Lymphocyte Development
Lead Research Organisation:
MRC London Institute of Medical Sciences
Abstract
Most cells within the body contain exactly the same information - identical DNA strands - but look and behave differently. Exactly how each cell is educated to do a specific job is not understood. What seems to be important is that cells turn on and turn off the right genes at the right time and in the right place. We are trying to figure out how information contained within the DNA of our genes is used to instruct a developing embryo to make cells with a particular function.||If this were understood, it may be possible to safely convert cells of one type to do a different job. For example, to divert cells that you dont need or are in surplus, to repair important tissue that is damaged by injury or disease. This tremendous potential for therapy provides additional incentive for trying to solve how cells make their different career choices and whether these choices are permanent or flexible.
Technical Summary
A central question in biology is how genetic information is interpreted to direct the ordered formation of different cell types within an organism.||Our group studies the molecular events that underlie co-ordinate gene activation and gene gene silencing, and how cell identity is conveyed through division, particularly in lymphocytes. ||These studies focus on understanding how key factors such as Ikaros regulate gene expression, the spatial position of loci in the nucleus and whether gene activity status is heritable.||We are examining the epigenetic regulation of stem cells, including the roles of non coding RNA, chromatin and Polycomb proteins in ES pluripotency and lineage-specific differentiation. This research programme uses replication timing, Chromatin (histone modification) profiling and ChIP analysis to map large-scale epigenetic changes that occur during development and ES cell differentiation.||We are evaluating the role of non-coding RNAs in transcriptional and post transcriptional gene silencing using mice carrying conditional alleles of the RNAseIII enzyme Dicer.||We are also investigating how cellular reprogramming is achieved using experimental heterokaryons, nuclear transfer and in trans-differentiating model systems.
Organisations
- MRC London Institute of Medical Sciences, United Kingdom (Lead Research Organisation)
- Regional Government of Valencia (Collaboration)
- University College London, United Kingdom (Collaboration)
- Marie Sklodowska-Curie Actions (Collaboration)
- University of Massachusetts Lowell, United States (Collaboration)
- University of Dundee, United Kingdom (Collaboration)
- University of California Los Angeles, United States (Collaboration)
- Helmholtz Association of German Research Centres (Collaboration)
- Ludwig Boltzmann Society (Collaboration)
- Icahn School of Medicine at Mount Sinai (Collaboration)
- Harvard University (Collaboration)
- Cardiff University, United Kingdom (Collaboration)
- Howard Hughes Medical Institute (Collaboration)
- Massachusetts General Hospital (Collaboration)
- Babraham Institute (Collaboration)
- Swiss Federal Institute of Technology (ETH), Zurich (Collaboration)
- University of Tokyo (Collaboration)
- Agency for Science, Technology and Research (A*STAR) (Collaboration)
- European Commission, Belgium (Collaboration)
- RIKEN, Japan (Collaboration)
- University of Oxford, United Kingdom (Collaboration)
- University of California, Irvine, United States (Collaboration)
- Max Planck Society (Collaboration)
- Hebrew University of Jerusalem (Collaboration)
- Research Institute of Molecular Pathology (IMP) (Collaboration)
- University of California, San Francisco, United States (Collaboration)
- Imperial College London, United Kingdom (Collaboration)
- Cancer Research UK Cambridge Institute (Collaboration)
- University of Cambridge, United Kingdom (Collaboration)
- Yale University (Collaboration)
- Broad Institute (Collaboration)
- University of Leeds, United Kingdom (Collaboration)
- Washington University in St Louis, United States (Collaboration)
- Duke University, United States (Collaboration)
- University of Sussex, United Kingdom (Collaboration)
- Radboud University Nijmegen, Netherlands (Collaboration)
- EMBL - European Bioinformatics Institute, United Kingdom (Collaboration)
Publications
Aragon L
(2013)
Condensin, cohesin and the control of chromatin states.
in Current opinion in genetics & development
Azuara V
(2006)
Chromatin signatures of pluripotent cell lines.
in Nature cell biology
Bagci H
(2013)
DNA demethylation in pluripotency and reprogramming: the role of tet proteins and cell division.
in Cell stem cell
Blevins R
(2015)
microRNAs regulate cell-to-cell variability of endogenous target gene expression in developing mouse thymocytes.
in PLoS genetics
Bowers SR
(2009)
A conserved insulator that recruits CTCF and cohesin exists between the closely related but divergently regulated interleukin-3 and granulocyte-macrophage colony-stimulating factor genes.
in Molecular and cellular biology
Brown KE
(2013)
Atypical heterochromatin organization and replication are rapidly acquired by somatic cells following fusion-mediated reprogramming by mouse ESCs.
in Cell cycle (Georgetown, Tex.)
Bruno L
(2019)
Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system.
in Nature immunology
Bruno L
(2008)
Directing T cell differentiation and function with small molecule inhibitors.
in Cell cycle (Georgetown, Tex.)
Bruno L
(2009)
Runx proteins regulate Foxp3 expression.
in The Journal of experimental medicine
| Description | BBSRC Genes and Developmental Biology, Board |
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| Description | House of Lords - genomic medicine |
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| Description | Wellcome Trust Expert Review Group |
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| Description | Boehringer Ingelheim Fonds Fellowship |
| Amount | £41,020 (GBP) |
| Organisation | Boehringer Ingelheim |
| Sector | Private |
| Country | Germany |
| Start | 10/2009 |
| End | 09/2011 |
| Description | British Heart Foundation |
| Amount | £57,476 (GBP) |
| Funding ID | PS8162 |
| Organisation | British Heart Foundation (BHF) |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2013 |
| End | 09/2017 |
| Description | Chain Florey Clinical Research Fellowship |
| Amount | £374,882 (GBP) |
| Funding ID | P38772 |
| Organisation | National Institute for Health Research |
| Department | NIHR Imperial Biomedical Research Centre |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 04/2011 |
| End | 03/2016 |
| Description | Commonwealth Scholarship and Fellowship/Imperial College London |
| Amount | £16,140 (GBP) |
| Organisation | Imperial College London |
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| Start | 10/2010 |
| End | 09/2013 |
| Description | Commonwealth Scholarship and Fellowship/Imperial College London |
| Amount | £97,584 (GBP) |
| Organisation | Government of the UK |
| Department | Commonwealth Scholarship Commission |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | EC Integrated Project (FP6) - HEROIC (12m euros across 16 participants) |
| Amount | £249,455 (GBP) |
| Funding ID | 18883 |
| Organisation | Sixth Framework Programme (FP6) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 11/2005 |
| End | 10/2010 |
| Description | EC Marie Curie Research Training Network (FP6) - Chromatin Plasticity |
| Amount | £132,522 (GBP) |
| Funding ID | 35733 |
| Organisation | Marie Sklodowska-Curie Actions |
| Sector | Charity/Non Profit |
| Country | Global |
| Start | 10/2006 |
| End | 10/2010 |
| Description | EC Network of Excellence (FP6) - EPIGENOME (12.5m euros across 30 participants) |
| Amount | £447,099 (GBP) |
| Organisation | Sixth Framework Programme (FP6) |
| Sector | Public |
| Country | European Union (EU) |
| Start | 06/2004 |
| End | 05/2010 |
| Description | EMBO Fellowship |
| Amount | £7,270 (GBP) |
| Organisation | European Molecular Biology Organisation |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 03/2007 |
| End | 05/2007 |
| Description | EMBO Long-Term Fellowship |
| Amount | £14,885 (GBP) |
| Organisation | European Molecular Biology Organisation |
| Sector | Charity/Non Profit |
| Country | Germany |
| Start | 05/2010 |
| End | 12/2010 |
| Description | ERC Advanced Grant (FP7) - REPLENICHE |
| Amount | £1,730,768 (GBP) |
| Funding ID | P36973 |
| Organisation | European Research Council (ERC) |
| Sector | Public |
| Country | Belgium |
| Start | 05/2012 |
| End | 04/2017 |
| Description | EU STATEGRA |
| Amount | £574,614 (GBP) |
| Funding ID | P39553 |
| Organisation | European Commission |
| Sector | Public |
| Country | European Union (EU) |
| Start | 10/2012 |
| End | 09/2015 |
| Description | Great Britain Saskawa Foundation |
| Amount | £3,200 (GBP) |
| Organisation | The Great Britain Sasakawa Foundation |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | |
| Description | Human Frontier Science Program (HFSP) Fellowship |
| Amount | £33,642 (GBP) |
| Organisation | Human Frontier Science Program (HFSP) |
| Sector | Charity/Non Profit |
| Country | France |
| Start | 07/2008 |
| End | 08/2011 |
| Description | Human Frontier Science Program (HFSP) Long-Term Fellowship/International Human Frontier Science Program Organisation |
| Amount | £93,780 (GBP) |
| Organisation | Human Frontier Science Program (HFSP) |
| Sector | Charity/Non Profit |
| Country | France |
| Start | 01/2011 |
| End | 12/2013 |
| Description | ICL Photonics - pump-priming for innovative |
| Amount | £790,654 (GBP) |
| Funding ID | P43051 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 02/2013 |
| End | 02/2017 |
| Description | Leukaemia Research Gordon Piller Studentship Award - Ikaros Tumor Suppressor |
| Amount | £136,389 (GBP) |
| Funding ID | P27047 |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 08/2015 |
| Description | Leukaemia Research Project Grant |
| Amount | £153,821 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2007 |
| End | 05/2010 |
| Description | Leukaemia Research Studentship |
| Amount | £150,000 (GBP) |
| Organisation | Leukaemia and Lymphoma Research |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 06/2007 |
| End | 10/2010 |
| Description | MRC Capacity Building Studentship |
| Amount | £65,106 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2007 |
| End | 10/2010 |
| Description | MRC Career Development Award in Stem Cell Research (joint MRC/Parkinson's Disease UK funding) |
| Amount | £126,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | |
| End | 09/2006 |
| Description | MRC Clinical Research Training Fellowship |
| Amount | £246,446 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 03/2009 |
| End | 04/2012 |
| Description | MRC Next Generation Imaging |
| Amount | £2,000,000 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 12/2012 |
| End | 12/2016 |
| Description | MRC Project Grant |
| Amount | £205,978 (GBP) |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 04/2007 |
| End | 03/2009 |
| Description | MRC-BHF Cardiovascular Stem Cell Research Strategic Development Grant |
| Amount | £125,000 (GBP) |
| Funding ID | G0901467 |
| Organisation | Medical Research Council (MRC) |
| Sector | Public |
| Country | United Kingdom |
| Start | 08/2010 |
| End | 08/2013 |
| Description | NIH Research Grant |
| Amount | £121,488 (GBP) |
| Organisation | National Institutes of Health (NIH) |
| Sector | Public |
| Country | United States |
| Start | |
| End | 06/2006 |
| Description | Portuguese Government, FCT Fellowship |
| Amount | £85,182 (GBP) |
| Organisation | New University of Lisbon |
| Department | Foundation for Science and Technology |
| Sector | Academic/University |
| Country | Portugal |
| Start | |
| End | 09/2008 |
| Description | Spanish Government Fellowship |
| Amount | £40,442 (GBP) |
| Organisation | Spanish Ministry of Science and Innovation |
| Sector | Private |
| Country | Spain |
| Start | 09/2007 |
| End | 09/2009 |
| Description | UK-China Scholarships for Excellence/Imperial College London + UK Department for Business Innovation and Skills (BIS) |
| Amount | £12,384 (GBP) |
| Organisation | Department for Business, Energy & Industrial Strategy |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | UK-China Scholarships for Excellence/Imperial College London + UK Department for Business Innovation and Skills (BIS) |
| Amount | £80,700 (GBP) |
| Organisation | Department for Business, Energy & Industrial Strategy |
| Sector | Public |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | UK-China Scholarships for Excellence/Imperial College London + UK Department for Business Innovation and Skills (BIS) |
| Amount | £25,200 (GBP) |
| Organisation | University of Leeds |
| Department | China Scholarship Council |
| Sector | Academic/University |
| Country | United Kingdom |
| Start | 10/2010 |
| End | 09/2013 |
| Description | Wellcome Trust Grant - cohesion in gene regulation |
| Amount | £1,787,619 (GBP) |
| Funding ID | P41623 |
| Organisation | Wellcome Trust |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 01/2013 |
| End | 12/2017 |
| Description | Wellcome Trust ISSF Brigem mice |
| Amount | £109,210 (GBP) |
| Funding ID | PS2384 |
| Organisation | Wellcome Trust |
| Department | Wellcome Trust Institutional Strategic Support Fund |
| Sector | Charity/Non Profit |
| Country | United Kingdom |
| Start | 08/2014 |
| End | 07/2015 |
| Title | Generation of dicer-conditional mutant mice |
| Description | Mouse model to study the impact of post-transcriptional regulation by microRNAs. |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Year Produced | 2006 |
| Provided To Others? | Yes |
| Impact | Numerous publications and ongoing research projects in approximately 40 labs world wide. |
| Title | Generation of luciferase-imprinting mice and ESCs |
| Description | Mice in which luciferase is expressed under the allelic control of Cdkn1c, D1k1, Ube3a, Nnat, IgG2, Atrx genes (and others). |
| Type Of Material | Model of mechanisms or symptoms - mammalian in vivo |
| Provided To Others? | No |
| Impact | Numerous collaborative studies using engineered ESCs. |
| Title | Induction of regulatory T cell differentiation |
| Description | A new method for the induction of regulatory T cell differentiation based on the use of clinically approved small molecules. |
| Type Of Material | Technology assay or reagent |
| Year Produced | 2008 |
| Provided To Others? | Yes |
| Impact | Numerous collaborative and independent research projects. |
| Description | Analysis of epigenetic changes in single cells of epigenetic changes in single cell - University of Singapore |
| Organisation | Agency for Science, Technology and Research (A*STAR) |
| Department | Institute of Molecular and Cell Biology, |
| Country | Singapore |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2014 |
| Description | Anne Ferguson-Smith |
| Organisation | University of Cambridge |
| Department | MRC Epidemiology Unit |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration. |
| Collaborator Contribution | Research collaboration. |
| Impact | Research collaboration and publication. |
| Start Year | 2016 |
| Description | Babraham Intstitute, Cambridge |
| Organisation | Babraham Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint research project and reagents and publication. |
| Collaborator Contribution | Research collaboration and publication. |
| Impact | Research collaboration and publication. |
| Start Year | 2009 |
| Description | Bioluminescence and DLK1 expression - University of Cambridge |
| Organisation | University of Cambridge |
| Department | Faculty of Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2013 |
| Description | Bioluminescence imaging (BRIGEM) of caknic expression |
| Organisation | Cardiff University |
| Department | School of Biosciences |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2012 |
| Description | Broad Institute, USA |
| Organisation | Broad Institute |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2011 |
| Description | Broad Institute, USA |
| Organisation | Harvard University |
| Department | Harvard Medical School |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2011 |
| Description | Broad Institute, USA |
| Organisation | Howard Hughes Medical Institute |
| Country | United States |
| Sector | Charity/Non Profit |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2011 |
| Description | CRUK Cambridge Research Institute |
| Organisation | Cancer Research UK Cambridge Institute |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint research projects and reagents and publications. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaborations and publications: PMID: 17363975 PMID: 17938583 |
| Start Year | 2007 |
| Description | Duke University School of Medicine, North Carolina, USA |
| Organisation | Duke University |
| Department | Department of Immunology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Research collaboration and publication |
| Collaborator Contribution | Research collaboration and publication |
| Impact | Research collaboration and publication. PMID: 21832993 |
| Start Year | 2011 |
| Description | EU STATEGRA project |
| Organisation | Regional Government of Valencia |
| Department | PrÃncipe Felipe Research Centre (CIPF) |
| Country | Spain |
| Sector | Academic/University |
| PI Contribution | FP7 project |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2012 |
| Description | Epigenome FP6 Network of Excellence, EU |
| Organisation | European Commission |
| Department | EC FP6 Collaborative Projects |
| Country | European Union (EU) |
| Sector | Academic/University |
| PI Contribution | Fellowship - Epigenome FP6 Network of Excellence |
| Collaborator Contribution | Fellowship |
| Impact | Fellowship - Epigenome FP6 Network of Excellence |
| Description | European bioinformatics Institute (EBI) |
| Organisation | EMBL European Bioinformatics Institute (EMBL - EBI) |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Computational biology |
| Impact | Research collaboration |
| Start Year | 2011 |
| Description | Harvard Medical School, USA |
| Organisation | Harvard University |
| Department | Harvard Medical School |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Joint research projects and reagents and publications. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaborations and publications: PMID: 18329371 PMID: 18238902 |
| Start Year | 2008 |
| Description | Hebrew University Medical School, Jerusalem |
| Organisation | Hebrew University of Jerusalem |
| Department | Department of Development Biology and Cancer Research |
| Country | Israel |
| Sector | Academic/University |
| PI Contribution | Joint research project and reagents and publication. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaboration and publication: PMID: 17311920 |
| Start Year | 2007 |
| Description | ICL Bioengineering (ICCS studentship) |
| Organisation | Imperial College London |
| Department | Department of Bioengineering |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Joint funding and expertise sharing |
| Impact | Research collaboration |
| Start Year | 2013 |
| Description | ICL Photonics - pump-priming for innovative |
| Organisation | Imperial College London |
| Department | Department of Physics |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2013 |
| Description | MRC Genome Damage and Stability Centre, University of Sussex |
| Organisation | University of Sussex |
| Department | Genome Damage and Stability Centre |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2009 |
| Description | Marie Curie Research Training Network, Heidelberg |
| Organisation | Marie Sklodowska-Curie Actions |
| Country | Global |
| Sector | Charity/Non Profit |
| PI Contribution | Chromatin Plasticity FP6 Marie Curie Research Training Network. |
| Collaborator Contribution | Fellowship |
| Impact | Chromatin Plasticity FP6 Marie Curie Research Training Network. |
| Start Year | 2006 |
| Description | Massachusetts General Hospital, USA |
| Organisation | Massachusetts General Hospital |
| Country | United States |
| Sector | Hospitals |
| PI Contribution | Joint research project and reagents and publication. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaboration and publication: PMID: 18238902 |
| Start Year | 2008 |
| Description | Max Planck Institute of Immunobiology |
| Organisation | Max Planck Society |
| Department | Max Planck Institute of Immunobiology and Epigenetics |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Joint research projects and reagents and publications. |
| Collaborator Contribution | Research project collaborations and publications. |
| Impact | Research collaborations and publications: PMID: 17363301 PMID: 17101802 |
| Start Year | 2007 |
| Description | Mount Sinai School of Medicine, Department of Medicine, Division of Nephrology, NY, USA |
| Organisation | Icahn School of Medicine at Mount Sinai |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Joint research project and reagents and publication. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaboration and publication: PMID: 18776119 |
| Start Year | 2007 |
| Description | Paul French |
| Organisation | Imperial College London |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration, grant writing, publications. |
| Collaborator Contribution | Research collaboration, publications. |
| Impact | Research collaboration, grant writing, publications. |
| Start Year | 2012 |
| Description | Radboud University Nijmegen, The Netherlands |
| Organisation | Radboud University Nijmegen |
| Department | Department of Molecular Biology |
| Country | Netherlands |
| Sector | Academic/University |
| PI Contribution | Fellowship - Heroic EU-FP6 Integrated Project. |
| Collaborator Contribution | Fellowship |
| Impact | Fellowship - Heroic EU-FP6 Integrated Project. |
| Description | Research Institute of Molecular Pathology, Austria |
| Organisation | Research Institute of Molecular Pathology (IMP) |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Joint research projects and reagents and publications. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaboration and publication: PMID: 17101802 |
| Start Year | 2007 |
| Description | Riken, Japan |
| Organisation | RIKEN |
| Country | Japan |
| Sector | Public |
| PI Contribution | Joint research project and reagents and publication. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaboration and publication: |
| Start Year | 2007 |
| Description | Rosalind John |
| Organisation | Cardiff University |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research Collaboration, publications. |
| Collaborator Contribution | Research Collaboration, publications. |
| Impact | Research collaboration, publications. |
| Start Year | 2015 |
| Description | Skirmantas Kriaucionis |
| Organisation | Ludwig Boltzmann Society |
| Department | Ludwig Boltzmann Institute for Lung Vascular Research |
| Country | Austria |
| Sector | Academic/University |
| PI Contribution | Research collaboration, publications. |
| Collaborator Contribution | Research collaboration, publications. |
| Impact | Grant writing, publications. Multidisciplinary collaboration. |
| Start Year | 2017 |
| Description | Stefan Kempa |
| Organisation | Helmholtz Association of German Research Centres |
| Department | The Max Delbrück Center for Molecular Medicine (MDC) |
| Country | Germany |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration. |
| Start Year | 2016 |
| Description | Swiss Federal Institute of Technology, Zurich |
| Organisation | ETH Zurich |
| Department | Institute for Chemical and Bioengineering |
| Country | Switzerland |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2011 |
| Description | Swiss Federal Institute of Technology, Zurich |
| Organisation | Imperial College London |
| Department | Department of Chemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2011 |
| Description | Tokyo - OZAWA/OHMIYA |
| Organisation | University of Tokyo |
| Department | School of Science |
| Country | Japan |
| Sector | Academic/University |
| PI Contribution | Research collaboration, workshop organisation. |
| Collaborator Contribution | Research collaboration, participation in workshop. |
| Impact | Research collaboration, workshop organisation. |
| Start Year | 2016 |
| Description | UCL, London |
| Organisation | University College London |
| Department | Division of Infection and Immunity |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Research collaboration and publication |
| Collaborator Contribution | Research collaboration and publication |
| Impact | Research collaboration and publication. PMID: 20542000 |
| Start Year | 2009 |
| Description | UCLA, USA |
| Organisation | University of California, Los Angeles (UCLA) |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Research collaboration and joint publications. |
| Collaborator Contribution | Research collaboration and publications. |
| Impact | Research collaboration and publications. |
| Description | University of California, Irvine |
| Organisation | University of California, Irvine |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Joint research project and reagents and publication. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaboration and publication: PMID: 18237772 |
| Start Year | 2008 |
| Description | University of California, San Francisco |
| Organisation | University of California, San Francisco |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Joint research project and reagents and publication. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaboration and publication: PMID: 18509048 |
| Start Year | 2008 |
| Description | University of Dundee |
| Organisation | University of Dundee |
| Department | Division of Cell and Developmental Biology |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint research project and reagents and publication. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaboration and publication: PMID: 18509048 |
| Start Year | 2008 |
| Description | University of Leeds, Institute for Molecular Medicine |
| Organisation | University of Leeds |
| Department | Leeds Institute of Molecular Medicine |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint research projects and reagents and publications. |
| Collaborator Contribution | Research project collaborations and publications. |
| Impact | Research collaborations and publications: PMID: 19339695 PMID: 19158269 |
| Start Year | 2009 |
| Description | University of Massachusetts Medical School, USA |
| Organisation | University of Massachusetts |
| Department | Department of Biochemistry and Molecular Pharmacology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Research collaboration |
| Collaborator Contribution | Research collaboration |
| Impact | Research collaboration |
| Start Year | 2011 |
| Description | University of Oxford, Department of Biochemistry |
| Organisation | University of Oxford |
| Department | Department of Biochemistry |
| Country | United Kingdom |
| Sector | Academic/University |
| PI Contribution | Joint research projects and reagents and publications. |
| Collaborator Contribution | Research project collaborations and publications. |
| Impact | Research collaborations and publications: PMID: 18237772 PMID: 19014663 |
| Start Year | 2008 |
| Description | Washington University in St Louis, USA |
| Organisation | Washington University in St Louis |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Joint research projects and reagents and publications. |
| Collaborator Contribution | Research project collaboration and publication. |
| Impact | Research collaborations and publications: PMID: 19201947 PMID: 19242417 |
| Start Year | 2008 |
| Description | Yale University School of Medicine, Connecticut, USA |
| Organisation | Yale University |
| Department | Department of Immunobiology |
| Country | United States |
| Sector | Academic/University |
| PI Contribution | Research collaboration and publication |
| Collaborator Contribution | Research collaboration and publication |
| Impact | Research collaboration and publication. PMID: 21832993 |
| Start Year | 2011 |
| Title | Use of PI3K M-TOR and Akt Inhibitors to Induce FOXP3 Expression and Generate Regulatory T Cells - A813/2031 |
| Description | Use of PI3K M-TOR and Akt Inhibitors to Induce FOXP3 Expression and Generate Regulatory T Cells. |
| IP Reference | US20100034786 |
| Protection | Patent granted |
| Year Protection Granted | 2009 |
| Licensed | No |
| Impact | Numerous collaborative and independent research projects and publications. |
| Title | Use of PI3K M-TOR and Akt Inhibitors to Induce FOXP3 Expression and Generate Regulatory T Cells. |
| Description | Use of PI3K M-TOR and Akt Inhibitors to Induce FOXP3 Expression and Generate Regulatory T Cells. |
| Type | Therapeutic Intervention - Drug |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2009 |
| Development Status | Actively seeking support |
| Impact | In progress. |
| Title | iPad app: the role of transcription factors in B cell development |
| Description | iPad app: the role of transcription factors in B cell development. |
| Type | Support Tool - For Fundamental Research |
| Current Stage Of Development | Initial development |
| Year Development Stage Completed | 2013 |
| Development Status | Under active development/distribution |
| Impact | In progress |
| Description | Biomedical Picture of the Day |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | Development and design of an 'image a day' website - launched in beta on 1.01.2012 and in fully-responsive (iPad/mobile friendly) mode on 1.04.2012. Freelance-editor-in-chief, science communications intern and writer community support the resource. The website has reached 50,000 people since it launched in 1 Jan. On tumblr (bpod-mrc.tumblr.com) there are 34,960 followers. On facebook.com/bpod.mrc there are around 2069 Likes. @BPoD_mrc has around 500 twitter followers. |
| Year(s) Of Engagement Activity | 2012,2013,2014 |
| URL | http://www.bpod.mrc.ac.uk |
| Description | Chain-Florey workshop 2015 |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Chain-Florey scheme brings medical graduates into the basic science laboratories of the MRC Clinical Sciences Centre at Imperial College for three-year PhDs. The scheme is funded jointly by the MRC and NIHR through the Imperial Biomedical Research Centre, and was founded to spur the development of the next generation of world-class academic clinicians. The scheme is named after Benjamin Chain and Ernst Florey, whose work on antibiotics is a tribute to scientific endeavour plus medical purpose. Since its inception in 2009, 17 Chain-Florey fellowships have been awarded. The first Chain-Florey lectureship came in 2014, with 4 lecturers now in place. Professor Josef Penninger was the keynote speaker at the 2015 Chain-Florey workshop. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://csc.mrc.ac.uk/chain-florey-workshop-2015-mice-men-haploid-cells/ |
| Description | Fabrics of Life: Animations for schools |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Professor Corkbot's cat invites primary school children to explore scientific themes including evolution and genetics. Schoolchildren design scientific experiments and produce celebratory animations. Schoolchildren learned about how science works, that science can be fun. Screening event for parents, teachers and pupils. |
| Year(s) Of Engagement Activity | 2009 |
| URL | http://www.corkbots.com |
| Description | Fabrics of Life: NOBELini |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | The NOBELini scheme paired 30 young scientists with 30 design students in a bid to celebrate scientific discovery through design. Pairs competed for £2000 prizes to create science-inspired design prototypes. A subsequent exhibition was held at the Science Museum's Dana Centre in February 2010. Science students broaden their horizons and improve their ability to communicate science. Fostered long-term collaborations / friendships between scientists and designers. Featured in Nature. |
| Year(s) Of Engagement Activity | 2009,2010 |
| URL | http://www.fabricsoflife.co.uk |
| Description | Fabrics of Life: Nobel Textiles |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | MRC funded five professional fashion and textile designers together with five MRC-based Nobel prize winners to celebrate scientific discovery. A two year dialogue preceeded the exhibition at the ICA/Saint James's Park. 3000 exhibition catalogues enlighten the public about key MRC Nobel prize winning discoveries. |
| Year(s) Of Engagement Activity | 2006,2007,2008,2009 |
| URL | http://www.nobeltextiles.com |
| Description | Fabrics of Life: Science for Scriptwriters |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | A group of TV drama scriptwriters were invited, through PAWS (Public Awareness of Women in Science), to learn about research at the CSC. Two scripts drafted. Awaiting approval from editors. |
| Year(s) Of Engagement Activity | 2007 |
| Description | Fabrics of Life: Scopic |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | Yes |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | A cross-disciplinary educational initiative for schoolchildren in years 6-8. It engages students in science through the arts, encouraging them to draw comparisons between biological (MicroSCOPIC) and astronomical (TeleSCOPIC) phenomena to produce works of art and loop-based electronic music. Schoolchildren learn that creativity is part of science. Featured in Science magazine. |
| Year(s) Of Engagement Activity | 2007,2008 |
| URL | http://www.myscopic.co.uk |
| Description | Fabrics of Life: Workshops |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Leading scientists shared research findings with art and design students in a bid to celebrate science. The worshops explored scientific themes through design media: Epigenetics (2007); Model organisms (2008); Evolution (2009); Synthetic and systems biology (2010); Big Data: designing with the materials of life (2014). Keeping art and design students up to date with and inspired by advances in science. |
| Year(s) Of Engagement Activity | 2007,2008,2009,2010,2014 |
| Description | Heroes of Health |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | To mark the MRC centenary, CSC published the comic book "Heroes of Health" featuring MRC scientists who made important discoveries a century ago. The comic also invited pupils to participate in a game in which they played either the role of patients suffering from diseases that were common 100 years ago, doctors trying to diagnose and treat them, or scientists trying to find cures. Four short films created by Kiki von Glasow highlighted contemporary MRC research. Ten workshops were delivered by the CSC to pupils in years 4-6 at schools in Greater London, Northampton, Rutland and Nottinghamshire to deliver resources and encourage participation in the competition. A selection of the work produced by primary school pupils was exhibited at the Strictly Science: keeping one step ahead exhibition in April 2013. Public recognition of the contribution of biomedical science to medical practice in Britain and worldwide. School children learned about how science works and its contribution to health and medical practice. |
| Year(s) Of Engagement Activity | 2013 |
| Description | Imagine the Future Competition for Primary Schools |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | National |
| Primary Audience | Schools |
| Results and Impact | Schools competition launched in September 2012 through a series of workshops delivered to UK primary schools (years 5 and 6) to share bespoke resources (4 x documentary films - Science in Progress : MRC Centenary Films - about current MRC research programmes), and a comic book (Heroes of Health - about the past 100 years of MRC research). Bespoke resources were provided free to support pupils in developing creative submissions for the Imagine the Future competition (closing Dec 21st 2012). The competition has been advertised to schools across the UK through the Association for Science Education. Selected works from primary schools across the UK were exhibited in the MRC centenary installation in April 2013. Although the competition has not yet closed, the workshops have helped to raise awareness of the existence of the Medical Research Council and its past and present contributions to society, particularly including the fact that it is supported by public funds. 9-11 year olds demonstrated considerable excitement at the prospect that they might have an influence on research that happens in the future. |
| Year(s) Of Engagement Activity | 2012,2013 |
| URL | http://www.csc.mrc.ac.uk/centenary |
| Description | Jarid 2 (website article) |
| Form Of Engagement Activity | A press release, press conference or response to a media enquiry/interview |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Media (as a channel to the public) |
| Results and Impact | An article summarising the findings of Amanda Fisher's article, published in Cell Reports. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://csc.mrc.ac.uk/a-new-conductor-takes-centre-stage-in-the-early-embryo/ |
| Description | Ministerial visit |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Policymakers/politicians |
| Results and Impact | George Freeman, Minister for Life Sciences, met John Savill (MRC Chief Executive Officer) and CSC Director Amanda Fisher for a visit of the MRC CSC imaging facilities and the research laboratories, to learn more about our research and how it might best be translated from the laboratory into advances in healthcare. After meeting some senior scientists, Freeman was introduced to the younger generation. A group of PhD students, post-doctoral researchers and Chain-Florey Fellows and Lecturers outlined their work. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://csc.mrc.ac.uk/ministerial-visit-gets-hearts-racing/ |
| Description | RCUK Equality, Diversity and Inclusion Action Plan: Formal launch and engagement workshop |
| Form Of Engagement Activity | A formal working group, expert panel or dialogue |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Professional Practitioners |
| Results and Impact | Workshop following the formal launch of the Research Councils' Equality, Diversity and Inclusion Action Plan published on 4th May. Our aim for the event is to bring senior leaders from our partner organisations in the research landscape together to promote the importance of equality, diversity and inclusion and to provide leadership to research and academic communities in creating a real step change. |
| Year(s) Of Engagement Activity | 2016 |
| URL | http://www.rcuk.ac.uk/media/news/160504/ |
| Description | Strictly Science: installation/exhibition and catalogue |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Public/other audiences |
| Results and Impact | As part of the Medical Research Council's centenary in 2013, a free interactive exhibition and acompanying catalogue - 'Strictly Science: keeping one step ahead' - invited visitors to engage in the past, present and future of medical research. The exhibition was held over 10 days (4-14 April 2013) at Imperial College London. A series of installations enabled the public to explore the past 100 years of MRC science, from watching scientists conduct century-old experiments to interacting with contemporary neurotechnologists investigating the brain. The opinions of public figures were shared alongside those of UK primary schoolchildren and the public was invited to add to this growing video archive of 'talking heads' recorded in the act of imagining the future. This was a rare opportunity for the public to learn about the enormous contribution taxpayer revenue has made, and continues to make to medical practice in Britain and worldwide. |
| Year(s) Of Engagement Activity | 2013 |
| URL | http://www.csc.mrc.ac.uk/PublicScience/centenary/StrictlyScience/ |
| Description | Suffrage Science Awards 2017 Royal Society |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The Suffrage Science scheme celebrates women in science for their scientific achievement and for their ability to inspire others. It encourages women to enter scientific subjects, and to stay. This public engagement scheme was initiated in 2011, by the MRC Clinical Sciences Centre (CSC)*, a biomedical research institute of the UK's Medical Research Council. The scheme began with a focus on women in the life sciences. In 2013, Suffrage Science expanded to recognise women in the engineering and physical sciences. On Tuesday 11 October 2016, a date recognised globally as Ada Lovelace Day, the scheme expanded again, with the formation of a third specialty area. This latest addition recognises women in mathematics and computing. *On January 1st 2017, the CSC was renamed the London Institute of Medical Sciences, or LMS. |
| Year(s) Of Engagement Activity | 2017 |
| URL | http://suffragescience.org/ |
| Description | Suffrage Science Maths&Computing Bletchley Park 11 October 2016 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Other audiences |
| Results and Impact | The Maths and Computing branch is the latest addition to the Suffrage Science scheme. It springs into life at Bletchley Park on Tuesday 11 October 2016, a date recognised globally as Ada Lovelace Day. |
| Year(s) Of Engagement Activity | 2016 |
| Description | Suffrage Science: events |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Suffrage Science was launched in 2011 to mark the centenary of International Women's Day 2011. Inspired by suffragette jewellery, the CSC collaborated with Central Saint Martin's College of Art and Design to run a competition to design jewellery and textiles to celebrate the collective contribution of female pioneers in the life sciences. In 2013, Imperial College London, Faculty of Medicine, sponsored a sequel jewellery competition for women in medical, physical and engineering sciences. Since then, heirloom jewellery has been handed on to a new generation of women scientists annually. Plans have recently made to expand Suffrage Science reach into Maths and Computational Sciences. The awards ceremonies are combined with inspirational, topical debates: Are women changing science? (2011); Suffragette-inspired Tea party (2013); Women's stories in science (2014); Is the world of science pale, male and stale? (2015); Inspiration in science and routes to change (2016). Recognition of the contribution of women scientists to the life and engineering sciences. Inspiration of future generations of women. Networking opportunity for women scientists. National media on events and publications (e.g. Guardian, The Scientist, Metro). |
| Year(s) Of Engagement Activity | 2011,2012,2013,2014,2015 |
| Description | Suffrage Science: publications |
| Form Of Engagement Activity | A magazine, newsletter or online publication |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Public/other audiences |
| Results and Impact | Suffrage Science was launched in 2011 to mark the centenary of International Women's Day 2011. Since then, heirloom jewellery has been handed on from one generation of leading women scientists to the next in an annual awards ceremony. This ceremony is accompanied by a booklet featuring conversations between the women scientists who received the heirloom jewellery across the life, medical, physical and engineering sciences. Recognition of the contribution of women scientists to the life and engineering sciences. Inspiration of future generations of women. |
| Year(s) Of Engagement Activity | 2011,2012,2014 |
| Description | The CSC's Suffrage Science film night - 15 November 2015 |
| Form Of Engagement Activity | A talk or presentation |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | The evening, hosted by the Tricycle theatre in North London, began with a screening of Suffragette the film - to remember those who gave the Suffrage Science scheme its name. After the screening, Helen Pankhurst joined a panel of four to discuss the making of the film and women's activism more broadly. Helen currently campaigns on behalf of the aid organisation Care International, which supports access to education for girls and women across the world. The other panellists comprised neuroscientist and Suffrage Science awardee Uta Frith, historian and Suffragette adviser Krista Cowman and Suffragette producer Alison Owen, with writer and broadcaster Vivienne Parry in the chair. |
| Year(s) Of Engagement Activity | 2015 |
| URL | http://csc.mrc.ac.uk/cscs-suffrage-science-film-night-15-november-2015/ |
| Description | Virtual Lab |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Type Of Presentation | Workshop Facilitator |
| Geographic Reach | International |
| Primary Audience | Schools |
| Results and Impact | Virtual Lab is a website that allows highschool pupils aged 14-19 to engage with and take part in contemporary scientific research. It was piloted with experiments on cell division and stem cell biology for GCSE and A-level students (aged 16-19) based on research from the CSC. In October 2011 an experiment exploring how the brain works will be launched. VL pilot experiments made students more enthusiastic about science, and influenced some of the participants' career choices. A detailed evaluation is available for download from the website. |
| Year(s) Of Engagement Activity | 2010,2011,2012 |
| URL | http://www.virtuallab.co.uk |
| Description | Women in Power |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | National |
| Primary Audience | Other audiences |
| Results and Impact | Invited speaker to an event during the London Fashion Week. |
| Year(s) Of Engagement Activity | 2019 |
| URL | https://www.evelyn.co.uk/evelyn-glennie-spoke-about-women-in-power-at-london-fashion-week-ss19-for-e... |
| Description | Workshop for Experimental and Computational Biology |
| Form Of Engagement Activity | Participation in an activity, workshop or similar |
| Part Of Official Scheme? | No |
| Geographic Reach | International |
| Primary Audience | Professional Practitioners |
| Results and Impact | Interdisciplinary workshop for Experimental and Computational Biology |
| Year(s) Of Engagement Activity | 2016 |