Assessment of the benefits and risks of cancer treatments

Lead Research Organisation: Medical Research Council

Abstract

Most people who get cancer now survive and this is in large part due to the effectiveness of treatments, such as chemotherapy and radiotherapy, and in the UK alone there are estimated to be over 2 million people who are cancer survivors. While the short term side effects of such treatments are well known, the long term health effects of these treatments were largely unknown. Our programme of research has previously demonstrated that radiotherapy treatment increases the long-term risk of heart disease in cancer patients and this has resulted in changes in clinical practice, such as taking measures to minimise the exposure of the heart to radiotherapy during treatment and also treating with lower doses of radiotherapy. This research allows clinicians to individualise the dose of radiotherapy given to each patient to maximise the benefit and minimise the long-term risk of heart disease. Our current research is looking in more detail at these risks from radiotherapy as well as collaborating with many other scientists worldwide to better understand the risks of various other treatments, such as anthracyclines. We are also carrying out research to better understand the long-term risks, particularly from heart disease, of cancer treatments in children, teenagers and young adults.

Technical Summary

The programme will continue a long-running area of research to produce uniquely reliable answer to important clinical questions concerned with the benefits and the main risks of treatments for various cancers, which includes breast cancer, lymphomas and all cancers diagnosed in children, teenagers and young adults. All currently available treatments have both short term side-effects, which are generally well documented, as well as less well studied long-term hazards. For example, our previous research has developed a dose-response relationship for use by clinicians to predict the radiation-related ischaemic heart disease risk for individual women irradiated for breast cancer, based on their cardiac radiation dose and their pre-existing risk factors. Our future work will further develop these risk/benefit prediction models to include valvular heart disease and pericarditis in breast cancer radiotherapy and for ischaemic heart disease, valvular heart disease, and heart failure in Hodgkin lymphoma radiotherapy. In addition, we will bring together the results from a number of treatment trials of anthracyclines for various cancers to reliably determine the risks of cardiovascular disease from these therapies. We will also analyse several large cohorts to more precisely determine the risk of cardiovascular disease from various cancer treatments using data from cancer registries that include around 2 million women with breast cancer and also determine these risks in children, teenagers and young adults using UK data on around 250,000 cancer survivors.

Publications

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Aleman BM (2014) Cardiovascular disease after cancer therapy. in EJC supplements : EJC : official journal of EORTC, European Organization for Research and Treatment of Cancer ... [et al.]

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Arriagada R (2009) OECI Workshop on late side-effects of cancer treatments. in European journal of cancer (Oxford, England : 1990)

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Aznar M (2017) The role of technology in clinical trials using stereotactic body radiotherapy. in The British journal of radiology

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Aznar M. C. (2016) Exposure of the Lungs in Breast Cancer Radiation Therapy: A Systematic Review of Lung Doses Published Between 2010 and 2015 in INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

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Aznar MC (2017) "To clip or not to clip. That is no question!" in European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

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Aznar MC (2018) Exposure of the lungs in breast cancer radiotherapy: A systematic review of lung doses published 2010-2015. in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

 
Description 'Mind the gap' between the development of therapeutic innovations and the clinical practice in oncology: A proposal of the European Organisation for Research and Treatment of Cancer (EORTC) to optimise cancer clinical research
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL https://www.sciencedirect.com/science/article/pii/S0959804917312534
 
Description ?????????? ???????????? ??????????? ???????????: ????????? ?????? ????????? (Management of toxicity of inhibitors of angiogenesis. Resolution of the board of Experts)
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL https://cyberleninka.ru/article/n/upravlenie-toksichnostyu-ingibitorov-angiogeneza-rezolyutsiya-sove...
 
Description Association of sleep duration and quality with blood lipids: a systematic review and meta-analysis of prospective studies
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
URL http://bmjopen.bmj.com/content/7/12/e018585
 
Guideline Title Recommendations for the follow-up care of female breast cancer survivors
Description Breast cancer follow up guidelines in Spain
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
Impact These results were used to inform breast cancer follow-up guidelines in Spain
URL https://link.springer.com/article/10.1007/s12094-017-1801-4
 
Guideline Title Up to Date
Description Cancer survivorship: Cardiovascular and respiratory issues
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
URL https://www.uptodate.com/contents/cancer-survivorship-cardiovascular-and-respiratory-issues
 
Guideline Title Royal College of Radiologists guidelines
Description Cardiac side-effects from breast cancer radiotherapy
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
 
Description Cardio-Onco-Hematología en la práctica clínica. Documento de consenso y recomendaciones (Cardio-Onco-Hematology in clinical practice. Consensus document and recommendations)
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL http://www.revespcardiol.org/es/cardio-onco-hematologia-practica-clinica-documento-deconsenso/articu...
 
Description Cardiotoxicity of radiation therapy for Hodgkin lymphoma and pediatric malignancies
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://www.uptodate.com/contents/cardiotoxicity-of-radiation-therapy-for-hodgkin-lymphoma-and-pedia...
 
Description Cardiovascular Adverse Events in Patients With Cancer Treated With Bevacizumab: A MetaAnalysis of More Than 20 000 Patients
Geographic Reach North America 
Policy Influence Type Citation in other policy documents
URL http://jaha.ahajournals.org/content/6/8/e006278
 
Description Cardiovascular Complications of Cancer Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 1
Geographic Reach North America 
Policy Influence Type Citation in systematic reviews
URL https://www.sciencedirect.com/science/article/pii/S0735109717409971
 
Description Cardiovascular Complications of Cancer Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 2
Geographic Reach North America 
Policy Influence Type Citation in systematic reviews
URL https://www.sciencedirect.com/science/article/pii/S073510971740996X
 
Guideline Title Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association
Description Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
URL http://circ.ahajournals.org/content/early/2018/01/31/CIR.0000000000000556.short
 
Description Cardiovascular diseases in patients receiving small molecules with anti-vascular endothelial growth factor activity: A meta-analysis of approximately 29,000 cancer patients
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL http://journals.sagepub.com/doi/abs/10.1177/2047487318755193
 
Description Citation in European Society of Cardiology
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
Impact Our work on the cardiovascular risks of radiotherapy for breast cancer have provided quantitative information that has been used in this position paper from the European Society of Cardiology
URL https://academic.oup.com/eurheartj/article-abstract/37/36/2768/2197413/2016-ESC-Position-Paper-on-ca...
 
Guideline Title Invasive Breast Cancer Version 1.2016, NCCN Clinical Practice Guidelines in Oncology
Description Citation in National Clinical Practice Guidelines in Oncology 2016
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
URL http://www.jnccn.org/content/14/3/324.short
 
Guideline Title Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update
Description Citation in a Guideline Update from the American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
Impact Our research has influenced which women receive radiotherapy following mastectomy for an invasive breast cancer
URL https://link.springer.com/article/10.1245/s10434-016-5558-8
 
Guideline Title Clinical use of biomarkers in breast cancer: Updated guidelines from the European Group on Tumor Markers (EGTM)
Description Clinical use of biomarkers in breast cancer: Updated guidelines from the European Group on Tumor Markers (EGTM)
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
Impact This article has clarified the importance of obtaining information on the hormonal receptor status for women with breast cancer before deciding on the best course of treatment for them
URL http://www.ejcancer.com/article/S0959-8049(17)30075-8/abstract
 
Description Coffee Decreases the Risk of Endometrial Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL http://www.mdpi.com/2072-6643/9/11/1223
 
Description Comprehensive review of cardiovascular toxicity of drugs and related agents
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL http://onlinelibrary.wiley.com/doi/10.1002/med.21476/full
 
Description Consensus paper on the "executive summary of the international conference on Mediterranean diet and health: a lifelong approach", an Italian initiative supported by the Mediterranean diet foundation and menarini foundation
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL https://www.sciencedirect.com/science/article/pii/S0899900718300121
 
Description Coronary heart disease and risk for cognitive impairment or dementia: Systematic review and meta-analysis
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184244
 
Description Current recommendations for diagnostic echocardiography in cancer patients
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL https://link.springer.com/article/10.1007/s00059-017-4542-9
 
Guideline Title DEGRO practical guidelines for radiotherapy of breast cancer VI: therapy of locoregional breast cancer recurrences
Description DEGRO (ie German Association for Radiation Oncology) practical guidelines for radiotherapy of breast cancer VI: therapy of locoregional breast cancer recurrences
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
Impact Our article provided quantitative information regarding the beneficial effect of radiotherapy following surgery for early breast cancer.
URL https://link.springer.com/article/10.1007/s00066-015-0939-7
 
Guideline Title DEGRO practical guidelines for radiotherapy of breast cancer VI: therapy of locoregional breast cancer recurrences
Description DEGRO practical guidelines for radiotherapy of breast cancer VI: therapy of locoregional breast cancer recurrences
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
Impact Our article provided quantitative information on the benefits of radiotherapy for women with early breast cancer
URL https://link.springer.com/article/10.1007/s00066-015-0939-7
 
Description Diagnostic protocol for cardiomyopathy secondary to cancer treatments
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL https://www.sciencedirect.com/science/article/pii/S0304541217302706
 
Description Documento di consenso ANMCO/AICO/AIOM: Snodi clinico-gestionali in ambito cardioncologico (Consensus documanet ANMCO / AICO / AIOM: Clinical -management in the field of cardiooncology)
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL https://www.researchgate.net/profile/Luigi_Tarantini/publication/313860736_Documento_di_consenso_ANM...
 
Guideline Title ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)
Description ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
URL https://www.romanianjournalcardiology.ro/wp-content/uploads/2017/10/ghid.pdf
 
Description Effect of long-term nutraceutical and dietary supplement use on cognition in the elderly: a 10-year systematic review of randomised controlled trials
Geographic Reach Europe 
Policy Influence Type Citation in systematic reviews
URL https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-longterm-nutr...
 
Description Effects of neighbourhood and household sanitation conditions on diarrhea morbidity: Systematic review and meta-analysis
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173808
 
Guideline Title Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO clinical practice guidelines
Description Estimating cardiac exposure from breast cancer radiotherapy in clinical practice
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
Impact Results were used to inform the following clinical practice guidelines: Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO clinical practice guidelines. Ann Oncol 2010; 21 (Suppl 5) v277-v282.
 
Description Evidence-based Review on the Use of Proton Therapy in Lymphoma From the Particle Therapy Cooperative Group (PTCOG) Lymphoma Subcommittee
Geographic Reach Europe 
Policy Influence Type Citation in systematic reviews
URL http://www.redjournal.org/article/S0360-3016(17)30901-X/fulltext
 
Guideline Title Interdisziplinäre Früherkennung, Diagnostik, Therapie und Nachsorge des Mammakarzinoms. Leitlinie der DGGG und DKG (S3-Level, AWMF-Registernummer 032/045OL, Dezember 2017) - Teil 2 mit Empfehlungen zur Therapie des primären, rezidivierten und fortgeschrittenen Mammakarzinoms
Description German Breast Cancer Treatment Guidelines
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
Impact The results of this meta analysis were used to inform German breast cancer treatment guidelines
URL https://www.thieme-connect.com/products/ejournals/html/10.1055/a-0646-4630
 
Description Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer
Geographic Reach Europe 
Policy Influence Type Citation in systematic reviews
URL https://link.springer.com/article/10.1007/s00066-018-1270-x
 
Description Inferring the effects of cancer treatment: Divergent results from Early Breast Cancer Trialists' Collaborative Group meta-analyses of randomized trials and observational data from SEER registries
Geographic Reach National 
Policy Influence Type Citation in clinical reviews
 
Guideline Title The Japanese Breast Cancer Society Clinical Practice Guideline for radiation treatment of breast cancer, 2015 edition
Description Influence on Japanese
Geographic Reach Asia 
Policy Influence Type Citation in clinical guidelines
Impact Our article provided quantitative information on the benefits and risks of radiotherapy for women with breast cancer
URL https://link.springer.com/article/10.1007/s12282-016-0672-9
 
Description Influenced design of HeartSpare 1A clinical study
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Clinical Study HeartSpare 1A Phase 3 randomised trial of voluntary deep-inspiratory breast hold versus active breathing control deep-inspiration breath hold with active breathing control. Recruitment completed and results published Bartlett FR, Colgan RM, Carr K, et al. The UK HeartSpare study: Randomised evaluation of voluntary deep-inspiratory breath-hold in women undergoing breast radiotherapy. Radioth Oncol 2013; 108: 242-7. Research paper from our team used in study design Darby SC, McGale P, Taylor CW, Peto R. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300 000 women in US SEER cancer registries. Lancet Oncol 2005;6:557-565. Impact of research Our work on heart disease after breast cancer radiotherapy highlighted the need for breast cancer radiotherapy that avoided the heart.
 
Description Influenced design of HeartSpare 1B clinical study
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact HeartSpare 1B Phase 3 randomised trial of voluntary breath-hold technique and prone radiotherapy. Recruitment completed and results published Bartlett FR, Colgan RM, Donovan EM, et al. The UK HeartSpare study (Stage 1B): Randomised comparison of voluntary breath-hold technique and prone radiotherapy after breast conserving surgery. Radioth Oncol 2015; 114: 66-72. Darby SD, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen MB, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P. Risk of ischemic heart disease in women irradiated for breast cancer. New England Journal of Medicine 2013;368:987-998 Our dose-response relationship for ischaemic heart disease after radiotherapy showed there was no evidence of a threshold heart dose below which there was no risk. The study was set up to investigate ways of reducing heart dose as much as possible in left breast radiotherapy.
 
Description Influenced design of HeartSpare 2 clinical study
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact HeartSpare 2 The aim of this study was to make heart-sparing breast radiotherapy available to all suitable patients across the NHS. Recruitment completed. Results not yet published Darby SD, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen MB, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P. Risk of ischemic heart disease in women irradiated for breast cancer. New England Journal of Medicine 2013;368:987-998 Our dose-response relationship for ischaemic heart disease after radiotherapy showed there was no evidence of a threshold heart dose below which there was no risk. The study was set up to reduce heart dose from left breast radiotherapy throughout the UK.
 
Description Influenced design of HeartSpare-plus clinical study
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact HeartSpare-plus This study aims to identify optimal radiotherapy techniques for treating locoregional lymph nodes in women whilst limiting the dose to normal tissues, in order to reduce the risks of radiation-induced heart disease and second cancers. Darby SD, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen MB, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P. Risk of ischemic heart disease in women irradiated for breast cancer. New England Journal of Medicine 2013;368:987-998 Our dose-response relationship for ischaemic heart disease after radiotherapy showed there was no evidence of a threshold heart dose below which there was no risk. The study was set up to reduce heart dose from left regional node irradiation.
 
Description Influenced design of proton beam therapy in breast cancer study
Geographic Reach National 
Policy Influence Type Influenced training of practitioners or researchers
Impact Proton beam therapy in breast cancer clinical study Study being designed. Darby SD, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen MB, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P. Risk of ischemic heart disease in women irradiated for breast cancer. New England Journal of Medicine 2013;368:987-998 The design of this study requires absolute estimates of the likely cardiac risks of breast cancer radiotherapy for included women. These will be calculated using Darby 2013. It also requires estimates of the risks for young women, and for women who also receive cardiotoxic chemotherapy, which will be informed by our other projects.
 
Guideline Title International Lymphoma Radiation Oncology Group guidelines
Description International Lymphoma Radiation Oncology Group guidelines
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
URL http://www.bloodjournal.org/content/132/16/1635.abstract?sso-checked=true
 
Description LA FIBRILLAZIONE ATRIALE NEL PAZIENTE ONCOLOGICO
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL http://www.anmco.it/uploads/u_cms/media/2018/1/14404d1d8c23eb76b57f6d3ccf069d31.pdf
 
Guideline Title London Cancer Alliance
Description Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300 000 women in US SEER cancer registries
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
Impact Our dose-response relationship, and our work on the relationship between maximum heart distance and mean heart dose were used to inform the London Cancer Alliance guidelines for heart sparing breast cancer radiotherapy (10th July 2014).
 
Description Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
URL http://www.tandfonline.com/doi/abs/10.1080/10408398.2017.1362630
 
Guideline Title NCCN guideliens for survivorship
Description NCCN guideliens for survivorship
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
URL http://www.jnccn.org/content/16/10/1216.short
 
Guideline Title NICE Breast Cancer Radiotherapy Guidance
Description NICE Breast Cancer Radiotherapy Guidance
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
Impact The results of this meta analysis informed the 2018 NICE breast cancer radiotherapy guidance.
URL https://www.nice.org.uk/guidance/ng101/documents/evidence-summary-9
 
Description Our systematic review of heart doses in breast cancer was quoted by: Sardar, P 2016. "Long-term cardiovascular mortality after radiotherapy for breast cancer: A systematic review and meta-analysis". DOI: 10.1002/clc.22631
Geographic Reach North America 
Policy Influence Type Citation in systematic reviews
URL http://onlinelibrary.wiley.com/doi/10.1002/clc.22631/full
 
Description Our work on the main risks of breast cancer radiotherapy (second cancer and heart disease) was used by the Clinical Translational Radiotherapy working group (CTRad) to inform the UK internal mammary chain research agenda.
Geographic Reach Local/Municipal/Regional 
Policy Influence Type Participation in a national consultation
 
Guideline Title Follow-up after treatment for breast cancer Practical guide to survivorship care for family physicians
Description Our work was used to assess the risk of heart disease after radiotherapy in "Follow-up after treatment for breast cancer Practical guide to survivorship care for family physicians"
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
URL http://www.cfp.ca/content/62/10/805.short
 
Guideline Title Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline
Description Our work was used to assess the risk of heart disease after radiotherapy in "Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline"
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
URL http://ascopubs.org/doi/abs/10.1200/JCO.2016.70.5400
 
Guideline Title 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)
Description Practice guidelines for European Society of Cardiology
Geographic Reach Europe 
Policy Influence Type Citation in clinical guidelines
URL https://www.ncbi.nlm.nih.gov/pubmed/27567406
 
Guideline Title Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guidelines
Description Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guidelines
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
URL http://ascopubs.org/doi/abs/10.1200/JCO.2016.70.5400
 
Description Proton therapy for locally advanced breast cancer: a systematic review of the literature
Geographic Reach Europe 
Policy Influence Type Citation in systematic reviews
URL https://www.sciencedirect.com/science/article/pii/S0305737217301986
 
Description Recommendations for the follow-up care of female breast cancer survivors: a guideline of the Spanish Society of Medical Oncology (SEOM), Spanish Society of General Medicine (SEMERGEN), Spanish Society for Family and Community Medicine (SEMFYC), Spanish Society for General and Family Physicians (SEMG), Spanish Society of Obstetrics and Gynecology (SEGO), Spanish Society of Radiation Oncology (SEOR), Spanish Society of Senology and Breast Pathology (SESPM), and Spanish Society of Cardiology (SEC)
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL https://link.springer.com/article/10.1007/s12094-017-1801-4
 
Guideline Title Expert Consensus for Multi-Modality Imaging Evaluation of Cardiovascular Complications of Radiotherapy in Adults: A Report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography . Journal of the American Society of Echocardiography 2013; 26: 1013-1032
Description Risk of ischemic heart disease in women irradiated for breast cancer
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in clinical guidelines
 
Guideline Title Risk of ischemic heart disease in women irradiated for breast cancer
Description Risk of ischemic heart disease in women irradiated for breast cancer II
Geographic Reach National 
Policy Influence Type Citation in clinical guidelines
Impact Results were used to inform the DEGRO (German society of radiation oncology) guidelines 2014 and 2015. DEGRO practical guidelines: radiotherapy of breast cancer III - radiotherapy of lymphatic pathways Strahlenther Onkol 2014; 190: 342-352. DEGRO practical guidelines for radiotherapy of breast cancer V - therapy for locally advanced and inflammatory breast cancer Strahlenther Onkol 2015; 191: 623-33.
 
Description Symptom practice guide for telephone assessment of patients with cancer treatment-related cardiotoxic dyspnea: Adaptation and evaluation of acceptability
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in other policy documents
URL https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-017-0026-6
 
Description TUMORE DEL RENE TERAPIA ONCOLOGICA E CARDIOTOSSICITA
Geographic Reach Europe 
Policy Influence Type Citation in other policy documents
URL http://www.anmco.it/uploads/u_cms/media/2018/1/14404d1d8c23eb76b57f6d3ccf069d31.pdf
 
Guideline Title The diagnosis and management of non-alcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
Description The diagnosis and management of non-alcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
Geographic Reach North America 
Policy Influence Type Citation in clinical guidelines
URL http://onlinelibrary.wiley.com/doi/10.1002/hep.29367/abstract;jsessionid=BFA49C715E6F589D30513A958D4...
 
Description The nature and efficacy of culturally-adapted psychosocial interventions for schizophrenia: a systematic review and meta-analysis
Geographic Reach Multiple continents/international 
Policy Influence Type Citation in systematic reviews
URL https://www.cambridge.org/core/journals/psychological-medicine/article/nature-and-efficacy-of-cultur...
 
Description CRUK Programme Grant Award
Amount £3,207,423 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 04/2016 
End 03/2021
 
Description Clinical Research Training
Amount £187,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2009 
End 08/2012
 
Description Non-Clinical Training
Amount £71,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 10/2012 
End 09/2016
 
Description Research Excellence Award
Amount £49,000 (GBP)
Organisation British Heart Foundation (BHF) 
Sector Charity/Non Profit
Country United Kingdom
Start 05/2009 
End 03/2014
 
Description Research grant
Amount £449,000 (GBP)
Organisation Department of Health (DH) 
Sector Public
Country United Kingdom
Start 01/2007 
End 12/2009
 
Description Research grant
Amount £80,000 (GBP)
Organisation Cancer Research UK 
Sector Charity/Non Profit
Country United Kingdom
Start 03/2010 
End 02/2011
 
Description Research grant
Amount £382,000 (GBP)
Organisation Department of Health (DH) 
Sector Public
Country United Kingdom
Start 12/2012 
End 11/2015
 
Description Research grant (RACE)
Amount £258,000 (GBP)
Organisation European Commission 
Sector Public
Country European Union (EU)
Start 08/2005 
End 10/2009
 
Title Cardiac Contouring Atlas 
Description This cardiac atlas enables reproducible contouring of segments of the left ventricle and main coronary arteries to facilitate future studies relating cardiac radiation doses to clinical outcomes. 
Type Of Material Physiological assessment or outcome measure 
Year Produced 2017 
Provided To Others? Yes  
Impact The heart is a complex anatomical organ and contouring the cardiac substructures is challenging. We have provided a reproducible method for contouring left ventricular and coronary arterial segments on radiotherapy CT-planning scans. 
URL http://www.thegreenjournal.com/article/S0167-8140(17)30030-0/abstract
 
Description Academic Collaborators 
Organisation Danish Breast Cancer Cooperative Group (DBCG)
Country Denmark 
Sector Academic/University 
PI Contribution CTSU co-ordinates data collection from a number of national and international partners, including other academic institutions and cancer registries. This disparate data is then cleaned, entered into a study database in order to undergo statistical analysis.
Collaborator Contribution Academic partners provide various datasets for our analyses and help to formulate and develop future research questions.
Impact Our research is making a significant contribution to the development of several clinical tools used by oncologists to predict the absolute benefits of various breast cancer treatments.
Start Year 2006
 
Description Academic Collaborators 
Organisation Netherlands Cancer Institute (NKI)
Country Netherlands 
Sector Academic/University 
PI Contribution CTSU co-ordinates data collection from a number of national and international partners, including other academic institutions and cancer registries. This disparate data is then cleaned, entered into a study database in order to undergo statistical analysis.
Collaborator Contribution Academic partners provide various datasets for our analyses and help to formulate and develop future research questions.
Impact Our research is making a significant contribution to the development of several clinical tools used by oncologists to predict the absolute benefits of various breast cancer treatments.
Start Year 2006
 
Description Academic Collaborators 
Organisation Oxford University Hospitals NHS Foundation Trust
Department Radiotherapy Physics
Country United Kingdom 
Sector Academic/University 
PI Contribution CTSU co-ordinates data collection from a number of national and international partners, including other academic institutions and cancer registries. This disparate data is then cleaned, entered into a study database in order to undergo statistical analysis.
Collaborator Contribution Academic partners provide various datasets for our analyses and help to formulate and develop future research questions.
Impact Our research is making a significant contribution to the development of several clinical tools used by oncologists to predict the absolute benefits of various breast cancer treatments.
Start Year 2006
 
Description Academic Collaborators 
Organisation University of Birmingham
Department Centre for Childhood Cancer Survivor Studies
Country United Kingdom 
Sector Academic/University 
PI Contribution CTSU co-ordinates data collection from a number of national and international partners, including other academic institutions and cancer registries. This disparate data is then cleaned, entered into a study database in order to undergo statistical analysis.
Collaborator Contribution Academic partners provide various datasets for our analyses and help to formulate and develop future research questions.
Impact Our research is making a significant contribution to the development of several clinical tools used by oncologists to predict the absolute benefits of various breast cancer treatments.
Start Year 2006
 
Description Academic Collaborators 
Organisation University of Oxford
Department CRUK/MRC Oxford Institute for Radiation Oncology
Country United Kingdom 
Sector Academic/University 
PI Contribution CTSU co-ordinates data collection from a number of national and international partners, including other academic institutions and cancer registries. This disparate data is then cleaned, entered into a study database in order to undergo statistical analysis.
Collaborator Contribution Academic partners provide various datasets for our analyses and help to formulate and develop future research questions.
Impact Our research is making a significant contribution to the development of several clinical tools used by oncologists to predict the absolute benefits of various breast cancer treatments.
Start Year 2006
 
Description Academic Collaborators 
Organisation University of Oxford
Department Department of Oncology
Country United Kingdom 
Sector Academic/University 
PI Contribution CTSU co-ordinates data collection from a number of national and international partners, including other academic institutions and cancer registries. This disparate data is then cleaned, entered into a study database in order to undergo statistical analysis.
Collaborator Contribution Academic partners provide various datasets for our analyses and help to formulate and develop future research questions.
Impact Our research is making a significant contribution to the development of several clinical tools used by oncologists to predict the absolute benefits of various breast cancer treatments.
Start Year 2006
 
Description Academic Collaborators 
Organisation University of Southern Denmark
Department Department of Oncology
Country Denmark 
Sector Academic/University 
PI Contribution CTSU co-ordinates data collection from a number of national and international partners, including other academic institutions and cancer registries. This disparate data is then cleaned, entered into a study database in order to undergo statistical analysis.
Collaborator Contribution Academic partners provide various datasets for our analyses and help to formulate and develop future research questions.
Impact Our research is making a significant contribution to the development of several clinical tools used by oncologists to predict the absolute benefits of various breast cancer treatments.
Start Year 2006
 
Description Big data in populations of cancer patients 
Organisation Public Health England
Country United Kingdom 
Sector Public 
PI Contribution We are developing models to predict the benefits and risks from the various different options available for treating women who have been diagnosed with breast cancer. During the course of this we are also helping Public Health England to improve the quality of their routine data.
Collaborator Contribution Public Health England have provided us with data on all 600,000 women diagnosed with breast cancer in England during 1997-2014. Items included are patient and tumour characteristics and, for those who have died, the date and cause of death.
Impact None so far
Start Year 2016
 
Description Clinical Collaborations within Oxford 
Organisation Oxford University Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution Dr Carolyn Taylor and Dr Frances Duane are collaborating with other breast oncologists to develop internal mammary nodal radiotherapy Dr David Cutter is collaborating with lymphoma oncologists to improve lymphoma radiotherapy Dr Marianne Aznar collaborates with radiotherapy physicists Mr Gurdeep Mannu collaborates with breast surgeons All four individuals are involved in teaching in Oxford University Hospitals NHS Trust
Collaborator Contribution Collaboration with oncologists, radiographers, physicists and surgeons has enabled the team to ensure that their research programme answers clinically relevant question, and remains up to date
Impact The collaboration involves oncologists, physicists, surgeons and radiographers. Outputs from these collaborations include: Audit of Cardiac dose from tangential breast cancer radiotherapy in the year 2010 C.W. Taylor (2010) Lorenzen EL, Taylor CW, Maraldo M, Nielsen MH, Offersen BV, Andersen MR, O'Dwyer D, Larsen L, Duxbury S, Jhitta B, Darby SC, Ewertz M, Brink C. Inter-observer variation in delineation of the heart and left anterior descending coronary artery in radiotherapy for breast cancer: A multi-centre study from Denmark and the UK. Radioth Oncol 2013;108:254-258. Taylor CW, Wang Z, Macaulay E, Jagsi R, Darby SC. Exposure of the heart in breast cancer radiotherapy: A systematic review of heart doses published during 2003-2013. Int J Radiat Oncol Biol Phys 2015;93:845-853.
Start Year 2010
 
Description Collaboration with Netherlands Cancer Institute to study the risk of colorectal cancer after radiotherapy for Hodgkin lymphoma 
Organisation Netherlands Cancer Institute (NKI)
Department Molecular Pathology Division
Country Netherlands 
Sector Hospitals 
PI Contribution We have provided expertise in dosimetry and in statistical analysis
Collaborator Contribution NKI staff have obtained information regarding patients treated at the NKI and other hospitals in the Netherlands, obtaining information on treatments received, risk factors for heart disease and outcomes
Impact doi: https://doi.org/10.1182/blood-2016-09-740332
Start Year 2016
 
Description Coventry University 
Organisation Coventry University
Country United Kingdom 
Sector Academic/University 
PI Contribution Supplied biological sample for microRNA analysis
Collaborator Contribution analysis is currently underway
Impact none yet
Start Year 2016
 
Description ESTRO course on Multidisciplinary Management of Breast Cancer 
Organisation European Society of Therapeutic and Radiation Oncology
PI Contribution Marianne Aznar and Sarah Darby are faculty members of the ESTRO (the European Society of Therapeutic and Radiation Oncology) course on the Multidisciplinary Management of Breast Cancer. Marianne covers aspects related to medical physics, while Sarah handles epidemiology and the effects of radiotherapy. This year the 3-day course was held in Dublin and attracted over 100 participants, most of whom were young radiation oncologists from around Europe who have recently started to specialise in breast cancer.
Collaborator Contribution event hosts
Impact ESTRO course provision
Start Year 2017
 
Description Independent Cancer Patients Voice 
Organisation Independent Cancer Patients' Voice
Country United Kingdom 
Sector Charity/Non Profit 
PI Contribution Discussions to ascertain views of patients on our decision aids
Collaborator Contribution Two representatives provide consumer/patient input to our work on decision aids
Impact Ongoing
Start Year 2015
 
Description Pathological study of DCiS 
Organisation Netherlands Cancer Institute (NKI)
Department Molecular Pathology Division
Country Netherlands 
Sector Hospitals 
PI Contribution Study design, statistical analysis
Collaborator Contribution Data regarding women diagnosed with DCIS at the NKI and other hospitals in the Netherlands, including pathological and radiological information.
Impact None as yet
Start Year 2016
 
Description Proton Therapy Centre, Prague 
Organisation Proton Therapy Center Czech Ltd
PI Contribution We have provided expert review of contouring and developed methods to predict late effects of radiation.
Collaborator Contribution PTC Prague contributed radiotherapy data for analysis
Impact • G. Ntentas, K. Dedeckova, M. Andrilik, M.C. Aznar, B. George, S. Darby, D. Cutter. Predicted Cardiac and Second Cancer Risks in Hodgkin Lymphoma Patients Treated with Advanced Proton Beam Therapy Compared to Photon Radiotherapy. ICML-14, Lugano, Switzerland. Haematological Oncology 35 (S2); June 2017; P173 • G. Ntentas, K. Dedeckova, M. Andrilik, M.C. Aznar, B. George, S. Darby, D. Cutter. Predicted Cardiac and Second Cancer Risks in Hodgkin Lymphoma Patients Treated With Advanced Proton Beam Therapy Compared to Photon Radiation Therapy. ASTRO 59 (2017), San Diego, USA. Vol. 99, Issue 2, S181
Start Year 2016
 
Description Radiation Dose and Outcomes in Breast Cancer 
Organisation Curie Institute Paris (Institut Curie)
Country France 
Sector Academic/University 
PI Contribution Intellectual input to study relating radiation doses to breast cancer outcomes in two randomised trials
Collaborator Contribution data provision
Impact n/a
Start Year 2017
 
Description Radiation Dose and Outcomes in Breast Cancer 
Organisation Korean Radiation Oncology Group
PI Contribution Intellectual input to study relating radiation doses to breast cancer outcomes in two randomised trials
Collaborator Contribution data provision
Impact n/a
Start Year 2017
 
Description Radiation Dose and Outcomes in Breast Cancer 
Organisation Leeds Teaching Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Intellectual input to study relating radiation doses to breast cancer outcomes in two randomised trials
Collaborator Contribution data provision
Impact n/a
Start Year 2017
 
Description Regional Nodal Radiotherapy Early Breast Cancer Trialists Collaborative Group writing committee 
Organisation Center Hospital Lyon Sud
Country France 
Sector Hospitals 
PI Contribution Statistical Analysis. Preparation of Report
Collaborator Contribution Individual patient data meta analysis of regional nodal breast cancer
Impact n/a
Start Year 2016
 
Description Regional Nodal Radiotherapy Early Breast Cancer Trialists Collaborative Group writing committee 
Organisation Curie Institute Paris (Institut Curie)
Country France 
Sector Academic/University 
PI Contribution Statistical Analysis. Preparation of Report
Collaborator Contribution Individual patient data meta analysis of regional nodal breast cancer
Impact n/a
Start Year 2016
 
Description Regional Nodal Radiotherapy Early Breast Cancer Trialists Collaborative Group writing committee 
Organisation Danish Breast Cancer Cooperative Group (DBCG)
Country Denmark 
Sector Academic/University 
PI Contribution Statistical Analysis. Preparation of Report
Collaborator Contribution Individual patient data meta analysis of regional nodal breast cancer
Impact n/a
Start Year 2016
 
Description Regional Nodal Radiotherapy Early Breast Cancer Trialists Collaborative Group writing committee 
Organisation Hospital Saint-Louis
Country France 
Sector Hospitals 
PI Contribution Statistical Analysis. Preparation of Report
Collaborator Contribution Individual patient data meta analysis of regional nodal breast cancer
Impact n/a
Start Year 2016
 
Description Regional Nodal Radiotherapy Early Breast Cancer Trialists Collaborative Group writing committee 
Organisation Leeds Teaching Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution Statistical Analysis. Preparation of Report
Collaborator Contribution Individual patient data meta analysis of regional nodal breast cancer
Impact n/a
Start Year 2016
 
Description Regional Nodal Radiotherapy Early Breast Cancer Trialists Collaborative Group writing committee 
Organisation McMaster University
Country Canada 
Sector Academic/University 
PI Contribution Statistical Analysis. Preparation of Report
Collaborator Contribution Individual patient data meta analysis of regional nodal breast cancer
Impact n/a
Start Year 2016
 
Description Regional Nodal Radiotherapy Early Breast Cancer Trialists Collaborative Group writing committee 
Organisation University of Cambridge
Country United Kingdom 
Sector Academic/University 
PI Contribution Statistical Analysis. Preparation of Report
Collaborator Contribution Individual patient data meta analysis of regional nodal breast cancer
Impact n/a
Start Year 2016
 
Description Sentinel Node Breast Cancer Trialists 
Organisation Derby Teaching Hospitals NHS Foundation Trust
Country United Kingdom 
Sector Public 
PI Contribution None yet
Collaborator Contribution The trialists in the collaboration will provide data as part of an EBCTCG meta-analysis
Impact n/a
Start Year 2017
 
Description Sentinel Node Breast Cancer Trialists 
Organisation German Medical Group
PI Contribution None yet
Collaborator Contribution The trialists in the collaboration will provide data as part of an EBCTCG meta-analysis
Impact n/a
Start Year 2017
 
Description Sentinel Node Breast Cancer Trialists 
Organisation Karolinska Institute
Country Sweden 
Sector Academic/University 
PI Contribution None yet
Collaborator Contribution The trialists in the collaboration will provide data as part of an EBCTCG meta-analysis
Impact n/a
Start Year 2017
 
Description Sentinel Node Breast Cancer Trialists 
Organisation Leeds Teaching Hospitals NHS Trust
Country United Kingdom 
Sector Public 
PI Contribution None yet
Collaborator Contribution The trialists in the collaboration will provide data as part of an EBCTCG meta-analysis
Impact n/a
Start Year 2017
 
Description Sentinel Node Breast Cancer Trialists 
Organisation San Raffaele Hospital
Country Italy 
Sector Hospitals 
PI Contribution None yet
Collaborator Contribution The trialists in the collaboration will provide data as part of an EBCTCG meta-analysis
Impact n/a
Start Year 2017
 
Description University of Florida 
Organisation University of Florida
Country United States 
Sector Academic/University 
PI Contribution Expert review of contouring and developed methods to predict late effects of radiation
Collaborator Contribution UFTPI contributed radiotherapy for data analysis
Impact none yet
Start Year 2015
 
Description University of Texas 
Organisation University of Texas
Department M. D. Anderson Cancer Center
Country United States 
Sector Academic/University 
PI Contribution academic collaboration
Collaborator Contribution provision of experise in retrospective dosimetry and provide doses for case/cohort studies involving over 300 survivors of Hodgkin Lymphoma
Impact none yet
Start Year 2017
 
Description University of Toronto 
Organisation University of Toronto
Country Canada 
Sector Academic/University 
PI Contribution Analysed the data
Collaborator Contribution PMCC contributed radiotherapy data for analysis.
Impact G. Ntentas, M.C. Aznar, D. Hodgson, S.C. Darby, S. Ahmed, A. Ng, D. Cutter. Cardiac Radiation Dose Reconstruction in the Study of Late Effects: A Comparison of Different Methods. ASTRO 59 (September 2017), San Diego, USA. IJROBP Vol. 99, Issue 2, E635
Start Year 2016
 
Description Annual National Oncology Team of the Year 
Form Of Engagement Activity Participation in an activity, workshop or similar
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact David Dodwell was a judge for the Annual National Oncology team of the year award sponsored by the British Medical Organisation. (May 2018)
Year(s) Of Engagement Activity 2018
 
Description British Breast Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Carolyn Taylor is a member of this group which meets twice per year to exchange breast cancer research ideas.
2015-present
Year(s) Of Engagement Activity 2015
 
Description Council of Cardio-Oncology of the European Society of Cardiology 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Marianne Aznar and Sarah Darby became members of the European Society of Cardiology's Council of Cardio-Oncology. This group, which was founded in August 2018 as a multidisciplinary constituent body to encourage the prevention, early diagnosis and management of cancer therapy-related cardiovascular diseases. Its aims are to bring together European & non-European specialists in the field and specialists from Oncology, Hematology, Radiotherapy and related disciplines to enhance the knowledge and the standard of care for Cardio-Oncology patients.
Year(s) Of Engagement Activity 2018
 
Description Council of the International Lymphoma Radiation Oncology Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact Marianne Aznar became a member of the Council for this Group in 2018.
Year(s) Of Engagement Activity 2018
 
Description European Organisation for Research and Treatment of Cancer (EORTC) Radiotherapy Quality Assurance (RT-QA) group. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Marianne Aznar became a member of the EORTC RT-QA group in 2018. Its purpose is to develop guidelines for quality assurance in clinical oncology trials, especially those involving new technologies such as proton therapy and the MR-linac.
Year(s) Of Engagement Activity 2018
 
Description Independent Cancer Patients' Voice 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact Regular meetings with patient representatives from the organisation Independent Cancer Patients' Voice who provide consumer input to our ongoing research.
Year(s) Of Engagement Activity 2018
 
Description Media coverage following NEJM publication: increase in heart disease risk following radiotherapy treatment for cancer 
Form Of Engagement Activity A magazine, newsletter or online publication
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Media (as a channel to the public)
Results and Impact US CBS news website: http://www.cbsnews.com/news/radiation-for-breast-cancer-may-raise-heart-disease-risk-for-women/


Increased awareness amongst patients and oncologists of the increased risk of heart disease in cancer patients who receive radiotherapy.
Year(s) Of Engagement Activity 2013
 
Description Media interview, BBC Radio4 
Form Of Engagement Activity A press release, press conference or response to a media enquiry/interview
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Public/other audiences
Results and Impact July 17 Carolyn Taylor. Interview on BBC 4 "Inside Health" on "Radiotherapy and smoking".
Year(s) Of Engagement Activity 2017
URL http://www.bbc.co.uk/programmes/b08yp16p
 
Description National Audit of Breast Cancer in Older Patients [NABCOP]. 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact David Dodwell is the lead oncologist on this NABCOP. NABCOP is a national clinical audit commissioned by the Healthcare Quality Improvement Partnership (HQIP) to support NHS providers to improve the quality of hospital care for older patients with breast cancer. This has been achieved by publishing information about the care provided by all NHS hospitals that deliver breast cancer care in England and Wales. Date 2018-
Year(s) Of Engagement Activity 2018
 
Description National Cancer Research Institute Breast cancer Clinical Studies Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Carolyn Taylor is a member of this multidisciplinary group of ~40 breast cancer professionals which meets three times per year to coordinate UK trials in breast cancer and to inform priorities, funding and education.
2015-present
Year(s) Of Engagement Activity 2015
 
Description Radiotherapy Information Strategy Group and the Clinical Working Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact David Cutter became a member - and the CTRad Representative - of this group which has been formed to improve the routine collection of radiotherapy data and to facilitate its use in improving services, clinical outcomes and research. Date 2018-
Year(s) Of Engagement Activity 2018
 
Description Secretariat of the Early Breast Cancer Trialists' Collaborative Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Professional Practitioners
Results and Impact The EBCTCG is based in the Nuffield Department of Population Health. It brings together the worldwide randomised data in early breast cancer. The resulting analyses influence breast cancer guidelines worldwide.
Carolyn Taylor is the clinical lead for radiotherapy and surgery within the EBCTCG
2004-present
Year(s) Of Engagement Activity Pre-2006
 
Description Twitter journal club 
Form Of Engagement Activity Engagement focused website, blog or social media channel
Part Of Official Scheme? No
Geographic Reach International
Primary Audience Other audiences
Results and Impact The following publication was the subject of a twitter journal club on 24th January 2016. Taylor, CW, Kirby AM. Cardiac side-effects from breast cancer radiotherapy. Clin Oncol 2015;27:621-9.
It had participation from the USA, Canada, Australia, Singapore, Saudi, UK and Spain

During the day there 465,000 page impressions (ie delivered tweets). Over the week that we first mentioned the journal club there were 1.6 million page impressions with 616 tweets from 180 participants with a big surge over Sunday 24th January
Year(s) Of Engagement Activity 2014
 
Description UK Breast Cancer Group 
Form Of Engagement Activity A formal working group, expert panel or dialogue
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Professional Practitioners
Results and Impact Carolyn Taylor is a member of this national group of breast oncologists which meets annually for breast cancer research updates, and to discuss guidelines.
2015-present
Year(s) Of Engagement Activity 2015
 
Description Visit from Independent Cancer Patients' Voice 
Form Of Engagement Activity Participation in an open day or visit at my research institution
Part Of Official Scheme? No
Geographic Reach National
Primary Audience Patients, carers and/or patient groups
Results and Impact Visit from Independent Cancer Patients' Voice representatives to the unit Monday 9th October. Ongoing intellectual input from them in meetings and teleconferences.
Year(s) Of Engagement Activity 2017