FLU PANDEMIC: Study of behavioural/biological determinants of transmission to inform seasonal/pandemic planning

Lead Research Organisation: Medical Research Council

Abstract

The recent emergence of bird flu has raised the prospect of a possible pandemic. For effective pandemic planning there is need to further investigate the effectiveness of antivirals, immunology, clinical responses and how and how quickly viruses spread. This study aims create a cohort of 2000 expert participants, which can be used for studies into pandemics. It will investigate the environmental factors influencing the transmission dynamics of seasonal influenzas to provide data that could be used to plan for pandemics. We will also use this cohort to help in the development of models and to inform trials of antiviral and behavioural interventions. The study will involve over 400 households across England, and will be weighted towards households with children because of their role in household transmission of viruses.

Technical Summary

The recent emergence and spread of highly pathogenic strains of avian influenza (H5N1) affecting humans raises the threat of a pandemic. Neuraminidase inhibitors have been demonstrated to be effective in reducing the duration and severity of seasonal influenza. However, their effectiveness is dependent on early administration and their benefits are modest. Early experience has shown high case fatality rates for H5N1 despite treatment with anti-virals and emergence of resistance. If a pandemic does occur studies investigating the effectiveness of antiviral, transmission dynamics, immunological and clinical response will be needed. There will be relatively little warning of a pandemic and the main wave will probably last only 10-12 weeks so it would be impossible to set up such studies without having a pre-enrolled cohort and established data collection methodologies.

Vaccines for influenza are aimed at haemaglutinin or neuramidase on the outside of the virus capsid. A major problem is that the genes coding for these proteins have a rapid mutation rate preventing the development of effective vaccines before mutations have occurred. T Cells respond to conserved internal virus proteins so that there is cross reactivity between different virus subtypes. If pandemic influenza were imminent, it would be possible to enhance this type of immunity by vaccination. Studies for influenza in mice and one study of influenza in humans, who were deliberately challenged with virus, suggest that this approach could work. T-cell responses have been shown to be important in recovery from influenza in animal studies but there are no data on T cell mediated protection in humans in natural respiratory influenza infection. Large scale community studies are needed to understand this response and its influence on disease severity. It should also be noted that there is a possibility that for a very aggressive influenza virus like H5N1 avian virus T cell response could aggravate the disease, but baseline information in seasonal influenza is badly needed.

We aim to: establish a preparedness cohort enabling timely study of pandemic influenza; use this cohort in the pre-pandemic period to elucidate the transmission dynamics, immunological correlates of protection and clinical outcomes of seasonal influenza; inform the development of influenza transmission models and empirical trials of antiviral and behavioural interventions.

In order to achieve these aims we propose to recruit and maintain a household cohort of 1000 people in 2006/7 and a further 1000 in 2007/8 to: create a pandemic preparedness cohort of 2000 "expert participants" enabling rapid studies in the event of a pandemic; conduct cohort studies in 2006/7 and 2007/8 investigating biological, behavioural and environmental facts influencing the transmission dynamics of seasonal influenza providing empirical data for mathematical models of seasonal and pandemic influenza; conduct nested case control studies to investigate the hypothesis that prior T- Cell immunity affects severity and transmissibility of influenza and to describe correlations between neutralising antibody titres and protection against infection and inform the development of empirical trails of antiviral and behavioural interventions.

The research is funded by the MRC and is a collaboration between GPRF, MRC Human Immunodeficiency Unit and the Health protection Agency.

Publications

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Fragaszy EB (2017) Cohort Profile: The Flu Watch Study. in International journal of epidemiology

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Fragaszy, EB Comment

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Hayward A (2009) Influenza A (H1N1) pandemic: true or false alarm. in Journal of epidemiology and community health

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Hayward A (2010) Does treatment with oseltamivir prevent transmission of influenza to household contacts? in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Hayward A (2014) Sociology of a pandemic in The Lancet Respiratory Medicine

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Hayward AC (2015) Natural T Cell-mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study. in American journal of respiratory and critical care medicine

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Jordan R (2009) Should healthcare workers have the swine flu vaccine? in BMJ (Clinical research ed.)

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Warren-Gash C (2010) Influenza and myocardial infarction. in Expert review of cardiovascular therapy

 
Description Development of HPA Community influenza surveillance
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description HPA estimates of burden of pandemic influenza
Geographic Reach UK 
Policy Influence Type Citation in other policy documents
Impact The Flu Watch work fed into the HPA modelling group that estimated the number of cases of pandemic influenza. This informed policy decisions on the response to the pandemic.
 
Description JCVI decision to recommend routine influenza immunisation of children
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
 
Description JCVI influenza vaccination committee
Geographic Reach UK 
Policy Influence Type Membership of a guidance committee
Impact Results of Flu Watch Data influenced decisions on national panjdemic vaccination strategy by demonstrating low level of severity of pandemic strain.
 
Description JCVI review of effectiveness and cost effectiveness of the national influenza vaccination programme
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
 
Description JCVI review of whether to introduce routine childhood vaccination for influenza
Geographic Reach Multiple continents/international 
Policy Influence Type Gave evidence to a government review
 
Description NERV-TAG
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description SPI-M
Geographic Reach National 
Policy Influence Type Participation in advisory committee
 
Description Clinical Research and Development Committee Research Funding from the BRC/UCLH Charities - Fast Track Grant - Charlotte Warren-Gash
Amount £37,890 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 12/2014 
End 03/2016
 
Description EPSRC IRC in Early-Warning Sensing Systems for Infectious Diseases
Amount £20,285 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Sector Academic/University
Country United Kingdom
Start 02/2016 
End 01/2017
 
Description Exploratory Project Funding call 'Early Warning Sensing Systems for Influenza'
Amount £113,040 (GBP)
Organisation Engineering and Physical Sciences Research Council (EPSRC) 
Department Flusurvey
Sector Public
Country United Kingdom
Start 08/2014 
End 07/2015
 
Description NIH/CDC call for funding on influenza transmission
Amount £6,900,000 (GBP)
Organisation National Institutes of Health (NIH) 
Sector Public
Country United States
Start  
 
Description NIHR 2011 call for Pandemic Research
Amount £431,356 (GBP)
Funding ID 11/46/09 
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 09/2013 
End 08/2016
 
Description NIHR methods fellowship
Amount £150,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start 03/2014 
End 03/2016
 
Description NIHR research training fellowship - Dr Logan Manikam
Amount £180,000 (GBP)
Organisation National Institute for Health Research 
Sector Public
Country United Kingdom
Start  
 
Description UCLH CBRC Clinical Research and Development Committee
Amount £30,000 (GBP)
Organisation National Institute for Health Research 
Department UCLH/UCL Biomedical Research Centre
Sector Public
Country United Kingdom
Start  
 
Description Wellcome Doctoral Training Award - Nischay Mehtha - variations in adult tonsillectomy rates
Amount £180,000 (GBP)
Organisation University of Oxford 
Department Wellcome Trust Doctoral Training Fellowship
Sector Academic/University
Country United Kingdom
Start  
 
Description Wellcome Mosaic extension
Amount £19,052 (GBP)
Organisation Wellcome Trust 
Sector Charity/Non Profit
Country United Kingdom
Start  
 
Title HPA serosurveillance 
Description Contributing to plans for ongoing HPA serosurveillance of influenza 
Type Of Material Database/Collection of Data/Biological Samples 
Year Produced 2011 
Provided To Others? Yes  
Impact Informing design of future national surveillance 
 
Title Use of Health Survey for England as a tool for monitoring population infection 
Description HSE is a national rolling household study including taking of blood. We have added influenza serology to this and can compare results to Flu Watch. THe HSE provides a way forward for obtaining some of the key parameters measured in Flu Watch more efficiently 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact NIHR funded grant exploring use of HSE as a tool for pandemic preparedness 
 
Title Weekly automated telephone calls for collection of data on illnesses in households 
Description We have developed (via subcontractors) tools for the automated monitoring of illnesses in household on a weekly basis using automated telphone calls 
Type Of Material Improvements to research infrastructure 
Year Produced 2009 
Provided To Others? Yes  
Impact We have provided ths to the Swine Flu Initiative BBSRC grant to monitor rates of illness in Pig Workers 
 
Title weekly automated online surveys for collection of household level data 
Description We developed the use of weekly online surveys for monitoring the incidence of illness in households 
Type Of Material Improvements to research infrastructure 
Provided To Others? No  
Impact Enabled subsequent development of similar methodologies for monitoring pandemnic influenza We propose to use this methodology in a Phase IIb Trial testing the efficacy of an improved influenza vaccine in older adults. We have submitted an itial funding application for this through the MRC's EME programme. 
 
Description COSI 
Organisation University of Cambridge
Department Department of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Organsation of collection of sera from Pig Farmers and Pig Workers
Collaborator Contribution Understanding of burden of influenza in populations working with pigs.Testing of human sera for evidence of range of swine flu viruses.
Impact Level of serologically confirmed influenza in pig workers. Paper in preparation outlining increased risk of influenza in pig workers compared to community controls
Start Year 2009
 
Description COSI 
Organisation University of Cambridge
Department Department of Veterinary Medicine
Country United Kingdom 
Sector Academic/University 
PI Contribution Collection of serological samples from pig workers - provision of non pig worker controls from Flu Watch
Collaborator Contribution Investigation of exposure to pigs as a risk factor for infection with influenza
Impact Immune responses in pigs vaccinated with adjuvanted and non-adjuvanted A(H1N1)pdm/09 influenza vaccines used in human immunization programmes. Lefevre EA, Carr BV, Inman CF, Prentice H, Brown IH, Brookes SM, Garcon F, Hill ML, Iqbal M, Elderfield RA, Barclay WS, Gubbins S, Bailey M, Charleston B; COSI. PLoS One. 2012;7(3):e32400. Epub 2012 Mar 9.
Start Year 2009
 
Description COSI 
Organisation Veterinary Laboratories Agency
Country United Kingdom 
Sector Public 
PI Contribution Organsation of collection of sera from Pig Farmers and Pig Workers
Collaborator Contribution Understanding of burden of influenza in populations working with pigs.Testing of human sera for evidence of range of swine flu viruses.
Impact Level of serologically confirmed influenza in pig workers. Paper in preparation outlining increased risk of influenza in pig workers compared to community controls
Start Year 2009
 
Description EMIT 
Organisation Nottingham University Hospitals NHS Trust
Department Division of Epidemiology and Public Health
Country United Kingdom 
Sector Academic/University 
PI Contribution EMIT: Evaluating Modes of Influenza Transmission using a Human Challenge $10,849,395 Model. Data annd expertisre from Flu Watch has been used to inform the design of this human challenge study to understand the role of earosols in transmission.
Collaborator Contribution Use of Human Challenge studies to study influenza transmission and immunity is complementary approach to observational studies of Influenza
Impact Multidisciplinary research project involving epidemiologisy, public health, aerobiology, virology, modelling.
Start Year 2011
 
Description EVIDENT 
Organisation University College London
Country United Kingdom 
Sector Academic/University 
PI Contribution 1) co-supervision of a Wellcome Doctoral Training award student (Nishay Mehtha) - Variations in adult tonsillectomy rates. 2) co-supervision of an NIHR research training fellow (Dr Logan Manikam) - respiratory infections in children with Down's syndrome.
Collaborator Contribution 1) co-supervision of a Wellcome Doctoral Training award student (Nishay Mehtha) - Variations in adult tonsillectomy rates. 2) co-supervision of an NIHR research training fellow (Dr Logan Manikam) - respiratory infections in children with Down's syndrome.
Impact none yet
Start Year 2013
 
Description Health Survey for England 
Organisation Department of Health (DH)
Country United Kingdom 
Sector Public 
PI Contribution Design of Influenza questions to include in the Health Survey for England in the pandemic year
Collaborator Contribution Use of HSE as a tool to monitor population infection rates in vaccinated and unvaccinated
Impact Recently awarded NIHR grant to explore use of Health Survey for England as a tool to monitor population levels of infection during a pandemic.
Start Year 2009
 
Description Health Survey for England 
Organisation National Centre for Social Research
Country United Kingdom 
Sector Academic/University 
PI Contribution Design of Influenza questions to include in the Health Survey for England in the pandemic year
Collaborator Contribution Use of HSE as a tool to monitor population infection rates in vaccinated and unvaccinated
Impact Recently awarded NIHR grant to explore use of Health Survey for England as a tool to monitor population levels of infection during a pandemic.
Start Year 2009
 
Description ICONIC 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Andrew Hayward is leading the epidemiological aspects of the grant which focuses on sequencing of all influenza isolates across 4 london trust as well as selected PHE samples.
Collaborator Contribution working with Wellcome Sanger Institute (sequencing side) and PHE (specimens and data)
Impact grant started autumn 2013
Start Year 2013
 
Description ICONIC 
Organisation The Wellcome Trust Sanger Institute
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Andrew Hayward is leading the epidemiological aspects of the grant which focuses on sequencing of all influenza isolates across 4 london trust as well as selected PHE samples.
Collaborator Contribution working with Wellcome Sanger Institute (sequencing side) and PHE (specimens and data)
Impact grant started autumn 2013
Start Year 2013
 
Description Influenza Mortality 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Flu Watch data on influenza occurrence provided to contribute to modelling of seasonal and pandemic case fatality rates.
Collaborator Contribution Bayesian approach to modelling of mortality
Impact Analysis ongoing
Start Year 2012
 
Description Influenza Mortality 
Organisation University of Cambridge
Department MRC Biostatistics Unit
Country United Kingdom 
Sector Public 
PI Contribution Flu Watch data on influenza occurrence provided to contribute to modelling of seasonal and pandemic case fatality rates.
Collaborator Contribution Bayesian approach to modelling of mortality
Impact Analysis ongoing
Start Year 2012
 
Description Influenza and Myocardial Infarction 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Department Primary Care PHC
Country United Kingdom 
Sector Academic/University 
PI Contribution Research into the triggering effect of influenza on MI using surveillance trends and contextualised using Flu Watch Data.
Collaborator Contribution Supervision of MRC Clinical Research Fellow Charlotte Warren Gash
Impact Influenza infection and acute myocardial infarction risk. C. Warren-Gash, A.Hayward, S.Thomas, H.Whitaker, L.Smeeth. Journal of Infectious Diseases. Warren-Gash C, Smeeth L, Hayward A. Influenza and myocardial infarction. Expert Rev Cardiovasc Ther. 2010 Feb;8(2):143-6. Warren-Gash C, Smeeth L, Hayward AC. Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review. Lancet Infect Dis. 2009 Oct;9(10):601-10.
Start Year 2007
 
Description Influenza and Myocardial Infarction 
Organisation University of Hong Kong
Department School of Public Health and Department of Community Medicine
Country Hong Kong 
Sector Academic/University 
PI Contribution Research into the triggering effect of influenza on MI using surveillance trends and contextualised using Flu Watch Data.
Collaborator Contribution Supervision of MRC Clinical Research Fellow Charlotte Warren Gash
Impact Influenza infection and acute myocardial infarction risk. C. Warren-Gash, A.Hayward, S.Thomas, H.Whitaker, L.Smeeth. Journal of Infectious Diseases. Warren-Gash C, Smeeth L, Hayward A. Influenza and myocardial infarction. Expert Rev Cardiovasc Ther. 2010 Feb;8(2):143-6. Warren-Gash C, Smeeth L, Hayward AC. Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review. Lancet Infect Dis. 2009 Oct;9(10):601-10.
Start Year 2007
 
Description Influenza in Homeless 
Organisation University College London Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Provision of Flu Watch data on general population eligibility and uptake to influenza vaccine to compare with equivalent data in homeless people
Collaborator Contribution Collection of data on influenza vaccine eligibility and uptake in homeless people
Impact Paper submitted to BMJ
Start Year 2012
 
Description MOSAIC 
Organisation Imperial College Healthcare NHS Trust
Department Respiratory Medicine
Country United Kingdom 
Sector Hospitals 
PI Contribution Collection of genetic samples from community controls to compare to severe cases of influenza
Collaborator Contribution Genetic analyses of determinants of severe influenza
Impact IFITM3 restricts the morbidity and mortality associated with influenza. Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. Nature. 2012 Mar 25;484(7395):519-23. doi: 10.1038/nature10921. Multidisciplinary collaboration. Geneticists, clinicians, epidemiologists
Start Year 2010
 
Description MOSAIC 
Organisation Medical Research Council (MRC)
Country United Kingdom 
Sector Academic/University 
PI Contribution Collection of genetic samples from community controls to compare to severe cases of influenza
Collaborator Contribution Genetic analyses of determinants of severe influenza
Impact IFITM3 restricts the morbidity and mortality associated with influenza. Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. Nature. 2012 Mar 25;484(7395):519-23. doi: 10.1038/nature10921. Multidisciplinary collaboration. Geneticists, clinicians, epidemiologists
Start Year 2010
 
Description NIHR Health Protection Research Unit in Respiratory Infection 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Andrew Hayward is the proposed director of this unit and led the bid. Bid focuses on public health research on influenza and TB and builds extensively on the Flu Watch methodology.
Collaborator Contribution UoN and RCGP are contributing primarily to the emergency response theme which focuses on pandemic response.
Impact short-listed and interviewed. awaiting result.
Start Year 2013
 
Description NIHR Health Protection Research Unit in Respiratory Infection 
Organisation Royal College of General Practitioners
Department RCGP Research and Surveillance Centre
Country United Kingdom 
Sector Academic/University 
PI Contribution Andrew Hayward is the proposed director of this unit and led the bid. Bid focuses on public health research on influenza and TB and builds extensively on the Flu Watch methodology.
Collaborator Contribution UoN and RCGP are contributing primarily to the emergency response theme which focuses on pandemic response.
Impact short-listed and interviewed. awaiting result.
Start Year 2013
 
Description NIHR Health Protection Research Unit in Respiratory Infection 
Organisation University of Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Andrew Hayward is the proposed director of this unit and led the bid. Bid focuses on public health research on influenza and TB and builds extensively on the Flu Watch methodology.
Collaborator Contribution UoN and RCGP are contributing primarily to the emergency response theme which focuses on pandemic response.
Impact short-listed and interviewed. awaiting result.
Start Year 2013
 
Description Tcell Vaccine Trial full grant application to MRC-EME scheme 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Contributed to trial design, particularly in the area of measuring outcomes and sample size.
Collaborator Contribution Led the application
Impact Awaiting to hear funding decision
Start Year 2013
 
Description Tcell Vaccine Trial outline grant application to MRC-EME 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution Flu Watch data used to develop power calculations for the trail. Flu Watch methodology will be used to collect outcome data being led by UCL.
Collaborator Contribution Oxford University has developed the Tcell vaccine and will lead the trial if funded.
Impact Tcell Vaccine Trial outline grant application submitted to MRC-EME
Start Year 2013
 
Description Trial of a T-cell vaccine 
Organisation University of Oxford
Country United Kingdom 
Sector Academic/University 
PI Contribution We are presently arranging a collaboration with the University of Oxford regarding a trial of a T-cell Vaccine.
Collaborator Contribution The contributions we will make are still be arranged
Impact .
Start Year 2016
 
Description UKCRC Translational Infection Research Initiative Strategy Development Grant - Influenza Transmission Strategy Development Group November 2007-November 2008 £80,000 
Organisation Imperial College London
Department Department of Epidemiology and Biostatistics
Country United Kingdom 
Sector Academic/University 
PI Contribution Working group to identify means of studying influenza transmission. Our data on household transmission rates were used to help design further work on human experimental models of influenza transmission.
Impact DH funded grant to assess the feasability of using human volunteers in studies of influenza transmission. The final report has been made to DH and this demonstrates that human volunteer studies have potential to be used for transmission studies. Further frunding for such studies is being sought.
Start Year 2008
 
Description UKCRC Translational Infection Research Initiative Strategy Development Grant - Influenza Transmission Strategy Development Group November 2007-November 2008 £80,000 
Organisation University of Nottingham
Department School of Community Health Sciences Nottingham
Country United Kingdom 
Sector Academic/University 
PI Contribution Working group to identify means of studying influenza transmission. Our data on household transmission rates were used to help design further work on human experimental models of influenza transmission.
Impact DH funded grant to assess the feasability of using human volunteers in studies of influenza transmission. The final report has been made to DH and this demonstrates that human volunteer studies have potential to be used for transmission studies. Further frunding for such studies is being sought.
Start Year 2008
 
Description i-sense exploratory grant 
Organisation Google
Country United States 
Sector Private 
PI Contribution Designing and running the patient and public engagement part of the project. Providing Flu Watch data for calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Collaborator Contribution LSHTM is running flusurvey surveillance project and piloting the diagnostic testing component. Public Health England is conducting PCR analysis of samples. Exploring with google possible collaboration on surveillance recruitment methods. Calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Impact 1) currently developing a smartphone app for participatory surveillance of influenza-like-illness 2) currently running flusurvey study for another year
Start Year 2014
 
Description i-sense exploratory grant 
Organisation London School of Hygiene and Tropical Medicine (LSHTM)
Country United Kingdom 
Sector Academic/University 
PI Contribution Designing and running the patient and public engagement part of the project. Providing Flu Watch data for calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Collaborator Contribution LSHTM is running flusurvey surveillance project and piloting the diagnostic testing component. Public Health England is conducting PCR analysis of samples. Exploring with google possible collaboration on surveillance recruitment methods. Calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Impact 1) currently developing a smartphone app for participatory surveillance of influenza-like-illness 2) currently running flusurvey study for another year
Start Year 2014
 
Description i-sense exploratory grant 
Organisation Microsoft Research
Country Global 
Sector Private 
PI Contribution Designing and running the patient and public engagement part of the project. Providing Flu Watch data for calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Collaborator Contribution LSHTM is running flusurvey surveillance project and piloting the diagnostic testing component. Public Health England is conducting PCR analysis of samples. Exploring with google possible collaboration on surveillance recruitment methods. Calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Impact 1) currently developing a smartphone app for participatory surveillance of influenza-like-illness 2) currently running flusurvey study for another year
Start Year 2014
 
Description i-sense exploratory grant 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution Designing and running the patient and public engagement part of the project. Providing Flu Watch data for calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Collaborator Contribution LSHTM is running flusurvey surveillance project and piloting the diagnostic testing component. Public Health England is conducting PCR analysis of samples. Exploring with google possible collaboration on surveillance recruitment methods. Calibration and validation of novel surveillance systems using twitter and internet search data (microsoft).
Impact 1) currently developing a smartphone app for participatory surveillance of influenza-like-illness 2) currently running flusurvey study for another year
Start Year 2014
 
Description Decipher My Data 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach Regional
Primary Audience Schools
Results and Impact DECIPHER MY DATA!
A research project conducted by Farr London through
scientific engagement with schools, promoting the idea
that students benefit from performing real science using
real data in the classroom. Findings from Decipher my
data! Flu! based on data from 27 schools show that
school sickness absence data are correlated with influenza
surveillance data and may provide a good warning
system for spotting flu outbreaks .
Year(s) Of Engagement Activity 2015
 
Description I'm a scientist Decipher my Data 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Schools
Results and Impact As part of a Wellcome trust funded public Engagement award we helped to design data collection from schools on school sickness absence. This was used to compare with trends in influenza surveillance with data provided in real time to schools. Flu Watch info included in educational materials,

http://flu.deciphermydata.org.uk/
40 schools partcipated in 2011/12

60 have expressed interest in participating for 2012/13
Year(s) Of Engagement Activity 2010,2011,2012
URL http://flu.deciphermydata.org.uk/