Performance events |
| Description | Artistic residency culminated in three performance events, part of the Cambridge Festival of Ideas: "a visual and theatrical performance with the participation of the LMB staff and students. The performance centres around a structure made up of a shed of curiosites, the space under the stairs, the parlour, the corridor and the study sitting in the atrium at the LMB building. Inspired by a year of conversations debating architectural ideas of home in the service of science, the event will invite the audience to explore the relationship between scientific research and everyday life in an interdisciplinary performance with live music performed by the scientists themselves." |
| Type Of Art | Performance (Music, Dance, Drama, etc) |
| Year Produced | 2016 |
| Impact | 239 performance attendees, 29 LMB staff involved in the performances. Visitors were "enchanted' and "surprised", and both scientists and visitors greatly valued conversations with each other that this unusal event facilitated. Media coverage on Cambridge TV and in Cambridge News newspaper. Film of performance event shared on YouTube. Scientists enthused and keen to take part in future engagement events. Half of visitors signed up to LMB Open Day mailing list. The event reached new audiences (one third not been to LMB before). Second artistic residency initiated as a direct result of attending performance (Kate Winter sketches). |
| URL | https://www.youtube.com/watch?v=kcsmf1X0n5Y |
| Title | Kate Winter lab and atrium sketches |
| Description | After first visiting the LMB for the Artists in Residence event, artist Kate Winter asked to return to draw the LMB's world-class building and cutting-edge science as part of her MA in Illustration. A series of sketches of the building and of scientists in labs were produced and shared with staff. |
| Type Of Art | Artwork |
| Year Produced | 2016 |
| Impact | Staff involved in sketches engaged and received copies pf sketches. Potential for using sketches further to engage public and to work with artists again. |
| Description | Development of super resolution microscopy capabilities in the UK |
| Geographic Reach | National |
| Policy Influence Type | Participation in a national consultation |
| Description | HFSP Collaborative Research Grant (Mark Skehel) |
| Amount | $1,050,000 (USD) |
| Funding ID | RGP0031/2017 |
| Organisation | Human Frontier Science Program (HFSP) |
| Sector | Charity/Non Profit |
| Country | France |
| Start | 01/2017 |
| End | 11/2020 |
| Description | Next Generation Optical Microscopy Initiative |
| Amount | £1,194,396 (GBP) |
| Organisation | UK Regenerative Medicine Platform |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 12/2012 |
| End | 03/2014 |
| Title | yeast arrestin mutants |
| Description | We have generated yeast strains lacking up to 11 genes, which lack the entire family of yeast arrestins, making it easy to identify which are required for the endocytosis of any given protein. |
| Type Of Material | Cell line |
| Provided To Others? | No |
| Impact | So far, only one publication in 2009 "Arrestin-mediated endocytosis of yeast plasma membrane transporters." |
| Description | APC/C post transalational modifications |
| Organisation | University College London |
| Department | UCL Cancer Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | To undertake the mass spectrometric identification and characterization of post-translational modifications of the APC/C - ubiquitin system. |
| Collaborator Contribution | Preparation of APC/C protein complex. Characterization of post translational modifications identified by mass spec |
| Impact | Nothing yet |
| Start Year | 2012 |
| Description | C21orf70 interacting partners |
| Organisation | University of Sheffield |
| Department | Department of Oncology and Metabolism |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Identification and characterization of novel genome maintenance factors. Specifically the identification by mass spectrometry of proteins interacting with C21orf70 (hSlx9 |
| Collaborator Contribution | Sample preparation and characterization of interacting partners identified by mass spec |
| Impact | Manuscript in preparation |
| Start Year | 2009 |
| Description | Jerome Boulanger with Ahmed Zahraoui |
| Organisation | Cochin Institute |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Study on the effect of MICAL-L1 and PACSINE3 on membrane recycling. JB is working on data analysis. |
| Collaborator Contribution | The collaborator made the experiments and wrote the paper. |
| Impact | Manuscript is under minor revision. |
| Start Year | 2011 |
| Description | Jerome Boulanger with Ahmed Zahraoui |
| Organisation | Curie Institute Paris (Institut Curie) |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Study on the effect of MICAL-L1 and PACSINE3 on membrane recycling. JB is working on data analysis. |
| Collaborator Contribution | The collaborator made the experiments and wrote the paper. |
| Impact | Manuscript is under minor revision. |
| Start Year | 2011 |
| Description | Jerome Boulanger with Charles Kervrann, Patrick Bouthemy INRIA Rennes and Jean Salamero |
| Organisation | Curie Institute Paris (Institut Curie) |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Modelling vesicle fusion at the plasma membrane. JB is contributing image analysis methods. |
| Collaborator Contribution | The collaborator made the experiments and wrote the paper. |
| Impact | Publication: Basset, A. et al. An extended model of vesicle fusion at the plasma membrane to estimate protein lateral diffusion from TIRF microscopy images. BMC Bioinformatics 18, 352 (2017). |
| Start Year | 2011 |
| Description | Jerome Boulanger with Laurent Condat and Nelly Pustelnick |
| Organisation | National Centre for Meteorological Research (CNRS) |
| Country | France |
| Sector | Academic/University |
| PI Contribution | Structured illumination microscopy image reconstruction method. JB is contributing to the design of the method. |
| Collaborator Contribution | The collaborator contributed to the design of the method and the writing of the manuscript. |
| Impact | Manuscript is under minor revision and a preprint is available online. |
| Start Year | 2011 |
| Description | Jerome Boulanger with Suman Maji and Hazique Aetesam |
| Organisation | Indian Institute of Technology Patna |
| Country | India |
| Sector | Academic/University |
| PI Contribution | Joint denoising deconvolution methods. JB is supervising a PhD student and providing direction and ideas to the project. |
| Collaborator Contribution | Collaborator performs experiments. |
| Impact | Nil to date |
| Start Year | 2017 |
| Description | Joint research fund with AZ/Medimmune |
| Organisation | AstraZeneca |
| Department | Research and Development AstraZeneca |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We are about to sign an agreement for a five year collaboration fund between AZ/Medimmune and LMB, funded by $10,000,000 from AZ and $5,000,000 (equivalent) from MRC. Projects will be led by LMB group leaders and selected by a steering committee of LMB, AZ an Medimmune senior staff, chaired by Hugh Pelham. |
| Collaborator Contribution | AZ and Medimmune will participate actively in joint projects, suggesting ideas and where appropriate supplying materials, access to equipment, and doing some experiments (such contributions being additional to the funding arrangement). |
| Impact | The final agreement is not quite signed yet, and no projects have actually started (though several are at advanced planning stages). |
| Start Year | 2014 |
| Description | Jon Howe collaboration with Larry Billing, Frank Reimann lab, Institute of Metabolic Studies |
| Organisation | University of Cambridge |
| Department | Institute of Metabolic Science (IMS) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are studying the co-packaging of the gastrointestinal hormones GLP-1, PYY and Insl5 into secretory vesicles in enteroendocrine cells using super-resolution microscopy. The LMB is providing access to a super-resolution microscope. JH is providing training and guidance during data acquisition and analysis. |
| Collaborator Contribution | The collaborators are preparing and imaging the samples, and analysing the data. |
| Impact | No published scientific papers but preliminary data has been presented at the IMS Wellcome Trust/MRC QQR meeting. |
| Start Year | 2017 |
| Description | Jon Howe collaboration with Omeed Darweesh |
| Organisation | University of Leicester |
| Department | Department of Molecular and Cell Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We are studying the sub-diffraction localisation of the pro-apoptotic protein Bak at the mitochondrial outer membrane (MOM) upon taxol-induced apoptosis using super-resolution microscopy. I am providing guidance on sample preparation and also imaging the samples for them. |
| Collaborator Contribution | The collaborators are preparing the samples. |
| Impact | No published scientific outputs. |
| Start Year | 2017 |
| Description | Mass Spec Facility collaboration with Artios Pharma Limited |
| Organisation | Artios Pharma Limited |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | We have used Hydrogen Deuterium Exchange Mass Spectrometry to identify lead series small molecule binding sites on the protein Alc1. |
| Collaborator Contribution | Artios have synthesised small molecule inhibitors of Alc1 following a high throughput compound screen. They are also determining the crystal structure of Alc1. |
| Impact | None yet |
| Start Year | 2017 |
| Description | PRMT1 substrates |
| Organisation | University of Birmingham |
| Department | College of Medical and Dental Sciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | To undertake the mass spectrometric identification and characterization of novel PRMT1 cancer specific substrate proteins |
| Collaborator Contribution | Protein purification and characterization of protein substrates identified by mass spec |
| Impact | Nothing yet |
| Start Year | 2013 |
| Description | Super resolution microscopy at the LMB |
| Organisation | Nikon |
| Department | Nikon UK |
| Country | United Kingdom |
| Sector | Private |
| PI Contribution | Novel protein labelling methods for super resolution microscopy |
| Collaborator Contribution | Access to their hardware and software design teams and enhanced training from Nikon experts. Nikon are sponsoring a MRC Industrial CASE studentship awarded to Vaclav Beranek who started on 1st October 2014. |
| Impact | Publication in the Journal of the American Chemical Society |
| Start Year | 2013 |
| Description | Tlg1 structure |
| Organisation | Medical Research Council (MRC) |
| Department | MRC Laboratory of Molecular Biology (LMB) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | We provided biochemical and genetic data to support structural studies of the Tlg1-Vps51 complex whose existence we had discovered. Our collaborators did the protein crystallisation and structure determination. |
| Impact | PMID: 16420526 |
| Title | CMIC filter list |
| Description | Jerome Boulanger is maintaining a GMIC filter list (Open-source framework for image processing). The software is an opensource framework for image processing . It is used by photographers , graphic designers , illustrators. |
| Type Of Technology | Software |
| Year Produced | 2017 |
| Open Source License? | Yes |
| Impact | None to report yet |
| URL | https://github.com/dtschump/gmic-community/commits/master/include/jerome_boulanger.gmic |
| Title | Introduction to ImageJ macro programming v1.0, Feb. 2016 |
| Description | Jerome Boulanger has developed an image processing course |
| Type Of Technology | Webtool/Application |
| Year Produced | 2016 |
| Impact | 20 internal staff have completed this course |
| URL | https://github.com/jboulanger/introduction-to-imagej-macros/releases/tag/1.0.0 |
| Description | 'How has Cambridge become the capital of UK Life Sciences - presentation by Hugh Pelham |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Industry/Business |
| Results and Impact | Hugh Pelham gave a presentation about LMB, and LMB's impact on researc and industry interaction during this external event. Other speakers included local industry leaders and senior academics. Event aimed to showcase how academia, industry and healthcare are working together to help make Cambridge the Capital of UK Life Sciences. Hugh's presentation increased understanding of LMB's part in this, and LMB's impact on society and industry. Event followed by interview with local newspaper. Videos of presentaion shared by event organisers, CUHP. Other URLs: http://cuhp.org.uk/media/blog/films-from-how-has-cambridge-become-the-capital-of-uk-life-sciences-17-january |
| Year(s) Of Engagement Activity | 2018 |
| URL | http://www.cambridgeindependent.co.uk/business/business-news/sir-hugh-pelham-on-killing-cancer-cells... |
| Description | 2017 Chemistry Nobel Prize media |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Following the announcment that Richard Henderson had been awarded the 2017 Chemistry Nobel Prize, a live press conference was arranged and broadcast over the internet, followed by visit to the cryo-EM facility, interviews & photography with Richard. On-the-day media waa followed up by further media interaction, including film and radio for Swedish Nobel media broadcasts. The media coverage greatly helped raise LMB's profile and the impact of Richard's Nobel Prize-winning research. Further URL: https://www.chemistryworld.com/feature/cryo-em-a-cold-hard-look-at-biology/3008131.article |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.youtube.com/watch?v=bUYfUmsLsvI |
| Description | AWiSe event |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | 10th annual 'What next for your career in science' event at LMB, organised by LMB and Cambridge AWiSE. Three speakers from diverse scientific industries discussed their respective professional experiences. The networking event welcomed early career researchers from all over Cambridge to hear about these different career opportunities. While all of the speakers hold PhDs in the life sciences, they have taken very different career paths and their talks focused on the key transition points that led them to their current positions. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/lmb-camawise-annual-next-career-science-event/ |
| Description | AZ / LMB Press Conference in the LMB Atrium. |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | 16 journalists from newspapers, BBC, ITV and Channel 4, came for AZ Press conference. Hugh was interviewed on camera. Broadcast on BBC, ITV and Channel 4 news, and newspaper coverage. This was part of efforts to promote AZ's move to Cambridge and their relationship with the MRC, and defend against the Pfizer bid to take them over |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://uk.reuters.com/article/2014/05/18/uk-astrazeneca-pfizer-cambridge-idUKKBN0DY08F20140518 |
| Description | AZ/LMB Blueskies fund research highlighted in local media |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Collaborated with AstraZeneca to produce press release highlighting Blueskies fund research output in local media. Helped establish productive media relationship with AZ and Cambridge Independent newspaper. Further interaction followed. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www.cambridgeindependent.co.uk/business/science/astrazeneca-and-lmb-in-cambridge-use-one-of-w... |
| Description | AZ/LMB NMR collbaration - highlighted in local media |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Collaborated with AstraZeneca to produce press release highlighting sharing of LMB's NMR facility with AZ, with aim of showcasing collaborative relationship and mutual benefits. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Artists in Residence hang-outs |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Artists in Residence spent time with 38 members of LMB (scientists from different research groups, plus domestic services and reception) to follow daily routines and capture what happens in the LMB. Information informed further development of the artist's residency and excerpts from conversations were displayed on the artists structure and during the performance event to reach a wider audience. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/homeinsci/2016/05/a-day-in-reception-at-the-lmb/ |
| Description | Artists in Residence launch event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Launch of the Artists in Residence's structure, with musical performances by LMB staff, speeches and catering. 139 attendees including LMB staff and invited guests from other cultural organisations in Cambridge. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/homeinsci/2016/05/the-artists-structure-is-in-time-to-share-plans-with... |
| Description | Artists in Residence lunch time conversations |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Four hostings/lunch time conversations entitled Bathroom, Kitchen, Living Room and Corridor in the Service of Science with successive themes of water, temperature, death and journeys were held by the artists with 29 members of LMB. Dicussions informed ideas for the final performance events. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/homeinsci/2016/09/conversations-with-artists/ |
| Description | Artists in Residence performance events |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Artistic residency culminated in three performance events, part of the Cambridge Festival of Ideas: "a visual and theatrical performance with the participation of the LMB staff and students. The performance centres around a structure made up of a shed of curiosites, the space under the stairs, the parlour, the corridor and the study sitting in the atrium at the LMB building. Inspired by a year of conversations debating architectural ideas of home in the service of science, the event will invite the audience to explore the relationship between scientific research and everyday life in an interdisciplinary performance with live music performed by the scientists themselves." 239 performance attendees, 29 LMB staff involved in the performances. Visitors were "enchanted' and "surprised", and both scientists and visitors greatly valued conversations with each other that this unusal event facilitated. Media coverage on Cambridge TV and in Cambridge News newspaper. Film of performance event shared on YouTube. Scientists enthused and keen to take part in future engagement events. Half of visitors signed up to LMB Open Day mailing list. The event reached new audiences (one third not been to LMB before). Second artistic residency initiated as a direct result of attending performance (Kate Winter sketches). |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.youtube.com/watch?v=kcsmf1X0n5Y |
| Description | Artists visits |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Visiting artists for the Artist in Residence programme. Tour of building and talk with Scientists. This is part of the required contribution to art which was a condition of planning permission for the building, which was agreed to be in the form of an artist in residence. The artist has yet to be selected, but these were candidates. Hopefully, at some point an artist in residence will be appointed. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Association of British Healthcare Industries tour of LMB |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | Tour of LMB for ABHI group, highlighting LMB workshops and cryo-electron micrscopy facility as an exmaple of an effective technology platform. |
| Year(s) Of Engagement Activity | 2017 |
| Description | AstraZeneca new building topping out: Hugh Pelham interview & film, inclusion on website |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Hugh Pelham interview by AstraZeneca (AZ) about MRC LMB / AZ Blueskies fund and benefits of proximity of the two organisations on the Cambridge Biomedical campus. Interview published on AZ online 360 degree CBC viewing platform. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.astrazeneca.com/our-science/cambridge.html |
| Description | BBC Genius behind film: Madeline Lancaster |
| Form Of Engagement Activity | A broadcast e.g. TV/radio/film/podcast (other than news/press) |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | BBC produced a film as part of their 'The Genius Behind' series about Madeline Lancaster's research using cerebral organoids: "The genius who grows tiny brains in a lab". Interviews and filming in labs at LMB. Broadcast in BBC website with accompanying web article. Increase in media requests for Madeline since broadcast. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.bbc.com/future/story/20160923-the-genius-who-grows-tiny-brains-in-a-lab |
| Description | BBC filming at LMB |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Filming for BBC2 Evan Davies 'How to Grow Britain' series, although footage was not used in the end. none |
| Year(s) Of Engagement Activity | 2014 |
| Description | BI Animal Research Workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Took part in the workshop working with VI form students from local colleges. Purpose: to have a debate about the use of animals in research. Ethical dilemmas posed & discussed in groups. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Babraham Ethics workshop: Liz Pryke facilitator |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | LMB Public Engagement Manager, Liz Pryke, acted as a discussion facilitator during an ethics workshop for secondary school children at the Babraham Research Institute aimed at educacting pupils about the reality of research using animals and to encourage debate. The experience will help inform LMB's openness concordat engagement activities. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.babraham.ac.uk/get-involved/secondary-schools/ethics-workshops |
| Description | Big Biology Day |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Hundreds of visitors discovered how tiny machines organise the insides of our cells at the LMB 'Mighty Molecular Motors' exhibit during the Big Biology Day at Hills Road Sixth Form College, Cambridge. The exhibit was created by Andrew Carter's group and 15 members of LMB volunteered to explain the exhibit to visitors. The exhibit will be shown again during LMB's 2017 Open Day and those involved have volunteered to be involved in further engagement activities. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/mighty-molecular-motors-big-biology-day/ |
| Description | Big Biology Day: Worms are cleverer than you think and LMB careers exhibit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | LMB participation in Big Biology Day public research open day at Hills Road Sixth Foirm College, Cambridge - part of Biology Week. Schafer and Taylor groups from LMB Neurobiology Division led delivery of the 'Worms are cleverer than you think' hands-on exhibit, and further communicated key messages on why we use worms in research via Twitter interview. Careers at LMB exhibit also delivered by Public Engagement team, LMB PhD student and Animal Technicians, aiming to showcase variety of careers at LMB. Worms are clever activity received great feedback from particpants, visitors and fellow exhibitors. Low attendance at careers fair limited effectiveness of this event. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://twitter.com/Spennis/status/919172594280038400 |
| Description | BioImage Informatics Workshop, Paris |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Jerome Boulanger was co-organiser of a meeting at Institut Pasteur, in Paris to discuss the state of the art in microscope image processing and its use in phenotyping in biology. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Bodyclocks/art MRC Festival of Medical Research workshop |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | St Albans Primary year 5 class came to LMB and took part in a workshop based on the body clock, which combined an interactive explanation of body clocks, lab tour and movement/drama activity on and around the artists structure. The aim was to test the structure and some performance ideas. The workshop provided the main image for the performance flyer. Video and image content recorded. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/homeinsci/2016/06/art-meets-science-local-school-children-learn-about-... |
| Description | Build your own SPIM Workshop at the 3rd Light Sheet Fluorescence Microscopy International Conference |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Mthias Pasche demonstrated the LMB Light sheet microscope to participants of a light sheet microscopy conference. Workshop participants could see the instrument working before deciding to build one of their own. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://openspim.org/Welcome_to_the_OpenSPIM_Wiki |
| Description | CamAST challenge project: including LMB visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | New 8-week challenge project 'Getting a taste for science' for 22 year 11 pupils developed and delivered by LMB Public Engagement Team and LMB researchers (1 day per week for 8 weeks). Aim to increase awareness and understanding of LMB, what being an academic researcher is really like, to inspire future scientists, and to enthuse LMB researchers about public engagement. Project includes two visits to LMB and involved over 20 LMB researchers. |
| Year(s) Of Engagement Activity | 2018 |
| Description | Cambridge PE Group meeting |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Professional Practitioners |
| Results and Impact | Bought the audience uopto speed on various outreach activities - recent school talks, careers fairs, UTC Challenge Project etc. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Cambridge Science Festival: See Your Cells at the Guildhall |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Hands-on microscope activity aiming to share wonders of microscopic world and ignite an interest in biological sciences. Hundreds of children and adults took part in activities over the two days. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www2.mrc-lmb.cam.ac.uk/hundreds-children-adults-enjoy-lmbs-see-cells-activity-cambridge-scie... |
| Description | Cambridge Science Festival: UTC talks at 6 - Brad Amos & Rebecca Taylor |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Talks for general audience during Cambridge Science Festival: 'Life through a Lens' by Brad Amos and 'Finding the fountain of youth: why we age and what we can do about it' by Rebecca Taylor. Talks attended by around 200 adults and children. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www2.mrc-lmb.cam.ac.uk/lmb-scientists-creating-fun-fascination-cambridge-science-festival/ |
| Description | Cambridge Science Festival: Worms are cleverer than you think at UTC |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Hands-on activity highlighting how nematode worm is used by LMB researchers to understand behaviour and ageing. Adults and children took part in 4 different activities, completing work book to take away |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www2.mrc-lmb.cam.ac.uk/lmb-scientists-creating-fun-fascination-cambridge-science-festival/ |
| Description | Cambridge Super-Resolution Microscopy Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Professional Practitioners |
| Results and Impact | The meeting arranged and co-ordinated by LMB Light Microscopy Facility was specifically intended to bring together academics from university departments, research centres and research units the Cambridge area. The activity was to present and discuss research in super-resolution microscopy. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Careers Carousel Event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Invited to Year 8 Careers Carousel event at H& E College. Spoke to about 80 students about the use of animals in research & those who care for them + Animal Technology as a career option |
| Year(s) Of Engagement Activity | 2016 |
| Description | Careers Fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Organised to attend the Spring Careers Fair at the College of West Anglia Milton, who teach the Animal Management courses. Introduced Animal Technology as a career option: this is asiduously ignored by the college tutors as a viable option. |
| Year(s) Of Engagement Activity | 2016 |
| Description | College Career Talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Invited to talk to 16-19 yos studying Animal Management at North Herts College, Hitchin, about the use of animals in research and careers in Animal Technology. |
| Year(s) Of Engagement Activity | 2016 |
| Description | College talk |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Arranged a speaker to attend Herts & Essex College, Bishops Stortford, to talk to students about the use of animals in research |
| Year(s) Of Engagement Activity | 2016 |
| Description | Committee on Exiting the EU round table discussion - hosted by LMB |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | LMB hosted roundtable discussion between Committee for Exiting the EU members, local MPs, business leaders and academic leaders on impact of Brexit on Life Sciences in Cambridge. Discussion followed by tour of LMB for Committee members, to increase their understanding of LMB research and impact on society. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www2.mrc-lmb.cam.ac.uk/committee-exiting-eu-visits-lmb/ |
| Description | DNA model on display at University of Cambridge Treasures exhibition in London |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | an exhibition enjoyed by the public not known to me |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.museums.cam.ac.uk/discoveries/about/ |
| Description | Daniel Zeichner MP visit to LMB: highlighted in local media |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Policymakers/politicians |
| Results and Impact | LMB hosted visit by Daniel Zeichner, MP for Cambridge city. Discussion with Hugh Pelham (LMB Director), Jan Lowe (LMB Deputy Director), and tour including electron microscopy facility and laboratories. Viist highlighted in Cambridge Independent newspaper. |
| Year(s) Of Engagement Activity | 2017 |
| Description | David Willetts and Andrew Lansley visited Hugh and toured the LMB. |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Minister for Universities and Science visited, and were given tour of LMB and EM suite. Met Hugh, Martin, Venki and Sjors David Willetts was very supportive, and subsequently helped us to win some freedoms from excessive controls in procurement, etc. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www2.mrc-lmb.cam.ac.uk/david-willetts-makes-a-return-visit-to-the-lmb/ |
| Description | Department for Business Energy Industry and Skills visit to MRC LMB |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Delegation from BEIS visited LMB as part of visit to Cambridge coordinated by the University of Cambridge. Aim: learn about range of activities in Cambridge including industry collbaortion, impact on local economy, international links. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Families Day at LMB mouse facility |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | Animal technicians and other staff working at Ares, LMB mouse facility, invited family to a visit and BBQ at the facility. Aim: to increase understanding about animal research and for staff to showcase their work. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Filming: Madeline Lancaster interview by BBC Wales for 'Inside My Brain' documentary |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | LMB News team coordinated interview and filming of Madeline Lancaster by BBC Wales team. Footage broadcast nationally in 'Inside My Brain' documentary. Aim to showcase Madeline's 'mini brain' research and how this may help increase understanding of brain development and disease. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www.bbc.co.uk/programmes/b09pb8rl |
| Description | Fourth edition of Mouse House News issued |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Fourth edition of 'Mouse House News' newsletter issued to LMB staff via message-list and intranet |
| Year(s) Of Engagement Activity | 2016 |
| Description | Guardian article "If you can work anywhere, where do you want to work'? |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | An article about modern work spaces featuring the LMB: photographs and interview with LMB Director, Hugh Pelham |
| Year(s) Of Engagement Activity | 2016 |
| URL | https://www.theguardian.com/lifeandstyle/2016/feb/27/office-makeover-can-work-anywhere-where-want-to... |
| Description | Herchel Smith Research Studentships Fund/Harvard tour |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Postgraduate students |
| Results and Impact | Tour of LMB for 24 Harvard and Cambridge University postgraduate students and 5 Harvard faculty members: visited research laboratories and support facilities, talked to LMB sceintists and facility staff. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Homerton 'Future of Healthcare' event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Hands-on activity highlighting LMB research that enables antibodies to be engineered as carriers of drugs to target cells: delivered as part of Homerton College 'Action Stations' healthcare event. |
| Year(s) Of Engagement Activity | 2018 |
| URL | https://www.youtube.com/watch?v=QSxafh2ouYo |
| Description | Hosting visits from those interested in the LMB building project |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | Visits from Roche, Public Health England, MRCT and others to discuss laboratory design and the move process. |
| Year(s) Of Engagement Activity | 2015 |
| Description | Hugh interviewed for BBC Look East broadcast on Biosciences in the Eastern Region |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Hugh interviewed on camera. Broadcast on BBC Look East as item about biosciences in the Eastern region. People mentioned they had seen me on TV. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Imagining the Brain - judged by Mathias Pasche |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Students from local schools were invited to participate in an art-science competition within 4 topic areas. Nearly 70 entries were received and judging resulted in 3 overall winners. The artwork was displayed for LMB staff and visitors to view. The project helped make science accessible and relevant to young people and helped raise the awareness of the LMB locally. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Insight on Research stories on LMB website |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | 24 Insight on Research stories that highlight recent research output published in 2015. Articles are published on the LMB external website, intranet and social media channels (Twitter, Facebook, LinkedIn). Articles are shared with MRC Coroporate comms for further dissemination as appropriate. 1 MRC press release based on LMB IoR stories in 2016 |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/news-and-events/insight-on-research/ |
| Description | Insight on Research stories on LMB website |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | 26 Insight on Research stories that highlight recent research output published in 2017. Articles are published on the LMB external website, intranet and social media channels (Twitter, Facebook, LinkedIn). Articles are shared with MRC Coroporate comms for further dissemination as appropriate. 6 MRC news story based on LMB IoR stories in 2017. 2 research stories further highlighted in national UK media (CryoEM structure of Tau, body clock impact on wound healing). Other relevant URLs: https://www.mrc.ac.uk/news/browse/researchers-create-first-3d-structures-of-active-dna/ ; https://www.mrc.ac.uk/news/browse/scientists-uncover-the-structure-of-tau-filaments-from-alzheimer-s-disease/ ; https://www.mrc.ac.uk/news/browse/toxic-formaldehyde-is-produced-inside-our-own-cells/ ; https://www.mrc.ac.uk/news/browse/scientists-unveil-structure-of-protein-critical-for-gene-expression/ ; https://www.mrc.ac.uk/news/browse/our-body-clocks-cause-wounds-sustained-at-night-to-heal-more-slowly/ ; https://www.mrc.ac.uk/news/browse/new-technique-trim-away-targets-and-rapidly-destroys-proteins-in-cells/ ; http://www.bbc.co.uk/news/health-40493868 ; http://www.bbc.co.uk/news/health-41918368 ; http://www.cambridgeindependent.co.uk/business/science/cambridge-scientists-discover-why-drinking-alcohol-increases-your-risk-of-cancer-1-5343456 |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://www2.mrc-lmb.cam.ac.uk/news-and-events/insight-on-research/ |
| Description | Interviews for Korean 'Science Donga' magazine article about LMB |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Interviews with Jan Lowe, Richard Henderson, Rebecca Taylor and Korean postdoc Byung-Gil Lee about LMB research management and to discuss "autonomy and responsibility of Public Science". Article published in Korean 'Science Donga' magazine, and an affiliated company of the Korean top-rated journal, The Donga Daily. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Kate Winter sketches in LMB |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | After first visiting the LMB for the Artists in Residence event, artist Kate Winter asked to return to draw the LMB's world-class building and cutting-edge science as part of her MA in Illustration. A series of sketches of the building and of scientists in labs were produced and shared with staff. |
| Year(s) Of Engagement Activity | 2016 |
| Description | LIYSF visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Undergraduate students |
| Results and Impact | Visit by 18 students and 1 tutor from the London International Youth Science Forum. Interactive tour of LMB, including LMB mechanical workshop, hands-on electron microscopy demo and introductions to asthma and cerbral organoid research. |
| Year(s) Of Engagement Activity | 2016 |
| Description | LIYSF visit |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | LMB hosted visit by 18 students from the London International Youth Science Forum. Visit inlcuded introductory presentation, tour, hands-on activity in Schafer lab, and career path Q&A with John O'Neill (group leader) and PhD student. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www2.mrc-lmb.cam.ac.uk/international-young-budding-scientists-visit-lmb/ |
| Description | LMB Alumni Symposium |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | keynote/invited speaker |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | LMB Alumni Symposium. Scientific lectures, and tours of the LMB building and facilities. Nearly 600 attendees from all over the world. We had universally positive feedback from alumni. The goal was to raise awareness of the new LMB, foster links and encourage alumni to send good people to LMB. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www2.mrc-lmb.cam.ac.uk/lmb-alumni-from-around-the-world-reunited-for-2-day-symposium/ |
| Description | LMB Insight on Research articles |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | 19 Insight on Research articles published on the LMB website during the year. These describe significant findings made by LMB scientists, in an easy to understand form. It is difficult to assess impact of web publication, but potential applicants to the LMB (students, postdocs, group leaders) often browse the website before applying. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www2.mrc-lmb.cam.ac.uk/news-and-events/insight-on-research/ |
| Description | LMB News articles |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | 31 LMB News articles published on the LMB website during the year. We record visits to our website and these pages are always amongst the most popular. Hard to say what effect web publication has, since the audience is unknown. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www2.mrc-lmb.cam.ac.uk/news-and-events/lmb-news/ |
| Description | LMB News stories on LMB website |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | 34 LMB News stories that highlight achievements and other LMB news were published in 2016. Articles are published on the LMB external website, intranet and social media channels (Twitter, Facebook, LinkedIn). Articles are shared with MRC Coroporate comms, which has resulted in a number of MRC Network, MRC Life and MRC Blog posts about LMB/LMB research/LMB scientists in 2016, and 6 MRC news articles |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/news-and-events/lmb-news/ |
| Description | LMB News stories on LMB website |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | 34 LMB News stories that highlight achievements and other LMB news were published in 2017. Articles are published on the LMB external website, intranet and social media channels (Twitter, Facebook, LinkedIn). Articles are shared with MRC Coroporate comms, which has resulted in a number of MRC Network, MRC Life and MRC Blog posts about LMB/LMB research/LMB scientists in 2017, and 2 MRC news articles. Nobel Prize announcement reported in international media. Other relevant URLs: https://www.mrc.ac.uk/news/browse/mrc-scientist-wins-2017-nobel-prize-in-chemistry/ ; https://www.mrc.ac.uk/news/browse/new-embo-members-announced-2017/ ; https://www.theguardian.com/science/2017/oct/04/nobel-prize-in-chemistry-awarded-for-method-to-visualise-biomolecules |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www2.mrc-lmb.cam.ac.uk/news-and-events/lmb-news |
| Description | LMB Open Day |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | 200 demonstrations to members of the public during the LMB Open Day Raised awareness of the the LMB regionally |
| Year(s) Of Engagement Activity | 2013 |
| Description | LMB Open Day (MRC Festival of Medical Research) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | LMB-wide open day for the public during the MRC Festival of Research. Aimed to increase awareness, understanding and support for LMB research, and to inpsire scientists of the future. Over 300 staff volunteered and over 2000 visitors on the day. Very positive feedback from visitors and staff. Raised profile of LMB (media coverage in Cambridge Independent newspaper, and Cambridge 105 radio), majority of visitors local, but some from other regions of the UK. Legacy: hands-on material re-used at further events, increase in staff keen to take part in public engagement. Other URLs: http://www.cambridgeindependent.co.uk/business/science/family-friendly-open-day-at-world-famous-laboratory-of-molecular-biology-in-cambridge-will-offer-amazing-insight-1-5065771 ; http://cambridge105.co.uk/summer-saturday-17-06-2017/ |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www2.mrc-lmb.cam.ac.uk/lmb-welcomes-2000-visitors-fun-packed-open-day/ |
| Description | London International Youth Science Forum |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | 20 international A'level students attended an introduction to an academic institution which sparked questions and discussions afterwards Nil |
| Year(s) Of Engagement Activity | 2013 |
| Description | Long Road 6th form students, interested in biomedical science careers, visited LMB. |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 11 students came on a tour of building, with a talk on drug design, and a careers discussion. This was to help 6th form students decide on a science-based career. They seemed to appreciate it and showed much interest. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Lord Prior of Brampton visit to LMB |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | LMB hosted visit by Lord Prior of Brampton, Parliamentary Under Secretary of State at BEIS. Viist included presentations about latest research, discussion about interaction with industry, and tour. |
| Year(s) Of Engagement Activity | 2017 |
| Description | MRC Alumni Symposium |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Demonstrations of mass spectrometry and the use of confocal microscopy to MRC LMB Alumni Raised awareness of the research activities of the LMB internationally |
| Year(s) Of Engagement Activity | 2014 |
| Description | MRC Apprentices networking event |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Public/other audiences |
| Results and Impact | 16 apprentices attended networking event at LMB, including tour of the LMB We are taking increasing numbers of apprentices, and this is an effective way of training a future workforce |
| Year(s) Of Engagement Activity | 2014 |
| Description | MRC Community event |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | People from all the MRC Units in Cambridge came to the LMB for a celebration event for the MRC Centenary People learnt about the history of the MRC |
| Year(s) Of Engagement Activity | 2013 |
| Description | Malaysian Nobelist Mindset group visit to LMB |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Visit to LMB for Malaysian Nobelist Mindset students, teachers, young doctorates and organising committee. Aimed to expose students to world-class science and research facilities and inspire them to undertake (Nobel prize-worthy) science, plus raise awareness and understanding of LMB. Visit included introduction to LMB, tour of lab and Q&A session with PhD student and group leader. Visiting students shared positive feedback, and evidence that they left with a good understanding of LMB collaborative ethos and world-class research, and had been inspired to pursue research careers. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Mark Walport, UKRI Chief Executive, visit to LMB |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Chief Executive of UKRI, Mark Walport, visited LMB to give a presentation to staff ahead of MRC becoming part of UKRI. Presentation followed by a tour of LMB and discussion with senior LMB researchers, with aim of increasing Mark Walport's understanding of LMB and to develop a productive working relationship. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Mature students summer school |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Talk sparked questions and discussions afterwards Nil |
| Year(s) Of Engagement Activity | 2013 |
| Description | Medimmune science fair |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Hugh gave keynote talk about LMB at internal AZ/Medimmune science fair, which was well received and commented on afterwards This helped Medimmune and AZ scientists learn about LMB, and will stimulate collaborations to be funded by the joint MRC/AZ scheme |
| Year(s) Of Engagement Activity | 2014 |
| Description | Microscopes 4 Schools |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Hands on microscopy activity showing pupils how to collect and examine their own cheek cells and to study minibeasts. The Intended purpose was to provide hands on experience with a microscope (a first for many pupils), a look into the world of cell biology and to enthuse pupils about biology as a subject. This activity was staged as a response to the UK wide British Science Week national educational initiative. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://www2.mrc-lmb.cam.ac.uk/microscopes4schools/about.php |
| Description | Microscopy 4 schools - What is life? |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 200 primary school children attended a hands on light microscopy exhibit held on the school premises. The purposes of this event which was organized by A. Gillingham and M. Pasche was to make the pupils familiar with light microscopy and to teach them how to use microscopes to look at cells and gain insight into the values of this technique in basic medical research. This activity was undertaken twice in 2016 at Queen Emma Primary School organized by M. Pasche and C. Mendoza-Topaz and at Morley Memorial Primary School organized by the Gurdon Institute and M. Pasche, J Howe, K. Roeper and S. Munro. |
| Year(s) Of Engagement Activity | 2015,2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/microscopes4schools/ |
| Description | New external LMB website launched |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Launch of new LMB external website. Presenting stakeholders and public with current information about the LMB. Includes news stories about LMB science. This is our main way of attracting and informing applicants for PhD and postdoctoral positions |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www2.mrc-lmb.cam.ac.uk/ |
| Description | Nippon TV filming for Nobel World Report |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Following the announcement that Yoshinori Ohsumi had been awarded the 2016 Nobel Prize in Physiology or Medicine, Nippon TV filmed an interview with Anne Bertolotti (Ohsumi's host during his prior visit to LMB) and followed the route Yoshinori Ohsumi took around LMB during his visit in Sepetmber 2016. Interview broadcast on Japanese TV in December 2016. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Nobel Media discussion panel |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | This was a local event, but was videoed for display on the Nobel Media website, where it may reach a wider audience. There was good interest from the audience. It was associated with talks from the Nobel Laureates Michael Brown and Joseph Goldstein. The idea is to stimulate debate and thinking, actual impact hard to assess. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.nobelprizeii.org/nobel-laureate/michael-brown/ |
| Description | Non-scientific staff seminars |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | These talks were introduced in 2010 to offer LMB's support staff the chance to find out more about the scientific work at the LMB, and how their role is critical to the success of the Lab. It is also a way for scientists to show their appreciation for all the help the support staff give. The scientists have also benefited from the chance to talk about their science to a lay audience, and some have been able to adapt the presenations for a wider general audience. Ben Nichols (April 2016), Rebecca Taylor (July 2016): using again at Cambridge Science Festival 2017,Madeline Lancaster (September 2016), Mark van Breugal (December 2016). Over 75 support staff attend each talk. Feedback has been very positive from speakers and audience. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Nuffield work experience placements |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | LMB hosted two Nuffield summer placements for A-Level students: one in LMB's crystallography department, one in flow cytometry. Pupils gave very positive feedback and one asked his project supervisor for supporting statements for his UCAS application |
| Year(s) Of Engagement Activity | 2016 |
| Description | Opening of new LMB by the Queen |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | The Queen and Prince Phillip visited the LMB and officially opened the new building. Coverage on TV, national newspapers Raised awareness of the LMB amongst public and invited stakeholders. Created interest in the open day a month later. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www2.mrc-lmb.cam.ac.uk/day-of-celebration-as-her-majesty-the-queen-opens-the-new-lmb-building... |
| Description | Oxbridge international summer school student visi |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Postdoc and LMB public engagement team hosted visit to LMB by international sixth form-aged students taking part in an Oxbridge summer school. Students took part in hands-on science activity and had tour of LMB. Left with increased awareness and understanding of LMB research, and increased enthusiasm for research career. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Parliament Life Science post-Brexit event |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Parliamentary drop-in event: How to secure the best for life sciences after Brexit: Meet the patients, researchers and other experts. Event involved two LMB Marie Sklodowska-Curie fellowship postdocs - researchers benfitting from international funding and collaboration opportunities. Aim to discuss opportunities and challenges for life sciences as a result of the UK's vote to leave the EU. |
| Year(s) Of Engagement Activity | 2017 |
| URL | https://twitter.com/The_MRC/status/829014248126824449 |
| Description | President of John Hopkins University visit to LMB as part of AstraZeneca key stakeholder visit to Cambridge |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Industry/Business |
| Results and Impact | LMB hosted visit by Ron Daniels, President of John Hopkins University, USA, and senior AstraZeneca staff, as part of AZ key stakeholder visit to Cambridge. Aim to showcase how LMB and AZ work together through the Blueskies fund. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Provision of various LMB images for articles, books, publications |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Provision of various LMB images for articles, books, publications. E.g. Royal Society Biographical Memoir of Francis Crick; BBC World Service; Wellcome Genome Campus; Francis Crick Institute; MRC; University of Cambridge; National Academy of Science; Nature journals; NHK Japanese Public TV; Nobel Museum; Royal Society; BEIS. |
| Year(s) Of Engagement Activity | 2017 |
| Description | Provision of various LMB images for articles, books, publications |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | "E.g. • British Society for Immunology 60th Anniversary Banner. • Monoclonal Antibodies Exhibition. • Royal Society Annual Report. • Chemical Heritage Foundation. • The Crick Institute Exhibition. • Wellcome Genome Campus Timeline Exhibition. • Journal of Molecular Biology special edition. • Cell article. • Siddharta Mukherje's The Gene. • MRC Head Office. • Nature Reviews. • Newnham College Women Scientists Event. • Science Museum new exhibition area. • Words4Science Nobel book. • Material was also supplied to two visitors, Sarah Hitchcock who has started work on a biography of Hugh Huxley. As well as providing her with resources, I helped arrange a number of interviews at LMB of staff and alumni. Paul Wassarman also visited to source images and material for the completion of his biography of John Kendrew. " |
| Year(s) Of Engagement Activity | 2016 |
| Description | Received AALAS prize recipients (from USA) |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Received Dr B Dauchy & Dr D Goldstein to the LMB & Ares. Full tour provided & exchange of knowledge. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Residential course for Biology and Genetics at Villiers Park |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | Sam Wynne teaching week-long course to 26 Gifted and Talented A-level students, including a full day of hands-on lab experience at the LMB on 30/7/14 These courses are aimed at stimulating the brightest school students, who hopefully will be inspired to pursue a scientific career. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www2.mrc-lmb.cam.ac.uk/news-and-events/public-engagement/residential-course-in-biology-and-ge... |
| Description | Roundtable discussion at Cambridge University Centre for Science and Policy |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | The discussion was with 7 senior civil servants and others (EC, Joseph Rowntree Foundation), CSaP "fellows" who had expressed an interest in new developments in genome manipulation, and what impact they might have on policy issues in the future. It is an informal method of educating policymakers. Perhaps a renewed realisation that the gap between experts and policymakers needs a constant effort to bridge. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Royal Institution |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Keynote/Invited Speaker |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Approximately 100 A'Level students attended the talk which sparked discussion Nil |
| Year(s) Of Engagement Activity | 2013 |
| Description | Royal Microscopy Society, Facility Managers Meeting |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Industry/Business |
| Results and Impact | The meeting arranged and co-ordinated by LMB Light Microscopy Facility was to discuss matters relating to the management of core light microscopy facilities. To share expertise in the diverse activities of such cores. To facilitate contacts between academics and industry representatives. To allow industry representatives to gauge the future requirements of a key part of their UK market. |
| Year(s) Of Engagement Activity | 2015 |
| Description | See your Cells - Cambridge Science Festival |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | A hands on demonstration of light microscopy display entitled 'See your Cells!' to show case light microscopy in cell biology and capabilities at the LMB which drew a large number of interested people. |
| Year(s) Of Engagement Activity | 2015 |
| Description | See your cells |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Members of the public attended the exhibit and asked questions Raised awareness of the LMB nationally |
| Year(s) Of Engagement Activity | 2014 |
| Description | Sixth Form Ethics Debate |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Invited to speak to VI Formers at H&E College about the ethics of using animals in medical research and societies use of animals. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Supplied images and material for documentary on the history of crystallography |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Diamond Light source made a 40-minute documentary of the history of Crystallography (partly based on our material) which is available on their website, to schools and was shown in local cinemas. This is to educate, impact not known at this time. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www.diamond.ac.uk/Home/News/LatestNews/02-09-14.html |
| Description | Support staff seminars: Marco Tripodi, Liz Miller, Julian Sale & Julian Gough |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Other audiences |
| Results and Impact | Continuation of scientific talks for support staff. Attended by over 75 support staff & positive feedback given. 2016 speakers: Marco Tripodi, Liz Miller, Julian Sale and Julian Gough |
| Year(s) Of Engagement Activity | 2017 |
| Description | TV and journalist interviews, mainly about AZ moving to Cambridge |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Various interviews with BBC East news reporters (TV and radio) about the effects of AZ moving to Cambridge. Print journalist interviews about LMB, in comparison to the Crick |
| Year(s) Of Engagement Activity | 2015 |
| Description | Talk to launch science festival at local school |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Talk was about science and being a scientist, and was part of a programme to try to raise standards and interest in science at Coleridge school by introducing students to a "real scientist". Science teachers and Senior leaders discussed things raised in my talk with the students afterwards, and the head teacher was very pleased with the outcome. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Tour of mouse facility for 'Mouse House Challenge Project' year 11 student |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Tour of LMB mouse facility for year 11 students completing 'Mouse House Challenge Project'. Aim to increase understanding of animal research and to showcase world class facilities. |
| Year(s) Of Engagement Activity | 2017 |
| Description | UTC Mouse House Challenge Project Year 2 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Purpose: Inform young persons about the use of animals in medical research: Why? How? Legislation, Regulation, Introduction to an SPF animal facility. IVC cages & cage design practical, Role of the NVS, Energy used & saved in animal facilities, Animal Facility tours, History of 'Animal Rights' & security. Role of the PELh, What is CRO is & why?, Role of the AWERB layperson, Role of the HOI. Career opportunities in Animal Technology presentation. Rat dissection. Poster judging. |
| Year(s) Of Engagement Activity | 2016,2017 |
| URL | http://www2.mrc-lmb.cam.ac.uk/lmb-inspires-next-generation-scientists-utcc-student-interactions/ |
| Description | UTCC EM demo - Nov |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 16 A-Level students from the University Technical College Cambridge, who study microscopy as part of their biology course, spent an afternoon at the LMB, broadening their knowledge of electron microscopes (EM). The visit included hands-on demonstration of EM, a laboratory tour and talk about research using EM and career paths by a postdoctoral scientist. Feedback positive and future visit requestes. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/utcc-students-hands-em-experience-lmb/ |
| Description | UTCC talks during Sci Fest |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Public/other audiences |
| Results and Impact | Greg Jefferis and John O'Neill gave talks about their research during the 2016 Cambridge Science Festival as part of the University Technical College Cambridge 'talks at 6' series. Audience in excess of 200 people per talk, positive feedback and lots of questions from the audience. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www2.mrc-lmb.cam.ac.uk/lmb-scientists-talk-cambridge-science-festival/ |
| Description | Various work experience placements |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Regional |
| Primary Audience | Schools |
| Results and Impact | LMB hosted 3 laboratory-based and 5 support services-based work experience placements in 2016 for school pupils (year 10 and 12) |
| Year(s) Of Engagement Activity | 2016 |
| Description | Visit by Cambridge Society for the Application of Research |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Undergraduate students |
| Results and Impact | 30 CSAR members visited for lecture and tour of building. LMBs record in translational research promoted. Society members showed great interest in LMB |
| Year(s) Of Engagement Activity | 2014 |
| Description | Visit by Canadian Trade Delegation led by High Commission of Canada |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | 9 people attended from the Canadian trade delegation, in collaboration with CUH. They were given a welcome lecture and tour of the building. none known |
| Year(s) Of Engagement Activity | 2014 |
| Description | Visit by Chancellor of the Exchequer George Osbourne, to give key speech at LMB before 100 guests |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Chancellor delivered key speech in front of TV cameras and 100 invited guests. He met Hugh and toured building (accompanied by David Willetts and George Freeman) Private meeting led to a letter to the Chancellor about flexibilities for research institutes, and some loosening of restrictions in procurement and promotions. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www2.mrc-lmb.cam.ac.uk/the-chancellor-george-osborne-visits-the-lmb-in-his-support-for-scienc... |
| Description | Visit by Chinese investors (with CU Hospitals) |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Chinese group of bioscience investors visiting hospital. They were given a short introduction to LMB and a tour. none known |
| Year(s) Of Engagement Activity | 2014 |
| Description | Visit by Kenyan Forensic Science lab visitors |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | 16 Kenyan Forensic Science lab visitors came on a tour of the LMB building none |
| Year(s) Of Engagement Activity | 2014 |
| Description | Visit by Korean Future Health Forum. |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Policymakers/politicians |
| Results and Impact | 16 visitors from the Korea Health Industry Development Institute(KHIDI) and Ministry of Health and Welfare Republic of Korea. Tour of LMB, and discussion with Hugh and Mick Hastings. They were keen to establish collaborations (though not very practical) We expressed readiness to consider future collaboration, if it fits with our remit. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Visit by Linda Geddes from New Scientist magazine |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Tour of LMB and discussions with various LMB Group Leaders none known |
| Year(s) Of Engagement Activity | 2014 |
| Description | Visit by Mr Takeuchi, Japanese journalist, to meet Hugh and tour building |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | Foreign and Commonwealth Office organised tour for this Japanese journalist I believe, wrote an article in the Japanese press about LMB |
| Year(s) Of Engagement Activity | 2014 |
| Description | Visit by Prof Anja Rovio for advice on laboratory design |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other academic audiences (collaborators, peers etc.) |
| Results and Impact | Prof Rovio is building a new lab in Finland and wanted to see the LMB and ask what works. We were able to give advice based on our experience of lab design and building, which no doubt will help in decisions about their new building. |
| Year(s) Of Engagement Activity | 2014 |
| Description | Visit by Sixth form students from Long Road BTEC Applied Science course |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 17 students came for talk and tour of building, including lab services. Part of our efforts to encourage the next generation of support staff, who are likely to be in short supply in Cambridge |
| Year(s) Of Engagement Activity | 2014 |
| Description | Visitors for LMB /AWISE alternative careers talk |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Postgraduate students |
| Results and Impact | Much interest and discussion about careers This is part of the career development process for PhD students, and no doubt got a few of them thinking hard about their careers |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www2.mrc-lmb.cam.ac.uk/what-next-after-academia-three-ways-to-forge-a-career-away-from-the-be... |
| Description | Visits from BIS, Science minister, Office for Life Sciences, MP, MEP |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | Hosted several different visits, with scientific presentations and discussions, with elected representatives and senior officials from Government: 1. Office for Life Sciences delegation including the Director, Nicole Mather 2. Gareth Davies, Director General, Business and Science, BIS 3. Chris Pope, BIS 4. Jo Johnson, science minister 5. Heidi Allen, parliamentary candidate (and later local MP) 6. Stuart Agnew, local MEP |
| Year(s) Of Engagement Activity | 2015 |
| Description | Visits of Stephen Perse, Stanway Foundation, Laxton Junior and Robert Arkenstall schools |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | 51 pupils visited in two lots as winners of the Crystal Growing Competition winners, Key Stage II & III. This is a always a stimulating educational experience for them. Schools continue to participate in this annual competition run by LMB. |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www2.mrc-lmb.cam.ac.uk/crystal-growing-competition-winning-schools-visit-the-lmb/ |
| Description | Women in science Wikipedia edit-a-thon at the LMB |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Edit-a-thon workshop for 20 participants and a panel discussion for up to 200 people Improved awareness of gender issues |
| Year(s) Of Engagement Activity | 2014 |
| URL | http://www2.mrc-lmb.cam.ac.uk/women-in-science-wikipedia-edit-a-thon/ |
| Description | Work experience placements |
| Form Of Engagement Activity | Participation in an open day or visit at my research institution |
| Part Of Official Scheme? | Yes |
| Geographic Reach | Local |
| Primary Audience | Schools |
| Results and Impact | Six school students came to the LMB on work experience. Mainly 2 weeks long. There will be further requests to host school children for work experience |
| Year(s) Of Engagement Activity | 2014 |