Child Growth and development

Lead Research Organisation: MRC Epidemiology Unit

Abstract

The aim of this programme is to predict and prevent childhood obesity by identifying genetic, dietary and other factors that act during infancy. The specific objectives are to identify genetic factors and patterns of early infant diet and growth that predict childhood obesity, and to develop and test interventions to avoid excessive infant weight gain and childhood obesity. |Childhood obesity is a major public health problem. Research is important because 1) currently there are no proven interventions to prevent childhood obesity, 2) rates of obesity are rising even in young children, 3) childhood obesity has important consequences for childhood health and development, as well as adult health.|This research is being performed in a number of UK birth cohort studies, including close collaborations with the Avon Longitudinal Study of Parents and Children (ALSPAC), the Southampton Womens Study (SWS), and the Cambridge Baby Growth Study (MRC Epidemiology Unit & Department of Paediatrics, University of Cambridge). Candidate genetic factors for study in DNA samples collected in children are selected by in collaboration with the Sanger Institute and University of Cambridge Genetics of Energy & Metabolism (GEM) consortium. Prediction models for risk of childhood obesity and its complications will be based on collaborative studies between investigators from a wide range of UK and international birth cohort studies. |A randomised controlled trial will be performed by recruiting mothers during pregnancy to test whether education to avoid excess infant nutrient intake will prevent rapid infant weight gain and childhood obesity risk. Future targeted interventions will be developed for testing in infants and young children identified to have high risk of childhood obesity.

Technical Summary

Childhood obesity has important consequences for morbidity and mortality in childhood and in later life. However, there is yet little evidence of effective strategies to prevent childhood obesity. The rising prevalence of obesity even in young pre-school children indicates that efforts to predict and prevent childhood obesity need to start very early in life. The aim of this programme is to promote the prediction and prevention of childhood obesity by identifying genetic, dietary and other factors that act during fetal and infant life.|My specific research objectives are 1) to identify common genetic variants associated with rapid infant weight gain and childhood obesity; 2) to develop prediction models for childhood obesity and its co-morbidities based on genetic variants, parental obesity, birth weight, infant weight gain, and infant diet, 3) together with the Units Prevention Programme (PI Simon Griffin) to develop and test interventions to avoid excessive infant weight gain and childhood obesity. These objectives are being tested through existing close collaborations with the Avon Longitudinal Study of Parents and Children (ALSPAC), the Southampton Womens Study (SWS), and the Cambridge Baby Growth Study (MRC Epidemiology Unit & Department of Paediatrics, University of Cambridge), and other population-based birth cohort studies. |Genetic variants are selected based on the results of genome-wide association studies for adult obesity, and timing of puberty, through our involvement in large international consortia. Many of these genetic variants appear to be very relevant to the risk of childhood obesity by influencing rates of weight gain even from the first months of life. Our studies aim to further characterise the infant growth, feeding and behavioural phenotypes that are associated with these genetic markers of adult obesity. |Prediction models for childhood obesity risk are based on meta-analysis of growth data from a wide range of birth cohort studies. Further refinement of these models will be explored by testing the addition of those early life phenotypes identified by our genetic studies, and through identification of biochemical biomarkers of infant growth and body composition. |The aetiological role of excess nutrient intake on rapid infant weight gain and childhood obesity risk will be tested by randomised controlled trial of parental education, support and behaviour change, which if successful will lead to wider pragmatic trials to test its application to public health.|In addition to my specific focus on the infant determinants of childhood obesity, I closely support the research in other programmes of the Epidemiology Unit to understand the role of childhood physical activity in the aetiology and prevention of childhood obesity. |These research objectives are also closely supported by clinical activities in setting up a secondary referral service for childhood obesity (through the Paediatric Endocrinology & Diabetes Service, Addenbrookes Hospital NHS Trust), and support for local community initiatives in school-based screening and treatment of childhood obesity.

Publications

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publication icon
Ahmed ML (2009) Childhood obesity and the timing of puberty. in Trends in endocrinology and metabolism: TEM

 
Description Finding a Path to Safety in Food Allergy: Assessment of the Global Burden, Causes, Prevention, Management, and Public Policy. Cited by National Academies Press on 30 Nov 2016
Geographic Reach North America 
Policy Influence Type Citation in systematic reviews
URL https://www.nap.edu/catalog/23658/finding-a-path-to-safety-in-food-allergy-assessment-of
 
Description Infant feeding policy
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL http://europepmc.org/abstract/MED/19602520
 
Description Institute of Medicine - Early Childhood Obesity Prevention Policies
Geographic Reach North America 
Policy Influence Type Citation in other policy documents
 
Description National Child Measurement Programme
Geographic Reach National 
Policy Influence Type Participation in a advisory committee
 
Description SACN Subgroup on Maternal & Infant Nutrition
Geographic Reach National 
Policy Influence Type Participation in advisory committee
Impact Scientific advice on maternal and infant nutrition
URL https://www.gov.uk/government/groups/scientific-advisory-committee-on-nutrition
 
Description The Interplay Between Environmental Chemical Exposures and Obesity: Proceedings of a Workshop Cited by National Academies Press on 26 Jul 2016
Geographic Reach North America 
Policy Influence Type Citation in systematic reviews
URL https://www.nap.edu/catalog/21880/the-interplay-between-environmental-chemical-exposures-and-obesity...
 
Description ESPE Collaborative research grant
Amount £50,000 (GBP)
Organisation European Society of Pediatric Endocrinology (ESPE) 
Sector Charity/Non Profit
Country United Kingdom
Start 08/2010 
End 08/2012
 
Description FSA contract, Diet and Nutrition survey in infants and young children
Amount £56,000 (GBP)
Funding ID NUA/0237 
Organisation Food Standards Agency (FSA) 
Sector Public
Country United Kingdom
Start 05/2009 
End 12/2011
 
Description Grand Challenges in Global Health
Amount $623,069 (USD)
Organisation Bill and Melinda Gates Foundation 
Sector Charity/Non Profit
Country United States
Start 01/2013 
End 12/2016
 
Description ICUK Project grant
Amount £276,823 (GBP)
Organisation Queen Mary University of London 
Department Innovation China UK
Sector Private
Country United Kingdom
Start 12/2009 
End 11/2012
 
Description MRC Health Services Research and Health of the Public Fellowship
Amount £249,349 (GBP)
Funding ID G0701655 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 08/2008 
End 08/2011
 
Description MRC/GSK Pilot programme to identify new targets and biomarkers
Amount £1,044,000 (GBP)
Funding ID G0701863 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 01/2008 
End 12/2009
 
Description NPRI Phase 4
Amount £770,115 (GBP)
Funding ID MR/J000361/1 
Organisation Medical Research Council (MRC) 
Department National Prevention Research Initiative (NPRI)
Sector Charity/Non Profit
Country United Kingdom
Start 03/2012 
End 09/2015
 
Description UKCRC Centre for Excellence in Public Health Research (Centre for Diet and Activity Research (CEDAR)) shared with A L Kinmonth, S Griffin, N Wareham
Amount £1,250,000 (GBP)
Funding ID RES-590-25-0003 
Organisation Economic and Social Research Council 
Sector Public
Country United Kingdom
Start 01/2008 
End 12/2013
 
Description UU Supplementary Strategic Partnership (Cambridge Initiative)
Amount £728,295 (GBP)
Funding ID MR/L00002/1 
Organisation Medical Research Council (MRC) 
Sector Public
Country United Kingdom
Start 04/2013 
End 03/2018
 
Title Cambridge Baby Growth Study 
Description Detailed data on infant growth and body composition Detailed data on infant diet and nutrition Biological samples and DNA 
Type Of Material Biological samples 
Year Produced 2006 
Provided To Others? Yes  
Impact Various publications 
 
Title ReproGen GWAS data 
Description Genomewide variant association parameters for reproductive ageing traits 
Type Of Material Database/Collection of data 
Year Produced 2014 
Provided To Others? Yes  
Impact Publicly available data which has contributed to other scientific publications by collaborators and other external investigators 
URL http://www.reprogen.org/data_download.html
 
Description Birth to 20 Study 
Organisation University of the Witwatersrand
Department Department of Paediatrics and Child Health
Country South Africa 
Sector Academic/University 
PI Contribution Provided expertise and training in abdominal fat assessment, and expertise in child growth and epidemiology
Collaborator Contribution Field work, study supervision and oversight
Impact Scientific publications
Start Year 2011
 
Description Cambridge Baby Growth Study 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Group
Country United Kingdom 
Sector Academic/University 
PI Contribution Research nurse support Study management Data analysis Publications
Collaborator Contribution Study management Co-supervision of research nurses Data analyses and publicationsDevelopment of infant diet diaries Adaptation of food database for infant diet Coding and analysis of diet diaries
Impact Publications Establishment of a study database Establishment of sample resource
Start Year 2006
 
Description Cambridge Baby Growth Study 
Organisation University of Cambridge
Department Department of Paediatrics
Country United Kingdom 
Sector Academic/University 
PI Contribution Research nurse support Study management Data analysis Publications
Collaborator Contribution Study management Co-supervision of research nurses Data analyses and publicationsDevelopment of infant diet diaries Adaptation of food database for infant diet Coding and analysis of diet diaries
Impact Publications Establishment of a study database Establishment of sample resource
Start Year 2006
 
Description Childhood body composition studies 
Organisation Federal University of Pelotas (UFPel)
Department Post Graduate Program in Epidemiology
Country Brazil 
Sector Academic/University 
PI Contribution Provision of expertise, training and ongoing supervision of quality control in abdominal ultrasound Development of local protocols Data analysis and manuscript preparation
Collaborator Contribution Collaboration on multi-site research projects Co-supervision of PhD student Sharing of data on childhood body composition from local studies Collaborative studies on MRI and ultrasound assessment in the newborn
Impact Publications: 19779473; 19127281; 20519560
Start Year 2008
 
Description Childhood body composition studies 
Organisation Hammersmith Hospital
Country United Kingdom 
Sector Hospitals 
PI Contribution Provision of expertise, training and ongoing supervision of quality control in abdominal ultrasound Development of local protocols Data analysis and manuscript preparation
Collaborator Contribution Collaboration on multi-site research projects Co-supervision of PhD student Sharing of data on childhood body composition from local studies Collaborative studies on MRI and ultrasound assessment in the newborn
Impact Publications: 19779473; 19127281; 20519560
Start Year 2008
 
Description Childhood body composition studies 
Organisation University Medical Center Gronigen
Country Netherlands 
Sector Hospitals 
PI Contribution Provision of expertise, training and ongoing supervision of quality control in abdominal ultrasound Development of local protocols Data analysis and manuscript preparation
Collaborator Contribution Collaboration on multi-site research projects Co-supervision of PhD student Sharing of data on childhood body composition from local studies Collaborative studies on MRI and ultrasound assessment in the newborn
Impact Publications: 19779473; 19127281; 20519560
Start Year 2008
 
Description Childhood body composition studies 
Organisation University of the Witwatersrand
Country South Africa 
Sector Academic/University 
PI Contribution Provision of expertise, training and ongoing supervision of quality control in abdominal ultrasound Development of local protocols Data analysis and manuscript preparation
Collaborator Contribution Collaboration on multi-site research projects Co-supervision of PhD student Sharing of data on childhood body composition from local studies Collaborative studies on MRI and ultrasound assessment in the newborn
Impact Publications: 19779473; 19127281; 20519560
Start Year 2008
 
Description DNSIYC 
Organisation Medical Research Council (MRC)
Department MRC Human Nutrition Research Group
Country United Kingdom 
Sector Academic/University 
PI Contribution Contribution to study management Advice and training on infant anthopometry Medical supervision
Collaborator Contribution Updating and maintenance of infant food database Establishment of national reference data on infant diet
Impact Grant funding from FSA. Report of the dress rehearsal submitted to FSA
Start Year 2009
 
Description Genetics of childhood obesity 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Academic/University 
PI Contribution Project leadership DNA genotyping
Collaborator Contribution Sharing of childhood growth data Provision of DNA samples Scientific collaborationSharing of study data Provision of DNA samples Genotyping Scientific collaboration
Impact Several Publications. Multiple disciplines include: birth cohort management; epidemiology; genetics and genomics
 
Description Genetics of childhood obesity 
Organisation University of Bristol
Department School of Social and Community Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Project leadership DNA genotyping
Collaborator Contribution Sharing of childhood growth data Provision of DNA samples Scientific collaborationSharing of study data Provision of DNA samples Genotyping Scientific collaboration
Impact Several Publications. Multiple disciplines include: birth cohort management; epidemiology; genetics and genomics
 
Description Growth in rural African fetuses and infants 
Organisation Medical Research Council (MRC)
Department MRC International Nutrition Group
Country United Kingdom 
Sector Academic/University 
PI Contribution Genetic analyses and expertise in child growth, epidemiology and endocrinology
Collaborator Contribution Field work including measurements of child growth and collection of DNA samples
Impact Bill & Melinda Gates Foundation research project grant
Start Year 2011
 
Description Infant manifestations of adult obesity susceptibility genotypes 
Organisation National Institute of Health and Medical Research (INSERM)
Department UMRS 1018 (Centre for Research in Epidemiology and Population Health (CESP))
Country France 
Sector Public 
PI Contribution I have lead the forming of this research collaboration and contribute to the leadership of the research projects
Collaborator Contribution Sharing of DNA samples and expertiseSharing of DNA samples and expertiseSharing of DNA samples and expertiseSharing of DNA samples and expertise
Impact ESPE collaborative research grant. Multiple disciplines: Epidemiology; Paediatric Endocrinology; Genetics
Start Year 2010
 
Description Infant manifestations of adult obesity susceptibility genotypes 
Organisation University Hospitals Leuven
Department Department of Paediatrics and Paediatric Surgery
Country Belgium 
Sector Hospitals 
PI Contribution I have lead the forming of this research collaboration and contribute to the leadership of the research projects
Collaborator Contribution Sharing of DNA samples and expertiseSharing of DNA samples and expertiseSharing of DNA samples and expertiseSharing of DNA samples and expertise
Impact ESPE collaborative research grant. Multiple disciplines: Epidemiology; Paediatric Endocrinology; Genetics
Start Year 2010
 
Description Infant manifestations of adult obesity susceptibility genotypes 
Organisation University of Barcelona
Country Spain 
Sector Academic/University 
PI Contribution I have lead the forming of this research collaboration and contribute to the leadership of the research projects
Collaborator Contribution Sharing of DNA samples and expertiseSharing of DNA samples and expertiseSharing of DNA samples and expertiseSharing of DNA samples and expertise
Impact ESPE collaborative research grant. Multiple disciplines: Epidemiology; Paediatric Endocrinology; Genetics
Start Year 2010
 
Description Infant manifestations of adult obesity susceptibility genotypes 
Organisation University of Cambridge
Department Department of Paediatrics
Country United Kingdom 
Sector Academic/University 
PI Contribution I have lead the forming of this research collaboration and contribute to the leadership of the research projects
Collaborator Contribution Sharing of DNA samples and expertiseSharing of DNA samples and expertiseSharing of DNA samples and expertiseSharing of DNA samples and expertise
Impact ESPE collaborative research grant. Multiple disciplines: Epidemiology; Paediatric Endocrinology; Genetics
Start Year 2010
 
Description InterConnect 
Organisation European Commission
Department Seventh Framework Programme (FP7)
Country European Union (EU) 
Sector Public 
PI Contribution Expertise in child growth and other early life risk factors for obesity and diabetes. Study design and performance of the study.
Collaborator Contribution International partnership to globally examine the genetic and environmental determinants of obesity and diabetes, by the identification of relevant studies, exposure and outcome variables, harmonisation, and the establishment of tools to allow federated data analyses.
Impact FP7 grant funding
Start Year 2013
 
Description NSHD 
Organisation University College London
Department MRC Unit for Lifelong Health and Ageing
Country United Kingdom 
Sector Academic/University 
PI Contribution Genotyping Analytical and report writing by myself and PhD student
Collaborator Contribution DNA samples Growth and other phenotype data
Impact Several high-impact scientific papers
Start Year 2008
 
Description Pelotas Birth Cohort Study 
Organisation Federal University of Pelotas (UFPel)
Department Department of Epidemiology
Country Brazil 
Sector Academic/University 
PI Contribution Expertise and training in assessment of abdominal fat, expertise in child growth and epidemiology, PhD supervision
Collaborator Contribution Field work, study supervision and oversight
Impact PhD scholarship
Start Year 2012
 
Description Reprogen Consortium 
Organisation Boston University
Department School of Medicine
Country United States 
Sector Academic/University 
PI Contribution Performance of genome-wide association studies and meta analysis. Expertise in genetic epidemiology and endocrinology
Collaborator Contribution This is the leading international consortium for the study of the genetic basis of reproductive ageing in women
Impact Scientific papers
Start Year 2009
 
Description Age at menarche - T2DM risk (KO, CE) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact American Diabetes Association Press release on "Age at menarche and type 2 diabetes risk: the EPIC-InterAct study." Diabetes Care, PMID: 24159179

Limited coverage in international news media.
Year(s) Of Engagement Activity 2013
 
Description Baby Milk BBC Radio Cambridgeshire interview (RL) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact BBC Radio Cambridgeshire interviewed RL, AMW and study participant about the Baby Milk study.

Interview broadcast by BBC Radio Cambridgeshire Breakfast Show on 18/08/14
Year(s) Of Engagement Activity 2014
URL http://www.bbc.co.uk/programmes/p0247b0r
 
Description Baby Milk Study 500th baby (RL, KO) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact MRC Epidemiology Unit press release "500th baby joins pioneering infant nutrition study at the University of Cambridge" issued to regional media outlets : Cambridge News, Peterborough Telegraph, BBC Radio Cambridgeshire, Heart FM. On 21 /07/14 published on Unit website and tweeted to @MumsnetCambs, @LocalSCambridge, @CambridgeNews @CambridgeCC @camscience @BBCCambs @enableeast @peterboroughtel@richardkendall @julianhuppert @SJacksonMP @JDjanogly @SteveBarclayMP.

Article in Cambridge News. News Editor BBC Cambridgeshire / BBC Look East requested interviews with parents/lead researchers for radio report after a tweet was forwarded to her. ITV News Anglia interiewed lead researcher and mum on 05/08/2014 Unit tweets retweeted by 8 accounts, including 2 of those targeted (@MumsnetCambs and @camscience).
Year(s) Of Engagement Activity 2014
URL http://www.mrc-epid.cam.ac.uk/500th-baby-joins-pioneering-infant-nutrition-study-at-the-university-o...
 
Description Big Wednesday event 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Unit took part in Cambridge City Council Chypps "Big Wednesday" event which had an urban festival theme. Stand focused on physical activity and included activities for chlidren to join in. 50-60 children participated in activities at the stand, and about 50 parents talked to volunteers about the Unit and its activities, and the importance of a healthy diet and physical activity.

To be determined.
Year(s) Of Engagement Activity 2014
URL https://www.cambridge.gov.uk/chypps-overview
 
Description Bustle article - Puberty Timing and Health 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Paper PubMed:26084728 was cited in Bustle article "5 Things Your Puberty Age Says About Your Health" http://www.bustle.com/articles/151116-5-things-your-puberty-age-says-about-your-health
Year(s) Of Engagement Activity 2016
URL http://www.bustle.com/articles/151116-5-things-your-puberty-age-says-about-your-health
 
Description CNN interview - role of genes in sexual behaviour 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact CNN International interview on the role of genes in sexual behaviour for web articles http://edition.cnn.com/2016/08/07/health/gallery/genes-sexual-behavior/index.html http://edition.cnn.com/2016/08/07/health/genes-decide-virginity-loss/
Year(s) Of Engagement Activity 2016
URL http://edition.cnn.com/2016/08/07/health/genes-decide-virginity-loss/
 
Description CU Press release Press release - Menarche Genes - Nature (KO, JP) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Cambridge University Press release "Age of puberty in girls influenced by which parent their genes are inherited from" on Nature paper "Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche".

Lead author JP received 14 requests for interviews from journalists. Reported in 22 articles in mainstream National and International media, including: http://www.bbc.co.uk/news/health-28417485
Year(s) Of Engagement Activity 2014
URL http://www.mrc-epid.cam.ac.uk/age-of-puberty-in-girls-imprinted-genes/
 
Description Cambridge Science Festival 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact Interactive stand at the Cambridge Science Festival. Typical attendance around 300 visitors, including children and adults.

Inquiries from school teachers and members of the public for further information. Excellent feedback from visitors and consistently good attendance at the stand.
Year(s) Of Engagement Activity 2007,2008,2009,2010,2011,2012,2013,2014,2015
URL http://www.cam.ac.uk/science-festival
 
Description Childhood obesity - UK trends and body composition measurements 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact This was a seminar for pediatric health professionals/pediatricians in Addenbrookes Hospital
presentation: Childhood obesity - UK trends and body composition measurements
Year(s) Of Engagement Activity 2016
 
Description Comment in Cambridge News 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Media (as a channel to the public)
Results and Impact Comment in Cambridge News "'Rapidly growing' babies should be targeted in fight against obesity, says obesity expert at Addenbrooke's Hospital in Cambridge"

To be determined
Year(s) Of Engagement Activity 2013
URL http://www.cambridge-news.co.uk/Cambridge/Rapidly-growing-babies-should-be-targeted-in-fight-against...
 
Description EDMaRC Workshop 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact EDMaRC Workshop: Regulation of the Pituitary-Gonadal Axis in Childhood, Adolescence and Adults; Minipuberty and Puberty. Invited speaker.
Year(s) Of Engagement Activity 2016
 
Description EPIC Norfolk Volunteer Panel presentation 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact Presentation to EPIC Norfolk Volunteer Panel "Measurement of Obesity, and what we can learn from it".
Year(s) Of Engagement Activity 2016
 
Description Early life, body composition in relation to cardio-metabolic outcomes 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Professional Practitioners
Results and Impact invited speaker to the Physiology meetings run by the Department of Pediatric, University of Cambridge and IMS, presentation for physiology meetings: Early life, body composition in relation to cardio-metabolic outcomes
Year(s) Of Engagement Activity 2016
 
Description East of England Wellbeing Show 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact MRC Epidemiology Stand and talk by Nick Wareham at East of England Well Being Show http://www.eastofenglandwell-beingshow.org.uk/ attended by approximately 1,000 members of the public. Our stand included promotional material for studies that are now recruiting, and an activity to see how exercise affects heart rate.

To be determined.
Year(s) Of Engagement Activity 2014
URL http://www.eastofenglandwell-beingshow.org.uk/
 
Description Fenland Study public meetings - Cambridge, Ely, Wisbech 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Study participants or study members
Results and Impact Public Meetings for Fenland Study participants in Cambridge, Ely, and Wisbech. The event consisted of a poster display & meet and greet session (30 minutes), followed by a presentation (20 minutes) and panel discussion with audience Q&A (40 minutes). The three meetings were well attended, with about 550 people in total, and there was a very high level of audience engagement, with many excellent questions and good feedback after the event.
Year(s) Of Engagement Activity 2016
 
Description Genetic Obesity Susceptibility (KO, CE) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact JAMA Pediatrics Press Release "Analysis Examines Genetic Obesity Susceptibility, Association with Body Size in Kids " on paper Pubmed 25329327. KO discussed implications of the study with a HealthDay reporter.

5 reports in Online international news media, including medical news media.
Year(s) Of Engagement Activity 2014
URL http://www.philly.com/philly/health/kidshealth/HealthDay692896_20141021_Tall__Heavy_1-Year-Olds_May_...
 
Description Guardian - Teenage obesity rates 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Quoted in article "Teenage obesity rates could be linked to body's 'energy saving mode'" in Guardian, commenting on new research from University of Exeter. https://www.theguardian.com/science/2016/sep/08/teenage-obesity-rates-could-be-linked-to-bodys-energy-saving-mode
Year(s) Of Engagement Activity 2016
URL https://www.theguardian.com/science/2016/sep/08/teenage-obesity-rates-could-be-linked-to-bodys-energ...
 
Description HillsFest 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact The day enables lower sixth students to try different activities and gain an insight into potential career paths through a variety of visiting companies and organisations. 10-15 students attend the session which involved both a theoretical and practical element, allowing students to get involved in live demonstrations of heart rate monitors and learn about movement monitors and tri-axial accelerometers.

During the session students actively participated in discussions around physical activity measurement and had many career and science related questions".
Year(s) Of Engagement Activity 2013,2014
 
Description ITV News Anglia about Baby Milk study (RL) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Media (as a channel to the public)
Results and Impact Raj Lakshman and study volunteer interviewed by reporter from ITV News Anglia about Baby Milk study

Report broadcast by ITV News Anglia in 6pm bulletin 06/08/14 Received positive feedback from volunteers involved in the study, and several additional requests to participate.
Year(s) Of Engagement Activity 2014
URL http://vimeo.com/102734731
 
Description Interview - Russian TV 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Featured in Russian TV documentary "Cold" which looked at her analysis of the genomes of indigenous Siberian populations for genetic variants accociated with cold adaptation and diet http://tvkultura.ru/video/show/brand_id/60162/episode_id/1267658/ Led to live interview with Maltese TVAM on 06/03/2016 http://www.tvm.com.mt/mt/programmes/tvam-4/ondemand/
Year(s) Of Engagement Activity 2016
URL http://tvkultura.ru/video/show/brand_id/60162/episode_id/1267658/
 
Description Interview TVAM Malta 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interview with Maltese TVAM on 06/03/2016 http://www.tvm.com.mt/mt/programmes/tvam-4/ondemand/ about her research looking at the genomes of indigenous Siberian populations to identify genetic variants associated with cold adaptation and diet
Year(s) Of Engagement Activity 2016
URL http://www.tvm.com.mt/mt/programmes/tvam-4/ondemand/
 
Description Kimbolton School visit 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Schools
Results and Impact Cathy Elks at Kimbolton School GCSE students and 6th Formers, talking about careers in research. 25-Apr-12


N/A
Year(s) Of Engagement Activity 2012
 
Description London Youth Science Forum 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Geographic Reach Regional
Primary Audience Public/other audiences
Results and Impact 10 Students visited the Unit as part of London International Youth Science Forum activities. Luca Lotta gave an ovreview of the Unit's research programmes, and an introduction to his own recent research on the discovery of biomarkers and causal mechanisms for the metabolic consequences of obesity. They were then taken on a tour of Unit facilities, which included demonstrations of body composition and physical activity assessment. They were also provided withprinted information on the Unit, it's organization and research activities.

To be determined.
Year(s) Of Engagement Activity 2014
URL http://www.liysf.org.uk/
 
Description MRC Open Day 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact MRC Epi Open Day in conjunction with MRC MDU / IMS. Attendance approx 80, with about half attending a lab tour of our testing facilities.

Feedback forms from approx 10% of visitors. Comments included increased awareness and intention to volunteer for studies.
Year(s) Of Engagement Activity 2013
 
Description NPRI Baby Milk Trial interview (RL) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact Interview with National Prevention Research Initiative regarding the Baby Milk Trial.

To be determined
Year(s) Of Engagement Activity 2014
 
Description Nature or Nurture - Cambridge Science Festival 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Public/other audiences
Results and Impact "Talk 'Nature Versus Nurture: What population genetics can tell us'. Lecture room with a capacity of 240 people was booked out.91% of respondents to our feedback request agreed the event was very good. 89% said it was pitched at the correct level for the audience."
Year(s) Of Engagement Activity 2016
 
Description Newsletters - Cambridge Baby Growth Study 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach Local
Primary Audience Participants in your research and patient groups
Results and Impact 6-monthly newsletters to over 1000 study participants

Feedback on study protocols
Year(s) Of Engagement Activity 2006,2007,2008,2009
 
Description Press Release - JAMA - LDL lowering and Diabetes 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact JAMA Press release "Certain LDL-C-Lowering Genetic Variants Associated with Higher Risk of Type 2 Diabetes" for paper "Association between Low-Density Lipoprotein Cholesterol Lowering Genetic Variants and Risk of Type 2 Diabetes" PubMed:27701660. Unit news blog post http://www.mrc-epid.cam.ac.uk/blog/new-genetic-analysis-provides-insight-side-effects-cholesterol-lowering-drugs/. Three reports in specialist online health & science news resources. http://www.medicalnewstoday.com/articles/313272.php, https://www.genomeweb.com/genetic-research/type-2-diabetes-risk-linked-genetic-variants-associated-low-ldl-cholesterol, http://www.newswise.com/articles/certain-ldl-c-lowering-genetic-variants-associated-with-higher-risk-of-type-2-diabetes. Featured in University of Cambridge School of Clinical Medicine newsletter on 14/10/2016.
Year(s) Of Engagement Activity 2016
URL http://www.mrc-epid.cam.ac.uk/blog/new-genetic-analysis-provides-insight-side-effects-cholesterol-lo...
 
Description Press release - Baby's genes and later life 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact MRC Epidemiology Unit Press release "How baby's genes influence birth weight and health in later life" issued too local and regional news outlets for paper "Genome-wide associations for birth weight and correlations with adult disease" PubMed:27680694. This press release was adapted from one issued to national and international media by the University of Exeter and University of Oxford. Ken Ong did a recorded interview for ITV Anglia, which was broadcast during their main evening news http://www.itv.com/news/anglia/update/2016-09-28/scientists-make-baby-birthweight-breakthrough/ and was also interviewed live by BBC Radio Cambridgeshire for their Breakfast News programme www.bbc.co.uk/programmes/p047l23s. Cambridge News also covered the paper http://www.cambridge-news.co.uk/cambridge-scientists-explain-link-between-low-weight-at-birth-and-risk-of-diabetes/story-29760402-detail/story.html There were also reports in the Guardian https://www.theguardian.com/science/2016/sep/28/birth-weight-influenced-by-genes-linked-to-disease-risk-study-reveals and more than a dozen national and international specialist online outlets arising from the Oxford, Exeter and Queensland press releases.
Year(s) Of Engagement Activity 2016
URL http://www.itv.com/news/anglia/update/2016-09-28/scientists-make-baby-birthweight-breakthrough/
 
Description Press release - Breast feeding and infant temperament 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Press release on a paper about Breast feeding and infant temperament PMID: 22253712. Positive coverage nationally and internationally in print and on line media, as well as regional TV interview.

Positive coverage was excellent, increased awareness.
Year(s) Of Engagement Activity 2012
 
Description Press release - GWAS for age at menarche 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Covered by 108 news reports internationally

UN
Year(s) Of Engagement Activity 2010
 
Description Press release - Genes link sexual maturity to body fat in women 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact November 29, 2010
Dear Drs. Murray, Ong and Murabito,

We are pleased to inform you that your article entitled "Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies"
Nature GeneticsVolume: 42,Pages: 1077-1085Year published: (2010)DOI:, doi:10.1038/ng.714; Received 10 May 2010; Accepted 19 October 2010; Published online 21 November 2010, was mentioned in the following major news arenas for the week of 18 Nov - 24 Nov.

· ABC News

· CBC (Canada)

· FOX News

· Globe and Mail (Canada)

· BBC News

· Daily Telegraph

· ABC (Australia)

· Times of India

Thank you for your contribution.

Nature Publishing Group is pleased to provide this service for our authors, and strives to achieve the widest possible readership for your research. Please direct questions and comments to Tara Packer, Author & Referee Services at t.packer@us.nature.com.

Sincerely,

Tara Packer
Head of Author & Referee Services
Nature Publishing Group
212-726-9292
212-334-3054
646-563-7120 (e-fax)


UN
Year(s) Of Engagement Activity 2010
 
Description Press release - Infant manifestations of adult obesity variants 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact National newspaper coverage
Local radio interview

UN
Year(s) Of Engagement Activity 2010
 
Description Press release - adipose storage - University of Cambridge 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact University of Cambridge press release "Inability to safely store fat increases risk of diabetes and heart disease" on Nature Genetics paper "Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance" PubMed:27841877. LL had phone interviews with journalists from BBC Radio 4 and BBC News online, and with Cambridge TV. Reported by BBC News online http://www.bbc.co.uk/news/health-37973303 and on the BBC Radio 4 Six O'Clock News http://www.bbc.co.uk/programmes/b082962f (segment starts at 21:58) and iPlayer/red button, and by NHS Choices http://www.nhs.uk/news/2016/11November/Pages/Fat-storage-problems-may-increase-diabetes-risk.aspx. Luca Lotta was interviewed by Cambridge TV http://www.cambridge-tv.co.uk/15-11-2016-evening-news/ (Interview starts at 4:50) and the paper was reported by Cambridge News and the Cambridge Network. Altmetric score on 123 on 16/11 reflected a substantial engagement on twitter. The paper was also covered in reports on at least 24 online news outlets, mostly medical and scientific but including some international outlets. Also featured in University of Cambridge School of Clinical Medicine newsletter on 25/11/2016 and Wolfson College newsletter.
Year(s) Of Engagement Activity 2016
URL http://www.bbc.co.uk/news/health-37973303
 
Description Press release - infant diet and weight gain 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact National and local radio interviews National press coverage

UN
Year(s) Of Engagement Activity 2006
 
Description Press release - mothers experiences of bottle-feeding 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact National press coverage

UN
Year(s) Of Engagement Activity 2009
 
Description Reproductive onset and success 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact "Press releases from Nature Genetics and the MRC Press Office on new publication PubMed:27089180. Press releases accompanied by Conversation article ""Losing your virginity: how we discovered that genes could play a part"" https://theconversation.com/losing-your-virginity-how-we-discovered-that-genes-could-play-a-part-58004 by JP & KO. JP, KO, FD gave phone interviews to journalists from The Verge, New Scientist, Boston globe, Scientific American, Wired, LiveSciance, Helsingin Sanomat, Daily Telegraph, STAT, VICE. KO recorded radio interview with ABC News (Australia). Press release featured on MRC, University of Cambridge and Unitnews blogs http://www.mrc-epid.cam.ac.uk/blog/uk-biobank-study-identifies-gene-changes-that-influence-timing-of-sexual-behaviour/.

Reported online in more than 100 national and international news outlets in at least 15 countries including Guardian https://www.theguardian.com/science/2016/apr/18/genes-influence-the-age-at-which-you-lose-your-virginity-first-sex-dna, PBS news http://www.pbs.org/newshour/rundown/love-in-this-club-genome-virginity/, and Daily Mail http://www.dailymail.co.uk/sciencetech/article-3546129/Is-DNA-making-promiscuous-Genes-linked-risk-taking-influence-people-s-sexual-activity.html. Print articles in Times, Sun and Daily Mail. The Conversation article was republished by at least 3 outlets, and received more than 25,000 views, including the Independent http://www.independent.co.uk/news/science/losing-virginity-genes-study-science-cambridge-genetics-a6990891.html. KO interview with ABC News was broadcast on 19/04/16 http://www.abc.net.au/worldtoday/content/2016/s4445929.htm. Very good follow-up article on CNN 08/08/2016 edition.cnn.com/2016/08/07/health/genes-decide-virginity-loss/"
Year(s) Of Engagement Activity 2016
URL https://theconversation.com/losing-your-virginity-how-we-discovered-that-genes-could-play-a-part-580...
 
Description SNPs and Human Diseases course 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited lecturer for a post graduate training course - SNPs and Human Diseases course
Year(s) Of Engagement Activity 2016
 
Description SNPs and human diseases 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Postgraduate students
Results and Impact Invited speaker - SNPs and human diseases, Lecture to Postgraduate students
Year(s) Of Engagement Activity 2016
 
Description US News and world report - healthiest month 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact Interviewed and quoted in online article "What's the Healthiest Month to Be Born In?" in U.S News and World Report http://health.usnews.com/wellness/slideshows/whats-the-healthiest-month-to-be-born-in.
Year(s) Of Engagement Activity 2016
URL http://health.usnews.com/wellness/slideshows/whats-the-healthiest-month-to-be-born-in