Lymphocyte Development

Lead Research Organisation: MRC London Institute of Medical Sciences

Abstract

Most cells within the body contain exactly the same information - identical DNA strands - but look and behave differently. Exactly how each cell is educated to do a specific job is not understood. What seems to be important is that cells turn on and turn off the right genes at the right time and in the right place. We are trying to figure out how information contained within the DNA of our genes is used to instruct a developing embryo to make cells with a particular function.||If this were understood, it may be possible to safely convert cells of one type to do a different job. For example, to divert cells that you dont need or are in surplus, to repair important tissue that is damaged by injury or disease. This tremendous potential for therapy provides additional incentive for trying to solve how cells make their different career choices and whether these choices are permanent or flexible.

Technical Summary

A central question in biology is how genetic information is interpreted to direct the ordered formation of different cell types within an organism.||Our group studies the molecular events that underlie co-ordinate gene activation and gene gene silencing, and how cell identity is conveyed through division, particularly in lymphocytes. ||These studies focus on understanding how key factors such as Ikaros regulate gene expression, the spatial position of loci in the nucleus and whether gene activity status is heritable.||We are examining the epigenetic regulation of stem cells, including the roles of non coding RNA, chromatin and Polycomb proteins in ES pluripotency and lineage-specific differentiation. This research programme uses replication timing, Chromatin (histone modification) profiling and ChIP analysis to map large-scale epigenetic changes that occur during development and ES cell differentiation.||We are evaluating the role of non-coding RNAs in transcriptional and post transcriptional gene silencing using mice carrying conditional alleles of the RNAseIII enzyme Dicer.||We are also investigating how cellular reprogramming is achieved using experimental heterokaryons, nuclear transfer and in trans-differentiating model systems.

Organisations

Publications

10 25 50
 
Description BBSRC Genes and Developmental Biology, Board
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description BBSRC Genes and Developmental Biology, Portfolio Evaluation Panel
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description BLUEPRINT (FP7) Scientific Advisory Board
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description BSCB ambassador
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Berlin Institute of Health (BIH) - Scientific Advisory Board
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
 
Description Biotechnology Center (BIOTEC), Technische Universität Dresden - Scientific Advisory Board
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
Impact Influence on the recruitment and research priorities of BIOTEC.
 
Description Centre d'Immunologie Marseille-Luminy (CIML) - International Scientific Advisory Board
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
 
Description Centre for Gene Regulation and Expression, Dundee - International Scientific Advisory Board
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
 
Description EMBO Science and Society Panel
Geographic Reach Europe 
Policy Influence Type Participation in advisory committee
 
Description ERC Synergy Grants - Evaluation Panel Member
Geographic Reach Europe 
Policy Influence Type Membership of a guidance committee
 
Description German Federal Ministry of Education and Research (BMBF) - Stem Cell Review Panel
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description House of Lords - genomic medicine
Geographic Reach National 
Policy Influence Type Gave evidence to a government review
 
Description House of Lords, Science and Technology Select Committee - inquiry on regenerative medicine
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Imanova Scientific Steering Committee
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description International Human Epigenome Consortium (IHEC) Scientific Steering Committee
Geographic Reach Multiple continents/international 
Policy Influence Type Membership of a guidance committee
 
Description MRC Strategy Board
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Max Planck Institute of Immunobiology (MPI-IB) - Scientific Advisory Board
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in advisory committee
 
Description PERAP RCUK
Geographic Reach National 
Policy Influence Type Membership of a guideline committee
URL http://www.rcuk.ac.uk/pe/public-engagement-with-research-strategy/
 
Description Research Councils UK (RCUK) Public Engagement with Research (PER) - Advisory Panel
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Wellcome Trust Expert Review Group
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Boehringer Ingelheim Fonds Fellowship
Amount £41,020 (GBP)
Organisation Boehringer Ingelheim 
Sector Private
Country Germany
Start 10/2009 
End 09/2011
 
Description British Heart Foundation
Amount £57,476 (GBP)
Funding ID PS8162 
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2013 
End 09/2017
 
Description Chain Florey Clinical Research Fellowship
Amount £374,882 (GBP)
Funding ID P38772 
Organisation National Institute for Health Research 
Department NIHR Imperial Biomedical Research Centre
Sector Academic/University
Country United Kingdom
Start 04/2011 
End 03/2016
 
Description Commonwealth Scholarship and Fellowship/Imperial College London
Amount £16,140 (GBP)
Organisation Imperial College London 
Sector Academic/University
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description Commonwealth Scholarship and Fellowship/Imperial College London
Amount £97,584 (GBP)
Organisation Government of the UK 
Department Commonwealth Scholarship Commission
Sector Public
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description EC Integrated Project (FP6) - HEROIC (12m euros across 16 participants)
Amount £249,455 (GBP)
Organisation Sixth Framework Programme (FP6) 
Sector Public
Country European Union (EU)
Start 11/2005 
End 10/2010
 
Description EC Marie Curie Research Training Network (FP6) - Chromatin Plasticity
Amount £132,522 (GBP)
Organisation Marie Sklodowska-Curie Actions 
Sector Academic/University
Country Global
Start 10/2006 
End 10/2010
 
Description EC Network of Excellence (FP6) - EPIGENOME (12.5m euros across 30 participants)
Amount £447,099 (GBP)
Organisation Sixth Framework Programme (FP6) 
Sector Public
Country European Union (EU)
Start 06/2004 
End 05/2010
 
Description EMBO Fellowship
Amount £7,270 (GBP)
Organisation European Molecular Biology Organisation 
Sector Learned Society
Country European Union (EU)
Start 03/2007 
End 05/2007
 
Description EMBO Long-Term Fellowship
Amount £14,885 (GBP)
Organisation European Molecular Biology Organisation 
Sector Learned Society
Country European Union (EU)
Start 05/2010 
End 12/2010
 
Description ERC Advanced Grant (FP7) - REPLENICHE
Amount £1,730,768 (GBP)
Funding ID P36973 
Organisation European Research Council (ERC) 
Sector Public
Country European Union (EU)
Start 05/2012 
End 04/2017
 
Description EU STATEGRA
Amount £574,614 (GBP)
Funding ID P39553 
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 10/2012 
End 09/2015
 
Description Great Britain Saskawa Foundation
Amount £3,200 (GBP)
Organisation The Great Britain Sasakawa Foundation 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Description Human Frontier Science Program (HFSP) Fellowship
Amount £33,642 (GBP)
Organisation Human Frontier Science Program (HFSP) 
Sector Charity/Non Profit
Country France
Start 07/2008 
End 08/2011
 
Description Human Frontier Science Program (HFSP) Long-Term Fellowship/International Human Frontier Science Program Organisation
Amount £93,780 (GBP)
Organisation Human Frontier Science Program (HFSP) 
Sector Charity/Non Profit
Country France
Start 01/2011 
End 12/2013
 
Description ICL Photonics - pump-priming for innovative
Amount £790,654 (GBP)
Funding ID P43051 
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 02/2013 
End 02/2017
 
Description Leukaemia Research Gordon Piller Studentship Award - Ikaros Tumor Suppressor
Amount £136,389 (GBP)
Funding ID P27047 
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2010 
End 08/2015
 
Description Leukaemia Research Project Grant
Amount £153,821 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2007 
End 05/2010
 
Description Leukaemia Research Studentship
Amount £150,000 (GBP)
Organisation Leukaemia and Lymphoma Research 
Sector Charity/Non Profit
Country United Kingdom
Start 06/2007 
End 10/2010
 
Description MRC Capacity Building Studentship
Amount £65,106 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 10/2007 
End 10/2010
 
Description MRC Career Development Award in Stem Cell Research (joint MRC/Parkinson's Disease UK funding)
Amount £126,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start  
End 09/2006
 
Description MRC Clinical Research Training Fellowship
Amount £246,446 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 03/2009 
End 04/2012
 
Description MRC Next Generation Imaging
Amount £2,000,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 12/2012 
End 12/2016
 
Description MRC Project Grant
Amount £205,978 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 04/2007 
End 03/2009
 
Description MRC-BHF Cardiovascular Stem Cell Research Strategic Development Grant
Amount £125,000 (GBP)
Organisation Medical Research Council (MRC) 
Sector Academic/University
Country United Kingdom
Start 08/2010 
End 08/2013
 
Description NIH Research Grant
Amount £121,488 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start  
End 06/2006
 
Description Portuguese Government, FCT Fellowship
Amount £85,182 (GBP)
Organisation New University of Lisbon 
Department Foundation for Science and Technology
Sector Academic/University
Country Portugal
Start  
End 09/2008
 
Description Spanish Government Fellowship
Amount £40,442 (GBP)
Organisation Spanish Ministry of Science and Innovation 
Sector Public
Country Spain
Start 09/2007 
End 09/2009
 
Description UK-China Scholarships for Excellence/Imperial College London + UK Department for Business Innovation and Skills (BIS)
Amount £12,384 (GBP)
Organisation Department for Business, Energy & Industrial Strategy 
Sector Public
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description UK-China Scholarships for Excellence/Imperial College London + UK Department for Business Innovation and Skills (BIS)
Amount £25,200 (GBP)
Organisation University of Leeds 
Department China Scholarship Council
Sector Academic/University
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description UK-China Scholarships for Excellence/Imperial College London + UK Department for Business Innovation and Skills (BIS)
Amount £80,700 (GBP)
Organisation Department for Business, Energy & Industrial Strategy 
Sector Public
Country United Kingdom
Start 10/2010 
End 09/2013
 
Description Wellcome Trust Grant - cohesion in gene regulation
Amount £1,787,619 (GBP)
Funding ID P41623 
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start 01/2013 
End 12/2017
 
Description Wellcome Trust ISSF Brigem mice
Amount £109,210 (GBP)
Funding ID PS2384 
Organisation Wellcome Trust 
Department Wellcome Trust Institutional Strategic Support Fund
Sector Charity/Non Profit
Country United Kingdom
Start 08/2014 
End 07/2015
 
Title Generation of dicer-conditional mutant mice 
Description Mouse model to study the impact of post-transcriptional regulation by microRNAs. 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Year Produced 2006 
Provided To Others? Yes  
Impact Numerous publications and ongoing research projects in approximately 40 labs world wide. 
 
Title Generation of luciferase-imprinting mice and ESCs 
Description Mice in which luciferase is expressed under the allelic control of Cdkn1c, D1k1, Ube3a, Nnat, IgG2, Atrx genes (and others). 
Type Of Material Model of mechanisms or symptoms - mammalian in vivo 
Provided To Others? No  
Impact Numerous collaborative studies using engineered ESCs. 
 
Title Induction of regulatory T cell differentiation 
Description A new method for the induction of regulatory T cell differentiation based on the use of clinically approved small molecules. 
Type Of Material Technology assay or reagent 
Year Produced 2008 
Provided To Others? Yes  
Impact Numerous collaborative and independent research projects. 
 
Description Analysis of epigenetic changes in single cells of epigenetic changes in single cell - University of Singapore 
Organisation Agency for Science, Technology and Research (A*STAR)
Department Institute of Molecular and Cell Biology,
Country Singapore 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2014
 
Description Anne Ferguson-Smith 
Organisation University of Cambridge
Department MRC Epidemiology Unit
Country United Kingdom 
Sector Multiple 
PI Contribution Research collaboration.
Collaborator Contribution Research collaboration.
Impact Research collaboration and publication.
Start Year 2016
 
Description Babraham Intstitute, Cambridge 
Organisation Babraham Institute
Country United Kingdom 
Sector Private 
PI Contribution Joint research project and reagents and publication.
Collaborator Contribution Research collaboration and publication.
Impact Research collaboration and publication.
Start Year 2009
 
Description Bioluminescence and DLK1 expression - University of Cambridge 
Organisation University of Cambridge
Department Faculty of Biology
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2013
 
Description Bioluminescence imaging (BRIGEM) of caknic expression 
Organisation Cardiff University
Department School of Biosciences
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2012
 
Description Broad Institute, USA 
Organisation Broad Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2011
 
Description Broad Institute, USA 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2011
 
Description Broad Institute, USA 
Organisation Howard Hughes Medical Institute
Country United States 
Sector Charity/Non Profit 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2011
 
Description CRUK Cambridge Research Institute 
Organisation Cancer Research UK Cambridge Institute
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint research projects and reagents and publications.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaborations and publications: PMID: 17363975 PMID: 17938583
Start Year 2007
 
Description Duke University School of Medicine, North Carolina, USA 
Organisation Duke University
Department Department of Immunology
Country United States 
Sector Academic/University 
PI Contribution Research collaboration and publication
Collaborator Contribution Research collaboration and publication
Impact Research collaboration and publication. PMID: 21832993
Start Year 2011
 
Description EU STATEGRA project 
Organisation Regional Government of Valencia
Department Príncipe Felipe Research Centre (CIPF)
Country Spain 
Sector Charity/Non Profit 
PI Contribution FP7 project
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2012
 
Description Epigenome FP6 Network of Excellence, EU 
Organisation European Commission
Department EC FP6 Collaborative Projects
Country European Union (EU) 
Sector Academic/University 
PI Contribution Fellowship - Epigenome FP6 Network of Excellence
Collaborator Contribution Fellowship
Impact Fellowship - Epigenome FP6 Network of Excellence
 
Description European bioinformatics Institute (EBI) 
Organisation EMBL European Bioinformatics Institute (EMBL - EBI)
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Computational biology
Impact Research collaboration
Start Year 2011
 
Description Harvard Medical School, USA 
Organisation Harvard University
Department Harvard Medical School
Country United States 
Sector Academic/University 
PI Contribution Joint research projects and reagents and publications.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaborations and publications: PMID: 18329371 PMID: 18238902
Start Year 2008
 
Description Hebrew University Medical School, Jerusalem 
Organisation Hebrew University of Jerusalem
Department Department of Development Biology and Cancer Research
Country Israel 
Sector Academic/University 
PI Contribution Joint research project and reagents and publication.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaboration and publication: PMID: 17311920
Start Year 2007
 
Description ICL Bioengineering (ICCS studentship) 
Organisation Imperial College London
Department Department of Bioengineering
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Joint funding and expertise sharing
Impact Research collaboration
Start Year 2013
 
Description ICL Photonics - pump-priming for innovative 
Organisation Imperial College London
Department Department of Physics
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2013
 
Description MRC Genome Damage and Stability Centre, University of Sussex 
Organisation University of Sussex
Department Genome Damage and Stability Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2009
 
Description Marie Curie Research Training Network, Heidelberg 
Organisation Marie Sklodowska-Curie Actions
Country Global 
Sector Academic/University 
PI Contribution Chromatin Plasticity FP6 Marie Curie Research Training Network.
Collaborator Contribution Fellowship
Impact Chromatin Plasticity FP6 Marie Curie Research Training Network.
Start Year 2006
 
Description Massachusetts General Hospital, USA 
Organisation Massachusetts General Hospital
Country United States 
Sector Hospitals 
PI Contribution Joint research project and reagents and publication.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaboration and publication: PMID: 18238902
Start Year 2008
 
Description Max Planck Institute of Immunobiology 
Organisation Max Planck Society
Department Max Planck Institute of Immunobiology and Epigenetics
Country Germany 
Sector Public 
PI Contribution Joint research projects and reagents and publications.
Collaborator Contribution Research project collaborations and publications.
Impact Research collaborations and publications: PMID: 17363301 PMID: 17101802
Start Year 2007
 
Description Mount Sinai School of Medicine, Department of Medicine, Division of Nephrology, NY, USA 
Organisation Icahn School of Medicine at Mount Sinai
Country United States 
Sector Academic/University 
PI Contribution Joint research project and reagents and publication.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaboration and publication: PMID: 18776119
Start Year 2007
 
Description Paul French 
Organisation Imperial College London
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration, grant writing, publications.
Collaborator Contribution Research collaboration, publications.
Impact Research collaboration, grant writing, publications.
Start Year 2012
 
Description Radboud University Nijmegen, The Netherlands 
Organisation Radboud University Nijmegen
Department Department of Molecular Biology
Country Netherlands 
Sector Academic/University 
PI Contribution Fellowship - Heroic EU-FP6 Integrated Project.
Collaborator Contribution Fellowship
Impact Fellowship - Heroic EU-FP6 Integrated Project.
 
Description Research Institute of Molecular Pathology, Austria 
Organisation Research Institute of Molecular Pathology (IMP)
Country Austria 
Sector Academic/University 
PI Contribution Joint research projects and reagents and publications.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaboration and publication: PMID: 17101802
Start Year 2007
 
Description Riken, Japan 
Organisation RIKEN
Country Japan 
Sector Private 
PI Contribution Joint research project and reagents and publication.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaboration and publication:
Start Year 2007
 
Description Rosalind John 
Organisation Cardiff University
Country United Kingdom 
Sector Academic/University 
PI Contribution Research Collaboration, publications.
Collaborator Contribution Research Collaboration, publications.
Impact Research collaboration, publications.
Start Year 2015
 
Description Skirmantas Kriaucionis 
Organisation Ludwig Boltzmann Society
Department Ludwig Boltzmann Institute for Lung Vascular Research
Country Austria 
Sector Charity/Non Profit 
PI Contribution Research collaboration, publications.
Collaborator Contribution Research collaboration, publications.
Impact Grant writing, publications. Multidisciplinary collaboration.
Start Year 2017
 
Description Stefan Kempa 
Organisation Helmholtz Association of German Research Centres
Department The Max Delbrück Center for Molecular Medicine (MDC)
Country Germany 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration.
Start Year 2016
 
Description Swiss Federal Institute of Technology, Zurich 
Organisation ETH Zurich
Department Institute for Chemical and Bioengineering
Country Switzerland 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2011
 
Description Swiss Federal Institute of Technology, Zurich 
Organisation Imperial College London
Department Department of Chemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2011
 
Description Tokyo - OZAWA/OHMIYA 
Organisation University of Tokyo
Department School of Science
Country Japan 
Sector Academic/University 
PI Contribution Research collaboration, workshop organisation.
Collaborator Contribution Research collaboration, participation in workshop.
Impact Research collaboration, workshop organisation.
Start Year 2016
 
Description UCL, London 
Organisation University College London
Department Division of Infection and Immunity
Country United Kingdom 
Sector Academic/University 
PI Contribution Research collaboration and publication
Collaborator Contribution Research collaboration and publication
Impact Research collaboration and publication. PMID: 20542000
Start Year 2009
 
Description UCLA, USA 
Organisation University of California, Los Angeles (UCLA)
Country United States 
Sector Academic/University 
PI Contribution Research collaboration and joint publications.
Collaborator Contribution Research collaboration and publications.
Impact Research collaboration and publications.
 
Description University of California, Irvine 
Organisation University of California, Irvine
Country United States 
Sector Academic/University 
PI Contribution Joint research project and reagents and publication.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaboration and publication: PMID: 18237772
Start Year 2008
 
Description University of California, San Francisco 
Organisation University of California, San Francisco
Country United States 
Sector Academic/University 
PI Contribution Joint research project and reagents and publication.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaboration and publication: PMID: 18509048
Start Year 2008
 
Description University of Dundee 
Organisation University of Dundee
Department Division of Cell and Developmental Biology
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint research project and reagents and publication.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaboration and publication: PMID: 18509048
Start Year 2008
 
Description University of Leeds, Institute for Molecular Medicine 
Organisation University of Leeds
Department Leeds Institute of Molecular Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint research projects and reagents and publications.
Collaborator Contribution Research project collaborations and publications.
Impact Research collaborations and publications: PMID: 19339695 PMID: 19158269
Start Year 2009
 
Description University of Massachusetts Medical School, USA 
Organisation University of Massachusetts
Department Department of Biochemistry and Molecular Pharmacology
Country United States 
Sector Academic/University 
PI Contribution Research collaboration
Collaborator Contribution Research collaboration
Impact Research collaboration
Start Year 2011
 
Description University of Oxford, Department of Biochemistry 
Organisation University of Oxford
Department Department of Biochemistry
Country United Kingdom 
Sector Academic/University 
PI Contribution Joint research projects and reagents and publications.
Collaborator Contribution Research project collaborations and publications.
Impact Research collaborations and publications: PMID: 18237772 PMID: 19014663
Start Year 2008
 
Description Washington University in St Louis, USA 
Organisation Washington University in St Louis
Country United States 
Sector Academic/University 
PI Contribution Joint research projects and reagents and publications.
Collaborator Contribution Research project collaboration and publication.
Impact Research collaborations and publications: PMID: 19201947 PMID: 19242417
Start Year 2008
 
Description Yale University School of Medicine, Connecticut, USA 
Organisation Yale University
Department Department of Immunobiology
Country United States 
Sector Academic/University 
PI Contribution Research collaboration and publication
Collaborator Contribution Research collaboration and publication
Impact Research collaboration and publication. PMID: 21832993
Start Year 2011
 
Title Use of PI3K M-TOR and Akt Inhibitors to Induce FOXP3 Expression and Generate Regulatory T Cells - A813/2031 
Description Use of PI3K M-TOR and Akt Inhibitors to Induce FOXP3 Expression and Generate Regulatory T Cells. 
IP Reference US2010034786  
Protection Patent granted
Year Protection Granted 2009
Licensed No
Impact Numerous collaborative and independent research projects and publications.
 
Title Use of PI3K M-TOR and Akt Inhibitors to Induce FOXP3 Expression and Generate Regulatory T Cells. 
Description Use of PI3K M-TOR and Akt Inhibitors to Induce FOXP3 Expression and Generate Regulatory T Cells. 
Type Therapeutic Intervention - Drug
Current Stage Of Development Initial development
Year Development Stage Completed 2009
Development Status Actively seeking support
Impact In progress. 
 
Title iPad app: the role of transcription factors in B cell development 
Description iPad app: the role of transcription factors in B cell development. 
Type Support Tool - For Fundamental Research
Current Stage Of Development Initial development
Year Development Stage Completed 2013
Development Status Under active development/distribution
Impact In progress 
 
Description Biomedical Picture of the Day 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact Development and design of an 'image a day' website - launched in beta on 1.01.2012 and in fully-responsive (iPad/mobile friendly) mode on 1.04.2012. Freelance-editor-in-chief, science communications intern and writer community support the resource.

The website has reached 50,000 people since it launched in 1 Jan. On tumblr (bpod-mrc.tumblr.com) there are 34,960 followers. On facebook.com/bpod.mrc there are around 2069 Likes. @BPoD_mrc has around 500 twitter followers.
Year(s) Of Engagement Activity 2012,2013,2014
URL http://www.bpod.mrc.ac.uk
 
Description Chain-Florey workshop 2015 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Chain-Florey scheme brings medical graduates into the basic science laboratories of the MRC Clinical Sciences Centre at Imperial College for three-year PhDs. The scheme is funded jointly by the MRC and NIHR through the Imperial Biomedical Research Centre, and was founded to spur the development of the next generation of world-class academic clinicians. The scheme is named after Benjamin Chain and Ernst Florey, whose work on antibiotics is a tribute to scientific endeavour plus medical purpose. Since its inception in 2009, 17 Chain-Florey fellowships have been awarded. The first Chain-Florey lectureship came in 2014, with 4 lecturers now in place.

Professor Josef Penninger was the keynote speaker at the 2015 Chain-Florey workshop.
Year(s) Of Engagement Activity 2015
URL http://csc.mrc.ac.uk/chain-florey-workshop-2015-mice-men-haploid-cells/
 
Description Fabrics of Life: Animations for schools 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Schools
Results and Impact Professor Corkbot's cat invites primary school children to explore scientific themes including evolution and genetics. Schoolchildren design scientific experiments and produce celebratory animations.

Schoolchildren learned about how science works, that science can be fun. Screening event for parents, teachers and pupils.
Year(s) Of Engagement Activity 2009
URL http://www.corkbots.com
 
Description Fabrics of Life: NOBELini 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact The NOBELini scheme paired 30 young scientists with 30 design students in a bid to celebrate scientific discovery through design. Pairs competed for £2000 prizes to create science-inspired design prototypes. A subsequent exhibition was held at the Science Museum's Dana Centre in February 2010.

Science students broaden their horizons and improve their ability to communicate science. Fostered long-term collaborations / friendships between scientists and designers. Featured in Nature.
Year(s) Of Engagement Activity 2009,2010
URL http://www.fabricsoflife.co.uk
 
Description Fabrics of Life: Nobel Textiles 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact MRC funded five professional fashion and textile designers together with five MRC-based Nobel prize winners to celebrate scientific discovery. A two year dialogue preceeded the exhibition at the ICA/Saint James's Park.

3000 exhibition catalogues enlighten the public about key MRC Nobel prize winning discoveries.
Year(s) Of Engagement Activity 2006,2007,2008,2009
URL http://www.nobeltextiles.com
 
Description Fabrics of Life: Science for Scriptwriters 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Media (as a channel to the public)
Results and Impact A group of TV drama scriptwriters were invited, through PAWS (Public Awareness of Women in Science), to learn about research at the CSC.

Two scripts drafted. Awaiting approval from editors.
Year(s) Of Engagement Activity 2007
 
Description Fabrics of Life: Scopic 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? Yes
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Schools
Results and Impact A cross-disciplinary educational initiative for schoolchildren in years 6-8. It engages students in science through the arts, encouraging them to draw comparisons between biological (MicroSCOPIC) and astronomical (TeleSCOPIC) phenomena to produce works of art and loop-based electronic music.

Schoolchildren learn that creativity is part of science. Featured in Science magazine.
Year(s) Of Engagement Activity 2007,2008
URL http://www.myscopic.co.uk
 
Description Fabrics of Life: Workshops 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Leading scientists shared research findings with art and design students in a bid to celebrate science. The worshops explored scientific themes through design media: Epigenetics (2007); Model organisms (2008); Evolution (2009); Synthetic and systems biology (2010); Big Data: designing with the materials of life (2014).

Keeping art and design students up to date with and inspired by advances in science.
Year(s) Of Engagement Activity 2007,2008,2009,2010,2014
 
Description Heroes of Health 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact To mark the MRC centenary, CSC published the comic book "Heroes of Health" featuring MRC scientists who made important discoveries a century ago. The comic also invited pupils to participate in a game in which they played either the role of patients suffering from diseases that were common 100 years ago, doctors trying to diagnose and treat them, or scientists trying to find cures. Four short films created by Kiki von Glasow highlighted contemporary MRC research. Ten workshops were delivered by the CSC to pupils in years 4-6 at schools in Greater London, Northampton, Rutland and Nottinghamshire to deliver resources and encourage participation in the competition. A selection of the work produced by primary school pupils was exhibited at the Strictly Science: keeping one step ahead exhibition in April 2013.

Public recognition of the contribution of biomedical science to medical practice in Britain and worldwide. School children learned about how science works and its contribution to health and medical practice.
Year(s) Of Engagement Activity 2013
 
Description Imagine the Future Competition for Primary Schools 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach National
Primary Audience Schools
Results and Impact Schools competition launched in September 2012 through a series of workshops delivered to UK primary schools (years 5 and 6) to share bespoke resources (4 x documentary films - Science in Progress : MRC Centenary Films - about current MRC research programmes), and a comic book (Heroes of Health - about the past 100 years of MRC research). Bespoke resources were provided free to support pupils in developing creative submissions for the Imagine the Future competition (closing Dec 21st 2012). The competition has been advertised to schools across the UK through the Association for Science Education. Selected works from primary schools across the UK were exhibited in the MRC centenary installation in April 2013.

Although the competition has not yet closed, the workshops have helped to raise awareness of the existence of the Medical Research Council and its past and present contributions to society, particularly including the fact that it is supported by public funds. 9-11 year olds demonstrated considerable excitement at the prospect that they might have an influence on research that happens in the future.
Year(s) Of Engagement Activity 2012,2013
URL http://www.csc.mrc.ac.uk/centenary
 
Description Jarid 2 (website article) 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact An article summarising the findings of Amanda Fisher's article, published in Cell Reports.
Year(s) Of Engagement Activity 2015
URL http://csc.mrc.ac.uk/a-new-conductor-takes-centre-stage-in-the-early-embryo/
 
Description Ministerial visit 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Policymakers/politicians
Results and Impact George Freeman, Minister for Life Sciences, met John Savill (MRC Chief Executive Officer) and CSC Director Amanda Fisher for a visit of the MRC CSC imaging facilities and the research laboratories, to learn more about our research and how it might best be translated from the laboratory into advances in healthcare. After meeting some senior scientists, Freeman was introduced to the younger generation. A group of PhD students, post-doctoral researchers and Chain-Florey Fellows and Lecturers outlined their work.
Year(s) Of Engagement Activity 2015
URL http://csc.mrc.ac.uk/ministerial-visit-gets-hearts-racing/
 
Description RCUK Equality, Diversity and Inclusion Action Plan: Formal launch and engagement workshop 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Workshop following the formal launch of the Research Councils' Equality, Diversity and Inclusion Action Plan published on 4th May. Our aim for the event is to bring senior leaders from our partner organisations in the research landscape together to promote the importance of equality, diversity and inclusion and to provide leadership to research and academic communities in creating a real step change.
Year(s) Of Engagement Activity 2016
URL http://www.rcuk.ac.uk/media/news/160504/
 
Description Strictly Science: installation/exhibition and catalogue 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Public/other audiences
Results and Impact As part of the Medical Research Council's centenary in 2013, a free interactive exhibition and acompanying catalogue - 'Strictly Science: keeping one step ahead' - invited visitors to engage in the past, present and future of medical research. The exhibition was held over 10 days (4-14 April 2013) at Imperial College London. A series of installations enabled the public to explore the past 100 years of MRC science, from watching scientists conduct century-old experiments to interacting with contemporary neurotechnologists investigating the brain. The opinions of public figures were shared alongside those of UK primary schoolchildren and the public was invited to add to this growing video archive of 'talking heads' recorded in the act of imagining the future.

This was a rare opportunity for the public to learn about the enormous contribution taxpayer revenue has made, and continues to make to medical practice in Britain and worldwide.
Year(s) Of Engagement Activity 2013
URL http://www.csc.mrc.ac.uk/PublicScience/centenary/StrictlyScience/
 
Description Suffrage Science Awards 2017 Royal Society 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The Suffrage Science scheme celebrates women in science for their scientific achievement and for their ability to inspire others. It encourages women to enter scientific subjects, and to stay. This public engagement scheme was initiated in 2011, by the MRC Clinical Sciences Centre (CSC)*, a biomedical research institute of the UK's Medical Research Council.

The scheme began with a focus on women in the life sciences. In 2013, Suffrage Science expanded to recognise women in the engineering and physical sciences. On Tuesday 11 October 2016, a date recognised globally as Ada Lovelace Day, the scheme expanded again, with the formation of a third specialty area. This latest addition recognises women in mathematics and computing. *On January 1st 2017, the CSC was renamed the London Institute of Medical Sciences, or LMS.
Year(s) Of Engagement Activity 2017
URL http://suffragescience.org/
 
Description Suffrage Science Maths&Computing Bletchley Park 11 October 2016 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The Maths and Computing branch is the latest addition to the Suffrage Science scheme. It springs into life at Bletchley Park on Tuesday 11 October 2016, a date recognised globally as Ada Lovelace Day.
Year(s) Of Engagement Activity 2016
 
Description Suffrage Science: events 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Suffrage Science was launched in 2011 to mark the centenary of International Women's Day 2011. Inspired by suffragette jewellery, the CSC collaborated with Central Saint Martin's College of Art and Design to run a competition to design jewellery and textiles to celebrate the collective contribution of female pioneers in the life sciences. In 2013, Imperial College London, Faculty of Medicine, sponsored a sequel jewellery competition for women in medical, physical and engineering sciences. Since then, heirloom jewellery has been handed on to a new generation of women scientists annually. Plans have recently made to expand Suffrage Science reach into Maths and Computational Sciences. The awards ceremonies are combined with inspirational, topical debates: Are women changing science? (2011); Suffragette-inspired Tea party (2013); Women's stories in science (2014); Is the world of science pale, male and stale? (2015); Inspiration in science and routes to change (2016).

Recognition of the contribution of women scientists to the life and engineering sciences. Inspiration of future generations of women. Networking opportunity for women scientists. National media on events and publications (e.g. Guardian, The Scientist, Metro).
Year(s) Of Engagement Activity 2011,2012,2013,2014,2015
 
Description Suffrage Science: publications 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Suffrage Science was launched in 2011 to mark the centenary of International Women's Day 2011. Since then, heirloom jewellery has been handed on from one generation of leading women scientists to the next in an annual awards ceremony. This ceremony is accompanied by a booklet featuring conversations between the women scientists who received the heirloom jewellery across the life, medical, physical and engineering sciences.

Recognition of the contribution of women scientists to the life and engineering sciences. Inspiration of future generations of women.
Year(s) Of Engagement Activity 2011,2012,2014
 
Description The CSC's Suffrage Science film night - 15 November 2015 
Form Of Engagement Activity A talk or presentation
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The evening, hosted by the Tricycle theatre in North London, began with a screening of Suffragette the film - to remember those who gave the Suffrage Science scheme its name.
After the screening, Helen Pankhurst joined a panel of four to discuss the making of the film and women's activism more broadly. Helen currently campaigns on behalf of the aid organisation Care International, which supports access to education for girls and women across the world. The other panellists comprised neuroscientist and Suffrage Science awardee Uta Frith, historian and Suffragette adviser Krista Cowman and Suffragette producer Alison Owen, with writer and broadcaster Vivienne Parry in the chair.
Year(s) Of Engagement Activity 2015
URL http://csc.mrc.ac.uk/cscs-suffrage-science-film-night-15-november-2015/
 
Description Virtual Lab 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Type Of Presentation Workshop Facilitator
Geographic Reach International
Primary Audience Schools
Results and Impact Virtual Lab is a website that allows highschool pupils aged 14-19 to engage with and take part in contemporary scientific research. It was piloted with experiments on cell division and stem cell biology for GCSE and A-level students (aged 16-19) based on research from the CSC. In October 2011 an experiment exploring how the brain works will be launched.

VL pilot experiments made students more enthusiastic about science, and influenced some of the participants' career choices. A detailed evaluation is available for download from the website.
Year(s) Of Engagement Activity 2010,2011,2012
URL http://www.virtuallab.co.uk
 
Description Women in Power 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Other audiences
Results and Impact Invited speaker to an event during the London Fashion Week.
Year(s) Of Engagement Activity 2019
URL https://www.evelyn.co.uk/evelyn-glennie-spoke-about-women-in-power-at-london-fashion-week-ss19-for-e...
 
Description Workshop for Experimental and Computational Biology 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Interdisciplinary workshop for Experimental and Computational Biology
Year(s) Of Engagement Activity 2016